SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_F_THAF6_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1aql | BILE-SALT ACTIVATEDLIPASE (Bos taurus) |
PF00135(COesterase) | 5 | GLY A 107SER A 194LEU A 285PHE A 393HIS A 435 | None | 0.70A | 1mx1F-1aqlA:48.2 | 1mx1F-1aqlA:35.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqg | D-GLUCARATEDEHYDRATASE (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 215GLY A 214VAL A 226LEU A 240LEU A 212 | None | 1.04A | 1mx1F-1bqgA:undetectable | 1mx1F-1bqgA:21.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1cle | CHOLESTEROL ESTERASE ([Candida]cylindracea) |
PF00135(COesterase) | 6 | GLY A 123GLY A 124SER A 209LEU A 304PHE A 415HIS A 449 | CLL A 801 (-3.3A)CLL A 801 (-3.3A)CLL A 801 ( 2.8A)CLL A 801 (-4.7A)NoneCLL A 801 (-4.8A) | 0.71A | 1mx1F-1cleA:39.8 | 1mx1F-1cleA:30.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1crl | LIPASE (Diutina rugosa) |
PF00135(COesterase) | 6 | GLY A 123GLY A 124SER A 209LEU A 304PHE A 415HIS A 449 | None | 0.80A | 1mx1F-1crlA:39.5 | 1mx1F-1crlA:30.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f89 | 32.5 KDA PROTEINYLR351C (Saccharomycescerevisiae) |
PF00795(CN_hydrolase) | 5 | VAL A 49LEU A 94LEU A 18LEU A 51PHE A 90 | None | 1.05A | 1mx1F-1f89A:undetectable | 1mx1F-1f89A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gut | MOLYBDATE BINDINGPROTEIN II (Clostridiumpasteurianum) |
PF03459(TOBE) | 5 | SER A 37VAL A 13LEU A 27LEU A 47LEU A 55 | None | 1.01A | 1mx1F-1gutA:undetectable | 1mx1F-1gutA:7.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gz7 | LIPASE 2 (Diutina rugosa) |
PF00135(COesterase) | 5 | GLY A 122GLY A 123LEU A 127PHE A 345HIS A 449 | None | 0.79A | 1mx1F-1gz7A:39.8 | 1mx1F-1gz7A:31.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gz7 | LIPASE 2 (Diutina rugosa) |
PF00135(COesterase) | 5 | GLY A 122GLY A 123SER A 209VAL A 296HIS A 449 | None | 1.02A | 1mx1F-1gz7A:39.8 | 1mx1F-1gz7A:31.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gz7 | LIPASE 2 (Diutina rugosa) |
PF00135(COesterase) | 6 | GLY A 123GLY A 124SER A 209LEU A 304PHE A 415HIS A 449 | None | 0.79A | 1mx1F-1gz7A:39.8 | 1mx1F-1gz7A:31.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iy9 | SPERMIDINE SYNTHASE (Bacillussubtilis) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 6 | GLY A 89GLY A 88VAL A 134LEU A 105LEU A 127LEU A 120 | None | 1.34A | 1mx1F-1iy9A:2.6 | 1mx1F-1iy9A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jkm | BREFELDIN A ESTERASE (Bacillussubtilis) |
PF07859(Abhydrolase_3) | 5 | GLY A 127GLY A 128SER A 202LEU A 268HIS A 338 | None | 0.90A | 1mx1F-1jkmA:18.3 | 1mx1F-1jkmA:23.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k4y | LIVERCARBOXYLESTERASE (Oryctolaguscuniculus) |
PF00135(COesterase) | 5 | GLY A 142GLY A 143SER A 221LEU A 255HIS A 467 | None | 0.60A | 1mx1F-1k4yA:63.7 | 1mx1F-1k4yA:82.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m6y | S-ADENOSYL-METHYLTRANSFERASE MRAW (Thermotogamaritima) |
PF01795(Methyltransf_5) | 5 | GLY A 37GLY A 36VAL A 75LEU A 68LEU A 101 | SAH A 401 (-3.3A)SAH A 401 (-4.1A)NoneNoneNone | 1.08A | 1mx1F-1m6yA:2.6 | 1mx1F-1m6yA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qon | ACETYLCHOLINESTERASE (Drosophilamelanogaster) |
PF00135(COesterase) | 5 | GLY A 150GLY A 151SER A 238PHE A 440HIS A 480 | I40 A 997 (-3.9A)SO4 A 593 (-3.4A)SO4 A 593 (-1.9A)SO4 A 593 (-4.5A)SO4 A 593 (-4.1A) | 0.48A | 1mx1F-1qonA:47.5 | 1mx1F-1qonA:29.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r5t | CYTIDINE DEAMINASE (Saccharomycescerevisiae) |
PF00383(dCMP_cyt_deam_1) | 5 | GLY A 97LEU A 132LEU A 131MET A 128MET A 67 | None | 1.03A | 1mx1F-1r5tA:undetectable | 1mx1F-1r5tA:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txg | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD(P)+] (Archaeoglobusfulgidus) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | GLY A 12VAL A 52LEU A 50LEU A 54LEU A 19 | None | 0.93A | 1mx1F-1txgA:undetectable | 1mx1F-1txgA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukc | ESTA (Aspergillusniger) |
PF00135(COesterase) | 5 | GLY A 127GLY A 128SER A 210PHE A 400HIS A 440 | EDO A1902 (-3.6A)EDO A1902 (-3.4A)EDO A1902 (-2.4A)NoneEDO A1902 ( 4.9A) | 0.59A | 1mx1F-1ukcA:37.7 | 1mx1F-1ukcA:29.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vav | ALGINATE LYASEPA1167 (Pseudomonasaeruginosa) |
PF08787(Alginate_lyase2) | 5 | GLY A 197VAL A 220LEU A 83LEU A 218LEU A 9 | None | 0.99A | 1mx1F-1vavA:undetectable | 1mx1F-1vavA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vma | CELL DIVISIONPROTEIN FTSY (Thermotogamaritima) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | GLY A 254GLY A 253LEU A 11LEU A 244LEU A 247 | None | 1.07A | 1mx1F-1vmaA:undetectable | 1mx1F-1vmaA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9a | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Entamoebahistolytica) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 244GLY A 243VAL A 178LEU A 268HIS A 42 | OHS A 245 ( 2.4A)NoneNoneNoneNone | 1.05A | 1mx1F-1y9aA:undetectable | 1mx1F-1y9aA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7b | CARBOXYLESTERASE (unculturedarchaeon) |
PF07859(Abhydrolase_3) | 5 | GLY A 82GLY A 83SER A 154LEU A 210HIS A 281 | None | 1.00A | 1mx1F-2c7bA:19.2 | 1mx1F-2c7bA:24.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dst | HYPOTHETICAL PROTEINTTHA1544 (Thermusthermophilus) |
no annotation | 6 | GLY A 72VAL A 28LEU A 48LEU A 102LEU A 26LEU A 100 | None | 1.21A | 1mx1F-2dstA:3.6 | 1mx1F-2dstA:12.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 5 | GLY A 146GLY A 147SER A 226PHE A 425HIS A 471 | TFC A 600 (-3.4A)TFC A 600 (-3.6A)TFC A 600 (-1.4A)NoneTFC A 600 (-4.2A) | 0.46A | 1mx1F-2fj0A:46.2 | 1mx1F-2fj0A:30.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7r | CXE CARBOXYLESTERASE (Actinidiaeriantha) |
PF07859(Abhydrolase_3) | 5 | GLY A 92GLY A 93SER A 169LEU A 22HIS A 306 | 4PA A 369 (-3.5A)4PA A 369 (-3.6A)4PA A 369 (-1.8A)None4PA A 369 (-4.8A) | 0.87A | 1mx1F-2o7rA:18.3 | 1mx1F-2o7rA:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okk | GLUTAMATEDECARBOXYLASE 2 (Homo sapiens) |
PF00282(Pyridoxal_deC) | 5 | GLY A 337VAL A 384LEU A 347LEU A 371LEU A 381 | None | 1.07A | 1mx1F-2okkA:undetectable | 1mx1F-2okkA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4z | METAL-DEPENDENTHYDROLASES OF THEBETA-LACTAMASESUPERFAMILY II (Caldanaerobactersubterraneus) |
PF00753(Lactamase_B) | 5 | GLY A 225GLY A 224VAL A 15LEU A 36LEU A 222 | None | 0.89A | 1mx1F-2p4zA:undetectable | 1mx1F-2p4zA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ps3 | HIGH-AFFINITY ZINCUPTAKE SYSTEMPROTEIN ZNUA (Escherichiacoli) |
PF01297(ZnuA) | 5 | GLY A 160VAL A 28LEU A 77LEU A 173LEU A 177 | None | 0.91A | 1mx1F-2ps3A:undetectable | 1mx1F-2ps3A:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qma | DIAMINOBUTYRATE-PYRUVATE TRANSAMINASEANDL-2,4-DIAMINOBUTYRATE DECARBOXYLASE (Vibrioparahaemolyticus) |
PF00282(Pyridoxal_deC) | 5 | GLY A 728VAL A 774LEU A 738LEU A 762LEU A 771 | None | 0.97A | 1mx1F-2qmaA:undetectable | 1mx1F-2qmaA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | GLY A 625VAL A 604LEU A 642LEU A 606LEU A 586 | None | 1.03A | 1mx1F-2vdcA:undetectable | 1mx1F-2vdcA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1v | NITRILASE HOMOLOG 2 (Mus musculus) |
PF00795(CN_hydrolase) | 5 | GLY A 121GLY A 120VAL A 110LEU A 107LEU A 118 | None | 1.03A | 1mx1F-2w1vA:undetectable | 1mx1F-2w1vA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 5 | GLY A 132VAL A 65LEU A 58LEU A 60LEU A 70 | None | 0.88A | 1mx1F-2xvgA:undetectable | 1mx1F-2xvgA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yh2 | ESTERASE (Pyrobaculumcalidifontis) |
PF07859(Abhydrolase_3) | 5 | GLY A 85GLY A 86SER A 157LEU A 213HIS A 284 | None | 0.89A | 1mx1F-2yh2A:19.3 | 1mx1F-2yh2A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zd2 | ATP12 ATPASE (Paracoccusdenitrificans) |
PF07542(ATP12) | 5 | GLY A1097VAL A1150LEU A1151LEU A1154LEU A1102 | None | 0.91A | 1mx1F-2zd2A:undetectable | 1mx1F-2zd2A:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjr | PUTATIVECARBOXYLESTERASE (Lactobacillusplantarum) |
PF07859(Abhydrolase_3) | 5 | GLY A 87VAL A 136LEU A 134LEU A 141LEU A 93 | None | 0.79A | 1mx1F-3bjrA:17.3 | 1mx1F-3bjrA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp7 | ALKALINE SERINEPROTEASE AL20 (Nesterenkoniaaethiopica) |
PF13365(Trypsin_2) | 5 | GLY A 166GLY A 167SER A 169VAL A 12HIS A 41 | FMT A 219 (-3.5A)FMT A 219 (-3.6A)FMT A 219 (-2.6A)NoneFMT A 219 (-3.9A) | 1.00A | 1mx1F-3cp7A:undetectable | 1mx1F-3cp7A:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csk | PROBABLEDIPEPTIDYL-PEPTIDASE3 (Saccharomycescerevisiae) |
PF03571(Peptidase_M49) | 5 | GLY A 71VAL A 91LEU A 88LEU A 707LEU A 703 | None | 1.05A | 1mx1F-3cskA:undetectable | 1mx1F-3cskA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e7o | MITOGEN-ACTIVATEDPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 104LEU A 57LEU A 77LEU A 106LEU A 76 | None | 1.01A | 1mx1F-3e7oA:undetectable | 1mx1F-3e7oA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fds | DNA POLYMERASESLIDING CLAMP C (Sulfolobussolfataricus) |
PF00705(PCNA_N)PF02747(PCNA_C) | 5 | GLY D 39VAL D 19LEU D 23LEU D 48PHE D 71 | None | 1.07A | 1mx1F-3fdsD:undetectable | 1mx1F-3fdsD:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdn | R-OXYNITRILE LYASEISOENZYME 1 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 6 | GLY A 35GLY A 104SER A 107LEU A 201LEU A 103LEU A 200 | FAD A 522 (-3.3A)NoneNoneNoneNoneNone | 1.48A | 1mx1F-3gdnA:undetectable | 1mx1F-3gdnA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gp0 | MITOGEN-ACTIVATEDPROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 102LEU A 55LEU A 75LEU A 104LEU A 74 | NoneNoneNIL A 1 ( 4.8A)NIL A 1 ( 4.3A)None | 0.94A | 1mx1F-3gp0A:undetectable | 1mx1F-3gp0A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3he1 | MAJOR EXPORTED HCP3PROTEIN (Pseudomonasaeruginosa) |
PF05638(T6SS_HCP) | 6 | GLY A 15GLY A 11VAL A 94LEU A 91LEU A 80MET A 7 | None | 1.24A | 1mx1F-3he1A:undetectable | 1mx1F-3he1A:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ils | AFLATOXINBIOSYNTHESISPOLYKETIDE SYNTHASE (Aspergillusparasiticus) |
PF00975(Thioesterase) | 5 | GLY A1874SER A1937VAL A2014PHE A2056HIS A2088 | None | 1.04A | 1mx1F-3ilsA:10.5 | 1mx1F-3ilsA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iq0 | PUTATIVE RIBOKINASEII (Escherichiacoli) |
PF00294(PfkB) | 5 | GLY A 136VAL A 148LEU A 182LEU A 139LEU A 186 | None | 1.04A | 1mx1F-3iq0A:undetectable | 1mx1F-3iq0A:19.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k9b | LIVERCARBOXYLESTERASE 1 (Homo sapiens) |
PF00135(COesterase) | 10 | GLY A1142GLY A1143SER A1221VAL A1254LEU A1255LEU A1363MET A1364MET A1425PHE A1426HIS A1468 | WW2 A 193 (-3.4A)WW2 A 193 (-3.4A)WW2 A 193 (-1.4A)NoneNoneWW2 A 193 (-3.8A)NoneNoneNoneNone | 0.52A | 1mx1F-3k9bA:62.0 | 1mx1F-3k9bA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lim | FRAGACEATOXIN C (Actiniafragacea) |
PF06369(Anemone_cytotox) | 5 | GLY A 36VAL A 18LEU A 19LEU A 71HIS A 175 | None | 1.02A | 1mx1F-3limA:undetectable | 1mx1F-3limA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mtj | HOMOSERINEDEHYDROGENASE (Thiobacillusdenitrificans) |
PF00742(Homoserine_dh)PF01842(ACT)PF03447(NAD_binding_3) | 5 | GLY A 16GLY A 15VAL A 76LEU A 8LEU A 78 | None | 0.66A | 1mx1F-3mtjA:undetectable | 1mx1F-3mtjA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mtj | HOMOSERINEDEHYDROGENASE (Thiobacillusdenitrificans) |
PF00742(Homoserine_dh)PF01842(ACT)PF03447(NAD_binding_3) | 5 | GLY A 17GLY A 15VAL A 76LEU A 8LEU A 78 | None | 0.90A | 1mx1F-3mtjA:undetectable | 1mx1F-3mtjA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nnm | CURA (Lyngbyamajuscula) |
PF05721(PhyH) | 5 | GLY A 130LEU A 95MET A 96PHE A 123HIS A 99 | NoneNoneNoneNoneFMT A 750 (-4.3A) | 1.07A | 1mx1F-3nnmA:undetectable | 1mx1F-3nnmA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ozx | RNASE L INHIBITOR (Sulfolobussolfataricus) |
PF00005(ABC_tran) | 5 | GLY A 215GLY A 216LEU A 243LEU A 222MET A 202 | None | 1.03A | 1mx1F-3ozxA:undetectable | 1mx1F-3ozxA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pe8 | ENOYL-COA HYDRATASE (Mycolicibacteriumsmegmatis) |
PF00378(ECH_1) | 5 | GLY A 103GLY A 102LEU A 136LEU A 108PHE A 38 | None ZN A 254 ( 4.1A)NoneNoneNone | 1.03A | 1mx1F-3pe8A:undetectable | 1mx1F-3pe8A:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfe | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Legionellapneumophila) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 6 | GLY A 126GLY A 127VAL A 434LEU A 23LEU A 448HIS A 96 | NoneNoneNoneNoneNone ZN A 501 (-3.3A) | 1.11A | 1mx1F-3pfeA:undetectable | 1mx1F-3pfeA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfr | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Actinobacillussuccinogenes) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 210GLY A 209VAL A 221LEU A 235LEU A 207 | None | 1.07A | 1mx1F-3pfrA:undetectable | 1mx1F-3pfrA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgu | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydomonasreinhardtii) |
PF00155(Aminotran_1_2) | 5 | GLY A 330GLY A 331VAL A 120LEU A 335LEU A 116 | None | 1.01A | 1mx1F-3qguA:undetectable | 1mx1F-3qguA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3red | HYDROXYNITRILE LYASE (Prunus mume) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 6 | GLY A 35GLY A 104SER A 107LEU A 201LEU A 103LEU A 200 | FAD A 773 (-3.4A)NoneNoneNoneNoneNone | 1.46A | 1mx1F-3redA:undetectable | 1mx1F-3redA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9g | ZINC FINGERCCCH-TYPE ANTIVIRALPROTEIN 1 (Rattusnorvegicus) |
no annotation | 5 | VAL A 64LEU A 51LEU A 27LEU A 23LEU A 32 | None | 1.06A | 1mx1F-3u9gA:undetectable | 1mx1F-3u9gA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut2 | CATALASE-PEROXIDASE2 (Magnaportheoryzae) |
PF00141(peroxidase) | 5 | GLY A 671GLY A 672VAL A 594LEU A 695LEU A 676 | None | 1.00A | 1mx1F-3ut2A:undetectable | 1mx1F-3ut2A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxo | CATALASE-PEROXIDASE (Synechococcuselongatus) |
PF00141(peroxidase) | 5 | GLY A 610GLY A 611VAL A 533LEU A 634LEU A 615 | None | 1.05A | 1mx1F-3wxoA:undetectable | 1mx1F-3wxoA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX ALPHA-CHAINFADB (Mycobacteriumtuberculosis) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | GLY A 151GLY A 152VAL A 169LEU A 170LEU A 139 | None | 0.68A | 1mx1F-4b3iA:3.3 | 1mx1F-4b3iA:22.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4be9 | STEROL ESTERASE (Ophiostomapiceae) |
PF00135(COesterase) | 5 | GLY A 133GLY A 134LEU A 138PHE A 356HIS A 465 | NonePGE A1554 ( 4.7A)NoneNoneNone | 0.78A | 1mx1F-4be9A:40.8 | 1mx1F-4be9A:31.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4be9 | STEROL ESTERASE (Ophiostomapiceae) |
PF00135(COesterase) | 6 | GLY A 134GLY A 135SER A 220LEU A 315PHE A 427HIS A 465 | PGE A1554 ( 4.7A)1PE A1553 (-3.3A)1PE A1553 (-2.9A)1PE A1553 (-4.3A)1PE A1553 (-4.7A)None | 0.67A | 1mx1F-4be9A:40.8 | 1mx1F-4be9A:31.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxw | FACTOR XA (Pseudonajatextilis) |
PF00089(Trypsin)PF14670(FXa_inhibition) | 5 | GLY A 364GLY A 197VAL A 221LEU A 187LEU A 207 | None | 1.07A | 1mx1F-4bxwA:undetectable | 1mx1F-4bxwA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1o | BETA-XYLOSIDASE (Parageobacillusthermoglucosidasius) |
PF03512(Glyco_hydro_52) | 5 | GLY A 52GLY A 53VAL A 268LEU A 54PHE A 136 | None | 1.05A | 1mx1F-4c1oA:undetectable | 1mx1F-4c1oA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d3y | LEGUMAIN (Cricetulusgriseus) |
PF01650(Peptidase_C13) | 5 | VAL A 412LEU A 413LEU A 361LEU A 416LEU A 360 | None | 0.87A | 1mx1F-4d3yA:2.6 | 1mx1F-4d3yA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgu | LEGUMAIN (Homo sapiens) |
PF01650(Peptidase_C13) | 5 | VAL A 407LEU A 408LEU A 356LEU A 411LEU A 355 | None | 0.88A | 1mx1F-4fguA:undetectable | 1mx1F-4fguA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnm | E3 ALPHA-ESTERASE-7CARBOXYLESTERASE (Lucilia cuprina) |
PF00135(COesterase) | 5 | GLY A 136GLY A 137SER A 218PHE A 421HIS A 471 | DPF A 601 (-3.4A)DPF A 601 (-3.7A)DPF A 601 (-1.5A)NoneDPF A 601 (-4.2A) | 0.48A | 1mx1F-4fnmA:37.3 | 1mx1F-4fnmA:29.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fsf | PENICILLIN-BINDINGPROTEIN 3 (Pseudomonasaeruginosa) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | GLY A 136GLY A 134VAL A 126LEU A 82LEU A 129 | None | 1.00A | 1mx1F-4fsfA:undetectable | 1mx1F-4fsfA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g0j | NON-STRUCTURALPROTEIN 2 (Rotavirus A) |
PF02509(Rota_NS35) | 5 | GLY A 141VAL A 93LEU A 91LEU A 4LEU A 88 | None | 0.99A | 1mx1F-4g0jA:undetectable | 1mx1F-4g0jA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gyi | RIO2 KINASE (Chaetomiumthermophilum) |
PF01163(RIO1)PF09202(Rio2_N) | 6 | GLY A 79GLY A 80LEU A 76LEU A 19LEU A 86HIS A 185 | NoneNoneNoneNoneNoneEDO A 403 (-4.1A) | 1.02A | 1mx1F-4gyiA:undetectable | 1mx1F-4gyiA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjt | ENOYL-COA HYDRATASE (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 5 | GLY A 102GLY A 101LEU A 135LEU A 107PHE A 37 | NoneGOL A 301 ( 4.3A)NoneNoneNone | 1.08A | 1mx1F-4jjtA:undetectable | 1mx1F-4jjtA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kbr | GLYCOLIPID TRANSFERPROTEINDOMAIN-CONTAININGPROTEIN 1 (Mus musculus) |
PF08718(GLTP) | 5 | VAL A 13LEU A 14LEU A 43LEU A 39LEU A 46 | None | 1.06A | 1mx1F-4kbrA:undetectable | 1mx1F-4kbrA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kzk | L-ARABINOSE ABCTRANSPORTER,PERIPLASMICL-ARABINOSE-BINDINGPROTEIN (Burkholderiathailandensis) |
PF00532(Peripla_BP_1) | 5 | GLY A 103GLY A 101VAL A 133LEU A 130LEU A 122 | None | 1.09A | 1mx1F-4kzkA:3.1 | 1mx1F-4kzkA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l5n | URACIL-DNAGLYCOSYLASE (Humanalphaherpesvirus1) |
PF03167(UDG) | 5 | GLY A 133SER A 102VAL A 116LEU A 113LEU A 117 | None | 1.06A | 1mx1F-4l5nA:undetectable | 1mx1F-4l5nA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mo9 | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 5 | GLY A 222SER A 220VAL A 323LEU A 327MET A 258 | None | 1.01A | 1mx1F-4mo9A:undetectable | 1mx1F-4mo9A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4my0 | GCN5-RELATEDN-ACETYLTRANSFERASE (Kribbellaflavida) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 5 | VAL A 301LEU A 319LEU A 340LEU A 303LEU A 357 | None | 1.01A | 1mx1F-4my0A:undetectable | 1mx1F-4my0A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n3n | EUKARYOTICTRANSLATIONINITIATION FACTOR5B-LIKE PROTEIN,EIF5B(517-C) (Chaetomiumthermophilum) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF11987(IF-2) | 5 | GLY A 901LEU A 859LEU A 887LEU A 862LEU A 886 | None | 1.07A | 1mx1F-4n3nA:undetectable | 1mx1F-4n3nA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzp | ARGININOSUCCINATESYNTHASE (Campylobacterjejuni) |
PF00764(Arginosuc_synth) | 5 | GLY A 283LEU A 92LEU A 247LEU A 187LEU A 233 | None | 1.03A | 1mx1F-4nzpA:undetectable | 1mx1F-4nzpA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qb9 | ENHANCEDINTRACELLULARSURVIVAL PROTEIN (Mycolicibacteriumsmegmatis) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 5 | GLY A 124GLY A 123SER A 121LEU A 97PHE A 26 | NoneNonePAR A 500 (-3.0A)NonePAR A 500 (-3.7A) | 0.97A | 1mx1F-4qb9A:undetectable | 1mx1F-4qb9A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi7 | CELLOBIOSEDEHYDROGENASE (Neurosporacrassa) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C)PF16010(CDH-cyt) | 5 | GLY A 237GLY A 238VAL A 753LEU A 419LEU A 423 | FAD A 902 (-4.5A)FAD A 902 ( 3.7A)NoneNoneNone | 0.97A | 1mx1F-4qi7A:2.0 | 1mx1F-4qi7A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qnl | TAIL FIBER PROTEIN (Escherichiavirus G7C) |
no annotation | 5 | GLY A 828VAL A 730LEU A 841LEU A 728LEU A 753 | None | 0.80A | 1mx1F-4qnlA:undetectable | 1mx1F-4qnlA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tyh | MITOGEN-ACTIVATEDPROTEIN KINASE 14 (Mus musculus) |
PF00069(Pkinase) | 5 | VAL B 102LEU B 55LEU B 75LEU B 104LEU B 74 | NoneNone39G B 401 (-4.3A)39G B 401 ( 4.7A)None | 1.06A | 1mx1F-4tyhB:undetectable | 1mx1F-4tyhB:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wy8 | ESTERASE (Rhizomucormiehei) |
PF07859(Abhydrolase_3) | 5 | GLY A 90GLY A 91SER A 164LEU A 217HIS A 291 | None | 0.83A | 1mx1F-4wy8A:18.5 | 1mx1F-4wy8A:22.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xii | CHOLINESTERASE (Homo sapiens) |
PF00135(COesterase) | 5 | GLY A 116GLY A 117SER A 198PHE A 398HIS A 438 | 40V A1001 (-3.2A)40V A1001 (-3.4A)40V A1001 (-3.1A)40V A1001 (-4.9A)40V A1001 (-3.6A) | 0.69A | 1mx1F-4xiiA:51.8 | 1mx1F-4xiiA:35.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yw5 | NEURAMINIDASE C (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 5 | GLY A 234GLY A 233VAL A 92LEU A 249LEU A 94 | None | 0.76A | 1mx1F-4yw5A:undetectable | 1mx1F-4yw5A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a1n | AMINOACYL TRNASYNTHASECOMPLEX-INTERACTINGMULTIFUNCTIONALPROTEIN 2 (Homo sapiens) |
PF00043(GST_C) | 5 | VAL B 148LEU B 183LEU B 138LEU B 142LEU B 135 | None | 0.96A | 1mx1F-5a1nB:undetectable | 1mx1F-5a1nB:17.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a2g | CARBOXYLIC ESTERHYDROLASE (Hungatellahathewayi) |
PF00135(COesterase) | 5 | GLY A 114SER A 200LEU A 233PHE A 379HIS A 416 | None | 0.89A | 1mx1F-5a2gA:38.0 | 1mx1F-5a2gA:31.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5azy | TRANSMEMBRANE EMP24DOMAIN-CONTAININGPROTEIN 10 (Rattusnorvegicus) |
PF01105(EMP24_GP25L) | 5 | GLY A 30VAL A 107LEU A 44LEU A 124HIS A 128 | SO4 A 201 (-3.2A)NoneNoneNoneSO4 A 201 (-3.6A) | 1.08A | 1mx1F-5azyA:undetectable | 1mx1F-5azyA:11.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cml | OSMC FAMILY PROTEIN (Rhodothermusmarinus) |
PF12146(Hydrolase_4) | 5 | GLY A 132VAL A 240LEU A 224LEU A 230PHE A 34 | None | 1.07A | 1mx1F-5cmlA:12.9 | 1mx1F-5cmlA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITBETA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome) | 5 | GLY K 6VAL K 127LEU K 115LEU K 143HIS K 132 | None | 0.85A | 1mx1F-5fmgK:undetectable | 1mx1F-5fmgK:17.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fv4 | CARBOXYLIC ESTERHYDROLASE (Sus scrofa) |
PF00135(COesterase) | 7 | GLY A 125GLY A 126SER A 204LEU A 238MET A 345PHE A 407HIS A 449 | None | 0.48A | 1mx1F-5fv4A:66.6 | 1mx1F-5fv4A:78.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hc4 | LIPOLYTIC ENZYME (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | GLY A 108GLY A 109SER A 188LEU A 24HIS A 317 | TRS A 402 (-3.3A)TRS A 402 (-3.4A)TRS A 402 (-2.3A)NoneTRS A 402 (-4.3A) | 0.60A | 1mx1F-5hc4A:20.5 | 1mx1F-5hc4A:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hx0 | UNCHARACTERIZEDPROTEIN DFER_1899 (Dyadobacterfermentans) |
PF13088(BNR_2) | 5 | GLY A 294GLY A 295VAL A 252LEU A 218LEU A 236 | ACT A 403 (-3.9A)NoneNoneACT A 403 ( 4.9A)None | 0.67A | 1mx1F-5hx0A:undetectable | 1mx1F-5hx0A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ja1 | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 5 | VAL A 246LEU A 243LEU A 255LEU A 251LEU A 258 | None | 1.05A | 1mx1F-5ja1A:9.7 | 1mx1F-5ja1A:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kqi | CATALASE-PEROXIDASE (Burkholderiapseudomallei) |
PF00141(peroxidase) | 5 | GLY A 636GLY A 637VAL A 559LEU A 660LEU A 641 | None | 1.07A | 1mx1F-5kqiA:undetectable | 1mx1F-5kqiA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lgg | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT1,ANAPHASE-PROMOTINGCOMPLEX SUBUNIT1,ANAPHASE-PROMOTINGCOMPLEX SUBUNIT1,ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF12859(ANAPC1) | 5 | GLY A 186VAL A 256LEU A 249LEU A 407LEU A 271 | None | 1.07A | 1mx1F-5lggA:undetectable | 1mx1F-5lggA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nh1 | GASDERMIN-D (Homo sapiens) |
PF04598(Gasdermin) | 5 | VAL A 352LEU A 356LEU A 479LEU A 312LEU A 475 | None | 1.04A | 1mx1F-5nh1A:undetectable | 1mx1F-5nh1A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8c | TRANSCRIPTIONALREGULATOR (Actinomycesoris) |
no annotation | 5 | GLY A 282SER A 286LEU A 291LEU A 204LEU A 294 | None | 0.93A | 1mx1F-5v8cA:undetectable | 1mx1F-5v8cA:9.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 5 | GLY A 109GLY A 110SER A 191PHE A 394HIS A 442 | EPE A 600 (-3.0A)EPE A 600 ( 4.4A)MLI A 601 ( 3.8A)MLI A 601 ( 4.1A)EPE A 600 ( 4.0A) | 0.47A | 1mx1F-5w1uA:39.2 | 1mx1F-5w1uA:30.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7f | UGGT (Thermomycesdupontii) |
PF01501(Glyco_transf_8) | 5 | GLY A1372LEU A1261LEU A1391LEU A1277LEU A1377 | None | 0.98A | 1mx1F-5y7fA:undetectable | 1mx1F-5y7fA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zvs | VP2 (Aquareovirus C) |
no annotation | 5 | GLY 2 350VAL 2 281LEU 2 285LEU 2 341LEU 2 260 | None | 0.93A | 1mx1F-5zvs2:undetectable | 1mx1F-5zvs2:9.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eub | ANGIOPOIETIN-RELATEDPROTEIN 4 (Homo sapiens) |
no annotation | 5 | VAL A 275LEU A 287LEU A 390LEU A 277HIS A 356 | NoneNoneNoneNone1PE A 501 ( 4.3A) | 0.95A | 1mx1F-6eubA:undetectable | 1mx1F-6eubA:7.48 |