SIMILAR PATTERNS OF AMINO ACIDS FOR 1MXD_A_ACRA732_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqy | PLASMINOGENACTIVATOR (Trimeresurusstejnegeri) |
PF00089(Trypsin) | 5 | GLY A 184GLU A 224GLY A 223GLY A 216GLY A 217 | NoneNoneNone0GJ A 1 (-3.5A)0GJ A 1 (-4.1A) | 1.07A | 1mxdA-1bqyA:0.0 | 1mxdA-1bqyA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3r | HDLP (HISTONEDEACETYLASE-LIKEPROTEIN) (Aquifexaeolicus) |
PF00850(Hist_deacetyl) | 5 | GLY A 140PRO A 22GLY A 295GLY A 296ASP A 258 | TSN A 502 ( 3.9A)TSN A 502 (-4.4A) ZN A 501 ( 4.1A)None ZN A 501 ( 2.5A) | 1.15A | 1mxdA-1c3rA:0.3 | 1mxdA-1c3rA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3d | [NIFE] HYDROGENASESMALL SUBUNIT (Desulfovibriodesulfuricans) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | GLY A 250PRO A 148GLY A 149GLY A 119GLY A 118 | F3S A 267 ( 4.5A)NoneNoneH2S A 904 (-3.5A)H2S A 904 ( 4.4A) | 1.01A | 1mxdA-1e3dA:0.0 | 1mxdA-1e3dA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fy1 | HEPARIN-BINDINGPROTEIN (Homo sapiens) |
PF00089(Trypsin) | 5 | GLY A 168GLY A 4GLY A 129GLY A 127ASP A 174 | NoneNAG A1451 ( 4.8A)NoneNoneNone | 1.14A | 1mxdA-1fy1A:0.0 | 1mxdA-1fy1A:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fy1 | HEPARIN-BINDINGPROTEIN (Homo sapiens) |
PF00089(Trypsin) | 5 | GLY A 197GLY A 3GLY A 129GLY A 127ASP A 174 | None | 1.22A | 1mxdA-1fy1A:0.0 | 1mxdA-1fy1A:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2u | 20 KDA NUCLEAR CAPBINDING PROTEIN (Homo sapiens) |
PF00076(RRM_1) | 5 | GLY X 147GLY X 150GLY X 132GLY X 131ASP X 74 | None | 1.11A | 1mxdA-1h2uX:undetectable | 1mxdA-1h2uX:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iip | CYCLOPHILIN 40 (Bos taurus) |
PF00160(Pro_isomerase)PF13176(TPR_7) | 5 | GLU A 96GLY A 63GLY A 94GLY A 95ASP A 86 | None | 1.20A | 1mxdA-1iipA:0.0 | 1mxdA-1iipA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k4q | GLUTATHIONEREDUCTASE (Homo sapiens) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 62GLY A 158GLY A 157ASP A 331ARG A 291 | FAD A 499 ( 3.7A)NoneFAD A 499 (-3.4A)FAD A 499 (-2.9A)FAD A 499 (-3.8A) | 1.11A | 1mxdA-1k4qA:1.1 | 1mxdA-1k4qA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7h | ALKALINE PHOSPHATASE (Pandalusborealis) |
PF00245(Alk_phosphatase) | 5 | GLY A 206GLU A 210GLY A 221GLY A 226ASP A 225 | None | 1.11A | 1mxdA-1k7hA:0.0 | 1mxdA-1k7hA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrw | METHANOLDEHYDROGENASESUBUNIT 1 (Paracoccusdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 5 | GLY A 573GLU A 55GLY A 53GLY A 518GLY A 56 | NonePQQ A 701 (-2.6A)NoneNoneNone | 1.10A | 1mxdA-1lrwA:0.0 | 1mxdA-1lrwA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m64 | FLAVOCYTOCHROME C3 (Shewanellafrigidimarina) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 5 | GLY A 382GLY A 250GLY A 249ASP A 232ARG A 246 | None | 1.12A | 1mxdA-1m64A:undetectable | 1mxdA-1m64A:22.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mwo | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 9 | GLY A 9LYS A 241PRO A 278GLU A 307GLY A 308GLY A 338GLY A 339ASP A 358ARG A 361 | None | 0.20A | 1mxdA-1mwoA:67.0 | 1mxdA-1mwoA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mwo | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 6 | GLY A 9LYS A 241PRO A 278GLY A 308GLY A 339ASP A 358 | None | 1.12A | 1mxdA-1mwoA:67.0 | 1mxdA-1mwoA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mwo | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | GLY A 10GLY A 338GLY A 339ASP A 358ARG A 361 | None | 0.74A | 1mxdA-1mwoA:67.0 | 1mxdA-1mwoA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mwo | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 6 | LYS A 241PRO A 278GLU A 307GLY A 308GLY A 338ASP A 358 | None | 1.22A | 1mxdA-1mwoA:67.0 | 1mxdA-1mwoA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oh2 | SUCROSE SPECIFICPORIN (Salmonellaenterica) |
PF02264(LamB) | 5 | GLY Q 463GLY Q 466GLY Q 470GLY Q 471ASP Q 448 | CA Q1484 ( 4.2A)NoneNoneNoneNone | 1.01A | 1mxdA-1oh2Q:undetectable | 1mxdA-1oh2Q:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pzn | DNA REPAIR ANDRECOMBINATIONPROTEIN RAD51 (Pyrococcusfuriosus) |
PF08423(Rad51)PF14520(HHH_5) | 5 | GLY A 163GLY A 111GLY A 127GLY A 126ASP A 121 | None | 1.16A | 1mxdA-1pznA:undetectable | 1mxdA-1pznA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukc | ESTA (Aspergillusniger) |
PF00135(COesterase) | 5 | GLY A 214GLU A 237GLY A 208GLY A 333ASP A 334 | None | 0.98A | 1mxdA-1ukcA:undetectable | 1mxdA-1ukcA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhe | AMINOPEPTIDASE/GLUCANASE HOMOLOG (Bacillussubtilis) |
PF05343(Peptidase_M42) | 5 | GLY A 92PRO A 163GLU A 71GLY A 73ASP A 182 | NoneNoneNoneNone ZN A 372 (-2.5A) | 0.98A | 1mxdA-1vheA:undetectable | 1mxdA-1vheA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w6s | METHANOLDEHYDROGENASESUBUNIT 1 (Methylobacteriumextorquens) |
PF01011(PQQ)PF13360(PQQ_2) | 5 | GLY A 573GLU A 55GLY A 53GLY A 518GLY A 56 | NonePQQ A1596 (-2.7A)NoneNoneNone | 1.12A | 1mxdA-1w6sA:undetectable | 1mxdA-1w6sA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | GLY A 111GLY A 328GLY A 87GLY A 86ASP A 118 | NoneACT A1501 (-3.5A)NoneNoneNone | 1.09A | 1mxdA-2bb0A:7.2 | 1mxdA-2bb0A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0v | METHANOLDEHYDROGENASE LARGESUBUNIT (Hyphomicrobiumdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 5 | GLY A 573GLU A 55GLY A 53GLY A 518GLY A 56 | NonePQQ A 601 (-2.7A)NoneNoneNone | 1.07A | 1mxdA-2d0vA:undetectable | 1mxdA-2d0vA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gez | L-ASPARAGINASE BETASUBUNIT (Lupinus luteus) |
PF01112(Asparaginase_2) | 5 | GLY B 287PRO B 282GLU B 248GLY B 246ASP B 224 | NoneNoneNone CL B 406 ( 3.8A)None | 1.12A | 1mxdA-2gezB:undetectable | 1mxdA-2gezB:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hlp | MALATE DEHYDROGENASE (Haloarculamarismortui) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 249GLY A 253GLY A 164GLY A 165ASP A 168 | None | 1.00A | 1mxdA-2hlpA:undetectable | 1mxdA-2hlpA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hqm | GLUTATHIONEREDUCTASE (Saccharomycescerevisiae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 65GLY A 170GLY A 169ASP A 334ARG A 295 | FAD A1001 (-3.5A)NoneFAD A1001 (-3.2A)FAD A1001 (-2.9A)FAD A1001 (-3.8A) | 0.94A | 1mxdA-2hqmA:undetectable | 1mxdA-2hqmA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0z | NAD(FAD)-UTILIZINGDEHYDROGENASES (Bacillus cereus) |
PF03486(HI0933_like) | 5 | GLY A 177GLU A 388GLY A 164GLY A 363GLY A 362 | NoneFAD A 501 (-3.8A)FAD A 501 (-3.3A)NoneNone | 0.98A | 1mxdA-2i0zA:undetectable | 1mxdA-2i0zA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7p | CELL DIVISIONPROTEIN FTSY (Thermusaquaticus) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | GLY D 112GLY D 145GLY D 146ASP D 139ARG D 142 | GNP D1400 (-3.5A)NoneNoneGNP D1400 ( 4.7A)GNP D1400 ( 3.9A) | 1.19A | 1mxdA-2j7pD:3.5 | 1mxdA-2j7pD:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7p | CELL DIVISIONPROTEIN FTSY (Thermusaquaticus) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | GLY D 112LYS D 256GLY D 145ASP D 139ARG D 142 | GNP D1400 (-3.5A)GNP D1400 (-3.8A)NoneGNP D1400 ( 4.7A)GNP D1400 ( 3.9A) | 1.18A | 1mxdA-2j7pD:3.5 | 1mxdA-2j7pD:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jir | PERIPLASMIC NITRATEREDUCTASE (Desulfovibriodesulfuricans) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | GLY A 472PRO A 137GLY A 110GLY A 356GLY A 357 | NoneCYN A 813 ( 4.6A)NoneNoneNone | 1.20A | 1mxdA-2jirA:undetectable | 1mxdA-2jirA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2puz | IMIDAZOLONEPROPIONASE (Agrobacteriumfabrum) |
PF01979(Amidohydro_1) | 5 | GLY A 117GLY A 335GLY A 93GLY A 92ASP A 124 | None | 0.90A | 1mxdA-2puzA:6.2 | 1mxdA-2puzA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q17 | FORMYLGLYCINEGENERATING ENZYME (Streptomycescoelicolor) |
PF03781(FGE-sulfatase) | 5 | GLY A 295GLU A 235GLY A 298GLY A 268GLY A 231 | None | 0.95A | 1mxdA-2q17A:undetectable | 1mxdA-2q17A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q17 | FORMYLGLYCINEGENERATING ENZYME (Streptomycescoelicolor) |
PF03781(FGE-sulfatase) | 5 | GLY A 295PRO A 140GLY A 298GLY A 268GLY A 231 | None | 1.14A | 1mxdA-2q17A:undetectable | 1mxdA-2q17A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zux | YESW PROTEIN (Bacillussubtilis) |
no annotation | 5 | GLY A 273GLU A 43GLY A 157GLY A 227ASP A 226 | NoneNoneNoneNone CA A 633 (-2.9A) | 1.17A | 1mxdA-2zuxA:undetectable | 1mxdA-2zuxA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zuy | YESX PROTEIN (Bacillussubtilis) |
PF01839(FG-GAP) | 5 | GLY A 240GLU A 9GLY A 124GLY A 194ASP A 193 | NoneNoneNoneNone CA A 624 (-3.0A) | 1.19A | 1mxdA-2zuyA:undetectable | 1mxdA-2zuyA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abz | BETA-GLUCOSIDASE I (Kluyveromycesmarxianus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF07691(PA14)PF14310(Fn3-like) | 5 | GLY A 355GLU A 588GLY A 585GLY A 112GLY A 114 | None | 1.18A | 1mxdA-3abzA:1.2 | 1mxdA-3abzA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b4w | ALDEHYDEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00171(Aldedh) | 5 | GLY A 346GLU A 340GLY A 341GLY A 357GLY A 358 | None | 1.00A | 1mxdA-3b4wA:undetectable | 1mxdA-3b4wA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb7 | INTERPAIN A (Prevotellaintermedia) |
PF01640(Peptidase_C10)PF13734(Inhibitor_I69) | 5 | LYS A 358PRO A 169GLY A 258GLY A 174GLY A 195 | None | 1.13A | 1mxdA-3bb7A:undetectable | 1mxdA-3bb7A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bt6 | INFLUENZA BHEMAGGLUTININ (HA) (Influenza Bvirus) |
PF00509(Hemagglutinin) | 5 | GLY A 6GLY B 12GLY B 4GLY B 1ASP B 112 | None | 0.94A | 1mxdA-3bt6A:undetectable | 1mxdA-3bt6A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c10 | HISTONE DEACETYLASE7A (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | GLY A 678PRO A 542GLY A 841GLY A 842ASP A 801 | TSN A 301 ( 3.7A)TSN A 301 ( 4.5A)TSN A 301 ( 3.9A)None ZN A 101 ( 2.5A) | 1.10A | 1mxdA-3c10A:undetectable | 1mxdA-3c10A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dgz | THIOREDOXINREDUCTASE 2 (Mus musculus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 57GLY A 157GLY A 156ASP A 326ARG A 285 | FAD A 500 (-3.5A)NoneFAD A 500 (-3.4A)FAD A 500 (-3.0A)FAD A 500 ( 3.7A) | 1.05A | 1mxdA-3dgzA:undetectable | 1mxdA-3dgzA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7m | XYLANASE INHIBITORTL-XI (Triticumaestivum) |
PF00314(Thaumatin) | 5 | GLY A 78GLY A 24GLY A 70GLY A 71ASP A 68 | None | 1.13A | 1mxdA-3g7mA:undetectable | 1mxdA-3g7mA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 1NADH-QUINONEOXIDOREDUCTASESUBUNIT 2 (Thermusthermophilus) |
PF01257(2Fe-2S_thioredx)PF01512(Complex1_51K)PF10531(SLBB)PF10589(NADH_4Fe-4S) | 5 | GLY 1 194PRO 2 19GLU 2 21GLY 2 22GLY 1 213 | None | 1.05A | 1mxdA-3i9v1:undetectable | 1mxdA-3i9v1:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl9 | GLUTAMYLAMINOPEPTIDASE (Streptococcuspneumoniae) |
PF05343(Peptidase_M42) | 5 | GLY A 90PRO A 162GLU A 69GLY A 71ASP A 181 | NoneNoneNoneNone ZN A 356 ( 2.4A) | 0.99A | 1mxdA-3kl9A:undetectable | 1mxdA-3kl9A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3max | HISTONE DEACETYLASE2 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | GLY A 154PRO A 34GLY A 306GLY A 307ASP A 269 | LLX A 400 (-3.6A)NoneLLX A 400 (-3.7A)None ZN A 379 ( 2.5A) | 1.07A | 1mxdA-3maxA:undetectable | 1mxdA-3maxA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myr | HYDROGENASE (NIFE)SMALL SUBUNIT HYDA (Allochromatiumvinosum) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | GLY A 251PRO A 147GLY A 148GLY A 120GLY A 119 | F3S A2003 ( 4.7A)NoneNoneNoneNone | 1.02A | 1mxdA-3myrA:undetectable | 1mxdA-3myrA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nio | GUANIDINOBUTYRASE (Pseudomonasaeruginosa) |
PF00491(Arginase) | 5 | GLY A 256PRO A 290GLY A 56GLY A 127GLY A 126 | None | 1.07A | 1mxdA-3nioA:undetectable | 1mxdA-3nioA:21.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qgv | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 7 | GLY A 9LYS A 241PRO A 278GLU A 307GLY A 308GLY A 338GLY A 339 | BCD A 601 (-3.7A)BCD A 601 (-2.4A)BCD A 601 (-4.0A)BCD A 601 (-2.9A)BCD A 601 (-3.5A)BCD A 601 ( 3.7A)BCD A 601 (-3.5A) | 0.17A | 1mxdA-3qgvA:65.1 | 1mxdA-3qgvA:86.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3qgv | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | LYS A 241PRO A 278GLU A 307GLY A 308GLY A 339 | BCD A 601 (-2.4A)BCD A 601 (-4.0A)BCD A 601 (-2.9A)BCD A 601 (-3.5A)BCD A 601 (-3.5A) | 0.92A | 1mxdA-3qgvA:65.1 | 1mxdA-3qgvA:86.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd8 | FUMARATE HYDRATASECLASS II (Mycolicibacteriumsmegmatis) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | GLY A 53GLY A 82GLY A 87ASP A 90ARG A 46 | None | 1.20A | 1mxdA-3rd8A:undetectable | 1mxdA-3rd8A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6h | N-ACETYLGLUTAMATEKINASE /N-ACETYLGLUTAMATESYNTHASE (Maricaulismaris) |
PF00696(AA_kinase)PF04768(NAT) | 5 | GLY A 153GLU A 180GLY A 179GLY A 184ASP A 183 | None | 1.18A | 1mxdA-3s6hA:undetectable | 1mxdA-3s6hA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ve2 | TRANSFERRIN-BINDINGPROTEIN 2 (Neisseriameningitidis) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 5 | GLY A 328PRO A 77GLU A 168GLY A 167GLY A 321 | None | 0.81A | 1mxdA-3ve2A:undetectable | 1mxdA-3ve2A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vex | O-CARBAMOYLTRANSFERASE TOBZ (Streptoalloteichustenebrarius) |
PF02543(Carbam_trans_N)PF16861(Carbam_trans_C) | 5 | GLY A 70GLY A 340GLY A 309GLY A 310ASP A 137 | NoneNoneCA0 A 602 ( 4.0A)CA0 A 602 (-3.2A)FE2 A 601 ( 3.3A) | 1.04A | 1mxdA-3vexA:1.5 | 1mxdA-3vexA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vns | NRPS ADENYLATIONPROTEIN CYTC1 (Streptomycessp.) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | PRO A 354GLU A 405GLY A 355GLY A 409ASP A 408 | None | 0.97A | 1mxdA-3vnsA:undetectable | 1mxdA-3vnsA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) |
PF00708(Acylphosphatase)PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 5 | GLY A 407GLY A 735GLY A 701GLY A 702ASP A 507 | NoneNoneAP2 A 806 ( 4.3A)AP2 A 806 (-3.3A) FE A 807 ( 3.1A) | 0.94A | 1mxdA-3vthA:undetectable | 1mxdA-3vthA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ze6 | PERIPLASMIC [NIFESE]HYDROGENASE, SMALLSUBUNIT (Desulfovibriovulgaris) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | GLY A 267PRO A 157GLY A 158GLY A 126GLY A 125 | SF4 A 285 ( 4.6A)NoneNoneNoneNone | 0.99A | 1mxdA-3ze6A:undetectable | 1mxdA-3ze6A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgu | MALATE DEHYDROGENASE (Haloferaxvolcanii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 225GLY A 229GLY A 145GLY A 146ASP A 149 | None | 1.01A | 1mxdA-4bguA:undetectable | 1mxdA-4bguA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bkx | HISTONE DEACETYLASE1 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | GLY B 149PRO B 29GLY B 301GLY B 302ASP B 264 | NoneNoneACT B 601 (-3.4A)None ZN B 600 ( 2.5A) | 1.14A | 1mxdA-4bkxB:undetectable | 1mxdA-4bkxB:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIBINTEGRIN BETA-3 (Homo sapiens) |
PF00362(Integrin_beta)PF01839(FG-GAP)PF07965(Integrin_B_tail)PF07974(EGF_2)PF08441(Integrin_alpha2)PF17205(PSI_integrin) | 5 | GLY B 463GLU A 642GLY A 643GLY A 603ASP A 511 | NoneNAG B3452 (-3.9A)NAG B3452 (-2.8A)NoneNone | 1.02A | 1mxdA-4cakB:undetectable | 1mxdA-4cakB:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cby | HISTONE DEACETYLASE4 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | GLY A 811PRO A 676GLY A 974GLY A 975ASP A 934 | KEE A2033 ( 4.2A)NoneKEE A2033 (-3.6A)KEE A2033 ( 4.9A) ZN A2034 ( 2.4A) | 1.08A | 1mxdA-4cbyA:undetectable | 1mxdA-4cbyA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gw9 | BACTERIOPHYTOCHROME (Rhodopseudomonaspalustris) |
PF00360(PHY)PF00989(PAS)PF01590(GAF)PF08446(PAS_2) | 5 | GLY A 178GLU A 174GLY A 176ASP A 481ARG A 440 | None | 1.09A | 1mxdA-4gw9A:undetectable | 1mxdA-4gw9A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hhr | ALPHA-DIOXYGENASE (Arabidopsisthaliana) |
PF03098(An_peroxidase) | 5 | GLY A 470GLU A 428GLY A 424GLY A 258ASP A 255 | None | 1.22A | 1mxdA-4hhrA:undetectable | 1mxdA-4hhrA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgg | ESTERASE TESA (Pseudomonasaeruginosa) |
PF13472(Lipase_GDSL_2) | 5 | GLY A 52GLY A 7GLY A 73GLY A 74ASP A 76 | None | 1.00A | 1mxdA-4jggA:undetectable | 1mxdA-4jggA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ko2 | PERIPLASMIC [NIFESE]HYDROGENASE SMALLSUBUNIT (Desulfomicrobiumbaculatum) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | GLY S 266PRO S 162GLY S 163GLY S 131GLY S 130 | SF4 S 302 ( 4.5A)NoneNoneNoneNone | 0.99A | 1mxdA-4ko2S:undetectable | 1mxdA-4ko2S:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kqc | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Brachyspiramurdochii) |
PF13407(Peripla_BP_4) | 5 | GLY A 229GLY A 264GLY A 263ASP A 262ARG A 152 | None | 1.03A | 1mxdA-4kqcA:undetectable | 1mxdA-4kqcA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mae | METHANOLDEHYDROGENASE (Methylacidiphilumfumariolicum) |
PF13360(PQQ_2) | 5 | GLY A 569GLU A 55GLY A 53GLY A 509GLY A 56 | NonePQQ A 602 (-2.5A)NoneNoneNone | 1.06A | 1mxdA-4maeA:undetectable | 1mxdA-4maeA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4on1 | PUTATIVEMETALLOPROTEASE II (Bacteroidesfragilis) |
PF00413(Peptidase_M10)PF16376(fragilysinNterm) | 5 | GLY A 312GLY A 307GLY A 271GLY A 270ASP A 274 | None | 1.12A | 1mxdA-4on1A:undetectable | 1mxdA-4on1A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ope | NRPS/PKS (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A4529PRO A4537GLY A4535GLY A4451GLY A4450 | None | 1.04A | 1mxdA-4opeA:undetectable | 1mxdA-4opeA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q51 | UNCHARACTERIZEDPROTEIN (Burkholderiacenocepacia) |
PF10703(MoaF)PF17409(MoaF_C) | 5 | GLY A 49PRO A 260GLY A 280GLY A 287ASP A 285 | None | 0.75A | 1mxdA-4q51A:undetectable | 1mxdA-4q51A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ucw | HYDROGENASE (NIFE)SMALL SUBUNIT HYDA (Desulfovibriofructosivorans) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | GLY A 247PRO A 145GLY A 146GLY A 119GLY A 118 | F3S A1266 (-4.6A)NoneNoneNoneNone | 1.05A | 1mxdA-4ucwA:undetectable | 1mxdA-4ucwA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wky | BETA-KETOACYLSYNTHASE (Streptomycesalbus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A 327PRO A 335GLY A 333GLY A 250GLY A 249 | None | 1.07A | 1mxdA-4wkyA:undetectable | 1mxdA-4wkyA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsh | UROPORPHYRINOGENDECARBOXYLASE (Pseudomonasaeruginosa) |
PF01208(URO-D) | 5 | GLY A 201GLY A 196GLY A 123ASP A 127ARG A 130 | None | 1.22A | 1mxdA-4wshA:5.6 | 1mxdA-4wshA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zrm | UDP-GLUCOSE4-EPIMERASE (Thermotogamaritima) |
PF01370(Epimerase) | 5 | GLY A 119GLU A 124GLY A 123GLY A 269ASP A 270 | None | 1.13A | 1mxdA-4zrmA:undetectable | 1mxdA-4zrmA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa5 | NIFE-HYDROGENASESMALL SUBUNIT, HOFK (Cupriavidusnecator) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | GLY A 287PRO A 184GLY A 185GLY A 150GLY A 149 | SF4 A 502 ( 4.1A)NoneNoneNoneNone | 1.05A | 1mxdA-5aa5A:undetectable | 1mxdA-5aa5A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dot | CARBAMOYL-PHOSPHATESYNTHASE [AMMONIA],MITOCHONDRIAL (Homo sapiens) |
PF00117(GATase)PF00988(CPSase_sm_chain)PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | GLY A 439GLY A 432GLY A 510GLY A 509ASP A 442 | None | 1.04A | 1mxdA-5dotA:undetectable | 1mxdA-5dotA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ds0 | PEPTIDASE M42 (Thaumarchaeotaarchaeon SCGCAB-539-E09) |
PF05343(Peptidase_M42) | 5 | GLY A 90PRO A 161GLU A 69GLY A 71ASP A 180 | NoneNoneNoneNone CO A 401 ( 2.3A) | 0.88A | 1mxdA-5ds0A:undetectable | 1mxdA-5ds0A:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fkr | ENDO-1,4-BETA-GLUCANASE/XYLOGLUCANASE,PUTATIVE, GLY74A (Cellvibriojaponicus) |
no annotation | 5 | GLY A 161PRO A 53GLY A 159GLY A 152GLY A 153 | None | 1.13A | 1mxdA-5fkrA:undetectable | 1mxdA-5fkrA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0h | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | GLY A 582PRO A 464GLY A 743GLY A 744ASP A 705 | E1Z A1801 (-3.6A)None ZN A1804 ( 4.2A)None ZN A1804 ( 2.5A) | 1.14A | 1mxdA-5g0hA:undetectable | 1mxdA-5g0hA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0h | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | GLY A 616GLY A 572GLY A 703GLY A 743ASP A 705 | NoneNoneNone ZN A1804 ( 4.2A) ZN A1804 ( 2.5A) | 1.18A | 1mxdA-5g0hA:undetectable | 1mxdA-5g0hA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hca | CALRETICULIN,CALRETICULIN (Entamoebahistolytica) |
no annotation | 5 | GLY C 94LYS C 47GLY C 319GLY C 98GLY C 99 | None | 1.11A | 1mxdA-5hcaC:undetectable | 1mxdA-5hcaC:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hy7 | PUTATIVE PRE-MRNASPLICING PROTEINYSF3 (Chaetomiumthermophilum) |
PF03178(CPSF_A)PF10433(MMS1_N)no annotation | 5 | GLY A 847PRO D 60GLU A 315ASP A 318ARG A 280 | None | 1.14A | 1mxdA-5hy7A:undetectable | 1mxdA-5hy7A:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilb | PROTEASE DO-LIKE 2,CHLOROPLASTIC,PROTEASE DO-LIKE 9 (Arabidopsisthaliana) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 224PRO A 265GLY A 266GLY A 229GLY A 228 | None | 1.03A | 1mxdA-5ilbA:undetectable | 1mxdA-5ilbA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ji5 | BUPHA.10154.A.B1 (Paraburkholderiaphymatum) |
PF00850(Hist_deacetyl) | 5 | GLY A 134PRO A 21GLY A 286GLY A 287ASP A 244 | EDO A 403 (-3.6A)None ZN A 401 ( 4.2A)None ZN A 401 (-2.5A) | 1.09A | 1mxdA-5ji5A:undetectable | 1mxdA-5ji5A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jsy | PERIPLASMIC [NIFESE]HYDROGENASE, SMALLSUBUNIT (Desulfovibriovulgaris) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | GLY A 267PRO A 157GLY A 158GLY A 126GLY A 125 | SF4 A 302 ( 4.6A)NoneNoneNoneNone | 0.99A | 1mxdA-5jsyA:undetectable | 1mxdA-5jsyA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwz | CELLULOSE-BINDINGFAMILY II (Streptomycessp. SirexAA-E) |
PF02012(BNR) | 5 | GLY A 132PRO A 24GLY A 130GLY A 123GLY A 124 | None | 1.14A | 1mxdA-5jwzA:undetectable | 1mxdA-5jwzA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l8v | DNA REPAIR ANDRECOMBINATIONPROTEIN RADA (Pyrococcusfuriosus) |
PF08423(Rad51) | 5 | GLY A 163GLY A 111GLY A 127GLY A 126ASP A 121 | None | 0.71A | 1mxdA-5l8vA:undetectable | 1mxdA-5l8vA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5svc | ACETONE CARBOXYLASEALPHA SUBUNIT (Xanthobacterautotrophicus) |
PF02538(Hydantoinase_B) | 5 | GLY A 464PRO A 553GLY A 510GLY A 629GLY A 550 | None | 0.94A | 1mxdA-5svcA:undetectable | 1mxdA-5svcA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5td7 | ZGC:55652 (Danio rerio) |
PF00850(Hist_deacetyl) | 5 | GLY A 178GLY A 135GLY A 265GLY A 305ASP A 267 | NoneNoneNoneFKS A 711 (-3.2A) ZN A 701 ( 2.6A) | 1.10A | 1mxdA-5td7A:undetectable | 1mxdA-5td7A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5te1 | ATP-CITRATE SYNTHASE (Homo sapiens) |
PF00549(Ligase_CoA)PF02629(CoA_binding)PF16114(Citrate_bind) | 5 | GLY A 281GLY A 665GLY A 380GLY A 381ARG A 379 | 7A2 A 901 ( 3.4A)7A2 A 901 ( 3.4A)NoneNone7A2 A 901 (-2.9A) | 1.13A | 1mxdA-5te1A:2.0 | 1mxdA-5te1A:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v36 | GLUTATHIONEREDUCTASE (Streptococcusmutans) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 46GLY A 141GLY A 140ASP A 303ARG A 263 | FAD A 501 ( 3.7A)NoneFAD A 501 (-3.3A)FAD A 501 (-2.9A)FAD A 501 ( 3.7A) | 1.08A | 1mxdA-5v36A:undetectable | 1mxdA-5v36A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vdn | GLUTATHIONEOXIDOREDUCTASE (Yersinia pestis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 56GLY A 151GLY A 150ASP A 313ARG A 273 | FAD A 502 (-3.5A)BDF A 503 (-4.9A)FAD A 502 (-3.3A)FAD A 502 (-2.9A)BDF A 503 ( 3.6A) | 1.07A | 1mxdA-5vdnA:undetectable | 1mxdA-5vdnA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdh | KINESIN-LIKE PROTEINKIFC1 (Homo sapiens) |
PF00225(Kinesin) | 5 | PRO A 435GLU A 431GLY A 432GLY A 425GLY A 426 | NoneNoneNoneUNX A 804 ( 3.2A)UNX A 804 ( 4.2A) | 1.19A | 1mxdA-5wdhA:undetectable | 1mxdA-5wdhA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9r | CITRATE-SODIUMSYMPORTER (Klebsiellapneumoniae) |
PF03390(2HCT) | 5 | GLY A 430GLY A 183GLY A 404GLY A 406ASP A 407 | NoneNoneFLC A 501 (-3.6A)NoneNone | 1.04A | 1mxdA-5x9rA:undetectable | 1mxdA-5x9rA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xm3 | GLUCOSEDEHYDROGENASE (Methylophagaaminisulfidivorans) |
no annotation | 5 | GLY A 604GLU A 86GLY A 84GLY A 549GLY A 87 | NonePQQ A 701 (-2.5A)NoneNoneNone | 1.15A | 1mxdA-5xm3A:undetectable | 1mxdA-5xm3A:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvd | HYDROGENASE-2 SMALLCHAIN (Citrobacter sp.MGH106) |
no annotation | 5 | GLY S 257PRO S 152GLY S 153GLY S 125GLY S 124 | F3S S 402 (-4.4A)NoneNoneNoneNone | 1.06A | 1mxdA-5xvdS:undetectable | 1mxdA-5xvdS:10.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en9 | HYDROGENASE-2 SMALLCHAIN (Escherichiacoli) |
no annotation | 5 | GLY S 218PRO S 254GLY S 252GLY S 211ASP S 212 | None | 1.18A | 1mxdA-6en9S:undetectable | 1mxdA-6en9S:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en9 | HYDROGENASE-2 SMALLCHAIN (Escherichiacoli) |
no annotation | 5 | GLY S 257PRO S 152GLY S 153GLY S 125GLY S 124 | F3S S 302 (-4.4A)NoneNoneNoneNone | 1.05A | 1mxdA-6en9S:undetectable | 1mxdA-6en9S:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eot | DIPEPTIDYL PEPTIDASE8 (Homo sapiens) |
no annotation | 5 | PRO A 799GLU A 793GLY A 797GLY A 790ASP A 788 | None | 1.17A | 1mxdA-6eotA:undetectable | 1mxdA-6eotA:11.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f45 | - (-) |
no annotation | 5 | GLY D 156PRO D 194GLY D 170GLY D 129GLY D 152 | None | 1.20A | 1mxdA-6f45D:undetectable | 1mxdA-6f45D:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f45 | - (-) |
no annotation | 5 | GLY D 209PRO D 128GLY D 117GLY D 157GLY D 125 | None | 1.11A | 1mxdA-6f45D:undetectable | 1mxdA-6f45D:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH DEHYDROGENASE[UBIQUINONE]FLAVOPROTEIN 1,MITOCHONDRIAL (Mus musculus) |
no annotation | 5 | GLY F 252GLY F 64GLY F 67GLY F 72ARG F 68 | NoneNoneFMN F 501 (-3.1A)FMN F 501 ( 4.9A)None | 0.92A | 1mxdA-6g2jF:undetectable | 1mxdA-6g2jF:13.29 |