SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX8_A_RTLA135_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpb DIHYDROLIPOYL-TRANSA
CETYLASE

(Azotobacter
vinelandii) 		PF00198
(2-oxoacid_dh) 		5 LEU A 467
ALA A 533
LEU A 536
PRO A 516
ILE A 503
 None
 1.31A 1mx8A-1dpbA:
undetectable		 1mx8A-1dpbA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
LEU A  20
ALA A  33
LEU A  36
ARG A  58
 None
 1.07A 1mx8A-1gglA:
19.6		 1mx8A-1gglA:
55.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
LEU A  20
ALA A  33
LEU A  36
PRO A  38
 None
 0.85A 1mx8A-1gglA:
19.6		 1mx8A-1gglA:
55.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
LEU A  20
ALA A  33
LEU A  36
TYR A  60
 None
 0.88A 1mx8A-1gglA:
19.6		 1mx8A-1gglA:
55.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
LEU A  36
PRO A  38
THR A  53
 None
 1.03A 1mx8A-1lpjA:
19.3		 1mx8A-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
LEU A  36
THR A  53
ARG A  58
 None
 0.93A 1mx8A-1lpjA:
19.3		 1mx8A-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
LEU A  36
THR A  53
PHE A  64
 None
 1.27A 1mx8A-1lpjA:
19.3		 1mx8A-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
LEU A  36
ARG A  58
 None
 0.79A 1mx8A-1lpjA:
19.3		 1mx8A-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
LEU A  36
PHE A  64
 None
 1.09A 1mx8A-1lpjA:
19.3		 1mx8A-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
LEU A  36
PRO A  38
 None
 0.65A 1mx8A-1lpjA:
19.3		 1mx8A-1lpjA:
56.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 5 LEU T 122
ALA T 134
LEU T 137
PRO T 109
ILE T 103
 None
None
None
None
NAD  T 321 ( 4.4A)
 1.27A 1mx8A-1lthT:
undetectable		 1mx8A-1lthT:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		12 PHE A  16
TYR A  19
LEU A  20
ALA A  33
LEU A  36
PRO A  38
THR A  53
ARG A  58
TYR A  60
MET A  62
PHE A  64
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 4.7A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.3A)
None
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 ( 3.8A)
RTL  A 135 (-3.5A)
 0.00A 1mx8A-1mx8A:
28.4		 1mx8A-1mx8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A 255
LEU A 254
PRO A 297
PHE A 682
ILE A 265
 None
 1.16A 1mx8A-1q8yA:
undetectable		 1mx8A-1q8yA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		5 TYR A   7
LEU A  34
ALA A  55
LEU A  54
ARG A  51
 None
 1.25A 1mx8A-1qjcA:
undetectable		 1mx8A-1qjcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 665
THR A 460
TYR A 491
MET A 488
PHE A 484
 None
 1.14A 1mx8A-1r8wA:
undetectable		 1mx8A-1r8wA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 TYR C   8
ALA C  27
MET C  74
PHE C  60
ILE C  30
 None
None
None
None
FAD  C4931 ( 4.8A)
 1.24A 1mx8A-1t3qC:
undetectable		 1mx8A-1t3qC:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 ALA A 176
LEU A 177
PRO A 332
THR A 240
ILE A 210
 None
 1.15A 1mx8A-1tlfA:
undetectable		 1mx8A-1tlfA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 LEU A 265
ALA A 314
LEU A 313
THR A 182
ILE A 350
 None
 1.29A 1mx8A-1tmoA:
undetectable		 1mx8A-1tmoA:
10.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
THR A  60
PHE A  70
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.1A)
None
None
 1.26A 1mx8A-1towA:
16.8		 1mx8A-1towA:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 PHE A 398
LEU A 374
THR A 450
TYR A 359
ILE A 343
 None
 1.21A 1mx8A-1w99A:
undetectable		 1mx8A-1w99A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc9 MULTIDRUG RESISTANCE
PROTEIN

(Vibrio cholerae) 		PF02321
(OEP) 		5 PHE A 465
LEU A 469
ALA A 194
PRO A 279
ILE A 189
 None
 1.21A 1mx8A-1yc9A:
undetectable		 1mx8A-1yc9A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 ALA A  95
LEU A  94
TYR A 335
MET A 333
ILE A 101
 None
 1.09A 1mx8A-1zbrA:
undetectable		 1mx8A-1zbrA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 PHE C 404
ALA C 346
TYR C 136
MET C 140
ILE C 112
 None
None
None
SMA  C 503 (-4.2A)
HEM  C 502 (-3.5A)
 1.29A 1mx8A-1zrtC:
undetectable		 1mx8A-1zrtC:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8f BETA-ELICITIN
CINNAMOMIN

(Phytophthora
cinnamomi) 		PF00964
(Elicitin) 		5 ALA A  65
LEU A  66
PRO A  68
TYR A  87
ILE A  60
 None
 1.26A 1mx8A-2a8fA:
undetectable		 1mx8A-2a8fA:
16.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  15
LEU A  19
ALA A  32
THR A  61
PHE A  71
 None
None
A80  A 201 ( 4.1A)
None
None
 0.87A 1mx8A-2cbrA:
16.7		 1mx8A-2cbrA:
42.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 PHE A 205
LEU A 165
ALA A 191
LEU A 202
ILE A 194
 None
 1.28A 1mx8A-2ddhA:
undetectable		 1mx8A-2ddhA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4) 		no annotation 5 PHE A 319
LEU A 318
ALA A  72
LEU A  73
ILE A  32
 None
 1.11A 1mx8A-2ddxA:
undetectable		 1mx8A-2ddxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m46 ARSENATE REDUCTASE,
PUTATIVE

(Staphylococcus
aureus) 		PF03960
(ArsC) 		5 PHE A   4
LEU A  20
ALA A  97
LEU A  96
PRO A  95
 None
 1.26A 1mx8A-2m46A:
undetectable		 1mx8A-2m46A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyh PUTATIVE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF08883
(DOPA_dioxygen) 		5 PHE A  85
LEU A 110
ALA A 101
PRO A  88
THR A  90
 None
 1.28A 1mx8A-2nyhA:
undetectable		 1mx8A-2nyhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqt HYPOTHETICAL PROTEIN
SPY0176

(Streptococcus
pyogenes) 		PF00359
(PTS_EIIA_2) 		5 TYR A  58
ALA A  29
LEU A  28
THR A  21
ILE A  48
 None
 1.30A 1mx8A-2oqtA:
undetectable		 1mx8A-2oqtA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00483
(NTP_transferase) 		5 LEU A  61
ALA A  53
LEU A  56
ARG A 217
TYR A 218
 None
 1.26A 1mx8A-2pa4A:
undetectable		 1mx8A-2pa4A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A 447
ALA A 417
LEU A 346
THR A 384
PHE A 297
 None
 1.18A 1mx8A-2pvsA:
undetectable		 1mx8A-2pvsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A 447
LEU A 346
THR A 384
PHE A 297
ILE A 358
 None
 1.28A 1mx8A-2pvsA:
undetectable		 1mx8A-2pvsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A 928
ALA A 994
ARG A1245
PHE A1257
ILE A 990
 None
 1.22A 1mx8A-2vdcA:
undetectable		 1mx8A-2vdcA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzv NFNB PROTEIN

(Mycolicibacterium
smegmatis) 		PF00881
(Nitroreductase) 		5 PHE A  45
LEU A 166
ALA A 143
TYR A 209
ILE A 175
 None
 1.16A 1mx8A-2wzvA:
undetectable		 1mx8A-2wzvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aay PUTATIVE THIOSULFATE
SULFURTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		5 PHE A  98
LEU A  82
THR A 133
ARG A  72
ILE A  43
 None
 1.24A 1mx8A-3aayA:
undetectable		 1mx8A-3aayA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima;
Thermotoga
maritima) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 TYR A 188
LEU B  49
ALA A 192
THR A  76
TYR A  86
 None
 1.15A 1mx8A-3al0A:
undetectable		 1mx8A-3al0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fez UNCHARACTERIZED
FERREDOXIN FOLD
PROTEIN RELATED TO
ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASES

(Listeria
monocytogenes) 		no annotation 5 TYR A 157
LEU A  29
THR A 106
TYR A  53
ILE A   6
 None
 1.09A 1mx8A-3fezA:
undetectable		 1mx8A-3fezA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01436
(NHL) 		5 LEU A 744
ALA A 693
LEU A 694
PRO A 696
ILE A 740
 None
 1.21A 1mx8A-3fw0A:
undetectable		 1mx8A-3fw0A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzi TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A  64
LEU A  63
ALA A  25
LEU A  28
ILE A  39
 EDO  A 226 ( 4.7A)
None
None
None
EDO  A 225 (-3.4A)
 1.14A 1mx8A-3gziA:
undetectable		 1mx8A-3gziA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		5 TYR 4 246
LEU 4 239
ALA 4 229
LEU 4 232
PHE 5  89
 None
 1.30A 1mx8A-3i9v4:
undetectable		 1mx8A-3i9v4:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  30
ALA A  34
LEU A  37
THR A 100
ILE A  57
 None
 1.30A 1mx8A-3iplA:
undetectable		 1mx8A-3iplA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN

(Bordetella
parapertussis) 		PF00571
(CBS) 		5 PHE A 165
LEU A 161
ALA A 173
LEU A 172
ILE A  81
 None
 1.10A 1mx8A-3jtfA:
undetectable		 1mx8A-3jtfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 PHE A 292
ALA A 309
LEU A 308
PHE A 393
ILE A 485
 None
 1.27A 1mx8A-3kf3A:
undetectable		 1mx8A-3kf3A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l93 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Yersinia pestis) 		PF01467
(CTP_transf_like) 		5 TYR A   7
LEU A  34
ALA A  55
LEU A  54
ARG A  51
 None
 1.28A 1mx8A-3l93A:
undetectable		 1mx8A-3l93A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN

(Thermoplasma
volcanium) 		PF12916
(DUF3834) 		5 LEU A 218
LEU A 138
PRO A 139
THR A 198
ILE A 223
 None
None
None
CL  A 230 ( 4.8A)
CL  A 228 (-4.6A)
 1.16A 1mx8A-3mstA:
undetectable		 1mx8A-3mstA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		5 LEU A 273
ALA A 280
LEU A 281
THR A 178
ILE A   6
 None
 1.29A 1mx8A-3n2tA:
undetectable		 1mx8A-3n2tA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 PHE A 422
TYR A 270
ALA A 335
LEU A 338
THR A 304
 None
 1.25A 1mx8A-3o7qA:
undetectable		 1mx8A-3o7qA:
13.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
ALA A  34
PRO A  39
THR A  54
 None
None
PAM  A 133 ( 3.7A)
PAM  A 133 (-4.4A)
PAM  A 133 ( 3.9A)
 0.98A 1mx8A-3pp6A:
17.7		 1mx8A-3pp6A:
35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4d SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF16451
(Spike_NTD) 		5 TYR B 258
LEU B  79
LEU B  97
PHE B 228
ILE B 104
 None
 1.21A 1mx8A-3r4dB:
undetectable		 1mx8A-3r4dB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sao EXTRACELLULAR FATTY
ACID-BINDING PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 PHE A  24
ALA A 143
TYR A 114
PHE A  65
ILE A  14
 None
None
NKN  A 161 (-4.0A)
NKN  A 161 (-4.6A)
None
 1.25A 1mx8A-3saoA:
5.6		 1mx8A-3saoA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1p ALPHA-1-ANTITRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		5 PHE A 312
LEU A 329
ALA A 332
LEU A 299
ILE A  76
 None
 1.01A 1mx8A-3t1pA:
undetectable		 1mx8A-3t1pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 PHE A 230
LEU A 244
ALA A 257
THR A 223
ILE A 253
 None
 1.16A 1mx8A-3vueA:
undetectable		 1mx8A-3vueA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 TYR A  10
LEU A   7
ALA A  38
PRO A 201
ILE A 297
 None
 1.28A 1mx8A-3vywA:
undetectable		 1mx8A-3vywA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 LEU A 197
ALA A 183
LEU A 182
THR A 288
ILE A 241
 None
 1.11A 1mx8A-3w6oA:
undetectable		 1mx8A-3w6oA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
PRO A  38
THR A  40
 2AN  A 201 ( 4.9A)
2AN  A 201 (-4.8A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
None
 1.07A 1mx8A-3wbgA:
17.1		 1mx8A-3wbgA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
PRO A  38
THR A  53
 2AN  A 201 ( 4.9A)
2AN  A 201 (-4.8A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 ( 4.0A)
 1.11A 1mx8A-3wbgA:
17.1		 1mx8A-3wbgA:
34.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR4
CRISPR SYSTEM CMR
SUBUNIT CMR5

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF03787
(RAMPs)
PF09701
(Cas_Cmr5) 		5 LEU F  98
ALA F 136
LEU F 137
PHE C 254
ILE F 131
 None
 1.03A 1mx8A-3x1lF:
undetectable		 1mx8A-3x1lF:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ALA A 706
LEU A 707
ARG A 904
PHE A 919
ILE A 713
 None
 1.23A 1mx8A-3zyvA:
undetectable		 1mx8A-3zyvA:
7.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
ALA A  34
PRO A  39
THR A  54
 None
None
NA  A1132 ( 4.0A)
None
None
 0.93A 1mx8A-4a60A:
16.3		 1mx8A-4a60A:
31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 LEU A  58
ALA A  34
PRO A  54
THR A 343
ILE A 140
 None
 1.13A 1mx8A-4atyA:
undetectable		 1mx8A-4atyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axs CARBAMATE KINASE

(Mycoplasma
penetrans) 		PF00696
(AA_kinase) 		5 PHE A 121
ALA A 160
PRO A 192
THR A 112
ILE A 163
 None
 1.30A 1mx8A-4axsA:
undetectable		 1mx8A-4axsA:
16.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
ALA A  36
PRO A  41
THR A  56
 None
 0.65A 1mx8A-4aznA:
16.5		 1mx8A-4aznA:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
ALA A  36
PRO A  41
THR A  56
 None
None
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.7A)
A9M  A1136 ( 4.3A)
 1.03A 1mx8A-4azpA:
16.9		 1mx8A-4azpA:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bcx AP-1 COMPLEX SUBUNIT
GAMMA-LIKE 2

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		5 PHE A 745
LEU A 725
ALA A 715
ARG A 760
ILE A 712
 None
 1.31A 1mx8A-4bcxA:
undetectable		 1mx8A-4bcxA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 LEU A 250
ALA A 306
LEU A 307
MET A 275
ILE A 258
 None
 1.26A 1mx8A-4bevA:
undetectable		 1mx8A-4bevA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 PHE A 168
LEU A  97
ALA A 100
TYR A 345
ILE A 328
 None
None
None
7AH  A1000 (-4.7A)
None
 1.26A 1mx8A-4cgnA:
undetectable		 1mx8A-4cgnA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 PHE A  35
TYR A  32
ALA A 209
ARG A 497
PHE A  19
 None
 1.16A 1mx8A-4djiA:
undetectable		 1mx8A-4djiA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A  14
ALA A  28
PRO A  55
PHE A 487
ILE A  59
 None
 1.21A 1mx8A-4dnsA:
undetectable		 1mx8A-4dnsA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 PHE A 258
TYR A 261
LEU A 262
ALA A 244
TYR A 281
 None
None
None
1PE  A 306 ( 4.6A)
GOL  A 304 (-4.0A)
 1.31A 1mx8A-4e13A:
undetectable		 1mx8A-4e13A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fer EXPANSIN-YOAJ

(Bacillus
subtilis) 		PF03330
(DPBB_1) 		5 LEU A 165
ALA A 127
TYR A 116
PHE A 206
ILE A 186
 None
 1.18A 1mx8A-4ferA:
undetectable		 1mx8A-4ferA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		5 LEU A 346
ALA A 324
ARG A 185
TYR A 249
PHE A 400
 None
None
EDO  A 616 ( 3.3A)
None
SO4  A 605 (-4.7A)
 1.26A 1mx8A-4fwwA:
undetectable		 1mx8A-4fwwA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kia LMO2213 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 TYR A 157
LEU A  29
THR A 106
TYR A  53
ILE A   6
 None
 1.14A 1mx8A-4kiaA:
undetectable		 1mx8A-4kiaA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
THR A  60
PHE A  70
 None
None
75D  A 201 ( 4.1A)
None
None
 1.27A 1mx8A-4nnsA:
16.6		 1mx8A-4nnsA:
33.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		5 LEU Y  77
ALA Y  43
LEU Y  42
THR Y  33
ILE Y  64
 None
 1.10A 1mx8A-4ox9Y:
undetectable		 1mx8A-4ox9Y:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 PHE A 231
ARG A 266
TYR A 270
PHE A 320
ILE A 223
 None
 1.29A 1mx8A-4phcA:
undetectable		 1mx8A-4phcA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvc NADPH-DEPENDENT
METHYLGLYOXAL
REDUCTASE GRE2

(Saccharomyces
cerevisiae) 		PF01073
(3Beta_HSD) 		5 PHE A 321
ALA A 248
TYR A 128
PHE A 236
ILE A 264
 None
 1.19A 1mx8A-4pvcA:
undetectable		 1mx8A-4pvcA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudarthrobacter
chlorophenolicus) 		PF01547
(SBP_bac_1) 		5 ALA A 311
LEU A 175
PRO A 174
THR A 294
ILE A 308
 None
None
None
LB2  A 501 ( 4.6A)
None
 1.31A 1mx8A-4r2fA:
undetectable		 1mx8A-4r2fA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN

(Geobacillus
thermodenitrificans) 		PF10609
(ParA) 		5 PHE A 151
TYR A 150
LEU A 280
LEU A  57
THR A 106
 None
 1.28A 1mx8A-4rz2A:
undetectable		 1mx8A-4rz2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz9 PRE-MRNA-SPLICING
FACTOR 38A

(Homo sapiens) 		PF03371
(PRP38) 		5 PHE A 147
LEU A 151
LEU A 102
THR A  68
ILE A 160
 None
 1.05A 1mx8A-4rz9A:
undetectable		 1mx8A-4rz9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rza PRE-MRNA-SPLICING
FACTOR 38A

(Homo sapiens) 		PF03371
(PRP38) 		5 PHE A 147
LEU A 151
LEU A 102
THR A  68
ILE A 160
 None
 1.02A 1mx8A-4rzaA:
undetectable		 1mx8A-4rzaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		5 LEU A 137
ALA A 130
LEU A 133
MET A 340
ILE A  73
 None
 1.03A 1mx8A-5a8qA:
undetectable		 1mx8A-5a8qA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 LEU A 171
ALA A 165
LEU A 164
ARG A 163
PHE A 151
 None
 1.28A 1mx8A-5b58A:
undetectable		 1mx8A-5b58A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PHE C 379
LEU C 368
ALA C 293
PHE C 396
ILE C 302
 None
 1.20A 1mx8A-5g5gC:
undetectable		 1mx8A-5g5gC:
11.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
LEU A  36
PRO A  38
THR A  53
 None
 1.00A 1mx8A-5gkbA:
17.2		 1mx8A-5gkbA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		5 PHE A 251
LEU A 403
ALA A 380
LEU A 379
PHE A 342
 None
 1.25A 1mx8A-5m8tA:
undetectable		 1mx8A-5m8tA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		6 PHE 1 123
LEU 1 128
ALA 1 309
TYR 1 227
MET 1 180
PHE 1 181
 None
 1.38A 1mx8A-5mz61:
undetectable		 1mx8A-5mz61:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		5 LEU A 204
ALA A 156
LEU A 155
PHE A 129
ILE A 304
 None
 1.28A 1mx8A-5ny5A:
undetectable		 1mx8A-5ny5A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		5 LEU A 204
ALA A 156
LEU A 155
PHE A 129
ILE A 304
 None
 1.28A 1mx8A-5o3mA:
undetectable		 1mx8A-5o3mA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE
BETA-HEXOSAMINIDASE

(Aspergillus
oryzae;
Aspergillus
oryzae) 		no annotation
no annotation 		5 PHE B 564
TYR B 567
LEU B 568
ALA B 535
PRO A  25
 None
 1.21A 1mx8A-5oarB:
undetectable		 1mx8A-5oarB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umu FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		no annotation 5 PHE A 797
LEU A 795
ALA A 707
LEU A 708
ILE A 699
 None
 1.10A 1mx8A-5umuA:
undetectable		 1mx8A-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 PHE A 527
LEU A 521
LEU A 540
PRO A 542
ILE A 231
 None
 1.20A 1mx8A-5uqeA:
undetectable		 1mx8A-5uqeA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w35 DNA PRIMASE

(Mycobacterium
tuberculosis) 		no annotation 5 PHE A 200
LEU A 205
LEU A 188
THR A 239
ILE A 208
 None
 1.17A 1mx8A-5w35A:
undetectable		 1mx8A-5w35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU A 277
PRO A 361
ARG A 374
TYR A 320
ILE A 292
 None
 1.27A 1mx8A-5w3fA:
undetectable		 1mx8A-5w3fA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		5 ALA A 352
LEU A 356
THR A 289
TYR A 286
ILE A 277
 None
 1.17A 1mx8A-5x62A:
undetectable		 1mx8A-5x62A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 5 LEU A 230
ALA A 160
LEU A 163
TYR A 149
ILE A 151
 None
 1.04A 1mx8A-5xmdA:
undetectable		 1mx8A-5xmdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqh PROTEIN ROGDI
HOMOLOG

(Homo sapiens) 		PF10259
(Rogdi_lz) 		5 PHE A 261
LEU A 153
ALA A 156
THR A  46
ILE A 124
 None
 1.18A 1mx8A-5xqhA:
undetectable		 1mx8A-5xqhA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Homo sapiens) 		no annotation 5 LEU A 103
ALA A 136
LEU A 137
ARG A 160
TYR A 209
 None
 1.28A 1mx8A-5yx9A:
undetectable		 1mx8A-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 5 ALA A 180
LEU A 179
PRO A 140
PHE A 453
ILE A 385
 None
 1.12A 1mx8A-6b0tA:
undetectable		 1mx8A-6b0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 ALA A 178
LEU A 111
MET A  66
PHE A  67
ILE A 173
 None
 1.30A 1mx8A-6eu6A:
undetectable		 1mx8A-6eu6A:
undetectable