SIMILAR PATTERNS OF AMINO ACIDS FOR 1MZ9_A_VDYA1002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 ILE A1022
LEU A1023
VAL A1009
ALA A1168
 None
 0.94A 1mz9A-1c0iA:
undetectable		 1mz9A-1c0iA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		4 ILE A 128
LEU A 131
VAL A 135
ALA A  81
 None
 0.91A 1mz9A-1ce7A:
undetectable		 1mz9A-1ce7A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		4 ILE A  40
LEU A  41
VAL A  24
ALA A 263
 None
 0.89A 1mz9A-1dj2A:
undetectable		 1mz9A-1dj2A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ILE A  72
LEU A  75
VAL A  79
ALA A  87
 None
 0.62A 1mz9A-1dkrA:
undetectable		 1mz9A-1dkrA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		4 ILE A  20
LEU A  30
VAL A  34
ALA A  40
 None
 0.97A 1mz9A-1gr0A:
undetectable		 1mz9A-1gr0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ILE A 364
LEU A 367
VAL A 371
ALA A 378
 None
 0.73A 1mz9A-1mu2A:
undetectable		 1mz9A-1mu2A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ILE B 364
LEU B 367
VAL B 371
ALA B 378
 None
 0.84A 1mz9A-1mu2B:
undetectable		 1mz9A-1mu2B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		4 ILE A 260
LEU A 190
VAL A  74
ALA A 135
 None
 0.97A 1mz9A-1n9bA:
undetectable		 1mz9A-1n9bA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE

(Mycobacterium
tuberculosis) 		PF02548
(Pantoate_transf) 		4 ILE A  79
LEU A  82
VAL A  86
ALA A  93
 None
 0.91A 1mz9A-1oy0A:
1.5		 1mz9A-1oy0A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ILE A 150
LEU A 107
VAL A 102
ALA A  97
 None
 0.95A 1mz9A-1oypA:
undetectable		 1mz9A-1oypA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1p EPITHELIAL-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ILE A 209
LEU A 189
VAL A 191
ALA A 194
 None
 0.99A 1mz9A-1q1pA:
undetectable		 1mz9A-1q1pA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida) 		PF02633
(Creatininase) 		4 ILE A 103
LEU A 106
VAL A 111
ALA A  21
 None
 0.98A 1mz9A-1q3kA:
undetectable		 1mz9A-1q3kA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r03 MITOCHONDRIAL
FERRITIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.78A 1mz9A-1r03A:
undetectable		 1mz9A-1r03A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		4 ILE A 368
LEU A 365
VAL A 361
ALA A 354
 None
 0.94A 1mz9A-1r4nA:
undetectable		 1mz9A-1r4nA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		4 ILE A 179
LEU A 182
VAL A 186
ALA A 190
 None
 0.79A 1mz9A-1r76A:
undetectable		 1mz9A-1r76A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t11 TRIGGER FACTOR

(Vibrio cholerae) 		PF00254
(FKBP_C)
PF05697
(Trigger_N)
PF05698
(Trigger_C) 		4 ILE A  35
LEU A  32
VAL A  28
ALA A  21
 None
 0.98A 1mz9A-1t11A:
undetectable		 1mz9A-1t11A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taf TFIID TBP ASSOCIATED
FACTOR 62

(Drosophila
melanogaster) 		PF02969
(TAF) 		4 ILE B  43
LEU B  40
VAL B  36
ALA B  29
 None
 0.98A 1mz9A-1tafB:
2.3		 1mz9A-1tafB:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		4 ILE A 395
LEU A 399
VAL A 343
ALA A 377
 None
 0.89A 1mz9A-1tdjA:
undetectable		 1mz9A-1tdjA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkn AMYLOID BETA A4
PROTEIN

(Homo sapiens) 		PF12925
(APP_E2) 		4 ILE A 537
LEU A 534
VAL A 530
ALA A 523
 None
 0.90A 1mz9A-1tknA:
undetectable		 1mz9A-1tknA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ILE A 332
LEU A 333
VAL A 340
ALA A 346
 None
 0.87A 1mz9A-1v9lA:
undetectable		 1mz9A-1v9lA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE A  18
LEU A  19
VAL A  26
ALA A  85
 None
 0.90A 1mz9A-1vc2A:
undetectable		 1mz9A-1vc2A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Pyrobaculum
aerophilum) 		PF01791
(DeoC) 		4 ILE A 137
LEU A 104
VAL A 107
ALA A  71
 None
 0.99A 1mz9A-1vcvA:
undetectable		 1mz9A-1vcvA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A 373
LEU A 376
VAL A 380
ALA A 388
 None
 0.92A 1mz9A-1vdkA:
undetectable		 1mz9A-1vdkA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		4 ILE A 336
LEU A 371
VAL A 411
ALA A 495
 None
 0.99A 1mz9A-1xnyA:
undetectable		 1mz9A-1xnyA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4

(Viscum album) 		PF00161
(RIP) 		4 ILE A 127
LEU A 130
VAL A 134
ALA A  81
 None
 1.01A 1mz9A-1yf8A:
undetectable		 1mz9A-1yf8A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9c STRIATED-MUSCLE
ALPHA TROPOMYOSIN

(Rattus
norvegicus) 		PF00261
(Tropomyosin) 		4 ILE A 172
LEU A 169
VAL A 165
ALA A 158
 None
 0.98A 1mz9A-2b9cA:
3.8		 1mz9A-2b9cA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		4 ILE A 262
LEU A 233
VAL A 210
ALA A 184
 None
 0.97A 1mz9A-2bexA:
undetectable		 1mz9A-2bexA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF02156
(Glyco_hydro_26) 		4 ILE A  11
LEU A   9
VAL A 250
ALA A 212
 None
 0.90A 1mz9A-2citA:
undetectable		 1mz9A-2citA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 555
LEU A 552
VAL A 548
ALA A 542
 None
 0.86A 1mz9A-2f3oA:
undetectable		 1mz9A-2f3oA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 ILE H 380
LEU H 383
VAL H 387
ALA H 393
 None
 0.93A 1mz9A-2fhgH:
undetectable		 1mz9A-2fhgH:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 ILE H 380
LEU H 383
VAL H 387
ALA H 394
 None
 0.97A 1mz9A-2fhgH:
undetectable		 1mz9A-2fhgH:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 ILE A 229
LEU A 227
VAL A 186
ALA A  72
 None
 1.00A 1mz9A-2gduA:
undetectable		 1mz9A-2gduA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 ILE A 647
LEU A 644
VAL A 640
ALA A 633
 None
 0.94A 1mz9A-2h4tA:
undetectable		 1mz9A-2h4tA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis) 		PF00227
(Proteasome) 		4 ILE A 137
LEU A 140
VAL A 144
ALA A 150
 None
 0.72A 1mz9A-2jayA:
undetectable		 1mz9A-2jayA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ILE A  86
LEU A  89
VAL A  93
ALA A 101
 None
 0.65A 1mz9A-2ji4A:
undetectable		 1mz9A-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
2-BINDING PROTEIN

(Homo sapiens) 		PF11527
(ARL2_Bind_BART) 		4 ILE A  31
LEU A  28
VAL A  24
ALA A  16
 None
 0.75A 1mz9A-2k9aA:
undetectable		 1mz9A-2k9aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		4 ILE A 201
LEU A 180
VAL A 159
ALA A 119
 None
 0.87A 1mz9A-2ntbA:
undetectable		 1mz9A-2ntbA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 189
LEU A 186
VAL A 182
ALA A 175
 None
 0.77A 1mz9A-2v55A:
undetectable		 1mz9A-2v55A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		4 ILE A 460
LEU A 396
VAL A 400
ALA A 408
 None
 1.00A 1mz9A-2x1mA:
undetectable		 1mz9A-2x1mA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Arabidopsis
thaliana) 		PF06090
(Ins_P5_2-kin) 		4 ILE A 307
LEU A 304
VAL A 300
ALA A 294
 None
 0.83A 1mz9A-2xalA:
undetectable		 1mz9A-2xalA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ILE A  94
LEU A  96
VAL A  98
ALA A 101
 None
 0.92A 1mz9A-2zj8A:
undetectable		 1mz9A-2zj8A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		4 ILE A  23
LEU A  24
VAL A  31
ALA A  65
 None
 0.90A 1mz9A-3adcA:
undetectable		 1mz9A-3adcA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 4 ILE A 613
LEU A 610
VAL A 606
ALA A 599
 None
 0.74A 1mz9A-3afbA:
undetectable		 1mz9A-3afbA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cje OSMC-LIKE PROTEIN

(Jannaschia sp.
CCS1) 		PF02566
(OsmC) 		4 ILE A  66
LEU A  69
VAL A  73
ALA A 136
 None
 0.93A 1mz9A-3cjeA:
undetectable		 1mz9A-3cjeA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		4 ILE A 293
LEU A 292
VAL A 353
ALA A 359
 None
 0.86A 1mz9A-3cmnA:
undetectable		 1mz9A-3cmnA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 ILE A  28
LEU A  33
VAL A  72
ALA A  80
 None
 0.98A 1mz9A-3d0cA:
undetectable		 1mz9A-3d0cA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8l ORF12

(Lactococcus
virus P2) 		no annotation 4 ILE A  37
LEU A  40
VAL A  44
ALA A  51
 None
 0.96A 1mz9A-3d8lA:
undetectable		 1mz9A-3d8lA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570

(Thermotoga
maritima) 		PF09936
(Methyltrn_RNA_4) 		4 ILE X 108
LEU X 137
VAL X   7
ALA X  35
 None
 1.01A 1mz9A-3dcmX:
undetectable		 1mz9A-3dcmX:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		4 ILE A1853
LEU A1856
VAL A1860
ALA A1867
 None
 0.76A 1mz9A-3edvA:
undetectable		 1mz9A-3edvA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		4 ILE A 438
LEU A 439
VAL A 428
ALA A 461
 None
 0.95A 1mz9A-3ehkA:
undetectable		 1mz9A-3ehkA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		4 ILE A  31
LEU A  34
VAL A  38
ALA A  46
 None
 0.62A 1mz9A-3ek5A:
undetectable		 1mz9A-3ek5A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7p NITROGEN FIXATION
PROTEIN

(Acidithiobacillus
ferrooxidans) 		PF03270
(DUF269) 		4 ILE A 146
LEU A 143
VAL A 139
ALA A 132
 None
 0.84A 1mz9A-3g7pA:
undetectable		 1mz9A-3g7pA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 ILE A  82
LEU A  85
VAL A  89
ALA A  97
 None
 0.95A 1mz9A-3gr8A:
undetectable		 1mz9A-3gr8A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 243
LEU A 240
VAL A 236
ALA A 231
 None
None
NAD  A 500 (-4.2A)
NAD  A 500 ( 4.5A)
 0.82A 1mz9A-3h3jA:
undetectable		 1mz9A-3h3jA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 ILE A 764
LEU A1110
VAL A1103
ALA A 933
 None
 0.78A 1mz9A-3jclA:
undetectable		 1mz9A-3jclA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6b BETA-AMYLOID-LIKE
PROTEIN

(Caenorhabditis
elegans) 		PF12925
(APP_E2) 		4 ILE A 406
LEU A 403
VAL A 399
ALA A 392
 None
 0.94A 1mz9A-3k6bA:
3.0		 1mz9A-3k6bA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ILE A 186
LEU A 190
VAL A 155
ALA A 144
 None
 0.99A 1mz9A-3l2zA:
undetectable		 1mz9A-3l2zA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 243
LEU A 240
VAL A 236
ALA A 231
 None
 0.85A 1mz9A-3pqdA:
undetectable		 1mz9A-3pqdA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A

(Homo sapiens) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 ILE A 395
LEU A 365
VAL A 367
ALA A 315
 None
 1.00A 1mz9A-3t1iA:
undetectable		 1mz9A-3t1iA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 ILE A 345
LEU A 342
VAL A 338
ALA A 331
 None
 1.01A 1mz9A-3tp9A:
undetectable		 1mz9A-3tp9A:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A 431
LEU A 428
VAL A 424
ALA A 417
 None
 0.94A 1mz9A-3tv2A:
undetectable		 1mz9A-3tv2A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ILE A 723
LEU A 720
VAL A 716
ALA A 759
 None
 0.98A 1mz9A-3ummA:
undetectable		 1mz9A-3ummA:
3.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v2p CARTILAGE
OLIGOMERIZATION
MATRIX PROTEIN
(COILED-COIL DOMAIN)

(Mus musculus) 		PF11598
(COMP) 		4 ILE A  58
LEU A  61
VAL A  65
ALA A  70
 None
 0.17A 1mz9A-3v2pA:
6.1		 1mz9A-3v2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnw FERRITIN HEAVY CHAIN

(Mus musculus) 		PF00210
(Ferritin) 		4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.80A 1mz9A-3wnwA:
undetectable		 1mz9A-3wnwA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 ILE L 101
LEU L  83
VAL L  87
ALA L  93
 None
 1.00A 1mz9A-3wxrL:
undetectable		 1mz9A-3wxrL:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		4 ILE X 234
LEU X 239
VAL X 279
ALA X  36
 None
None
None
ACT  X1290 (-4.4A)
 0.84A 1mz9A-4ac1X:
undetectable		 1mz9A-4ac1X:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 ILE A 100
LEU A 103
VAL A 107
ALA A 116
 None
 0.87A 1mz9A-4bg5A:
undetectable		 1mz9A-4bg5A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Synechococcus
elongatus) 		PF13561
(adh_short_C2) 		4 ILE A 208
LEU A 246
VAL A 146
ALA A 163
 None
 0.97A 1mz9A-4dmmA:
undetectable		 1mz9A-4dmmA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyx FERRITIN HEAVY CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.83A 1mz9A-4dyxA:
undetectable		 1mz9A-4dyxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A  49
LEU A  46
VAL A  42
ALA A  36
 None
 0.95A 1mz9A-4e0bA:
undetectable		 1mz9A-4e0bA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A 148
LEU A 151
VAL A 155
ALA A 123
 None
 0.74A 1mz9A-4e6eA:
undetectable		 1mz9A-4e6eA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebj AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF01909
(NTP_transf_2) 		4 ILE A 165
LEU A 162
VAL A 158
ALA A 151
 None
 0.79A 1mz9A-4ebjA:
undetectable		 1mz9A-4ebjA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		4 ILE A 224
LEU A 221
VAL A 217
ALA A 211
 None
 0.93A 1mz9A-4eswA:
undetectable		 1mz9A-4eswA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 4 ILE A 165
LEU A 162
VAL A 158
ALA A 151
 None
 0.78A 1mz9A-4gjiA:
undetectable		 1mz9A-4gjiA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		4 ILE A  87
LEU A 184
VAL A 140
ALA A  68
 None
 0.88A 1mz9A-4gs1A:
undetectable		 1mz9A-4gs1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyc SENSORY RHODOPSIN II
TRANSDUCER

(Natronomonas
pharaonis) 		no annotation 4 ILE B  68
LEU B  65
VAL B  61
ALA B  54
 None
 0.98A 1mz9A-4gycB:
2.6		 1mz9A-4gycB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 189
LEU A 140
VAL A 138
ALA A 135
 None
 0.97A 1mz9A-4hyqA:
undetectable		 1mz9A-4hyqA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 ILE B 530
LEU B 529
VAL B 500
ALA B 191
 None
 1.01A 1mz9A-4i0wB:
undetectable		 1mz9A-4i0wB:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ILE A2726
LEU A2725
VAL A2723
ALA A2753
 None
 0.99A 1mz9A-4ikcA:
undetectable		 1mz9A-4ikcA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		4 ILE A 132
LEU A 135
VAL A 139
ALA A  82
 None
 0.92A 1mz9A-4jkxA:
undetectable		 1mz9A-4jkxA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 ILE A 181
LEU A 184
VAL A 188
ALA A 196
 None
 0.71A 1mz9A-4kpgA:
undetectable		 1mz9A-4kpgA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ILE A 175
LEU A 174
VAL A 220
ALA A 187
 None
 0.94A 1mz9A-4l1kA:
undetectable		 1mz9A-4l1kA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 187
LEU A 184
VAL A 180
ALA A 173
 None
 0.91A 1mz9A-4m0xA:
undetectable		 1mz9A-4m0xA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE

([Bacillus]
selenitireducens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 247
LEU A 248
VAL A  29
ALA A  58
 None
 1.01A 1mz9A-4m1qA:
undetectable		 1mz9A-4m1qA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 ILE A 181
LEU A 184
VAL A 188
ALA A 196
 None
 0.89A 1mz9A-4m1zA:
undetectable		 1mz9A-4m1zA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7a U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		4 ILE F  98
LEU F  42
VAL F  40
ALA F 105
 None
 0.82A 1mz9A-4m7aF:
undetectable		 1mz9A-4m7aF:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		4 ILE A 270
LEU A 262
VAL A 234
ALA A 208
 None
 1.01A 1mz9A-4n18A:
undetectable		 1mz9A-4n18A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 665
LEU A 664
VAL A 545
ALA A 616
 None
 1.00A 1mz9A-4oqjA:
undetectable		 1mz9A-4oqjA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		4 ILE A 246
LEU A 242
VAL A 258
ALA A 265
 None
 0.97A 1mz9A-4p1cA:
undetectable		 1mz9A-4p1cA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		4 ILE A 173
LEU A 153
VAL A 156
ALA A 140
 None
 0.96A 1mz9A-4p69A:
undetectable		 1mz9A-4p69A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 ILE A 201
LEU A 197
VAL A 176
ALA A 212
 None
 0.94A 1mz9A-4pzvA:
undetectable		 1mz9A-4pzvA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		4 ILE A 245
LEU A 253
VAL A 446
ALA A 267
 None
 0.95A 1mz9A-4r8fA:
undetectable		 1mz9A-4r8fA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd9 AMYLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF12925
(APP_E2) 		4 ILE A 456
LEU A 453
VAL A 449
ALA A 442
 None
 0.99A 1mz9A-4rd9A:
1.9		 1mz9A-4rd9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkf RAS-RELATED PROTEIN
RAB-3

(Drosophila
melanogaster) 		PF00071
(Ras) 		4 ILE A 181
LEU A 178
VAL A 174
ALA A 165
 None
None
None
GNP  A 201 (-3.7A)
 0.95A 1mz9A-4rkfA:
undetectable		 1mz9A-4rkfA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsj CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		4 ILE A 530
LEU A 526
VAL A 553
ALA A 560
 None
 0.99A 1mz9A-4rsjA:
2.7		 1mz9A-4rsjA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 ILE B 457
LEU B 455
VAL B 444
ALA B 251
 None
 0.92A 1mz9A-4tx2B:
undetectable		 1mz9A-4tx2B:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		4 ILE A 123
LEU A 121
VAL A 215
ALA A 220
 None
 0.95A 1mz9A-4wr2A:
undetectable		 1mz9A-4wr2A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		4 ILE A  81
LEU A  78
VAL A  74
ALA A  69
 None
 0.91A 1mz9A-4wujA:
undetectable		 1mz9A-4wujA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 ILE A  84
LEU A  87
VAL A  91
ALA A 214
 None
 0.81A 1mz9A-4ydhA:
undetectable		 1mz9A-4ydhA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn0 AMYLOID BETA A4
PROTEIN

(Mus musculus) 		PF12925
(APP_E2) 		4 ILE B 462
LEU B 459
VAL B 455
ALA B 449
 None
 0.97A 1mz9A-4yn0B:
3.3		 1mz9A-4yn0B:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avy FIBRITIN

(Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 ILE A 443
LEU A 446
VAL A 450
 None
 0.44A 1mz9B-1avyA:
2.1		 1mz9B-1avyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 ILE A 377
LEU A 380
VAL A 384
 None
 0.39A 1mz9B-1cbgA:
undetectable		 1mz9B-1cbgA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnt CILIARY NEUROTROPHIC
FACTOR

(Homo sapiens) 		PF01110
(CNTF) 		3 ILE 1 109
LEU 1 112
VAL 1 116
 None
 0.16A 1mz9B-1cnt1:
undetectable		 1mz9B-1cnt1:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgr CANAVALIN

(Canavalia
ensiformis) 		no annotation 3 ILE X 268
LEU X 283
VAL Y 365
 None
 0.42A 1mz9B-1dgrX:
undetectable		 1mz9B-1dgrX:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 ILE A  72
LEU A  75
VAL A  79
 None
 0.23A 1mz9B-1dkrA:
undetectable		 1mz9B-1dkrA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em9 GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 3 ILE A  19
LEU A  22
VAL A  26
 None
 0.37A 1mz9B-1em9A:
0.0		 1mz9B-1em9A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		3 ILE E1215
LEU E1218
VAL E1222
 None
 0.43A 1mz9B-1f51E:
undetectable		 1mz9B-1f51E:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		3 ILE A 160
LEU A 163
VAL A 167
 None
 0.50A 1mz9B-1g8pA:
0.0		 1mz9B-1g8pA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 SYNTAXIN 8

(Rattus
norvegicus) 		no annotation 3 ILE D 183
LEU D 186
VAL D 190
 None
 0.49A 1mz9B-1gl2D:
4.5		 1mz9B-1gl2D:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		3 ILE A 401
LEU A 404
VAL A 408
 None
 0.38A 1mz9B-1gqrA:
undetectable		 1mz9B-1gqrA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ILE A 177
LEU A 180
VAL A 184
 None
 0.29A 1mz9B-1gsqA:
undetectable		 1mz9B-1gsqA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		3 ILE A 162
LEU A 165
VAL A 169
 None
 0.40A 1mz9B-1gxsA:
undetectable		 1mz9B-1gxsA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htm HEMAGGLUTININ HA2
CHAIN

(uncultured beta
proteobacterium
UMTRA-608) 		PF00509
(Hemagglutinin) 		3 ILE B  77
LEU B  80
VAL B  84
 None
 0.30A 1mz9B-1htmB:
2.6		 1mz9B-1htmB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k66 PHYTOCHROME RESPONSE
REGULATOR RCPB

(Tolypothrix sp.
PCC 7601) 		PF00072
(Response_reg) 		3 ILE A 125
LEU A 128
VAL A 132
 None
 0.44A 1mz9B-1k66A:
undetectable		 1mz9B-1k66A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 ILE A 184
LEU A 187
VAL A 191
 None
 0.46A 1mz9B-1kxhA:
undetectable		 1mz9B-1kxhA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 ILE A 325
LEU A 328
VAL A 332
 None
 0.41A 1mz9B-1lq2A:
undetectable		 1mz9B-1lq2A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT

(Gallus gallus) 		PF08702
(Fib_alpha) 		3 ILE A 120
LEU A 123
VAL A 127
 None
 0.37A 1mz9B-1m1jA:
4.5		 1mz9B-1m1jA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4x PBCV-1 VIRUS CAPSID

(Paramecium
bursaria
Chlorella virus
1) 		PF04451
(Capsid_NCLDV)
PF16903
(Capsid_N) 		3 ILE A 152
LEU A 151
VAL A  72
 None
 0.45A 1mz9B-1m4xA:
undetectable		 1mz9B-1m4xA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		3 ILE A  21
LEU A  24
VAL A  28
 None
 0.29A 1mz9B-1m6jA:
undetectable		 1mz9B-1m6jA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mql HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ILE B  77
LEU B  80
VAL B  84
 None
 0.40A 1mz9B-1mqlB:
undetectable		 1mz9B-1mqlB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 ILE A 364
LEU A 367
VAL A 371
 None
 0.27A 1mz9B-1mu2A:
undetectable		 1mz9B-1mu2A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 ILE B 364
LEU B 367
VAL B 371
 None
 0.47A 1mz9B-1mu2B:
undetectable		 1mz9B-1mu2B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ILE A 258
LEU A 261
VAL A 265
 None
 0.35A 1mz9B-1navA:
undetectable		 1mz9B-1navA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 ILE A 351
LEU A 354
VAL A 358
 None
 0.49A 1mz9B-1ndfA:
undetectable		 1mz9B-1ndfA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa) 		PF05184
(SapB_1) 		3 ILE A  11
LEU A  14
VAL A  18
 None
 0.33A 1mz9B-1nklA:
undetectable		 1mz9B-1nklA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkz LIGHT-HARVESTING
PROTEIN B-800/850,
ALPHA CHAIN

(Rhodoblastus
acidophilus) 		PF00556
(LHC) 		3 ILE A  16
LEU A  19
VAL A  23
 None
None
RG1  B 401 ( 4.5A)
 0.21A 1mz9B-1nkzA:
2.8		 1mz9B-1nkzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		3 ILE A 373
LEU A 376
VAL A 380
 None
 0.27A 1mz9B-1o5wA:
undetectable		 1mz9B-1o5wA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 3 ILE A  96
LEU A 132
VAL A 136
 None
 0.46A 1mz9B-1onsA:
undetectable		 1mz9B-1onsA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 3 ILE A 208
LEU A 211
VAL A 215
 None
 0.34A 1mz9B-1oy1A:
undetectable		 1mz9B-1oy1A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS

(Burkholderia
pseudomallei) 		PF01007
(IRK) 		3 ILE A 126
LEU A 129
VAL A 133
 None
 0.36A 1mz9B-1p7bA:
undetectable		 1mz9B-1p7bA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 3 ILE A  19
LEU A  22
VAL A  26
 None
 0.24A 1mz9B-1p7nA:
undetectable		 1mz9B-1p7nA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		3 ILE A 485
LEU A 488
VAL A 492
 None
 0.26A 1mz9B-1pduA:
undetectable		 1mz9B-1pduA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 ILE A 326
LEU A 329
VAL A 333
 None
 0.20A 1mz9B-1pgjA:
undetectable		 1mz9B-1pgjA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		3 ILE A 261
LEU A 264
VAL A 268
 None
 0.40A 1mz9B-1pvjA:
undetectable		 1mz9B-1pvjA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ILE A 312
LEU A 315
VAL A 319
 None
 0.31A 1mz9B-1q4xA:
undetectable		 1mz9B-1q4xA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 ILE A 175
LEU A 174
VAL A 127
 None
 0.37A 1mz9B-1q5aA:
undetectable		 1mz9B-1q5aA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5

(Mycobacterium
tuberculosis) 		PF00668
(Condensation)
PF16911
(PapA_C) 		3 ILE A 406
LEU A 409
VAL A 413
 None
 0.22A 1mz9B-1q9jA:
undetectable		 1mz9B-1q9jA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		3 ILE A 323
LEU A 326
VAL A 330
 None
 0.40A 1mz9B-1qhbA:
undetectable		 1mz9B-1qhbA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 3 ILE A 469
LEU A 472
VAL A 476
 None
 0.49A 1mz9B-1qi9A:
undetectable		 1mz9B-1qi9A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		3 ILE A  56
LEU A  59
VAL A  63
 None
 0.36A 1mz9B-1qmyA:
undetectable		 1mz9B-1qmyA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu1 PROTEIN (INFLUENZA
RECOMBINANT HA2
CHAIN)

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ILE A  77
LEU A  80
VAL A  84
 None
 0.31A 1mz9B-1qu1A:
2.4		 1mz9B-1qu1A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4v HYPOTHETICAL PROTEIN
AQ_328

(Aquifex
aeolicus) 		PF09123
(DUF1931) 		3 ILE A  49
LEU A  52
VAL A  56
 None
 0.22A 1mz9B-1r4vA:
undetectable		 1mz9B-1r4vA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6e TYPEIII-SECRETED
PROTEIN EFFECTOR:
INVASION-ASSOCIATED
PROTEIN

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		3 ILE A 137
LEU A 141
VAL A 161
 None
 0.47A 1mz9B-1r6eA:
undetectable		 1mz9B-1r6eA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00926
(DHBP_synthase) 		3 ILE A 123
LEU A 126
VAL A 130
 None
 0.28A 1mz9B-1snnA:
undetectable		 1mz9B-1snnA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ILE B 206
LEU B 209
VAL B 213
 None
 0.21A 1mz9B-1sxjB:
undetectable		 1mz9B-1sxjB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ILE D 341
LEU D 344
VAL D 348
 None
 0.37A 1mz9B-1sxjD:
undetectable		 1mz9B-1sxjD:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2k TRANSCRIPTION FACTOR
AP-1

(Homo sapiens) 		PF00170
(bZIP_1) 		3 ILE C 277
LEU C 280
VAL C 284
 None
 0.22A 1mz9B-1t2kC:
4.0		 1mz9B-1t2kC:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ILE B 430
LEU B 433
VAL B 437
 None
 0.33A 1mz9B-1t3qB:
undetectable		 1mz9B-1t3qB:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tbx HYPOTHETICAL 11.0
KDA PROTEIN

(Sulfolobus
spindle-shaped
virus 1) 		no annotation 3 ILE A  23
LEU A  67
VAL A  56
 None
 0.49A 1mz9B-1tbxA:
undetectable		 1mz9B-1tbxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		3 ILE A 187
LEU A 190
VAL A 194
 None
 0.28A 1mz9B-1tdfA:
undetectable		 1mz9B-1tdfA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ILE A 353
LEU A 356
VAL A 360
 ILE  A 353 ( 0.7A)
LEU  A 356 ( 0.6A)
VAL  A 360 ( 0.6A)
 0.40A 1mz9B-1tedA:
undetectable		 1mz9B-1tedA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz9 MANNONATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF03786
(UxuA) 		3 ILE A  47
LEU A  50
VAL A  54
 None
 0.26A 1mz9B-1tz9A:
undetectable		 1mz9B-1tz9A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		3 ILE A  78
LEU A  81
VAL A  85
 None
 0.32A 1mz9B-1u10A:
undetectable		 1mz9B-1u10A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		3 ILE A 528
LEU A 531
VAL A 535
 None
 0.34A 1mz9B-1u2lA:
undetectable		 1mz9B-1u2lA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		3 ILE A 436
LEU A 439
VAL A 443
 None
 0.33A 1mz9B-1u6zA:
undetectable		 1mz9B-1u6zA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		3 ILE A 209
LEU A 212
VAL A 216
 None
 0.47A 1mz9B-1uazA:
undetectable		 1mz9B-1uazA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug0 SPLICING FACTOR 4

(Mus musculus) 		PF01805
(Surp) 		3 ILE A  31
LEU A  34
VAL A  38
 None
 0.38A 1mz9B-1ug0A:
undetectable		 1mz9B-1ug0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ILE A  65
LEU A  68
VAL A  72
 None
 0.46A 1mz9B-1ulzA:
undetectable		 1mz9B-1ulzA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		3 ILE A2136
LEU A2139
VAL A2143
 None
 0.30A 1mz9B-1uyvA:
undetectable		 1mz9B-1uyvA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B

(Pyrococcus
horikoshii) 		PF01008
(IF-2B) 		3 ILE A  48
LEU A  51
VAL A  55
 None
 0.39A 1mz9B-1vb5A:
undetectable		 1mz9B-1vb5A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		3 ILE A 112
LEU A 110
VAL A 108
 FAD  A 400 (-3.7A)
None
None
 0.44A 1mz9B-1vdcA:
undetectable		 1mz9B-1vdcA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vke CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY
PROTEIN

(Thermotoga
maritima) 		PF02627
(CMD) 		3 ILE A  96
LEU A  99
VAL A 103
 None
 0.19A 1mz9B-1vkeA:
undetectable		 1mz9B-1vkeA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		3 ILE A  66
LEU A  69
VAL A  73
 None
 0.42A 1mz9B-1vmeA:
undetectable		 1mz9B-1vmeA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmu HEMOGLOBIN A AND D
BETA CHAIN

(Aldabrachelys
gigantea) 		PF00042
(Globin) 		3 ILE B 111
LEU B 110
VAL B  23
 None
 0.46A 1mz9B-1wmuB:
undetectable		 1mz9B-1wmuB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4p PUTATIVE SPLICING
FACTOR,
ARGININE/SERINE-RICH
14

(Homo sapiens) 		PF01805
(Surp) 		3 ILE A  11
LEU A  14
VAL A  18
 None
 0.47A 1mz9B-1x4pA:
undetectable		 1mz9B-1x4pA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7h PUTATIVE KETOACYL
REDUCTASE

(Streptomyces
coelicolor) 		PF00106
(adh_short) 		3 ILE A  70
LEU A  73
VAL A  77
 None
 0.15A 1mz9B-1x7hA:
undetectable		 1mz9B-1x7hA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M

(Homo sapiens) 		PF00179
(UQ_con) 		3 ILE A 114
LEU A 115
VAL A 110
 None
 0.24A 1mz9B-1y8xA:
undetectable		 1mz9B-1y8xA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 ILE A 619
LEU A 622
VAL A 626
 None
 0.27A 1mz9B-1ygpA:
undetectable		 1mz9B-1ygpA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 ILE A 310
LEU A 313
VAL A 317
 None
 0.24A 1mz9B-1yt3A:
undetectable		 1mz9B-1yt3A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxb PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Streptomyces
coelicolor) 		PF01503
(PRA-PH) 		3 ILE A  65
LEU A  68
VAL A  72
 None
 0.19A 1mz9B-1yxbA:
undetectable		 1mz9B-1yxbA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		3 ILE E 354
LEU E 357
VAL E 361
 None
 0.38A 1mz9B-1z5xE:
undetectable		 1mz9B-1z5xE:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk8 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF13305
(WHG) 		3 ILE A 119
LEU A 122
VAL A 126
 None
 0.33A 1mz9B-1zk8A:
undetectable		 1mz9B-1zk8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3v SITE-SPECIFIC
RECOMBINASE INTI4

(Vibrio cholerae) 		PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4) 		3 ILE A 111
LEU A 114
VAL A 118
 None
 0.40A 1mz9B-2a3vA:
undetectable		 1mz9B-2a3vA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 ILE A  77
LEU A  80
VAL A  84
 None
 0.24A 1mz9B-2aazA:
undetectable		 1mz9B-2aazA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahz POTASSIUM CHANNEL
PROTEIN

(Bacillus cereus) 		PF07885
(Ion_trans_2) 		3 ILE A  51
LEU A  54
VAL A  58
 None
 0.39A 1mz9B-2ahzA:
undetectable		 1mz9B-2ahzA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 ILE A 327
LEU A 292
VAL A 299
 None
 0.48A 1mz9B-2awaA:
undetectable		 1mz9B-2awaA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axp HYPOTHETICAL PROTEIN
BSU20280

(Bacillus
subtilis) 		PF02223
(Thymidylate_kin) 		3 ILE A 128
LEU A 131
VAL A 135
 None
 0.40A 1mz9B-2axpA:
undetectable		 1mz9B-2axpA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 ILE A 595
LEU A 598
VAL A 602
 None
 0.40A 1mz9B-2btvA:
undetectable		 1mz9B-2btvA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 ILE A 138
LEU A 141
VAL A 145
 None
 0.49A 1mz9B-2bvmA:
undetectable		 1mz9B-2bvmA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		3 ILE A 268
LEU A 283
VAL A 365
 None
 0.46A 1mz9B-2cavA:
undetectable		 1mz9B-2cavA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cff 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)
METHYLIDENEAMINO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		3 ILE A  56
LEU A  52
VAL A  50
 None
 0.46A 1mz9B-2cffA:
undetectable		 1mz9B-2cffA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 ILE A 225
LEU A 228
VAL A 232
 None
 0.48A 1mz9B-2csdA:
undetectable		 1mz9B-2csdA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		3 ILE A 461
LEU A 464
VAL A 468
 None
 0.18A 1mz9B-2d1cA:
undetectable		 1mz9B-2d1cA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5z SPLICING FACTOR,
ARGININE/SERINE-RICH
8

(Homo sapiens) 		PF01805
(Surp) 		3 ILE A  28
LEU A  31
VAL A  35
 None
 0.35A 1mz9B-2e5zA:
undetectable		 1mz9B-2e5zA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		3 ILE A 298
LEU A 301
VAL A 305
 None
 0.27A 1mz9B-2e87A:
undetectable		 1mz9B-2e87A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		3 ILE A 246
LEU A 249
VAL A 253
 None
 0.46A 1mz9B-2ekcA:
undetectable		 1mz9B-2ekcA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ILE A 336
LEU A 339
VAL A 343
 None
 0.42A 1mz9B-2ep5A:
undetectable		 1mz9B-2ep5A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f22 BH3987

(Bacillus
halodurans) 		PF05163
(DinB) 		3 ILE A 104
LEU A 107
VAL A 111
 None
 0.47A 1mz9B-2f22A:
undetectable		 1mz9B-2f22A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 ILE A 626
LEU A 629
VAL A 633
 None
 0.49A 1mz9B-2f57A:
undetectable		 1mz9B-2f57A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 3 ILE H 380
LEU H 383
VAL H 387
 None
 0.35A 1mz9B-2fhgH:
undetectable		 1mz9B-2fhgH:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fno AGR_PAT_752P

(Agrobacterium
fabrum) 		no annotation 3 ILE A 194
LEU A 197
VAL A 201
 None
None
SCN  A 238 ( 4.4A)
 0.45A 1mz9B-2fnoA:
undetectable		 1mz9B-2fnoA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fu2 HYPOTHETICAL PROTEIN
SPY2152

(Streptococcus
pyogenes) 		PF08951
(EntA_Immun) 		3 ILE A  69
LEU A  72
VAL A  76
 None
 0.36A 1mz9B-2fu2A:
undetectable		 1mz9B-2fu2A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		3 ILE A  59
LEU A  50
VAL A   6
 None
 0.50A 1mz9B-2g5xA:
undetectable		 1mz9B-2g5xA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 ILE A 356
LEU A 359
VAL A 363
 None
 0.27A 1mz9B-2gjxA:
undetectable		 1mz9B-2gjxA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 3 ILE I 356
LEU I 359
VAL I 363
 None
 0.32A 1mz9B-2gk1I:
undetectable		 1mz9B-2gk1I:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsl HYPOTHETICAL PROTEIN

(Fusobacterium
nucleatum) 		PF00636
(Ribonuclease_3) 		3 ILE A  41
LEU A  44
VAL A  48
 None
 0.48A 1mz9B-2gslA:
undetectable		 1mz9B-2gslA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		3 ILE A 125
LEU A 128
VAL A 132
 None
 0.44A 1mz9B-2gwgA:
undetectable		 1mz9B-2gwgA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5j CASPASE-3, P17
SUBUNIT

(Homo sapiens) 		PF00656
(Peptidase_C14) 		3 ILE A  96
LEU A  99
VAL A 103
 None
 0.26A 1mz9B-2h5jA:
undetectable		 1mz9B-2h5jA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 ILE B 363
LEU B 362
VAL B 360
 None
 0.44A 1mz9B-2hdnB:
undetectable		 1mz9B-2hdnB:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		3 ILE A 109
LEU A 112
VAL A 116
 None
 0.47A 1mz9B-2horA:
undetectable		 1mz9B-2horA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 ILE A1022
LEU A1023
VAL A1009
ALA A1168
 None
 0.96A 1mz9C-1c0iA:
0.0		 1mz9C-1c0iA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 LEU A 515
VAL A 445
ALA A 467
CYH A 493
 None
 0.92A 1mz9C-1c4oA:
0.0		 1mz9C-1c4oA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		4 ILE A 128
LEU A 131
VAL A 135
ALA A  81
 None
 0.90A 1mz9C-1ce7A:
undetectable		 1mz9C-1ce7A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		4 ILE A  40
LEU A  41
VAL A  24
ALA A 263
 None
 0.83A 1mz9C-1dj2A:
0.0		 1mz9C-1dj2A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ILE A  72
LEU A  75
VAL A  79
ALA A  87
 None
 0.58A 1mz9C-1dkrA:
undetectable		 1mz9C-1dkrA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		4 ILE A 198
LEU A 196
VAL A 154
ALA A 102
 None
 0.91A 1mz9C-1eceA:
undetectable		 1mz9C-1eceA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus gallus) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 ILE A 673
LEU A 672
ALA A 905
CYH A 908
 None
 0.96A 1mz9C-1efyA:
0.0		 1mz9C-1efyA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 291
LEU A 245
VAL A 243
ALA A 240
 None
 0.96A 1mz9C-1escA:
0.0		 1mz9C-1escA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		4 ILE A  20
LEU A  30
VAL A  34
ALA A  40
 None
 0.91A 1mz9C-1gr0A:
0.0		 1mz9C-1gr0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2s SENSORY RHODOPSIN II
TRANSDUCER

(Natronomonas
pharaonis) 		no annotation 4 ILE B  68
LEU B  65
VAL B  61
ALA B  54
 None
 0.97A 1mz9C-1h2sB:
2.6		 1mz9C-1h2sB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		4 ILE A 131
LEU A  38
VAL A  36
ALA A  33
 None
 0.84A 1mz9C-1htwA:
undetectable		 1mz9C-1htwA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 415
VAL A 411
ALA A 311
CYH A 307
 None
 0.91A 1mz9C-1kfiA:
undetectable		 1mz9C-1kfiA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ILE A 364
LEU A 367
VAL A 371
ALA A 378
 None
 0.72A 1mz9C-1mu2A:
undetectable		 1mz9C-1mu2A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 ILE B 364
LEU B 367
VAL B 371
ALA B 378
 None
 0.83A 1mz9C-1mu2B:
undetectable		 1mz9C-1mu2B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE

(Mycobacterium
tuberculosis) 		PF02548
(Pantoate_transf) 		4 ILE A  79
LEU A  82
VAL A  86
ALA A  93
 None
 0.94A 1mz9C-1oy0A:
undetectable		 1mz9C-1oy0A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida) 		PF02633
(Creatininase) 		4 ILE A 103
LEU A 106
VAL A 111
ALA A  21
 None
 0.98A 1mz9C-1q3kA:
undetectable		 1mz9C-1q3kA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r03 MITOCHONDRIAL
FERRITIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.78A 1mz9C-1r03A:
undetectable		 1mz9C-1r03A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		4 ILE A 368
LEU A 365
VAL A 361
ALA A 354
 None
 0.87A 1mz9C-1r4nA:
undetectable		 1mz9C-1r4nA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		4 ILE A 179
LEU A 182
VAL A 186
ALA A 190
 None
 0.84A 1mz9C-1r76A:
undetectable		 1mz9C-1r76A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 ILE A  83
LEU A  85
VAL A 124
ALA A 114
 None
 0.95A 1mz9C-1rzmA:
undetectable		 1mz9C-1rzmA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 ILE A 221
LEU A 217
VAL A 170
ALA A 143
 None
 0.91A 1mz9C-1s0uA:
undetectable		 1mz9C-1s0uA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t11 TRIGGER FACTOR

(Vibrio cholerae) 		PF00254
(FKBP_C)
PF05697
(Trigger_N)
PF05698
(Trigger_C) 		4 ILE A  35
LEU A  32
VAL A  28
ALA A  21
 None
 0.90A 1mz9C-1t11A:
undetectable		 1mz9C-1t11A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taf TFIID TBP ASSOCIATED
FACTOR 62

(Drosophila
melanogaster) 		PF02969
(TAF) 		4 ILE B  43
LEU B  40
VAL B  36
ALA B  29
 None
 0.97A 1mz9C-1tafB:
2.3		 1mz9C-1tafB:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		4 ILE A 209
LEU A 207
VAL A 163
CYH A 118
 None
 0.98A 1mz9C-1tcdA:
undetectable		 1mz9C-1tcdA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		4 ILE A 395
LEU A 399
VAL A 343
ALA A 377
 None
 0.94A 1mz9C-1tdjA:
undetectable		 1mz9C-1tdjA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkn AMYLOID BETA A4
PROTEIN

(Homo sapiens) 		PF12925
(APP_E2) 		4 ILE A 537
LEU A 534
VAL A 530
ALA A 524
 None
 0.95A 1mz9C-1tknA:
undetectable		 1mz9C-1tknA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ILE A 332
LEU A 333
VAL A 340
ALA A 346
 None
 0.95A 1mz9C-1v9lA:
undetectable		 1mz9C-1v9lA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE A  18
LEU A  19
VAL A  26
ALA A  85
 None
 0.91A 1mz9C-1vc2A:
undetectable		 1mz9C-1vc2A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A 373
LEU A 376
VAL A 380
ALA A 388
 None
 0.98A 1mz9C-1vdkA:
undetectable		 1mz9C-1vdkA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9c STRIATED-MUSCLE
ALPHA TROPOMYOSIN

(Rattus
norvegicus) 		PF00261
(Tropomyosin) 		4 ILE A 172
LEU A 169
VAL A 165
ALA A 158
 None
 0.98A 1mz9C-2b9cA:
3.8		 1mz9C-2b9cA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		4 ILE A 262
LEU A 233
VAL A 210
ALA A 184
 None
 0.94A 1mz9C-2bexA:
undetectable		 1mz9C-2bexA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF02156
(Glyco_hydro_26) 		4 ILE A  11
LEU A   9
VAL A 250
ALA A 212
 None
 0.85A 1mz9C-2citA:
undetectable		 1mz9C-2citA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		4 ILE A  86
LEU A  23
VAL A  48
ALA A  52
 None
 0.98A 1mz9C-2dwcA:
undetectable		 1mz9C-2dwcA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 555
LEU A 552
VAL A 548
ALA A 542
 None
 0.88A 1mz9C-2f3oA:
undetectable		 1mz9C-2f3oA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f95 SENSORY RHODOPSIN II
TRANSDUCER

(Natronomonas
pharaonis) 		no annotation 4 ILE B  68
LEU B  65
VAL B  61
ALA B  54
 None
 0.98A 1mz9C-2f95B:
undetectable		 1mz9C-2f95B:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 ILE H 380
LEU H 383
VAL H 387
ALA H 393
 None
 0.82A 1mz9C-2fhgH:
undetectable		 1mz9C-2fhgH:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 ILE A 229
LEU A 227
VAL A 186
ALA A  72
 None
 0.88A 1mz9C-2gduA:
undetectable		 1mz9C-2gduA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 ILE A 581
LEU A 579
VAL A 440
ALA A 444
 None
 0.92A 1mz9C-2gq3A:
undetectable		 1mz9C-2gq3A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 ILE A 647
LEU A 644
VAL A 640
ALA A 633
 None
 0.97A 1mz9C-2h4tA:
undetectable		 1mz9C-2h4tA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis) 		PF00227
(Proteasome) 		4 ILE A 137
LEU A 140
VAL A 144
ALA A 150
 None
 0.73A 1mz9C-2jayA:
undetectable		 1mz9C-2jayA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ILE A  86
LEU A  89
VAL A  93
ALA A 101
 None
 0.58A 1mz9C-2ji4A:
undetectable		 1mz9C-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
2-BINDING PROTEIN

(Homo sapiens) 		PF11527
(ARL2_Bind_BART) 		4 ILE A  31
LEU A  28
VAL A  24
ALA A  16
 None
 0.77A 1mz9C-2k9aA:
undetectable		 1mz9C-2k9aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		4 ILE A 201
LEU A 180
VAL A 159
ALA A 119
 None
 0.88A 1mz9C-2ntbA:
undetectable		 1mz9C-2ntbA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		4 ILE A   8
LEU A  76
ALA A 107
CYH A 108
 None
 0.87A 1mz9C-2pn1A:
undetectable		 1mz9C-2pn1A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LEU A 131
VAL A 134
ALA A  64
CYH A  65
 None
 0.94A 1mz9C-2q6zA:
undetectable		 1mz9C-2q6zA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 189
LEU A 186
VAL A 182
ALA A 175
 None
 0.70A 1mz9C-2v55A:
undetectable		 1mz9C-2v55A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Arabidopsis
thaliana) 		PF06090
(Ins_P5_2-kin) 		4 ILE A 307
LEU A 304
VAL A 300
ALA A 294
 None
 0.83A 1mz9C-2xalA:
undetectable		 1mz9C-2xalA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		4 ILE A  23
LEU A  24
VAL A  31
ALA A  65
 None
 0.96A 1mz9C-3adcA:
undetectable		 1mz9C-3adcA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 4 ILE A 613
LEU A 610
VAL A 606
ALA A 599
 None
 0.73A 1mz9C-3afbA:
undetectable		 1mz9C-3afbA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1

(Symbiobacterium
toebii) 		PF00551
(Formyl_trans_N) 		5 ILE A 105
LEU A 106
VAL A 137
ALA A 153
CYH A 135
 None
 1.41A 1mz9C-3aufA:
undetectable		 1mz9C-3aufA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 ILE A 618
LEU A 619
VAL A 661
ALA A 717
CYH A 715
 None
 1.10A 1mz9C-3c2gA:
undetectable		 1mz9C-3c2gA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cje OSMC-LIKE PROTEIN

(Jannaschia sp.
CCS1) 		PF02566
(OsmC) 		4 ILE A  66
LEU A  69
VAL A  73
ALA A 136
 None
 0.87A 1mz9C-3cjeA:
undetectable		 1mz9C-3cjeA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		4 ILE A 293
LEU A 292
VAL A 353
ALA A 359
 None
 0.75A 1mz9C-3cmnA:
undetectable		 1mz9C-3cmnA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN

(Bifidobacterium
adolescentis) 		PF01168
(Ala_racemase_N) 		4 ILE A  36
LEU A  33
VAL A  29
ALA A  22
 None
 0.97A 1mz9C-3cpgA:
undetectable		 1mz9C-3cpgA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		4 ILE A  28
LEU A  33
VAL A  72
ALA A  80
 None
 0.94A 1mz9C-3d0cA:
undetectable		 1mz9C-3d0cA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8l ORF12

(Lactococcus
virus P2) 		no annotation 4 ILE A  37
LEU A  40
VAL A  44
ALA A  51
 None
 0.96A 1mz9C-3d8lA:
undetectable		 1mz9C-3d8lA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		4 ILE A1853
LEU A1856
VAL A1860
ALA A1867
 None
 0.82A 1mz9C-3edvA:
undetectable		 1mz9C-3edvA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		4 ILE A 438
LEU A 439
VAL A 428
ALA A 461
 None
 0.97A 1mz9C-3ehkA:
undetectable		 1mz9C-3ehkA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		4 ILE A  31
LEU A  34
VAL A  38
ALA A  46
 None
 0.64A 1mz9C-3ek5A:
undetectable		 1mz9C-3ek5A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A 168
LEU A 167
VAL A 132
ALA A 276
 DRK  A   1 ( 4.2A)
None
None
None
 0.95A 1mz9C-3f3zA:
undetectable		 1mz9C-3f3zA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7p NITROGEN FIXATION
PROTEIN

(Acidithiobacillus
ferrooxidans) 		PF03270
(DUF269) 		4 ILE A 146
LEU A 143
VAL A 139
ALA A 132
 None
 0.80A 1mz9C-3g7pA:
undetectable		 1mz9C-3g7pA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 243
LEU A 240
VAL A 236
ALA A 231
 None
None
NAD  A 500 (-4.2A)
NAD  A 500 ( 4.5A)
 0.81A 1mz9C-3h3jA:
undetectable		 1mz9C-3h3jA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		4 ILE A 345
LEU A 344
ALA A 311
CYH A 310
 None
 0.67A 1mz9C-3hvyA:
undetectable		 1mz9C-3hvyA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 ILE A 764
LEU A1110
VAL A1103
ALA A 933
 None
 0.79A 1mz9C-3jclA:
undetectable		 1mz9C-3jclA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 ILE A 195
VAL A 217
ALA A 252
CYH A 251
 None
 0.86A 1mz9C-3k9dA:
undetectable		 1mz9C-3k9dA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ILE A 186
LEU A 190
VAL A 155
ALA A 144
 None
 0.91A 1mz9C-3l2zA:
undetectable		 1mz9C-3l2zA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lki FRUCTOKINASE

(Xylella
fastidiosa) 		PF00294
(PfkB) 		4 ILE A 224
LEU A 227
VAL A 202
ALA A 143
 None
 0.96A 1mz9C-3lkiA:
undetectable		 1mz9C-3lkiA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 ILE A  83
LEU A  85
VAL A 124
ALA A 114
 None
 0.96A 1mz9C-3pg8A:
undetectable		 1mz9C-3pg8A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 243
LEU A 240
VAL A 236
ALA A 231
 None
 0.84A 1mz9C-3pqdA:
undetectable		 1mz9C-3pqdA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A

(Homo sapiens) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 ILE A 395
LEU A 365
VAL A 367
ALA A 315
 None
 0.94A 1mz9C-3t1iA:
undetectable		 1mz9C-3t1iA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A 431
LEU A 428
VAL A 424
ALA A 417
 None
 0.90A 1mz9C-3tv2A:
undetectable		 1mz9C-3tv2A:
8.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v2p CARTILAGE
OLIGOMERIZATION
MATRIX PROTEIN
(COILED-COIL DOMAIN)

(Mus musculus) 		PF11598
(COMP) 		4 ILE A  58
LEU A  61
VAL A  65
ALA A  70
 None
 0.23A 1mz9C-3v2pA:
undetectable		 1mz9C-3v2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnw FERRITIN HEAVY CHAIN

(Mus musculus) 		PF00210
(Ferritin) 		4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.79A 1mz9C-3wnwA:
undetectable		 1mz9C-3wnwA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		4 ILE X 234
LEU X 239
VAL X 279
ALA X  36
 None
None
None
ACT  X1290 (-4.4A)
 0.79A 1mz9C-4ac1X:
undetectable		 1mz9C-4ac1X:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 ILE A  70
LEU A  67
VAL A  63
ALA A  56
 None
 0.98A 1mz9C-4av6A:
undetectable		 1mz9C-4av6A:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 ILE A 100
LEU A 103
VAL A 107
ALA A 116
 None
 0.85A 1mz9C-4bg5A:
undetectable		 1mz9C-4bg5A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 528
LEU A 526
VAL A 562
ALA A 614
 None
 0.98A 1mz9C-4c7vA:
undetectable		 1mz9C-4c7vA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Synechococcus
elongatus) 		PF13561
(adh_short_C2) 		4 ILE A 208
LEU A 246
VAL A 146
ALA A 163
 None
 0.95A 1mz9C-4dmmA:
undetectable		 1mz9C-4dmmA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyx FERRITIN HEAVY CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 ILE A 145
LEU A 148
VAL A 152
ALA A 160
 None
 0.84A 1mz9C-4dyxA:
undetectable		 1mz9C-4dyxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A  49
LEU A  46
VAL A  42
ALA A  36
 None
 0.98A 1mz9C-4e0bA:
undetectable		 1mz9C-4e0bA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A 148
LEU A 151
VAL A 155
ALA A 123
 None
 0.72A 1mz9C-4e6eA:
undetectable		 1mz9C-4e6eA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebj AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF01909
(NTP_transf_2) 		4 ILE A 165
LEU A 162
VAL A 158
ALA A 151
 None
 0.81A 1mz9C-4ebjA:
undetectable		 1mz9C-4ebjA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 4 ILE A 165
LEU A 162
VAL A 158
ALA A 151
 None
 0.73A 1mz9C-4gjiA:
undetectable		 1mz9C-4gjiA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		4 ILE A  87
LEU A 184
VAL A 140
ALA A  68
 None
 0.88A 1mz9C-4gs1A:
undetectable		 1mz9C-4gs1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyc SENSORY RHODOPSIN II
TRANSDUCER

(Natronomonas
pharaonis) 		no annotation 4 ILE B  68
LEU B  65
VAL B  61
ALA B  54
 None
 0.96A 1mz9C-4gycB:
undetectable		 1mz9C-4gycB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 189
LEU A 140
VAL A 138
ALA A 135
 None
 0.90A 1mz9C-4hyqA:
undetectable		 1mz9C-4hyqA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		4 ILE A  97
LEU A  96
VAL A 464
ALA A 290
 None
 0.99A 1mz9C-4i59A:
undetectable		 1mz9C-4i59A:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		4 ILE A 132
LEU A 135
VAL A 139
ALA A  82
 None
 0.96A 1mz9C-4jkxA:
undetectable		 1mz9C-4jkxA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ILE A 198
LEU A 174
VAL A 153
CYH A 157
 None
 0.79A 1mz9C-4kngA:
undetectable		 1mz9C-4kngA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 ILE A 181
LEU A 184
VAL A 188
ALA A 196
 None
 0.67A 1mz9C-4kpgA:
undetectable		 1mz9C-4kpgA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ILE A 175
LEU A 174
VAL A 220
ALA A 187
 None
 0.83A 1mz9C-4l1kA:
undetectable		 1mz9C-4l1kA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 187
LEU A 184
VAL A 180
ALA A 173
 None
 0.92A 1mz9C-4m0xA:
undetectable		 1mz9C-4m0xA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		4 ILE A 181
LEU A 184
VAL A 188
ALA A 196
 None
 0.87A 1mz9C-4m1zA:
undetectable		 1mz9C-4m1zA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7a U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		4 ILE F  98
LEU F  42
VAL F  40
ALA F 105
 None
 0.79A 1mz9C-4m7aF:
undetectable		 1mz9C-4m7aF:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		4 ILE A 270
LEU A 262
VAL A 234
ALA A 208
 None
 0.98A 1mz9C-4n18A:
undetectable		 1mz9C-4n18A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		4 ILE B 450
LEU B 388
VAL B 382
CYH B 380
 None
 0.99A 1mz9C-4oicB:
undetectable		 1mz9C-4oicB:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		4 ILE A 246
LEU A 242
VAL A 258
ALA A 265
 None
 0.90A 1mz9C-4p1cA:
undetectable		 1mz9C-4p1cA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 ILE A 201
LEU A 197
VAL A 176
ALA A 212
 None
 0.97A 1mz9C-4pzvA:
undetectable		 1mz9C-4pzvA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP2
COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3 102
LEU 3  46
VAL 2 191
ALA 2 126
 None
 0.97A 1mz9C-4q4y3:
undetectable		 1mz9C-4q4y3:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		4 ILE A 333
LEU A 336
ALA A 420
CYH A 418
 None
 0.82A 1mz9C-4r10A:
undetectable		 1mz9C-4r10A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 LEU A 124
CYH A 105
ALA A 333
CYH A 332
 None
 1.00A 1mz9D-1bwdA:
0.0		 1mz9D-1bwdA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 LEU A 200
VAL A 198
ALA A 190
CYH A 191
 None
 1.14A 1mz9D-1gjuA:
0.0		 1mz9D-1gjuA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 LEU A 155
VAL A 157
ALA A 186
CYH A 190
 None
 1.07A 1mz9D-1imjA:
0.0		 1mz9D-1imjA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		4 LEU A 167
VAL A   3
CYH A  65
ALA A  62
 None
 1.03A 1mz9D-1jaxA:
0.0		 1mz9D-1jaxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 415
VAL A 411
ALA A 311
CYH A 307
 None
 1.05A 1mz9D-1kfiA:
0.0		 1mz9D-1kfiA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 250
VAL A 255
CYH A 257
ALA A 181
 None
 1.19A 1mz9D-1kolA:
0.0		 1mz9D-1kolA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A 215
VAL A 284
ALA A 279
CYH A 280
 None
 1.12A 1mz9D-1lrkA:
0.0		 1mz9D-1lrkA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 376
VAL A 389
ALA A 396
CYH A 393
 None
 1.00A 1mz9D-1q5nA:
0.5		 1mz9D-1q5nA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5z MAJOR NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Aliivibrio
fischeri) 		PF00881
(Nitroreductase) 		4 LEU A  85
VAL A  83
ALA A  79
CYH A  80
 None
 1.14A 1mz9D-1v5zA:
undetectable		 1mz9D-1v5zA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF06052
(3-HAO) 		4 VAL A 132
CYH A 125
ALA A 127
CYH A 128
 None
FE  A 301 (-2.4A)
FE  A 301 ( 4.7A)
FE  A 301 (-2.2A)
 1.12A 1mz9D-1yfyA:
undetectable		 1mz9D-1yfyA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		4 LEU A  11
VAL A  16
CYH A 133
ALA A 130
 None
 0.86A 1mz9D-1zmrA:
undetectable		 1mz9D-1zmrA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		4 LEU C 197
VAL C 326
CYH C 325
ALA C  42
 None
 0.95A 1mz9D-2af4C:
undetectable		 1mz9D-2af4C:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 LEU B 105
VAL B 109
CYH B 112
ALA A 110
 None
 1.13A 1mz9D-2b7hB:
undetectable		 1mz9D-2b7hB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		4 VAL A 328
CYH A 325
ALA A 322
CYH A 324
 None
 1.17A 1mz9D-2bnhA:
undetectable		 1mz9D-2bnhA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhg TRNA SELENOCYSTEINE
ASSOCIATED PROTEIN
(SECP43)

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A 103
VAL A 168
ALA A 153
CYH A 157
 None
 1.19A 1mz9D-2dhgA:
undetectable		 1mz9D-2dhgA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 LEU A 359
VAL A 400
ALA A 407
CYH A 404
 None
 1.03A 1mz9D-2h21A:
undetectable		 1mz9D-2h21A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 LEU A  89
VAL A  93
CYH A  96
ALA A 101
 None
 1.14A 1mz9D-2ji4A:
undetectable		 1mz9D-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jm1 TRANSCRIPTIONAL
REGULATOR ATRX

(Homo sapiens) 		no annotation 4 VAL A 178
CYH A 171
ALA A 173
CYH A 174
 None
ZN  A   1 (-2.3A)
ZN  A   1 ( 4.5A)
ZN  A   1 (-2.3A)
 0.96A 1mz9D-2jm1A:
undetectable		 1mz9D-2jm1A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le1 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		PF10604
(Polyketide_cyc2) 		4 LEU A  93
VAL A  95
CYH A 103
ALA A  12
 None
 1.19A 1mz9D-2le1A:
undetectable		 1mz9D-2le1A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 LEU A 196
VAL A 108
ALA A 115
CYH A 112
 None
 1.07A 1mz9D-2oerA:
undetectable		 1mz9D-2oerA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		4 LEU A 162
VAL A 165
CYH A 168
ALA A  63
 None
 1.11A 1mz9D-2prdA:
undetectable		 1mz9D-2prdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LEU A 131
VAL A 134
ALA A  64
CYH A  65
 None
 0.96A 1mz9D-2q6zA:
undetectable		 1mz9D-2q6zA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A  86
CYH A 188
ALA A 174
CYH A 177
 None
 1.09A 1mz9D-2qq5A:
undetectable		 1mz9D-2qq5A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 LEU A 772
CYH A 736
ALA A 738
CYH A 739
 None
ZN  A1006 (-2.3A)
ZN  A1006 ( 4.2A)
ZN  A1006 (-2.3A)
 0.99A 1mz9D-2r6fA:
undetectable		 1mz9D-2r6fA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn2 CHROMOSOME
REPLICATION
INITIATION PROTEIN

(Geobacillus
kaustophilus) 		no annotation 4 LEU A  76
VAL A  72
CYH A  68
ALA A  58
 None
 1.19A 1mz9D-2vn2A:
undetectable		 1mz9D-2vn2A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 233
CYH A 153
ALA A 198
CYH A 151
 None
 1.18A 1mz9D-2wbiA:
undetectable		 1mz9D-2wbiA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wex APOLIPOPROTEIN M

(Homo sapiens) 		PF11032
(ApoM) 		4 LEU A 175
VAL A 158
CYH A 157
CYH A 128
 None
 1.14A 1mz9D-2wexA:
undetectable		 1mz9D-2wexA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 107
VAL A 111
CYH A 114
ALA A 193
 None
 0.92A 1mz9D-2wnrA:
undetectable		 1mz9D-2wnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 176
VAL A   7
CYH A   8
ALA A  67
 None
 1.07A 1mz9D-2x3eA:
undetectable		 1mz9D-2x3eA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		4 LEU A 495
VAL A 479
CYH A 477
ALA A 454
 None
 1.14A 1mz9D-2xgoA:
undetectable		 1mz9D-2xgoA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 153
VAL A 123
ALA A 130
CYH A 127
 None
 1.17A 1mz9D-2z01A:
undetectable		 1mz9D-2z01A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		4 VAL A 342
CYH A 332
ALA A 323
CYH A 320
 None
 1.12A 1mz9D-2zfuA:
undetectable		 1mz9D-2zfuA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9j MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 2

(Mus musculus) 		PF00641
(zf-RanBP) 		4 LEU C 681
CYH C 670
ALA C 672
CYH C 673
 None
ZN  C   1 (-2.3A)
ZN  C   1 ( 4.6A)
ZN  C   1 (-2.3A)
 0.95A 1mz9D-3a9jC:
undetectable		 1mz9D-3a9jC:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b84 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00651
(BTB) 		4 LEU A  16
VAL A  43
CYH A  46
CYH A  47
 None
UNK  A 900 ( 4.8A)
UNK  A 900 ( 1.7A)
UNK  A 901 ( 2.0A)
 1.10A 1mz9D-3b84A:
undetectable		 1mz9D-3b84A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A  59
VAL A  31
ALA A  38
CYH A  39
 None
 1.07A 1mz9D-3berA:
undetectable		 1mz9D-3berA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		4 LEU A 323
VAL A 306
CYH A 305
ALA A 303
 None
 1.18A 1mz9D-3bjeA:
undetectable		 1mz9D-3bjeA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0q A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD)
PF14815
(NUDIX_4) 		4 LEU A  17
VAL A 210
CYH A 214
ALA A 216
 None
None
SF4  A 400 (-2.4A)
SF4  A 400 ( 4.7A)
 1.01A 1mz9D-3g0qA:
undetectable		 1mz9D-3g0qA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gj6 NUCLEAR PORE COMPLEX
PROTEIN NUP153

(Rattus
norvegicus) 		PF00641
(zf-RanBP) 		4 LEU B 686
CYH B 678
ALA B 680
CYH B 681
 None
ZN  B 300 (-2.6A)
ZN  B 300 ( 4.9A)
ZN  B 300 (-3.0A)
 0.85A 1mz9D-3gj6B:
undetectable		 1mz9D-3gj6B:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0n UNCHARACTERIZED
PROTEIN DUF1470

(Jannaschia sp.
CCS1) 		PF07336
(ABATE)
PF11706
(zf-CGNR) 		4 LEU A  15
CYH A 147
ALA A 149
CYH A 152
 None
ZN  A 201 ( 2.3A)
ZN  A 201 (-4.4A)
ZN  A 201 ( 2.3A)
 1.05A 1mz9D-3h0nA:
undetectable		 1mz9D-3h0nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h15 PROTEIN MCM10
HOMOLOG

(Xenopus laevis) 		PF09329
(zf-primase) 		4 LEU A 317
CYH A 381
ALA A 383
CYH A 391
 None
ZN  A 500 (-2.4A)
ZN  A 500 ( 4.4A)
ZN  A 500 (-2.3A)
 1.10A 1mz9D-3h15A:
undetectable		 1mz9D-3h15A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 LEU A 158
VAL A  95
CYH A  42
ALA A  66
 None
 0.92A 1mz9D-3jzdA:
undetectable		 1mz9D-3jzdA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 LEU X  86
VAL X 288
CYH X 292
ALA X 294
 None
None
SF4  X 400 (-2.2A)
SF4  X 400 ( 4.9A)
 1.06A 1mz9D-3n5nX:
undetectable		 1mz9D-3n5nX:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)

(Archaeoglobus
fulgidus) 		PF12804
(NTP_transf_3) 		4 LEU A 153
VAL A 158
CYH A 113
ALA A 111
 None
 0.82A 1mz9D-3ngwA:
undetectable		 1mz9D-3ngwA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnq N-TERMINAL DOMAIN OF
MOLONEY MURINE
LEUKEMIA VIRUS
INTEGRASE

(Murine leukemia
virus) 		PF16721
(zf-H3C2) 		4 LEU A  88
CYH A  95
ALA A  97
CYH A  98
 None
ZN  A 201 (-2.2A)
ZN  A 201 ( 4.4A)
ZN  A 201 (-2.3A)
 0.72A 1mz9D-3nnqA:
undetectable		 1mz9D-3nnqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 VAL A 986
CYH A 936
ALA A 933
CYH A 932
 None
 1.11A 1mz9D-3nzuA:
undetectable		 1mz9D-3nzuA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2a PUTATIVE
THIOREDOXIN-LIKE
PROTEIN

(Yersinia pestis) 		PF00085
(Thioredoxin) 		4 LEU A  14
CYH A   5
ALA A   7
CYH A   8
 None
ZN  A 151 (-2.3A)
ZN  A 151 ( 4.9A)
ZN  A 151 (-2.3A)
 1.16A 1mz9D-3p2aA:
undetectable		 1mz9D-3p2aA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		4 LEU A 304
CYH A 221
ALA A 255
CYH A 223
 None
 1.15A 1mz9D-3uykA:
undetectable		 1mz9D-3uykA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5k ZINC FINGER PROTEIN
SNAI1

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13912
(zf-C2H2_6) 		4 LEU B 250
CYH B 238
ALA B 240
CYH B 241
 None
ZN  B 504 (-2.3A)
ZN  B 504 ( 4.3A)
ZN  B 504 (-2.2A)
 0.92A 1mz9D-3w5kB:
undetectable		 1mz9D-3w5kB:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 1.17A 1mz9D-4axgA:
undetectable		 1mz9D-4axgA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 496
CYH A 813
ALA A 815
CYH A 810
 None
ZN  A1923 (-2.1A)
ZN  A1923 ( 4.9A)
ZN  A1923 (-2.2A)
 0.90A 1mz9D-4ay2A:
undetectable		 1mz9D-4ay2A:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A1168
VAL A1172
ALA A1179
CYH A1176
 None
 1.03A 1mz9D-4b4cA:
undetectable		 1mz9D-4b4cA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 LEU A 466
VAL A 232
CYH A 233
ALA A 264
 None
 1.14A 1mz9D-4c90A:
undetectable		 1mz9D-4c90A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU H 187
VAL H 174
ALA H  77
CYH H 102
 None
 1.17A 1mz9D-4cr4H:
undetectable		 1mz9D-4cr4H:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		4 LEU A 195
VAL A 260
CYH A 264
ALA A 333
 None
 1.08A 1mz9D-4f3nA:
undetectable		 1mz9D-4f3nA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 858
CYH A 672
ALA A 666
CYH A 665
 None
 1.13A 1mz9D-4f9oA:
undetectable		 1mz9D-4f9oA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 LEU C  95
VAL C 102
CYH C  50
ALA C 198
 None
 1.11A 1mz9D-4fzwC:
undetectable		 1mz9D-4fzwC:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		4 LEU A 151
VAL A 147
CYH A 144
ALA A 269
 None
 0.94A 1mz9D-4glfA:
undetectable		 1mz9D-4glfA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		4 LEU A 437
VAL A  90
CYH A  91
ALA A  54
 None
 1.16A 1mz9D-4itaA:
undetectable		 1mz9D-4itaA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		4 LEU A 117
VAL A 126
ALA A 171
CYH A 167
 None
 1.12A 1mz9D-4jxjA:
undetectable		 1mz9D-4jxjA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 LEU A 414
VAL A 422
ALA A 327
CYH A 426
 None
 1.17A 1mz9D-4k70A:
undetectable		 1mz9D-4k70A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1

(Caenorhabditis
elegans) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 457
VAL A 369
CYH A 368
ALA A 316
 None
 1.00A 1mz9D-4l15A:
undetectable		 1mz9D-4l15A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs ACETALDEHYDE
DEHYDROGENASE

(Thermomonospora
curvata) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 LEU B 258
VAL B 279
ALA B 167
CYH B 227
 CL  B 402 (-4.8A)
CL  B 402 (-3.8A)
None
None
 1.14A 1mz9D-4lrsB:
undetectable		 1mz9D-4lrsB:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		4 VAL A 117
CYH A 116
ALA A 161
CYH A 160
 HEM  A 608 ( 4.8A)
HEM  A 607 (-1.7A)
HEM  A 607 (-3.9A)
HEM  A 608 ( 1.8A)
 1.04A 1mz9D-4n4kA:
undetectable		 1mz9D-4n4kA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 LEU A 342
CYH A 365
ALA A 367
CYH A 368
 None
ZN  A 501 (-2.4A)
ZN  A 501 ( 4.6A)
ZN  A 501 (-2.3A)
 1.04A 1mz9D-4nqyA:
undetectable		 1mz9D-4nqyA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 LEU A 345
CYH A 365
ALA A 367
CYH A 368
 None
ZN  A 501 (-2.4A)
ZN  A 501 ( 4.6A)
ZN  A 501 (-2.3A)
 0.71A 1mz9D-4nqyA:
undetectable		 1mz9D-4nqyA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzg INTEGRASE P46

(Murine leukemia
virus) 		PF16721
(zf-H3C2) 		4 LEU A  88
CYH A  95
ALA A  97
CYH A  98
 None
ZN  A 201 (-2.2A)
ZN  A 201 ( 4.7A)
ZN  A 201 (-2.2A)
 0.64A 1mz9D-4nzgA:
undetectable		 1mz9D-4nzgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		4 LEU A 293
VAL A 273
ALA A 280
CYH A 277
 None
 1.16A 1mz9D-4ofxA:
undetectable		 1mz9D-4ofxA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 LEU A 120
VAL A 125
CYH A 129
ALA A 160
 None
 1.15A 1mz9D-4perA:
undetectable		 1mz9D-4perA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		4 LEU A  64
VAL A  66
CYH A  67
ALA A  69
 None
 1.14A 1mz9D-4qdkA:
undetectable		 1mz9D-4qdkA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A  30
VAL A  33
ALA A 419
CYH A 420
 None
 0.99A 1mz9D-4xgiA:
undetectable		 1mz9D-4xgiA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF00180
(Iso_dh) 		4 VAL A 218
CYH A 167
ALA A 182
CYH A 185
 None
 1.19A 1mz9D-4y1pA:
undetectable		 1mz9D-4y1pA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 LEU A  10
VAL A  12
CYH A  13
ALA A  15
 None
 1.17A 1mz9D-4zhtA:
undetectable		 1mz9D-4zhtA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		4 LEU A 185
VAL A 286
CYH A 288
ALA A 261
 None
 1.08A 1mz9D-4zpxA:
undetectable		 1mz9D-4zpxA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 LEU C 675
CYH C 571
ALA C 568
CYH C 567
 None
 0.84A 1mz9D-5a5tC:
undetectable		 1mz9D-5a5tC:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 195
VAL A 174
ALA A 255
CYH A 233
 None
 1.14A 1mz9D-5b37A:
undetectable		 1mz9D-5b37A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		4 LEU A  11
VAL A  16
CYH A 133
ALA A 130
 None
 0.85A 1mz9D-5bt8A:
undetectable		 1mz9D-5bt8A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 4 LEU A 280
VAL A 288
CYH A 289
ALA A 312
 None
 1.13A 1mz9D-5czcA:
undetectable		 1mz9D-5czcA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er3 SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13407
(Peripla_BP_4) 		4 LEU A  90
VAL A  88
ALA A  85
CYH A  86
 None
 1.14A 1mz9D-5er3A:
undetectable		 1mz9D-5er3A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 LEU A 390
VAL A 394
CYH A 397
ALA A 401
 None
 0.85A 1mz9D-5flzA:
undetectable		 1mz9D-5flzA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		4 LEU B  85
VAL B  89
CYH B  92
ALA B 231
 None
 1.16A 1mz9D-5fn3B:
undetectable		 1mz9D-5fn3B:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0f HDAC6

(Danio rerio) 		PF02148
(zf-UBP) 		4 VAL A1056
CYH A1049
ALA A1051
CYH A1052
 None
ZN  A2082 (-2.2A)
ZN  A2082 ( 4.3A)
ZN  A2082 (-2.4A)
 0.82A 1mz9D-5g0fA:
undetectable		 1mz9D-5g0fA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 LEU A1458
VAL A1478
CYH A1479
CYH A1481
 None
None
ZN  A1703 (-2.3A)
ZN  A1703 (-2.3A)
 1.00A 1mz9D-5gutA:
undetectable		 1mz9D-5gutA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn THIOREDOXIN-1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		4 LEU K  94
CYH K  35
ALA K  29
CYH K  32
 None
 1.04A 1mz9D-5iknK:
undetectable		 1mz9D-5iknK:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwx 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02542
(YgbB) 		4 LEU A  41
VAL A  45
ALA A  52
CYH A  49
 None
 1.13A 1mz9D-5iwxA:
undetectable		 1mz9D-5iwxA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Mus musculus) 		PF07496
(zf-CW)
PF13589
(HATPase_c_3) 		4 LEU A 422
CYH A 413
ALA A 415
CYH A 416
 None
ZN  A 501 (-2.1A)
ZN  A 501 ( 4.8A)
ZN  A 501 (-2.0A)
 1.13A 1mz9D-5ix1A:
undetectable		 1mz9D-5ix1A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 LEU A  17
VAL A 210
CYH A 214
ALA A 216
 None
None
SF4  A 301 (-2.3A)
SF4  A 301 ( 4.8A)
 1.00A 1mz9D-5kn8A:
undetectable		 1mz9D-5kn8A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 379
VAL A 108
ALA A  89
CYH A  86
 None
 1.12A 1mz9D-5ks1A:
undetectable		 1mz9D-5ks1A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 LEU A 422
VAL A 417
ALA A 365
CYH A 382
 None
 1.10A 1mz9D-5l6sA:
undetectable		 1mz9D-5l6sA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		4 LEU A 185
VAL A 235
CYH A 234
ALA A 198
 None
 1.12A 1mz9D-5nlaA:
undetectable		 1mz9D-5nlaA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 4 LEU A4616
CYH A4579
ALA A4581
CYH A4582
 None
ZN  A4705 (-2.3A)
None
ZN  A4705 (-2.3A)
 1.15A 1mz9D-5o6cA:
undetectable		 1mz9D-5o6cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 4 LEU A 429
VAL A 514
CYH A 513
ALA A 247
 None
None
None
79M  A 707 ( 3.7A)
 1.15A 1mz9D-5oc9A:
undetectable		 1mz9D-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svi MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Homo sapiens) 		PF07496
(zf-CW) 		4 LEU A 422
CYH A 413
ALA A 415
CYH A 416
 None
ZN  A 501 (-2.3A)
ZN  A 501 ( 4.8A)
ZN  A 501 (-2.3A)
 1.19A 1mz9D-5sviA:
undetectable		 1mz9D-5sviA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 1.10A 1mz9D-5t47A:
undetectable		 1mz9D-5t47A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 4 LEU A 183
VAL A  13
ALA A  67
CYH A  16
 None
 1.17A 1mz9D-5wgcA:
undetectable		 1mz9D-5wgcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU B  55
CYH B 131
ALA B 128
CYH B 127
 None
 0.99A 1mz9D-5wybB:
undetectable		 1mz9D-5wybB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 LEU D 800
VAL D 803
ALA D 809
CYH D 810
 None
 0.91A 1mz9D-5xbkD:
undetectable		 1mz9D-5xbkD:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE
SUBUNIT ABC10-ALPHA

(Komagataella
phaffii) 		PF03604
(DNA_RNApol_7kD) 		4 LEU L  42
CYH L  33
ALA L  35
CYH L  36
 None
ZN  L 101 (-2.6A)
None
ZN  L 101 (-2.4A)
 0.95A 1mz9D-5xogL:
undetectable		 1mz9D-5xogL:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yje PROTEIN HIRA

(Homo sapiens) 		no annotation 4 LEU A 768
VAL A 759
CYH A 749
ALA A 742
 None
 1.07A 1mz9D-5yjeA:
undetectable		 1mz9D-5yjeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 237
VAL A 173
CYH A 194
ALA A 169
 None
 1.12A 1mz9D-6c49A:
undetectable		 1mz9D-6c49A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 5 LEU A 241
VAL A 184
CYH A 211
ALA A 175
CYH A 178
 None
 1.44A 1mz9D-6c9bA:
undetectable		 1mz9D-6c9bA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 267
VAL A 262
CYH A 296
ALA A 321
 None
 1.21A 1mz9E-1a3xA:
0.0		 1mz9E-1a3xA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		4 LEU A 301
VAL A 267
CYH A 266
ALA A 218
 None
 1.08A 1mz9E-1gq7A:
0.0		 1mz9E-1gq7A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE

(Saccharomyces
cerevisiae) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A  64
VAL A  66
CYH A  67
ALA A  72
 None
 1.20A 1mz9E-1ig0A:
0.0		 1mz9E-1ig0A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		4 LEU A 167
VAL A   3
CYH A  65
ALA A  62
 None
 1.05A 1mz9E-1jaxA:
0.0		 1mz9E-1jaxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 250
VAL A 255
CYH A 257
ALA A 181
 None
 1.22A 1mz9E-1kolA:
0.0		 1mz9E-1kolA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 374
VAL A 372
CYH A 370
ALA A 361
 None
 1.28A 1mz9E-1m54A:
0.0		 1mz9E-1m54A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6

(Saccharopolyspora
erythraea) 		PF00975
(Thioesterase) 		4 LEU A  56
VAL A 101
CYH A  73
ALA A 148
 None
 1.29A 1mz9E-1mo2A:
0.0		 1mz9E-1mo2A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 246
VAL A 185
CYH A 188
ALA A 207
 None
 1.17A 1mz9E-1rw9A:
0.0		 1mz9E-1rw9A:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		4 LEU A 170
VAL A 181
CYH A 179
ALA A 130
 None
 1.21A 1mz9E-1tjrA:
0.0		 1mz9E-1tjrA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm6 DIHYDRODIPICOLINATE
REDUCTASE

(Thermotoga
maritima) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 LEU A  54
VAL A  58
CYH A  61
ALA A  66
 None
 1.12A 1mz9E-1vm6A:
undetectable		 1mz9E-1vm6A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 370
VAL A 394
CYH A 393
ALA A 304
 None
 1.29A 1mz9E-1wl4A:
undetectable		 1mz9E-1wl4A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 LEU A 382
VAL A 386
CYH A 389
ALA A 394
 None
 1.28A 1mz9E-2a2dA:
undetectable		 1mz9E-2a2dA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		4 LEU C  21
VAL C 321
CYH C 325
ALA C  12
 None
 1.29A 1mz9E-2af4C:
undetectable		 1mz9E-2af4C:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		4 LEU C 197
VAL C 326
CYH C 325
ALA C  42
 None
 1.13A 1mz9E-2af4C:
undetectable		 1mz9E-2af4C:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 LEU B 105
VAL B 109
CYH B 112
ALA A 110
 None
 1.11A 1mz9E-2b7hB:
undetectable		 1mz9E-2b7hB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		4 LEU A   3
VAL A 206
CYH A 225
ALA A 222
 None
 1.13A 1mz9E-2fk6A:
undetectable		 1mz9E-2fk6A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 263
VAL A 267
CYH A 270
ALA A 275
 None
 1.10A 1mz9E-2hfsA:
undetectable		 1mz9E-2hfsA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		4 LEU A 758
VAL A 718
CYH A 717
ALA A 707
 None
 1.25A 1mz9E-2hwkA:
undetectable		 1mz9E-2hwkA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A  71
VAL A  75
CYH A  78
ALA A  55
 None
 1.08A 1mz9E-2irwA:
undetectable		 1mz9E-2irwA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A  71
VAL A  75
CYH A  78
ALA A  83
 None
 1.08A 1mz9E-2irwA:
undetectable		 1mz9E-2irwA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 LEU A  89
VAL A  93
CYH A  96
ALA A 101
 None
 0.94A 1mz9E-2ji4A:
undetectable		 1mz9E-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 LEU A  37
VAL A 111
CYH A 112
ALA A 193
 None
 1.25A 1mz9E-2l7bA:
undetectable		 1mz9E-2l7bA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le1 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		PF10604
(Polyketide_cyc2) 		4 LEU A  93
VAL A  95
CYH A 103
ALA A  12
 None
 1.23A 1mz9E-2le1A:
undetectable		 1mz9E-2le1A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		4 LEU A  28
VAL A  30
CYH A  31
ALA A  34
 None
 1.22A 1mz9E-2odfA:
undetectable		 1mz9E-2odfA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		4 LEU A 162
VAL A 165
CYH A 168
ALA A  63
 None
 1.08A 1mz9E-2prdA:
undetectable		 1mz9E-2prdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzg UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 33

(Homo sapiens) 		PF02148
(zf-UBP) 		4 LEU A 123
VAL A 121
CYH A 114
ALA A 116
 None
None
ZN  A 131 (-2.3A)
ZN  A 131 ( 4.4A)
 1.29A 1mz9E-2uzgA:
undetectable		 1mz9E-2uzgA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 340
VAL A 335
CYH A 369
ALA A 394
 None
 1.04A 1mz9E-2vgiA:
undetectable		 1mz9E-2vgiA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 340
VAL A 335
CYH A 369
ALA A 399
 None
 1.20A 1mz9E-2vgiA:
undetectable		 1mz9E-2vgiA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 107
VAL A 111
CYH A 114
ALA A 193
 None
 0.94A 1mz9E-2wnrA:
undetectable		 1mz9E-2wnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 176
VAL A   7
CYH A   8
ALA A  67
 None
 0.93A 1mz9E-2x3eA:
undetectable		 1mz9E-2x3eA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 LEU C 288
VAL C 360
CYH C 361
ALA C 366
 None
 1.28A 1mz9E-2ynmC:
undetectable		 1mz9E-2ynmC:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		4 LEU A 125
VAL A 121
CYH A 118
ALA A 265
 None
 1.09A 1mz9E-2zm2A:
undetectable		 1mz9E-2zm2A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcv PUTATIVE
GLYCOSYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF00535
(Glycos_transf_2) 		4 LEU A 208
VAL A 214
CYH A 114
ALA A 109
 None
 1.26A 1mz9E-3bcvA:
undetectable		 1mz9E-3bcvA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 206
VAL A 214
CYH A 217
ALA A 222
 None
 1.13A 1mz9E-3cosA:
undetectable		 1mz9E-3cosA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		4 LEU A  71
VAL A  75
CYH A  78
ALA A  55
 None
 1.08A 1mz9E-3dwfA:
undetectable		 1mz9E-3dwfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		4 LEU A  71
VAL A  75
CYH A  78
ALA A  83
 None
 1.14A 1mz9E-3dwfA:
undetectable		 1mz9E-3dwfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		4 LEU A  22
VAL A  37
CYH A  40
ALA A  41
 None
None
ZN  A 210 (-2.1A)
None
 1.25A 1mz9E-3f9kA:
undetectable		 1mz9E-3f9kA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 131
VAL A 187
CYH A 188
ALA A 154
 None
 1.27A 1mz9E-3fcjA:
undetectable		 1mz9E-3fcjA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcn AN ALPHA-HELICAL
PROTEIN OF UNKNOWN
FUNCTION (PFAM01724)

(Rhodospirillum
rubrum) 		PF01724
(DUF29) 		4 LEU A 146
VAL A  61
CYH A  65
ALA A 115
 None
 1.17A 1mz9E-3fcnA:
undetectable		 1mz9E-3fcnA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		4 LEU A 123
VAL A 121
CYH A 120
ALA A 118
 None
 1.20A 1mz9E-3fj1A:
undetectable		 1mz9E-3fj1A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		4 LEU A 122
VAL A 120
CYH A 119
ALA A 117
 None
 1.15A 1mz9E-3hbaA:
undetectable		 1mz9E-3hbaA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei) 		PF00348
(polyprenyl_synt) 		4 LEU A 280
VAL A  61
CYH A  65
ALA A 192
 None
None
MLA  A 309 (-4.4A)
None
 1.14A 1mz9E-3ipiA:
undetectable		 1mz9E-3ipiA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 LEU A 158
VAL A  95
CYH A  42
ALA A  66
 None
 0.82A 1mz9E-3jzdA:
undetectable		 1mz9E-3jzdA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		4 LEU A 185
VAL A 286
CYH A 288
ALA A 261
 None
 1.17A 1mz9E-3k1jA:
undetectable		 1mz9E-3k1jA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 LEU A 330
VAL A 333
CYH A 336
ALA A 816
 None
 1.29A 1mz9E-3n23A:
undetectable		 1mz9E-3n23A:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)

(Archaeoglobus
fulgidus) 		PF12804
(NTP_transf_3) 		4 LEU A 153
VAL A 158
CYH A 113
ALA A 111
 None
 0.89A 1mz9E-3ngwA:
undetectable		 1mz9E-3ngwA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 202
VAL A 191
CYH A 165
ALA A 164
 None
None
None
NAD  A 701 (-3.7A)
 1.19A 1mz9E-3om9A:
undetectable		 1mz9E-3om9A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		4 LEU A 202
VAL A  25
CYH A  24
ALA A  14
 None
 1.19A 1mz9E-3pl0A:
undetectable		 1mz9E-3pl0A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  85
VAL A  17
CYH A  15
ALA A  10
 None
 1.15A 1mz9E-3t8qA:
undetectable		 1mz9E-3t8qA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2

(Burkholderia
pseudomallei) 		PF00793
(DAHP_synth_1) 		4 LEU A 146
VAL A 150
CYH A 153
ALA A 127
 None
 1.20A 1mz9E-3tmqA:
undetectable		 1mz9E-3tmqA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zt9 SERINE PHOSPHATASE

(Moorella
thermoacetica) 		PF07228
(SpoIIE) 		4 LEU A   4
VAL A  89
CYH A  87
ALA A  98
 None
 1.06A 1mz9E-3zt9A:
undetectable		 1mz9E-3zt9A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 0.99A 1mz9E-4axgA:
undetectable		 1mz9E-4axgA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 135
VAL A 221
CYH A 220
ALA A 197
 None
 1.28A 1mz9E-4b0nA:
undetectable		 1mz9E-4b0nA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 LEU A 466
VAL A 232
CYH A 233
ALA A 264
 None
 1.25A 1mz9E-4c90A:
undetectable		 1mz9E-4c90A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 LEU A 405
VAL A 355
CYH A 343
ALA A 332
 None
 1.28A 1mz9E-4ci8A:
undetectable		 1mz9E-4ci8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 PROTEIN CAF40

(Saccharomyces
cerevisiae) 		PF04078
(Rcd1) 		4 LEU B 245
VAL B 250
CYH B 253
ALA B 268
 None
 1.10A 1mz9E-4cv5B:
undetectable		 1mz9E-4cv5B:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 LEU A 853
VAL A 872
CYH A 897
ALA A 899
 None
 1.13A 1mz9E-4ecnA:
undetectable		 1mz9E-4ecnA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		4 LEU A 195
VAL A 260
CYH A 264
ALA A 333
 None
 0.99A 1mz9E-4f3nA:
undetectable		 1mz9E-4f3nA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 LEU C  95
VAL C 102
CYH C  50
ALA C 198
 None
 1.14A 1mz9E-4fzwC:
undetectable		 1mz9E-4fzwC:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		4 LEU A  60
VAL A  64
CYH A  67
ALA A 284
 None
 1.29A 1mz9E-4g1uA:
undetectable		 1mz9E-4g1uA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		4 LEU A 151
VAL A 147
CYH A 144
ALA A 269
 None
 1.00A 1mz9E-4glfA:
undetectable		 1mz9E-4glfA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 266
VAL A 261
CYH A 295
ALA A 320
 None
 1.15A 1mz9E-4hyvA:
undetectable		 1mz9E-4hyvA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 251
VAL A 256
CYH A 258
ALA A 182
 None
 1.24A 1mz9E-4jlwA:
undetectable		 1mz9E-4jlwA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmu GAG-POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00540
(Gag_p17) 		4 LEU A   8
VAL A  88
CYH A  87
ALA A 100
 None
 1.20A 1mz9E-4jmuA:
undetectable		 1mz9E-4jmuA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 261
VAL A 237
CYH A 236
ALA A 208
 None
 1.29A 1mz9E-4jn7A:
undetectable		 1mz9E-4jn7A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Mus musculus) 		PF00106
(adh_short) 		4 LEU A  71
VAL A  75
CYH A  78
ALA A  83
 None
 1.16A 1mz9E-4k26A:
undetectable		 1mz9E-4k26A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1

(Caenorhabditis
elegans) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 457
VAL A 369
CYH A 368
ALA A 316
 None
 0.95A 1mz9E-4l15A:
undetectable		 1mz9E-4l15A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		4 LEU A 293
VAL A 291
CYH A 289
ALA A 280
 None
 1.22A 1mz9E-4ofxA:
undetectable		 1mz9E-4ofxA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 LEU A 120
VAL A 125
CYH A 129
ALA A 160
 None
 1.21A 1mz9E-4perA:
undetectable		 1mz9E-4perA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 LEU A 332
VAL A 328
CYH A 325
ALA A 322
 None
 1.26A 1mz9E-4perA:
undetectable		 1mz9E-4perA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		4 LEU A  64
VAL A  66
CYH A  67
ALA A  69
 None
 1.24A 1mz9E-4qdkA:
undetectable		 1mz9E-4qdkA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiu NITRONATE
MONOOXYGENASE FAMILY
PROTEIN

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		4 LEU A 258
VAL A 243
CYH A 245
ALA A 338
 None
 1.26A 1mz9E-4qiuA:
undetectable		 1mz9E-4qiuA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		4 LEU A 134
VAL A 127
CYH A 105
ALA A  67
 None
 1.12A 1mz9E-4rltA:
undetectable		 1mz9E-4rltA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides) 		PF13419
(HAD_2) 		4 LEU A 210
VAL A 193
CYH A 191
ALA A 184
 None
 1.29A 1mz9E-4uarA:
undetectable		 1mz9E-4uarA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		4 LEU A1509
VAL A1363
CYH A1362
ALA A1368
 None
 1.11A 1mz9E-4w4tA:
undetectable		 1mz9E-4w4tA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LEU A 441
VAL A 426
CYH A 424
ALA A 396
 None
 1.28A 1mz9E-4xr9A:
undetectable		 1mz9E-4xr9A:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 297
VAL A 292
CYH A 326
ALA A 351
 None
 1.19A 1mz9E-4yj5A:
undetectable		 1mz9E-4yj5A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 LEU A  10
VAL A  12
CYH A  13
ALA A  15
 None
 1.29A 1mz9E-4zhtA:
undetectable		 1mz9E-4zhtA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		4 LEU A 185
VAL A 286
CYH A 288
ALA A 261
 None
 1.08A 1mz9E-4zpxA:
undetectable		 1mz9E-4zpxA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		4 LEU A 182
VAL A 340
CYH A 341
ALA A 529
 None
 1.25A 1mz9E-4zweA:
undetectable		 1mz9E-4zweA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 261
VAL A 273
CYH A 276
ALA A 302
 None
 1.22A 1mz9E-5ahkA:
undetectable		 1mz9E-5ahkA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 LEU A 337
VAL A 340
CYH A 343
ALA A 823
 None
 1.19A 1mz9E-5aw4A:
undetectable		 1mz9E-5aw4A:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 4 LEU A 280
VAL A 288
CYH A 289
ALA A 312
 None
 1.26A 1mz9E-5czcA:
undetectable		 1mz9E-5czcA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 LEU A 390
VAL A 394
CYH A 397
ALA A 401
 None
 0.90A 1mz9E-5flzA:
undetectable		 1mz9E-5flzA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 LEU A 198
VAL A 202
CYH A 205
ALA A 161
 None
 1.03A 1mz9E-5k8fA:
undetectable		 1mz9E-5k8fA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 LEU B 205
VAL B 231
CYH B 232
ALA B 269
 None
 1.28A 1mz9E-5l3xB:
undetectable		 1mz9E-5l3xB:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 374
VAL A 372
CYH A 370
ALA A 361
 None
 1.17A 1mz9E-5mmsA:
undetectable		 1mz9E-5mmsA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		4 LEU A 185
VAL A 235
CYH A 234
ALA A 198
 None
 1.23A 1mz9E-5nlaA:
undetectable		 1mz9E-5nlaA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 4 LEU A 429
VAL A 514
CYH A 513
ALA A 247
 None
None
None
79M  A 707 ( 3.7A)
 1.29A 1mz9E-5oc9A:
undetectable		 1mz9E-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 0.93A 1mz9E-5t47A:
undetectable		 1mz9E-5t47A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud6 DIHYDRODIPICOLINATE
SYNTHASE

(Cyanidioschyzon
merolae) 		no annotation 4 LEU A 108
VAL A  84
CYH A  82
ALA A  42
 None
 1.26A 1mz9E-5ud6A:
undetectable		 1mz9E-5ud6A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v10 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 LEU A  80
VAL A 100
CYH A 110
ALA A  68
 None
 1.08A 1mz9E-5v10A:
undetectable		 1mz9E-5v10A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		4 LEU A 267
VAL A 270
CYH A 273
ALA A 327
 None
 1.25A 1mz9E-5v57A:
undetectable		 1mz9E-5v57A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 LEU A 133
VAL A 108
CYH A  74
ALA A  86
 None
 1.20A 1mz9E-5vxcA:
undetectable		 1mz9E-5vxcA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 4 LEU A 339
VAL A 357
CYH A 359
ALA A 373
 None
 1.18A 1mz9E-5w19A:
undetectable		 1mz9E-5w19A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xso RESPONSE REGULATOR
FIXJ

(Bradyrhizobium
japonicum) 		no annotation 4 LEU A  20
VAL A  53
CYH A  51
ALA A 119
 None
 1.23A 1mz9E-5xsoA:
undetectable		 1mz9E-5xsoA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yje PROTEIN HIRA

(Homo sapiens) 		no annotation 4 LEU A 768
VAL A 759
CYH A 749
ALA A 742
 None
 0.98A 1mz9E-5yjeA:
undetectable		 1mz9E-5yjeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykh PUMILIO HOMOLOG 1

(Homo sapiens) 		no annotation 4 LEU A 173
VAL A 183
CYH A 186
ALA A 190
 None
 1.18A 1mz9E-5ykhA:
undetectable		 1mz9E-5ykhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 237
VAL A 173
CYH A 194
ALA A 169
 None
 1.05A 1mz9E-6c49A:
undetectable		 1mz9E-6c49A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 4 LEU A 272
VAL A 406
CYH A 404
ALA A 418
 None
 1.26A 1mz9E-6cddA:
undetectable		 1mz9E-6cddA:
16.67