SIMILAR PATTERNS OF AMINO ACIDS FOR 1MZ9_A_VDYA1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides)
PF01266
(DAO)
4 ILE A1022
LEU A1023
VAL A1009
ALA A1168
None
0.94A 1mz9A-1c0iA:
undetectable
1mz9A-1c0iA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)


(Viscum album)
PF00161
(RIP)
4 ILE A 128
LEU A 131
VAL A 135
ALA A  81
None
0.91A 1mz9A-1ce7A:
undetectable
1mz9A-1ce7A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE


(Arabidopsis
thaliana)
PF00709
(Adenylsucc_synt)
4 ILE A  40
LEU A  41
VAL A  24
ALA A 263
None
0.89A 1mz9A-1dj2A:
undetectable
1mz9A-1dj2A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE


(Bacillus
subtilis)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
4 ILE A  72
LEU A  75
VAL A  79
ALA A  87
None
0.62A 1mz9A-1dkrA:
undetectable
1mz9A-1dkrA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE


(Mycobacterium
tuberculosis)
PF01658
(Inos-1-P_synth)
4 ILE A  20
LEU A  30
VAL A  34
ALA A  40
None
0.97A 1mz9A-1gr0A:
undetectable
1mz9A-1gr0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2)
PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb)
4 ILE A 364
LEU A 367
VAL A 371
ALA A 378
None
0.73A 1mz9A-1mu2A:
undetectable
1mz9A-1mu2A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb)
4 ILE B 364
LEU B 367
VAL B 371
ALA B 378
None
0.84A 1mz9A-1mu2B:
undetectable
1mz9A-1mu2B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae)
PF13354
(Beta-lactamase2)
4 ILE A 260
LEU A 190
VAL A  74
ALA A 135
None
0.97A 1mz9A-1n9bA:
undetectable
1mz9A-1n9bA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE


(Mycobacterium
tuberculosis)
PF02548
(Pantoate_transf)
4 ILE A  79
LEU A  82
VAL A  86
ALA A  93
None
0.91A 1mz9A-1oy0A:
1.5
1mz9A-1oy0A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
4 ILE A 150
LEU A 107
VAL A 102
ALA A  97
None
0.95A 1mz9A-1oypA:
undetectable
1mz9A-1oypA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1p EPITHELIAL-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
4 ILE A 209
LEU A 189
VAL A 191
ALA A 194
None
0.99A 1mz9A-1q1pA:
undetectable
1mz9A-1q1pA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida)
PF02633
(Creatininase)
4 ILE A 103
LEU A 106
VAL A 111
ALA A  21
None
0.98A 1mz9A-1q3kA:
undetectable
1mz9A-1q3kA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r03 MITOCHONDRIAL
FERRITIN


(Homo sapiens)
PF00210
(Ferritin)
4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
None
0.78A 1mz9A-1r03A:
undetectable
1mz9A-1r03A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1


(Homo sapiens)
PF00899
(ThiF)
4 ILE A 368
LEU A 365
VAL A 361
ALA A 354
None
0.94A 1mz9A-1r4nA:
undetectable
1mz9A-1r4nA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense)
PF09492
(Pec_lyase)
4 ILE A 179
LEU A 182
VAL A 186
ALA A 190
None
0.79A 1mz9A-1r76A:
undetectable
1mz9A-1r76A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t11 TRIGGER FACTOR

(Vibrio cholerae)
PF00254
(FKBP_C)
PF05697
(Trigger_N)
PF05698
(Trigger_C)
4 ILE A  35
LEU A  32
VAL A  28
ALA A  21
None
0.98A 1mz9A-1t11A:
undetectable
1mz9A-1t11A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taf TFIID TBP ASSOCIATED
FACTOR 62


(Drosophila
melanogaster)
PF02969
(TAF)
4 ILE B  43
LEU B  40
VAL B  36
ALA B  29
None
0.98A 1mz9A-1tafB:
2.3
1mz9A-1tafB:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE


(Escherichia
coli)
PF00291
(PALP)
PF00585
(Thr_dehydrat_C)
4 ILE A 395
LEU A 399
VAL A 343
ALA A 377
None
0.89A 1mz9A-1tdjA:
undetectable
1mz9A-1tdjA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkn AMYLOID BETA A4
PROTEIN


(Homo sapiens)
PF12925
(APP_E2)
4 ILE A 537
LEU A 534
VAL A 530
ALA A 523
None
0.90A 1mz9A-1tknA:
undetectable
1mz9A-1tknA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE


(Pyrobaculum
islandicum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ILE A 332
LEU A 333
VAL A 340
ALA A 346
None
0.87A 1mz9A-1v9lA:
undetectable
1mz9A-1v9lA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ILE A  18
LEU A  19
VAL A  26
ALA A  85
None
0.90A 1mz9A-1vc2A:
undetectable
1mz9A-1vc2A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Pyrobaculum
aerophilum)
PF01791
(DeoC)
4 ILE A 137
LEU A 104
VAL A 107
ALA A  71
None
0.99A 1mz9A-1vcvA:
undetectable
1mz9A-1vcvA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II


(Thermus
thermophilus)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 ILE A 373
LEU A 376
VAL A 380
ALA A 388
None
0.92A 1mz9A-1vdkA:
undetectable
1mz9A-1vdkA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT


(Streptomyces
coelicolor)
PF01039
(Carboxyl_trans)
4 ILE A 336
LEU A 371
VAL A 411
ALA A 495
None
0.99A 1mz9A-1xnyA:
undetectable
1mz9A-1xnyA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4


(Viscum album)
PF00161
(RIP)
4 ILE A 127
LEU A 130
VAL A 134
ALA A  81
None
1.01A 1mz9A-1yf8A:
undetectable
1mz9A-1yf8A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9c STRIATED-MUSCLE
ALPHA TROPOMYOSIN


(Rattus
norvegicus)
PF00261
(Tropomyosin)
4 ILE A 172
LEU A 169
VAL A 165
ALA A 158
None
0.98A 1mz9A-2b9cA:
3.8
1mz9A-2b9cA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR


(Homo sapiens)
PF13516
(LRR_6)
4 ILE A 262
LEU A 233
VAL A 210
ALA A 184
None
0.97A 1mz9A-2bexA:
undetectable
1mz9A-2bexA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum)
PF02156
(Glyco_hydro_26)
4 ILE A  11
LEU A   9
VAL A 250
ALA A 212
None
0.90A 1mz9A-2citA:
undetectable
1mz9A-2citA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2


(Archaeoglobus
fulgidus)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 ILE A 555
LEU A 552
VAL A 548
ALA A 542
None
0.86A 1mz9A-2f3oA:
undetectable
1mz9A-2f3oA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT


(Mycobacterium
tuberculosis)
no annotation 4 ILE H 380
LEU H 383
VAL H 387
ALA H 393
None
0.93A 1mz9A-2fhgH:
undetectable
1mz9A-2fhgH:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT


(Mycobacterium
tuberculosis)
no annotation 4 ILE H 380
LEU H 383
VAL H 387
ALA H 394
None
0.97A 1mz9A-2fhgH:
undetectable
1mz9A-2fhgH:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE


(Bifidobacterium
adolescentis)
PF00128
(Alpha-amylase)
PF09244
(DUF1964)
4 ILE A 229
LEU A 227
VAL A 186
ALA A  72
None
1.00A 1mz9A-2gduA:
undetectable
1mz9A-2gduA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL


(Rattus
norvegicus)
PF00755
(Carn_acyltransf)
4 ILE A 647
LEU A 644
VAL A 640
ALA A 633
None
0.94A 1mz9A-2h4tA:
undetectable
1mz9A-2h4tA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis)
PF00227
(Proteasome)
4 ILE A 137
LEU A 140
VAL A 144
ALA A 150
None
0.72A 1mz9A-2jayA:
undetectable
1mz9A-2jayA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
4 ILE A  86
LEU A  89
VAL A  93
ALA A 101
None
0.65A 1mz9A-2ji4A:
undetectable
1mz9A-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
2-BINDING PROTEIN


(Homo sapiens)
PF11527
(ARL2_Bind_BART)
4 ILE A  31
LEU A  28
VAL A  24
ALA A  16
None
0.75A 1mz9A-2k9aA:
undetectable
1mz9A-2k9aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii)
PF01095
(Pectinesterase)
4 ILE A 201
LEU A 180
VAL A 159
ALA A 119
None
0.87A 1mz9A-2ntbA:
undetectable
1mz9A-2ntbA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A 189
LEU A 186
VAL A 182
ALA A 175
None
0.77A 1mz9A-2v55A:
undetectable
1mz9A-2v55A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE


(Mycolicibacterium
smegmatis)
PF09334
(tRNA-synt_1g)
4 ILE A 460
LEU A 396
VAL A 400
ALA A 408
None
1.00A 1mz9A-2x1mA:
undetectable
1mz9A-2x1mA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE


(Arabidopsis
thaliana)
PF06090
(Ins_P5_2-kin)
4 ILE A 307
LEU A 304
VAL A 300
ALA A 294
None
0.83A 1mz9A-2xalA:
undetectable
1mz9A-2xalA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5)
4 ILE A  94
LEU A  96
VAL A  98
ALA A 101
None
0.92A 1mz9A-2zj8A:
undetectable
1mz9A-2zj8A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE


(Methanocaldococcus
jannaschii)
PF08433
(KTI12)
4 ILE A  23
LEU A  24
VAL A  31
ALA A  65
None
0.90A 1mz9A-3adcA:
undetectable
1mz9A-3adcA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus)
no annotation 4 ILE A 613
LEU A 610
VAL A 606
ALA A 599
None
0.74A 1mz9A-3afbA:
undetectable
1mz9A-3afbA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cje OSMC-LIKE PROTEIN

(Jannaschia sp.
CCS1)
PF02566
(OsmC)
4 ILE A  66
LEU A  69
VAL A  73
ALA A 136
None
0.93A 1mz9A-3cjeA:
undetectable
1mz9A-3cjeA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus)
PF10103
(Zincin_2)
4 ILE A 293
LEU A 292
VAL A 353
ALA A 359
None
0.86A 1mz9A-3cmnA:
undetectable
1mz9A-3cmnA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE


(Oceanobacillus
iheyensis)
PF00701
(DHDPS)
4 ILE A  28
LEU A  33
VAL A  72
ALA A  80
None
0.98A 1mz9A-3d0cA:
undetectable
1mz9A-3d0cA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8l ORF12

(Lactococcus
virus P2)
no annotation 4 ILE A  37
LEU A  40
VAL A  44
ALA A  51
None
0.96A 1mz9A-3d8lA:
undetectable
1mz9A-3d8lA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570


(Thermotoga
maritima)
PF09936
(Methyltrn_RNA_4)
4 ILE X 108
LEU X 137
VAL X   7
ALA X  35
None
1.01A 1mz9A-3dcmX:
undetectable
1mz9A-3dcmX:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1


(Homo sapiens)
PF00435
(Spectrin)
4 ILE A1853
LEU A1856
VAL A1860
ALA A1867
None
0.76A 1mz9A-3edvA:
undetectable
1mz9A-3edvA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis)
PF00190
(Cupin_1)
4 ILE A 438
LEU A 439
VAL A 428
ALA A 461
None
0.95A 1mz9A-3ehkA:
undetectable
1mz9A-3ehkA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris)
PF00696
(AA_kinase)
4 ILE A  31
LEU A  34
VAL A  38
ALA A  46
None
0.62A 1mz9A-3ek5A:
undetectable
1mz9A-3ek5A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7p NITROGEN FIXATION
PROTEIN


(Acidithiobacillus
ferrooxidans)
PF03270
(DUF269)
4 ILE A 146
LEU A 143
VAL A 139
ALA A 132
None
0.84A 1mz9A-3g7pA:
undetectable
1mz9A-3g7pA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus)
PF00724
(Oxidored_FMN)
4 ILE A  82
LEU A  85
VAL A  89
ALA A  97
None
0.95A 1mz9A-3gr8A:
undetectable
1mz9A-3gr8A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1


(Staphylococcus
aureus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ILE A 243
LEU A 240
VAL A 236
ALA A 231
None
None
NAD  A 500 (-4.2A)
NAD  A 500 ( 4.5A)
0.82A 1mz9A-3h3jA:
undetectable
1mz9A-3h3jA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus)
PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD)
4 ILE A 764
LEU A1110
VAL A1103
ALA A 933
None
0.78A 1mz9A-3jclA:
undetectable
1mz9A-3jclA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6b BETA-AMYLOID-LIKE
PROTEIN


(Caenorhabditis
elegans)
PF12925
(APP_E2)
4 ILE A 406
LEU A 403
VAL A 399
ALA A 392
None
0.94A 1mz9A-3k6bA:
3.0
1mz9A-3k6bA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN


(Mycobacterium
tuberculosis)
PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
4 ILE A 186
LEU A 190
VAL A 155
ALA A 144
None
0.99A 1mz9A-3l2zA:
undetectable
1mz9A-3l2zA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ILE A 243
LEU A 240
VAL A 236
ALA A 231
None
0.85A 1mz9A-3pqdA:
undetectable
1mz9A-3pqdA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A


(Homo sapiens)
PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind)
4 ILE A 395
LEU A 365
VAL A 367
ALA A 315
None
1.00A 1mz9A-3t1iA:
undetectable
1mz9A-3t1iA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF00581
(Rhodanese)
PF00753
(Lactamase_B)
4 ILE A 345
LEU A 342
VAL A 338
ALA A 331
None
1.01A 1mz9A-3tp9A:
undetectable
1mz9A-3tp9A:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II


(Burkholderia
pseudomallei)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
4 ILE A 431
LEU A 428
VAL A 424
ALA A 417
None
0.94A 1mz9A-3tv2A:
undetectable
1mz9A-3tv2A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE


(Salmonella
enterica)
PF02769
(AIRS_C)
PF13507
(GATase_5)
4 ILE A 723
LEU A 720
VAL A 716
ALA A 759
None
0.98A 1mz9A-3ummA:
undetectable
1mz9A-3ummA:
3.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v2p CARTILAGE
OLIGOMERIZATION
MATRIX PROTEIN
(COILED-COIL DOMAIN)


(Mus musculus)
PF11598
(COMP)
4 ILE A  58
LEU A  61
VAL A  65
ALA A  70
None
0.17A 1mz9A-3v2pA:
6.1
1mz9A-3v2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnw FERRITIN HEAVY CHAIN

(Mus musculus)
PF00210
(Ferritin)
4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
None
0.80A 1mz9A-3wnwA:
undetectable
1mz9A-3wnwA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
4 ILE L 101
LEU L  83
VAL L  87
ALA L  93
None
1.00A 1mz9A-3wxrL:
undetectable
1mz9A-3wxrL:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE


(Trichoderma
reesei)
PF00704
(Glyco_hydro_18)
4 ILE X 234
LEU X 239
VAL X 279
ALA X  36
None
None
None
ACT  X1290 (-4.4A)
0.84A 1mz9A-4ac1X:
undetectable
1mz9A-4ac1X:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi)
PF05714
(Borrelia_lipo_1)
4 ILE A 100
LEU A 103
VAL A 107
ALA A 116
None
0.87A 1mz9A-4bg5A:
undetectable
1mz9A-4bg5A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Synechococcus
elongatus)
PF13561
(adh_short_C2)
4 ILE A 208
LEU A 246
VAL A 146
ALA A 163
None
0.97A 1mz9A-4dmmA:
undetectable
1mz9A-4dmmA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyx FERRITIN HEAVY CHAIN

(Homo sapiens)
PF00210
(Ferritin)
4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
None
0.83A 1mz9A-4dyxA:
undetectable
1mz9A-4dyxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ILE A  49
LEU A  46
VAL A  42
ALA A  36
None
0.95A 1mz9A-4e0bA:
undetectable
1mz9A-4e0bA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ


(Thermobifida
fusca)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
4 ILE A 148
LEU A 151
VAL A 155
ALA A 123
None
0.74A 1mz9A-4e6eA:
undetectable
1mz9A-4e6eA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebj AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE


(Pseudomonas
aeruginosa)
PF01909
(NTP_transf_2)
4 ILE A 165
LEU A 162
VAL A 158
ALA A 151
None
0.79A 1mz9A-4ebjA:
undetectable
1mz9A-4ebjA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13


(Candida
albicans)
PF09084
(NMT1)
4 ILE A 224
LEU A 221
VAL A 217
ALA A 211
None
0.93A 1mz9A-4eswA:
undetectable
1mz9A-4eswA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri)
no annotation 4 ILE A 165
LEU A 162
VAL A 158
ALA A 151
None
0.78A 1mz9A-4gjiA:
undetectable
1mz9A-4gjiA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica)
PF04261
(Dyp_perox)
4 ILE A  87
LEU A 184
VAL A 140
ALA A  68
None
0.88A 1mz9A-4gs1A:
undetectable
1mz9A-4gs1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyc SENSORY RHODOPSIN II
TRANSDUCER


(Natronomonas
pharaonis)
no annotation 4 ILE B  68
LEU B  65
VAL B  61
ALA B  54
None
0.98A 1mz9A-4gycB:
2.6
1mz9A-4gycB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus)
PF13472
(Lipase_GDSL_2)
4 ILE A 189
LEU A 140
VAL A 138
ALA A 135
None
0.97A 1mz9A-4hyqA:
undetectable
1mz9A-4hyqA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens)
PF00082
(Peptidase_S8)
4 ILE B 530
LEU B 529
VAL B 500
ALA B 191
None
1.01A 1mz9A-4i0wB:
undetectable
1mz9A-4i0wB:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ


(Homo sapiens)
PF00102
(Y_phosphatase)
4 ILE A2726
LEU A2725
VAL A2723
ALA A2753
None
0.99A 1mz9A-4ikcA:
undetectable
1mz9A-4ikcA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN


(Viscum album)
PF00161
(RIP)
4 ILE A 132
LEU A 135
VAL A 139
ALA A  82
None
0.92A 1mz9A-4jkxA:
undetectable
1mz9A-4jkxA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
4 ILE A 181
LEU A 184
VAL A 188
ALA A 196
None
0.71A 1mz9A-4kpgA:
undetectable
1mz9A-4kpgA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE


(Xanthomonas
oryzae)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
4 ILE A 175
LEU A 174
VAL A 220
ALA A 187
None
0.94A 1mz9A-4l1kA:
undetectable
1mz9A-4l1kA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE


(Rhodococcus
opacus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ILE A 187
LEU A 184
VAL A 180
ALA A 173
None
0.91A 1mz9A-4m0xA:
undetectable
1mz9A-4m0xA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE


([Bacillus]
selenitireducens)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ILE A 247
LEU A 248
VAL A  29
ALA A  58
None
1.01A 1mz9A-4m1qA:
undetectable
1mz9A-4m1qA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
4 ILE A 181
LEU A 184
VAL A 188
ALA A 196
None
0.89A 1mz9A-4m1zA:
undetectable
1mz9A-4m1zA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7a U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7


(Saccharomyces
cerevisiae)
PF01423
(LSM)
4 ILE F  98
LEU F  42
VAL F  40
ALA F 105
None
0.82A 1mz9A-4m7aF:
undetectable
1mz9A-4m7aF:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN


(Klebsiella
pneumoniae)
PF02826
(2-Hacid_dh_C)
4 ILE A 270
LEU A 262
VAL A 234
ALA A 208
None
1.01A 1mz9A-4n18A:
undetectable
1mz9A-4n18A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 ILE A 665
LEU A 664
VAL A 545
ALA A 616
None
1.00A 1mz9A-4oqjA:
undetectable
1mz9A-4oqjA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A


(Pseudomonas
mendocina)
PF02332
(Phenol_Hydrox)
4 ILE A 246
LEU A 242
VAL A 258
ALA A 265
None
0.97A 1mz9A-4p1cA:
undetectable
1mz9A-4p1cA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE


(Escherichia
coli)
PF06315
(AceK)
4 ILE A 173
LEU A 153
VAL A 156
ALA A 140
None
0.96A 1mz9A-4p69A:
undetectable
1mz9A-4p69A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE


(Francisella
tularensis)
PF00809
(Pterin_bind)
PF01288
(HPPK)
4 ILE A 201
LEU A 197
VAL A 176
ALA A 212
None
0.94A 1mz9A-4pzvA:
undetectable
1mz9A-4pzvA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1


(Saccharomyces
cerevisiae)
PF02127
(Peptidase_M18)
4 ILE A 245
LEU A 253
VAL A 446
ALA A 267
None
0.95A 1mz9A-4r8fA:
undetectable
1mz9A-4r8fA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd9 AMYLOID-LIKE PROTEIN
1


(Homo sapiens)
PF12925
(APP_E2)
4 ILE A 456
LEU A 453
VAL A 449
ALA A 442
None
0.99A 1mz9A-4rd9A:
1.9
1mz9A-4rd9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkf RAS-RELATED PROTEIN
RAB-3


(Drosophila
melanogaster)
PF00071
(Ras)
4 ILE A 181
LEU A 178
VAL A 174
ALA A 165
None
None
None
GNP  A 201 (-3.7A)
0.95A 1mz9A-4rkfA:
undetectable
1mz9A-4rkfA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsj CHROMOSOME PARTITION
PROTEIN SMC


(Pyrococcus
furiosus)
PF06470
(SMC_hinge)
4 ILE A 530
LEU A 526
VAL A 553
ALA A 560
None
0.99A 1mz9A-4rsjA:
2.7
1mz9A-4rsjA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE


(Actinoplanes
teichomyceticus)
PF00668
(Condensation)
4 ILE B 457
LEU B 455
VAL B 444
ALA B 251
None
0.92A 1mz9A-4tx2B:
undetectable
1mz9A-4tx2B:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA


(Shewanella
loihica)
PF01156
(IU_nuc_hydro)
4 ILE A 123
LEU A 121
VAL A 215
ALA A 220
None
0.95A 1mz9A-4wr2A:
undetectable
1mz9A-4wr2A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY


(Trichoderma
reesei)
PF13426
(PAS_9)
4 ILE A  81
LEU A  78
VAL A  74
ALA A  69
None
0.91A 1mz9A-4wujA:
undetectable
1mz9A-4wujA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1


(Homo sapiens)
PF06367
(Drf_FH3)
PF06371
(Drf_GBD)
4 ILE A  84
LEU A  87
VAL A  91
ALA A 214
None
0.81A 1mz9A-4ydhA:
undetectable
1mz9A-4ydhA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn0 AMYLOID BETA A4
PROTEIN


(Mus musculus)
PF12925
(APP_E2)
4 ILE B 462
LEU B 459
VAL B 455
ALA B 449
None
0.97A 1mz9A-4yn0B:
3.3
1mz9A-4yn0B:
10.62