SIMILAR PATTERNS OF AMINO ACIDS FOR 1MXG_A_ACRA444_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		4 TYR A 166
TRP A 183
HIS A 195
GLY A  60
 None
 1.32A 1mxgA-1a88A:
undetectable		 1mxgA-1a88A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase) 		4 TYR A  14
TRP A  13
TYR A  56
GLY A  48
 None
 1.38A 1mxgA-1bplA:
12.4		 1mxgA-1bplA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 TYR A 486
TYR A 418
GLY A 725
TRP A 415
 None
 1.14A 1mxgA-1hwwA:
3.4		 1mxgA-1hwwA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 TYR A 468
ASN A 326
TRP A 452
GLY A 324
 None
 1.37A 1mxgA-1hxjA:
10.5		 1mxgA-1hxjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ly7 FRATAXIN

(Homo sapiens) 		PF01491
(Frataxin_Cyay) 		4 ASN A 172
TRP A 168
TYR A 205
GLY A 207
 None
 1.32A 1mxgA-1ly7A:
undetectable		 1mxgA-1ly7A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (LIGHT
SUBUNIT)

(Paracoccus
denitrificans) 		PF02975
(Me-amine-dh_L) 		4 TYR L 117
ASN L 103
GLY L  93
TRP L  13
 None
 1.36A 1mxgA-1mdaL:
undetectable		 1mxgA-1mdaL:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 TYR A   8
HIS A  61
TYR A  60
GLY A  56
 None
 1.17A 1mxgA-1mjfA:
undetectable		 1mxgA-1mjfA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A   3
ASN A 328
TRP A 331
HIS A 390
TYR A 392
GLY A 394
TRP A 399
 None
 0.30A 1mxgA-1mwoA:
66.0		 1mxgA-1mwoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 TYR C 461
TYR B 391
GLY D 658
TRP B 388
 None
 1.04A 1mxgA-1o7dC:
4.0		 1mxgA-1o7dC:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 TYR A 144
HIS A 177
TYR A  53
GLY A 131
 NHE  A 354 (-4.9A)
None
None
None
 1.23A 1mxgA-1q1qA:
undetectable		 1mxgA-1q1qA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 TYR A 159
HIS A 192
TYR A  68
GLY A 146
 None
 1.27A 1mxgA-1q20A:
undetectable		 1mxgA-1q20A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		4 TYR A 361
TRP A 362
GLY A 373
TRP A 169
 None
 1.26A 1mxgA-1vffA:
6.7		 1mxgA-1vffA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 TYR A  14
TRP A  13
TYR A  56
GLY A  48
 None
 1.37A 1mxgA-1vjsA:
40.2		 1mxgA-1vjsA:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl1 6-PHOSPHOGLUCONOLACT
ONASE

(Thermotoga
maritima) 		PF01182
(Glucosamine_iso) 		4 TYR A 115
ASN A  80
HIS A 138
GLY A  42
 None
None
CIT  A 300 (-4.0A)
CIT  A 300 (-3.5A)
 1.25A 1mxgA-1vl1A:
undetectable		 1mxgA-1vl1A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 936
ASN A 962
TYR A 958
GLY A 960
 None
None
None
IOD  A9052 ( 4.3A)
 1.32A 1mxgA-1xc6A:
10.1		 1mxgA-1xc6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 264
HIS A  42
TYR A 267
GLY A 243
 None
 1.34A 1mxgA-1y9aA:
undetectable		 1mxgA-1y9aA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbm HYPOTHETICAL PROTEIN
AF1704

(Archaeoglobus
fulgidus) 		PF02621
(VitK2_biosynth) 		4 TYR A  50
ASN A  42
HIS A 143
GLY A 101
 None
 1.37A 1mxgA-1zbmA:
undetectable		 1mxgA-1zbmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 TYR A 167
TRP A 184
HIS A 196
GLY A  61
 None
 1.26A 1mxgA-1zoiA:
undetectable		 1mxgA-1zoiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 TRP X 246
HIS X 319
TYR X 252
GLY X 254
 None
 1.19A 1mxgA-2b5dX:
4.2		 1mxgA-2b5dX:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 TYR A  16
TRP A  15
TYR A  58
GLY A  50
 None
None
GLC  A 605 (-4.8A)
None
 1.36A 1mxgA-2d3lA:
39.8		 1mxgA-2d3lA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		4 TYR A 222
ASN A  96
TYR A 102
GLY A 104
 None
 1.12A 1mxgA-2gfqA:
undetectable		 1mxgA-2gfqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		4 TYR A  85
TRP A 160
HIS A 145
TYR A  27
 None
 1.19A 1mxgA-2gm8A:
undetectable		 1mxgA-2gm8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		4 TYR A  85
TRP A 160
TYR A  27
GLY A  29
 None
 1.22A 1mxgA-2gm8A:
undetectable		 1mxgA-2gm8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iex DIHYDROXYNAPTHOIC
ACID SYNTHETASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		4 ASN A 136
HIS A  33
TYR A 116
GLY A  67
 None
 1.08A 1mxgA-2iexA:
2.6		 1mxgA-2iexA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 TRP A 357
HIS A 329
TYR A 362
GLY A 364
 None
 1.33A 1mxgA-2incA:
undetectable		 1mxgA-2incA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TYR A  20
ASN A  11
TRP A   5
TYR A   7
 None
 1.24A 1mxgA-2it4A:
undetectable		 1mxgA-2it4A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mta METHYLAMINE
DEHYDROGENASE (LIGHT
SUBUNIT)

(Paracoccus
denitrificans) 		PF02975
(Me-amine-dh_L) 		4 TYR L 119
ASN L 104
GLY L  93
TRP L  13
 None
TRQ  L  57 ( 4.8A)
None
None
 1.27A 1mxgA-2mtaL:
undetectable		 1mxgA-2mtaL:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 TYR A 155
TRP A 177
TYR A 175
GLY A 202
 None
 1.31A 1mxgA-2o6sA:
undetectable		 1mxgA-2o6sA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2orz NEUROPILIN-1

(Rattus
norvegicus) 		PF00754
(F5_F8_type_C) 		4 TYR A 565
ASN A 451
TRP A 484
GLY A 453
 None
 1.36A 1mxgA-2orzA:
undetectable		 1mxgA-2orzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		4 TYR A  28
TRP A  13
TYR A 189
GLY A   6
 None
 1.28A 1mxgA-2oxtA:
undetectable		 1mxgA-2oxtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 ASN A 128
HIS A  67
TYR A  93
GLY A  90
 None
SAH  A 301 (-3.9A)
None
SAH  A 301 (-3.4A)
 1.23A 1mxgA-2pbfA:
undetectable		 1mxgA-2pbfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbz HYPOTHETICAL PROTEIN

(Thermococcus
kodakarensis) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 ASN A 214
HIS A 253
TYR A 172
GLY A 271
 None
None
ATP  A 400 (-4.7A)
None
 1.21A 1mxgA-2pbzA:
undetectable		 1mxgA-2pbzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		4 ASN A 505
TRP A 504
GLY A 712
TRP A 388
 None
 1.25A 1mxgA-2pggA:
undetectable		 1mxgA-2pggA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ASN A 149
TRP A  53
HIS A 201
TYR A 199
 None
 1.37A 1mxgA-2pxjA:
undetectable		 1mxgA-2pxjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		4 TYR A 163
TRP A  78
TYR A 124
GLY A 118
 None
 1.31A 1mxgA-2uz0A:
undetectable		 1mxgA-2uz0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdt LEVANSUCRASE

(Bacillus
subtilis) 		PF02435
(Glyco_hydro_68) 		4 TYR A  37
ASN A 335
TYR A 271
GLY A 311
 None
 1.25A 1mxgA-2vdtA:
undetectable		 1mxgA-2vdtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2i 2-OXOGLUTARATE
OXYGENASE

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ASN A 150
TRP A  54
HIS A 202
TYR A 200
 None
 1.35A 1mxgA-2w2iA:
undetectable		 1mxgA-2w2iA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		4 TYR A 380
ASN A 412
GLY A  77
TRP A 155
 None
 1.20A 1mxgA-2y2wA:
5.7		 1mxgA-2y2wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		4 ASN A 121
HIS A 166
TYR A 145
GLY A 147
 None
 1.30A 1mxgA-2yvaA:
undetectable		 1mxgA-2yvaA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 TYR A  10
HIS A  63
TYR A  62
GLY A  58
 AG3  A1001 (-4.9A)
AG3  A1001 (-4.0A)
AG3  A1001 (-4.5A)
None
 1.09A 1mxgA-2zsuA:
undetectable		 1mxgA-2zsuA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 TRP A 353
HIS A 403
TYR A 404
GLY A 408
 None
 1.26A 1mxgA-3a24A:
10.6		 1mxgA-3a24A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 TYR A 210
ASN A 464
TYR A 430
GLY A 425
 None
 1.32A 1mxgA-3aflA:
undetectable		 1mxgA-3aflA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 HIS A 234
TYR A 208
GLY A 203
TRP A 235
 MLA  A4892 ( 4.8A)
MLA  A4892 (-4.6A)
None
None
 1.33A 1mxgA-3bf8A:
undetectable		 1mxgA-3bf8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 TYR A   6
ASN A 668
TYR A 630
GLY A 572
 None
 1.35A 1mxgA-3dduA:
undetectable		 1mxgA-3dduA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 264
HIS A  42
TYR A 267
GLY A 243
 None
 1.32A 1mxgA-3fplA:
undetectable		 1mxgA-3fplA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ico 6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacterium
tuberculosis) 		PF01182
(Glucosamine_iso) 		4 TYR A 123
ASN A  83
HIS A 152
GLY A  43
 None
None
SO4  A 248 (-3.8A)
None
 1.31A 1mxgA-3icoA:
undetectable		 1mxgA-3icoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASN A  55
HIS A 213
TYR A 212
GLY A 216
 None
 1.37A 1mxgA-3iplA:
undetectable		 1mxgA-3iplA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 TYR A  90
ASN A  59
TRP A  69
GLY A  31
 None
 1.13A 1mxgA-3k2kA:
3.3		 1mxgA-3k2kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfv TIGHT JUNCTION
PROTEIN ZO-3

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 TYR A 706
TRP A 783
HIS A 517
TYR A 493
 None
 1.30A 1mxgA-3kfvA:
undetectable		 1mxgA-3kfvA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 TYR A  18
TRP A 140
HIS A 286
GLY A 306
 None
None
None
LLX  A 400 (-3.7A)
 1.04A 1mxgA-3maxA:
undetectable		 1mxgA-3maxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 TYR A  18
TRP A 140
HIS A 286
GLY A 307
 None
 1.10A 1mxgA-3maxA:
undetectable		 1mxgA-3maxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mse CALCIUM-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF10591
(SPARC_Ca_bdg)
PF13202
(EF-hand_5) 		4 TYR B  39
HIS B  51
TYR B  45
GLY B  53
 None
 1.32A 1mxgA-3mseB:
undetectable		 1mxgA-3mseB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myv SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 298
TRP A 297
TYR A 330
GLY A 332
 None
None
EDO  A 503 ( 3.9A)
None
 1.30A 1mxgA-3myvA:
undetectable		 1mxgA-3myvA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 948
ASN A 974
TYR A 970
GLY A 972
 None
 1.23A 1mxgA-3ogrA:
10.5		 1mxgA-3ogrA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		4 TYR A 144
ASN A 636
TYR A 650
GLY A 638
 None
 1.17A 1mxgA-3ohnA:
undetectable		 1mxgA-3ohnA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		7 TYR A   3
ASN A 328
TRP A 331
HIS A 390
TYR A 392
GLY A 394
TRP A 399
 None
 0.55A 1mxgA-3qgvA:
65.4		 1mxgA-3qgvA:
86.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr3 MICROCIN IMMUNITY
PROTEIN MCCF

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		4 TYR A  16
HIS A 303
TYR A 111
GLY A 209
 None
 1.16A 1mxgA-3sr3A:
undetectable		 1mxgA-3sr3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ASN A  23
TRP A  26
TYR A  14
GLY A  16
 None
 1.33A 1mxgA-3ti7A:
undetectable		 1mxgA-3ti7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 ASN A 117
TRP A 121
HIS A 369
GLY A  99
 None
HEM  A 500 (-3.9A)
HEM  A 500 (-3.8A)
None
 1.37A 1mxgA-3tk3A:
undetectable		 1mxgA-3tk3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		4 TYR A 124
ASN A  84
HIS A 153
GLY A  44
 None
 1.20A 1mxgA-3tx2A:
undetectable		 1mxgA-3tx2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01261
(AP_endonuc_2) 		4 TYR A  70
TRP A 103
HIS A 144
GLY A 141
 None
 1.36A 1mxgA-3u0hA:
6.6		 1mxgA-3u0hA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 ASN A  55
TYR A  54
GLY A  57
TRP A 110
 SO4  A 803 (-3.8A)
None
None
None
 1.21A 1mxgA-3wnpA:
13.4		 1mxgA-3wnpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		4 TYR A 326
TRP A 322
HIS A 272
GLY A 269
 None
None
B3P  A1560 ( 4.7A)
None
 1.23A 1mxgA-3zxlA:
undetectable		 1mxgA-3zxlA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 TYR A   7
TRP A 129
HIS A 276
GLY A 296
 None
None
None
ACT  A 501 (-3.0A)
 1.02A 1mxgA-4a69A:
undetectable		 1mxgA-4a69A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 TYR A   7
TRP A 129
HIS A 276
GLY A 297
 None
 1.07A 1mxgA-4a69A:
undetectable		 1mxgA-4a69A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 4 TYR A 515
HIS A 368
TYR A 367
GLY A 363
 HEM  A 701 (-4.7A)
None
None
None
 1.26A 1mxgA-4b2nA:
undetectable		 1mxgA-4b2nA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 TYR B2845
HIS B2774
TYR B2647
GLY B2641
 None
 1.28A 1mxgA-4bedB:
undetectable		 1mxgA-4bedB:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 TYR B  13
TRP B 135
HIS B 281
GLY B 302
 None
 1.10A 1mxgA-4bkxB:
undetectable		 1mxgA-4bkxB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1

(Branchiostoma
floridae) 		PF01353
(GFP) 		4 TYR A 175
HIS A   7
TYR A  61
GLY A  28
 None
None
CR2  A  60 ( 3.5A)
None
 1.33A 1mxgA-4dknA:
undetectable		 1mxgA-4dknA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 TYR A 236
ASN A 345
HIS A 296
GLY A 299
 None
 1.35A 1mxgA-4fixA:
undetectable		 1mxgA-4fixA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 ASN A 195
HIS A 109
TYR A 157
GLY A 153
 None
ZN  A 301 ( 3.3A)
GK8  A 305 (-4.6A)
None
 1.15A 1mxgA-4gk8A:
5.3		 1mxgA-4gk8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h9d HNH ENDONUCLEASE

(Geobacter
metallireducens) 		PF14279
(HNH_5) 		4 TRP A  88
HIS A  39
TYR A  40
GLY A  42
 None
 1.37A 1mxgA-4h9dA:
undetectable		 1mxgA-4h9dA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ASN A 153
TRP A  57
HIS A 205
TYR A 203
 None
 1.35A 1mxgA-4hooA:
undetectable		 1mxgA-4hooA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 930
ASN A 956
TYR A 952
GLY A 954
 None
 1.27A 1mxgA-4iugA:
8.5		 1mxgA-4iugA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ASN A 150
TRP A  54
HIS A 202
TYR A 200
 None
 1.34A 1mxgA-4lxlA:
undetectable		 1mxgA-4lxlA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		no annotation 4 TYR A 446
ASN A 480
HIS A 325
TYR A 322
 None
 1.18A 1mxgA-4m01A:
undetectable		 1mxgA-4m01A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		4 TYR A 166
TRP A  81
TYR A 127
GLY A 121
 None
 1.33A 1mxgA-4rotA:
undetectable		 1mxgA-4rotA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 TYR L 414
TYR L 541
GLY L 539
TRP L 519
 None
 1.26A 1mxgA-4tkxL:
undetectable		 1mxgA-4tkxL:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE

(Populus
trichocarpa) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 HIS A 292
TYR A 293
GLY A 295
TRP A  77
 None
None
None
GSH  A 500 ( 4.1A)
 0.91A 1mxgA-4ussA:
undetectable		 1mxgA-4ussA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxw PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 TYR B 207
ASN B 200
HIS B 236
TYR B 201
 None
 1.34A 1mxgA-4xxwB:
undetectable		 1mxgA-4xxwB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 TYR A 109
ASN C 369
TYR C 328
GLY C 324
 None
 1.03A 1mxgA-5aa5A:
undetectable		 1mxgA-5aa5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 TYR A 117
ASN A  53
HIS A 533
GLY A 526
 None
LSS  A1818 (-3.4A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.5A)
 1.38A 1mxgA-5ah5A:
undetectable		 1mxgA-5ah5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II) 		4 TYR A  50
ASN A 412
TYR A 414
GLY A 235
 None
 1.35A 1mxgA-5b47A:
undetectable		 1mxgA-5b47A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II) 		4 TYR A 414
HIS A  81
TYR A  50
GLY A  10
 None
 1.28A 1mxgA-5b47A:
undetectable		 1mxgA-5b47A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 TYR B 156
ASN B 136
TYR B 219
GLY B 211
 None
 1.26A 1mxgA-5do8B:
21.6		 1mxgA-5do8B:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 TYR A 367
ASN A 318
TYR A 290
GLY A 286
 None
 1.33A 1mxgA-5gllA:
undetectable		 1mxgA-5gllA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		4 TYR A 122
ASN A  65
HIS A  57
TYR A  62
 None
 1.32A 1mxgA-5gzhA:
undetectable		 1mxgA-5gzhA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 TYR A 386
HIS A 142
GLY A 200
TRP A 140
 None
 1.33A 1mxgA-5huuA:
undetectable		 1mxgA-5huuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 TYR A 393
HIS A 150
GLY A 208
TRP A 148
 None
 1.32A 1mxgA-5hvmA:
2.3		 1mxgA-5hvmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 260
ASN A 140
TYR A 355
GLY A 145
 GAL  A4001 ( 4.6A)
GAL  A4001 (-3.8A)
None
None
 1.26A 1mxgA-5ihrA:
10.1		 1mxgA-5ihrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 932
ASN A 958
TYR A 954
GLY A 956
 None
 1.23A 1mxgA-5ihrA:
10.1		 1mxgA-5ihrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		4 TYR A  72
HIS A 295
TYR A  85
TRP A 324
 None
 1.30A 1mxgA-5jp9A:
undetectable		 1mxgA-5jp9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 TYR A 302
ASN A 305
TYR A 361
GLY A 358
 None
 1.13A 1mxgA-5jqkA:
undetectable		 1mxgA-5jqkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 ASN A 643
HIS A  62
TYR A 267
GLY A 269
 None
 1.03A 1mxgA-5jxfA:
undetectable		 1mxgA-5jxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 567
ASN A 550
HIS A 590
GLY A 181
 None
 1.25A 1mxgA-5k6oA:
2.7		 1mxgA-5k6oA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 TYR B 256
ASN B  11
HIS B  33
GLY B  30
 None
 1.26A 1mxgA-5l9wB:
undetectable		 1mxgA-5l9wB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		4 ASN A 516
HIS A 455
TYR A 454
GLY A 451
 None
 1.15A 1mxgA-5loiA:
undetectable		 1mxgA-5loiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 4 TYR A 131
TRP A 113
TYR A  71
GLY A  73
 None
 1.02A 1mxgA-5ykbA:
24.1		 1mxgA-5ykbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbg OUTER MEMBRANE
PROTEIN

(Helicobacter
pylori) 		no annotation 4 ASN A 113
HIS A 142
TYR A 144
GLY A 133
 None
 1.23A 1mxgA-6gbgA:
undetectable		 1mxgA-6gbgA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbg OUTER MEMBRANE
PROTEIN

(Helicobacter
pylori) 		no annotation 4 ASN A 113
HIS A 142
TYR A 144
GLY A 146
 None
 0.97A 1mxgA-6gbgA:
undetectable		 1mxgA-6gbgA:
11.78