SIMILAR PATTERNS OF AMINO ACIDS FOR 1MXG_A_ACRA443_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		4 SER A 230
THR A 231
LEU A 328
GLU A 154
 None
 1.13A 1mxgA-1cjyA:
undetectable		 1mxgA-1cjyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehx SCAFFOLDIN PROTEIN

([Clostridium]
cellulolyticum) 		PF03442
(CBM_X2) 		4 THR A  24
ASN A   7
LEU A  68
GLU A  37
 None
 1.20A 1mxgA-1ehxA:
undetectable		 1mxgA-1ehxA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		4 SER A 356
THR A 359
ASN A 260
LEU A 259
 None
 1.11A 1mxgA-1ezfA:
undetectable		 1mxgA-1ezfA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 SER A  67
THR A  66
ASN A  63
LEU A  59
 None
 1.04A 1mxgA-1f59A:
undetectable		 1mxgA-1f59A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A1344
LEU A1368
ASP A1378
GLU A1414
 None
 1.14A 1mxgA-1larA:
undetectable		 1mxgA-1larA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 THR B 290
ASN B 255
ASP B 256
LYS B 249
 None
 1.20A 1mxgA-1mu2B:
undetectable		 1mxgA-1mu2B:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		8 SER A 132
THR A 140
ASN A 142
LEU A 144
ASP A 145
GLU A 150
LYS A 169
TRP A 171
 None
 0.52A 1mxgA-1mwoA:
66.0		 1mxgA-1mwoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 SER A  67
THR A  66
ASN A  63
LEU A  59
 None
 1.02A 1mxgA-1qgrA:
undetectable		 1mxgA-1qgrA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrh ECO RI ENDONCULEASE

(Escherichia
coli) 		PF02963
(EcoRI) 		4 SER A 195
ASN A 199
LEU A 201
ASP A 202
 None
 0.77A 1mxgA-1qrhA:
undetectable		 1mxgA-1qrhA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh8 PICCOLO PROTEIN

(Rattus
norvegicus) 		PF00168
(C2) 		4 SER A4757
THR A4758
LEU A4752
GLU A4750
 None
 1.19A 1mxgA-1rh8A:
undetectable		 1mxgA-1rh8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 SER A 941
THR A 940
ASN A 938
LYS A 868
 None
 1.20A 1mxgA-1rjbA:
undetectable		 1mxgA-1rjbA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 THR A  30
ASN A  27
ASP A  25
GLU A 197
 None
 1.20A 1mxgA-1rrhA:
undetectable		 1mxgA-1rrhA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR

(Caenorhabditis
elegans) 		PF09287
(CEP1-DNA_bind) 		4 SER A 335
THR A 341
ASP A 303
LYS A 286
 None
 1.15A 1mxgA-1t4wA:
undetectable		 1mxgA-1t4wA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 THR B   7
LEU B  40
ASP B  39
GLU B  42
 None
 1.05A 1mxgA-1tyeB:
undetectable		 1mxgA-1tyeB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		4 SER A 160
THR A 163
ASN A 158
GLU A 133
 None
 0.91A 1mxgA-1u60A:
undetectable		 1mxgA-1u60A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5q GLUTAMATE RECEPTOR
INTERACTING PROTEIN
1A-L HOMOLOG

(Mus musculus) 		PF00595
(PDZ) 		4 THR A  96
LEU A  89
ASP A  92
GLU A  85
 None
 1.11A 1mxgA-1v5qA:
undetectable		 1mxgA-1v5qA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 THR A 353
ASN A 383
LEU A 384
ASP A 382
 None
 0.88A 1mxgA-2cvoA:
undetectable		 1mxgA-2cvoA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 SER A  33
THR A  32
LEU A 128
ASP A 127
 None
 0.95A 1mxgA-2dy0A:
undetectable		 1mxgA-2dy0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ASN A 328
LEU A 329
ASP A 327
GLU A  54
 None
 0.99A 1mxgA-2ep5A:
undetectable		 1mxgA-2ep5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		4 THR A 329
LEU A 359
ASP A 361
GLU A  90
 None
 1.07A 1mxgA-2hmaA:
undetectable		 1mxgA-2hmaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 THR A 290
ASN A 320
LEU A 321
ASP A 319
 None
 0.91A 1mxgA-2i3aA:
undetectable		 1mxgA-2i3aA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxr TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00791
(ZU5) 		4 THR A   1
LEU A  52
GLU A  61
LYS A  44
 None
 1.20A 1mxgA-2kxrA:
undetectable		 1mxgA-2kxrA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		4 SER A1246
LEU A1270
ASP A1280
GLU A1316
 None
 1.14A 1mxgA-2nv5A:
undetectable		 1mxgA-2nv5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p57 GTPASE-ACTIVATING
PROTEIN ZNF289

(Homo sapiens) 		PF01412
(ArfGap) 		4 SER A  35
THR A  66
ASP A  69
TRP A  72
 UNX  A 204 (-3.2A)
None
None
None
 1.17A 1mxgA-2p57A:
undetectable		 1mxgA-2p57A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 SER A 344
ASP A  61
GLU A  66
TRP A 412
 None
 1.14A 1mxgA-2pncA:
undetectable		 1mxgA-2pncA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc5 STREPTOGRAMIN B
LACTONASE

(Staphylococcus
cohnii) 		no annotation 4 SER A  99
LEU A 136
ASP A 120
GLU A 175
 SER  A  99 ( 0.0A)
LEU  A 136 ( 0.6A)
ASP  A 120 ( 0.5A)
GLU  A 175 ( 0.6A)
 1.21A 1mxgA-2qc5A:
undetectable		 1mxgA-2qc5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 THR A 448
LEU A  44
GLU A  77
TRP A 445
 None
 1.19A 1mxgA-2r66A:
undetectable		 1mxgA-2r66A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmk SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF02185
(HR1) 		4 SER B 126
ASN B 124
ASP B 191
GLU B 194
 None
 1.08A 1mxgA-2rmkB:
undetectable		 1mxgA-2rmkB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 ASN A 178
ASP A 199
GLU A 462
TRP A 200
 EDO  A1876 (-3.2A)
MVL  A1865 ( 2.9A)
MVL  A1865 ( 2.8A)
MVL  A1865 (-4.2A)
 1.20A 1mxgA-2vmfA:
7.7		 1mxgA-2vmfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT

(Aquifex
aeolicus) 		PF02222
(ATP-grasp) 		4 ASN A 335
LEU A 263
ASP A 264
GLU A  19
 None
 1.18A 1mxgA-2z04A:
undetectable		 1mxgA-2z04A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 SER A 756
THR A 754
GLU A 742
LYS A 745
 None
 1.22A 1mxgA-3a6pA:
undetectable		 1mxgA-3a6pA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 THR A 106
ASN A 141
ASP A 103
GLU A 158
 None
 1.14A 1mxgA-3al8A:
undetectable		 1mxgA-3al8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmb REGULATOR OF
NUCLEOSIDE
DIPHOSPHATE KINASE

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF14760
(Rnk_N) 		4 THR A  55
ASN A   9
LEU A  11
ASP A  12
 None
 0.91A 1mxgA-3bmbA:
undetectable		 1mxgA-3bmbA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A  64
THR A  63
ASP A  90
TRP A  94
 None
 1.01A 1mxgA-3dipA:
6.3		 1mxgA-3dipA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		4 ASN A 423
LEU A 441
ASP A 440
GLU A 445
 None
 1.00A 1mxgA-3djaA:
undetectable		 1mxgA-3djaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 SER A 120
ASP A 175
GLU A 146
LYS A 178
 GOL  A 786 (-4.7A)
None
None
None
 1.22A 1mxgA-3dmkA:
undetectable		 1mxgA-3dmkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		4 SER A 401
THR A 420
ASN A 403
LYS A 348
 None
 0.87A 1mxgA-3javA:
undetectable		 1mxgA-3javA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 SER A 237
THR A 236
LEU A 176
TRP A 246
 None
 1.11A 1mxgA-3jxfA:
undetectable		 1mxgA-3jxfA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae) 		no annotation 4 SER A1051
ASN A1049
LEU A1058
ASP A1055
 None
 1.11A 1mxgA-3kfoA:
undetectable		 1mxgA-3kfoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0i DRRA

(Legionella
pneumophila) 		PF14860
(DrrA_P4M) 		4 SER A 358
ASN A 355
LEU A 352
TRP A 353
 None
 1.21A 1mxgA-3l0iA:
undetectable		 1mxgA-3l0iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		4 SER A 187
ASN A 157
ASP A 165
GLU A 135
 CSO  A 211 ( 4.0A)
None
None
None
 1.09A 1mxgA-3na8A:
9.5		 1mxgA-3na8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkj VILLIN-1

(Gallus gallus) 		PF02209
(VHP) 		4 SER A  56
THR A  54
LEU A  69
GLU A  72
 None
 1.16A 1mxgA-3nkjA:
undetectable		 1mxgA-3nkjA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3x GP41-5

(synthetic
construct) 		no annotation 4 SER A  55
THR A  54
ASN A  51
LYS A  29
 None
 1.12A 1mxgA-3o3xA:
undetectable		 1mxgA-3o3xA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 SER A 471
ASN A 473
ASP A 468
GLU A 393
 None
None
None
SM5  A   1 (-4.3A)
 1.09A 1mxgA-3omvA:
undetectable		 1mxgA-3omvA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A 869
LEU A 893
ASP A 905
GLU A 941
 None
 1.19A 1mxgA-3qciA:
undetectable		 1mxgA-3qciA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		8 SER A 132
THR A 140
ASN A 142
LEU A 144
ASP A 145
GLU A 150
LYS A 169
TRP A 171
 None
 0.23A 1mxgA-3qgvA:
65.4		 1mxgA-3qgvA:
86.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qil CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		4 SER A1502
LEU A1549
ASP A1546
GLU A1552
 None
 1.13A 1mxgA-3qilA:
undetectable		 1mxgA-3qilA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 SER A 645
ASN A 660
LEU A 663
ASP A 664
 None
NDP  A 802 ( 4.3A)
None
None
 0.96A 1mxgA-3slkA:
2.3		 1mxgA-3slkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 SER A 101
THR A  59
ASN A  61
ASP A  36
 None
 1.20A 1mxgA-3so4A:
undetectable		 1mxgA-3so4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 SER A 113
ASN A  74
ASP A  72
GLU A 385
 None
 1.18A 1mxgA-3t33A:
undetectable		 1mxgA-3t33A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 THR A 430
ASP A  25
GLU A 417
LYS A 457
 None
 1.16A 1mxgA-3u44A:
undetectable		 1mxgA-3u44A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 THR A 135
ASN A 137
ASP A 133
GLU A 226
 None
SO4  A 601 ( 4.9A)
None
None
 1.13A 1mxgA-3wfoA:
undetectable		 1mxgA-3wfoA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 THR A 135
ASN A 137
ASP A 133
GLU A 226
 None
SO4  A1001 ( 4.5A)
None
None
 1.21A 1mxgA-3wfpA:
undetectable		 1mxgA-3wfpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdh ACETYLCHOLINE
BINDING PROTEIN

(Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		4 SER A 198
THR A 177
ASN A 200
LEU A 174
 None
 1.21A 1mxgA-3zdhA:
undetectable		 1mxgA-3zdhA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 SER A 132
LEU A  70
ASP A  72
GLU A 211
 None
 1.20A 1mxgA-3zkbA:
undetectable		 1mxgA-3zkbA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 SER A 181
ASN A 186
LEU A 190
ASP A 187
 None
CD  B1454 (-3.6A)
None
None
 1.11A 1mxgA-4az3A:
undetectable		 1mxgA-4az3A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A1411
LEU A1435
ASP A1445
GLU A1481
 None
 1.08A 1mxgA-4bpcA:
undetectable		 1mxgA-4bpcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 SER A 157
THR A 158
ASN A 263
ASP A 259
 None
 1.18A 1mxgA-4c9mA:
undetectable		 1mxgA-4c9mA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 SER A 424
THR A 205
LEU A 221
GLU A 327
 None
 1.10A 1mxgA-4cp8A:
undetectable		 1mxgA-4cp8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 SER A 342
LEU A 442
ASP A 443
GLU A  98
 None
 0.93A 1mxgA-4dnsA:
undetectable		 1mxgA-4dnsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii) 		PF00022
(Actin) 		4 SER A 350
THR A 351
GLU A 361
LYS A 373
 None
 1.20A 1mxgA-4efhA:
undetectable		 1mxgA-4efhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi4 AEROTAXIS TRANSDUCER
AER2

(Pseudomonas
aeruginosa) 		PF13188
(PAS_8) 		4 SER A 183
THR A 201
ASN A 181
ASP A 180
 None
 1.11A 1mxgA-4hi4A:
undetectable		 1mxgA-4hi4A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idl SINGLE DOMAIN
ANTIBODY VHH A9

(Lama glama) 		PF07686
(V-set) 		4 SER A 122
THR A  14
ASP A  89
GLU A  46
 None
 1.22A 1mxgA-4idlA:
undetectable		 1mxgA-4idlA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		4 ASN C 296
LEU C 334
ASP C 333
GLU C 339
 None
 1.21A 1mxgA-4ifdC:
undetectable		 1mxgA-4ifdC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		4 SER A  51
THR A  47
ASP A 153
GLU A 231
 None
 1.22A 1mxgA-4mcaA:
undetectable		 1mxgA-4mcaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		4 SER A 183
LEU A 211
ASP A 214
GLU A  18
 None
 1.21A 1mxgA-4mptA:
undetectable		 1mxgA-4mptA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 SER A 181
ASN A 186
LEU A 190
ASP A 187
 SER  A 181 ( 0.0A)
ASN  A 186 ( 0.6A)
LEU  A 190 ( 0.6A)
ASP  A 187 ( 0.6A)
 1.12A 1mxgA-4mwtA:
undetectable		 1mxgA-4mwtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 SER B 435
ASN B 431
GLU B 554
LYS B 478
 None
None
EDO  B 703 (-2.9A)
EDO  B 703 ( 3.4A)
 1.16A 1mxgA-4ni2B:
undetectable		 1mxgA-4ni2B:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ERYTHROCYTE-BINDING
ANTIGEN-175

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 SER A  68
LEU A  96
ASP A  97
GLU A 173
 None
 1.20A 1mxgA-4qexA:
undetectable		 1mxgA-4qexA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 SER A 941
THR A 940
ASN A 938
LYS A 868
 None
 0.97A 1mxgA-4rt7A:
undetectable		 1mxgA-4rt7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 4 ASN B  41
LEU B  35
ASP B  38
GLU B  31
 None
 1.00A 1mxgA-4tqoB:
undetectable		 1mxgA-4tqoB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 SER A  31
THR A  32
LEU A  70
GLU A  69
 None
 1.06A 1mxgA-4uw2A:
undetectable		 1mxgA-4uw2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 SER A 525
THR A 524
ASN A 146
LEU A 533
 None
 1.23A 1mxgA-4wd9A:
undetectable		 1mxgA-4wd9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		4 THR A 128
ASN A 130
ASP A 126
GLU A 215
 None
FLC  A 501 ( 3.6A)
FLC  A 501 ( 4.7A)
FLC  A 501 ( 4.8A)
 1.08A 1mxgA-4x4wA:
undetectable		 1mxgA-4x4wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru RNL

(Capnocytophaga
gingivalis) 		PF16542
(PNKP_ligase) 		4 SER B 291
ASN B 289
ASP B 286
GLU B  37
 None
GOL  B 503 ( 4.4A)
None
GOL  B 503 ( 4.6A)
 1.21A 1mxgA-4xruB:
undetectable		 1mxgA-4xruB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 SER A  57
ASN A  55
LEU A  87
ASP A  88
 None
 1.04A 1mxgA-4z5yA:
undetectable		 1mxgA-4z5yA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 SER A  96
THR A  94
ASN B 100
LEU A  87
 None
 1.01A 1mxgA-5bn4A:
undetectable		 1mxgA-5bn4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		4 SER A 325
THR A 324
LEU A 321
ASP A 322
 None
 1.21A 1mxgA-5dneA:
undetectable		 1mxgA-5dneA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9c HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		4 SER A 490
THR A 358
LEU A 406
ASP A 403
 None
 0.96A 1mxgA-5e9cA:
4.4		 1mxgA-5e9cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		4 THR A 150
ASN A 146
ASP A 124
TRP A 126
 None
 1.20A 1mxgA-5gkqA:
undetectable		 1mxgA-5gkqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		4 THR A 337
ASN A 295
LEU A 298
GLU A 262
 None
 0.96A 1mxgA-5h05A:
27.2		 1mxgA-5h05A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A1745
LEU A1769
ASP A1781
GLU A1817
 None
 1.08A 1mxgA-5h08A:
undetectable		 1mxgA-5h08A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN

(Exiguobacterium
antarcticum) 		PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4) 		4 SER A  62
ASN A  33
LEU A 180
ASP A 183
 None
 0.96A 1mxgA-5h3hA:
undetectable		 1mxgA-5h3hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 THR A 193
ASN A 406
LEU A 209
GLU A 312
 None
 1.20A 1mxgA-5i8iA:
undetectable		 1mxgA-5i8iA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis) 		no annotation 4 SER A 476
THR A 482
ASP A 484
GLU A 438
 None
 0.91A 1mxgA-5irbA:
undetectable		 1mxgA-5irbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 SER B 363
THR B 364
LEU B 461
GLU B 290
 None
 1.11A 1mxgA-5iz5B:
undetectable		 1mxgA-5iz5B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 SER A 133
ASN A 103
LEU A 563
ASP A 562
 KCX  A 129 ( 2.8A)
None
None
None
 1.14A 1mxgA-5j84A:
undetectable		 1mxgA-5j84A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		4 SER A 490
THR A 358
LEU A 406
ASP A 403
 None
 1.00A 1mxgA-5la7A:
8.7		 1mxgA-5la7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		4 SER A 108
THR A 199
LEU A 176
GLU A 474
 None
None
SIN  A 501 (-4.8A)
None
 0.92A 1mxgA-5mz8A:
undetectable		 1mxgA-5mz8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 4 SER A 280
THR A 277
LEU A 274
TRP A  22
 None
 1.13A 1mxgA-5n4aA:
undetectable		 1mxgA-5n4aA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4w CULLIN-2

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 SER A 328
THR A 327
GLU A 289
LYS A 349
 None
 0.94A 1mxgA-5n4wA:
undetectable		 1mxgA-5n4wA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 4 SER A  90
THR A 153
LEU A  86
TRP A  87
 None
 1.13A 1mxgA-5nfgA:
undetectable		 1mxgA-5nfgA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 SER A 307
THR A 309
ASN A 419
GLU A 809
 MGD  A2002 ( 3.9A)
None
None
None
 1.19A 1mxgA-5nqdA:
undetectable		 1mxgA-5nqdA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyp STRUCTURAL PROTEIN
VP2

(Sacbrood virus) 		no annotation 4 SER B  16
THR B  25
ASP B  27
GLU B   6
 None
 1.20A 1mxgA-5oypB:
undetectable		 1mxgA-5oypB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3j INOSITOL
MONOPHOSPHATASE

(Medicago
truncatula) 		PF00459
(Inositol_P) 		4 SER A 254
THR A 204
LEU A 260
ASP A 259
 None
 1.11A 1mxgA-5t3jA:
undetectable		 1mxgA-5t3jA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 SER E 180
ASN A 871
LEU A 874
ASP A 875
 None
 1.09A 1mxgA-5v8fE:
undetectable		 1mxgA-5v8fE:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load)
no annotation 		4 SER B  53
THR B  52
LEU A  63
GLU A 109
 None
 1.14A 1mxgA-5w94B:
undetectable		 1mxgA-5w94B:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsz LPMO10A

(Bacillus
thuringiensis) 		PF03067
(LPMO_10) 		4 SER A  11
LEU A 144
ASP A 163
TRP A  65
 None
 1.22A 1mxgA-5wszA:
undetectable		 1mxgA-5wszA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 169
THR A 165
ASP A 163
GLU A 219
 None
 1.23A 1mxgA-5ykdA:
4.2		 1mxgA-5ykdA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 4 SER A 197
ASN A 235
ASP A 236
GLU A 243
 None
 1.20A 1mxgA-6bwcA:
2.2		 1mxgA-6bwcA:
12.18