SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_F_THAF6_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aql BILE-SALT ACTIVATED
LIPASE


(Bos taurus)
PF00135
(COesterase)
5 GLY A 107
SER A 194
LEU A 285
PHE A 393
HIS A 435
None
0.70A 1mx1F-1aqlA:
48.2
1mx1F-1aqlA:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE


(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 215
GLY A 214
VAL A 226
LEU A 240
LEU A 212
None
1.04A 1mx1F-1bqgA:
undetectable
1mx1F-1bqgA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea)
PF00135
(COesterase)
6 GLY A 123
GLY A 124
SER A 209
LEU A 304
PHE A 415
HIS A 449
CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.7A)
None
CLL  A 801 (-4.8A)
0.71A 1mx1F-1cleA:
39.8
1mx1F-1cleA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa)
PF00135
(COesterase)
6 GLY A 123
GLY A 124
SER A 209
LEU A 304
PHE A 415
HIS A 449
None
0.80A 1mx1F-1crlA:
39.5
1mx1F-1crlA:
30.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f89 32.5 KDA PROTEIN
YLR351C


(Saccharomyces
cerevisiae)
PF00795
(CN_hydrolase)
5 VAL A  49
LEU A  94
LEU A  18
LEU A  51
PHE A  90
None
1.05A 1mx1F-1f89A:
undetectable
1mx1F-1f89A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gut MOLYBDATE BINDING
PROTEIN II


(Clostridium
pasteurianum)
PF03459
(TOBE)
5 SER A  37
VAL A  13
LEU A  27
LEU A  47
LEU A  55
None
1.01A 1mx1F-1gutA:
undetectable
1mx1F-1gutA:
7.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
5 GLY A 122
GLY A 123
LEU A 127
PHE A 345
HIS A 449
None
0.79A 1mx1F-1gz7A:
39.8
1mx1F-1gz7A:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
5 GLY A 122
GLY A 123
SER A 209
VAL A 296
HIS A 449
None
1.02A 1mx1F-1gz7A:
39.8
1mx1F-1gz7A:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
6 GLY A 123
GLY A 124
SER A 209
LEU A 304
PHE A 415
HIS A 449
None
0.79A 1mx1F-1gz7A:
39.8
1mx1F-1gz7A:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
6 GLY A  89
GLY A  88
VAL A 134
LEU A 105
LEU A 127
LEU A 120
None
1.34A 1mx1F-1iy9A:
2.6
1mx1F-1iy9A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis)
PF07859
(Abhydrolase_3)
5 GLY A 127
GLY A 128
SER A 202
LEU A 268
HIS A 338
None
0.90A 1mx1F-1jkmA:
18.3
1mx1F-1jkmA:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE


(Oryctolagus
cuniculus)
PF00135
(COesterase)
5 GLY A 142
GLY A 143
SER A 221
LEU A 255
HIS A 467
None
0.60A 1mx1F-1k4yA:
63.7
1mx1F-1k4yA:
82.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW


(Thermotoga
maritima)
PF01795
(Methyltransf_5)
5 GLY A  37
GLY A  36
VAL A  75
LEU A  68
LEU A 101
SAH  A 401 (-3.3A)
SAH  A 401 (-4.1A)
None
None
None
1.08A 1mx1F-1m6yA:
2.6
1mx1F-1m6yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster)
PF00135
(COesterase)
5 GLY A 150
GLY A 151
SER A 238
PHE A 440
HIS A 480
I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
0.48A 1mx1F-1qonA:
47.5
1mx1F-1qonA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5t CYTIDINE DEAMINASE

(Saccharomyces
cerevisiae)
PF00383
(dCMP_cyt_deam_1)
5 GLY A  97
LEU A 132
LEU A 131
MET A 128
MET A  67
None
1.03A 1mx1F-1r5tA:
undetectable
1mx1F-1r5tA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]


(Archaeoglobus
fulgidus)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 GLY A  12
VAL A  52
LEU A  50
LEU A  54
LEU A  19
None
0.93A 1mx1F-1txgA:
undetectable
1mx1F-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger)
PF00135
(COesterase)
5 GLY A 127
GLY A 128
SER A 210
PHE A 400
HIS A 440
EDO  A1902 (-3.6A)
EDO  A1902 (-3.4A)
EDO  A1902 (-2.4A)
None
EDO  A1902 ( 4.9A)
0.59A 1mx1F-1ukcA:
37.7
1mx1F-1ukcA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167


(Pseudomonas
aeruginosa)
PF08787
(Alginate_lyase2)
5 GLY A 197
VAL A 220
LEU A  83
LEU A 218
LEU A   9
None
0.99A 1mx1F-1vavA:
undetectable
1mx1F-1vavA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY


(Thermotoga
maritima)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 GLY A 254
GLY A 253
LEU A  11
LEU A 244
LEU A 247
None
1.07A 1mx1F-1vmaA:
undetectable
1mx1F-1vmaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Entamoeba
histolytica)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 244
GLY A 243
VAL A 178
LEU A 268
HIS A  42
OHS  A 245 ( 2.4A)
None
None
None
None
1.05A 1mx1F-1y9aA:
undetectable
1mx1F-1y9aA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon)
PF07859
(Abhydrolase_3)
5 GLY A  82
GLY A  83
SER A 154
LEU A 210
HIS A 281
None
1.00A 1mx1F-2c7bA:
19.2
1mx1F-2c7bA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544


(Thermus
thermophilus)
no annotation 6 GLY A  72
VAL A  28
LEU A  48
LEU A 102
LEU A  26
LEU A 100
None
1.21A 1mx1F-2dstA:
3.6
1mx1F-2dstA:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fj0 CARBOXYLIC ESTER
HYDROLASE


(Manduca sexta)
PF00135
(COesterase)
5 GLY A 146
GLY A 147
SER A 226
PHE A 425
HIS A 471
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
None
TFC  A 600 (-4.2A)
0.46A 1mx1F-2fj0A:
46.2
1mx1F-2fj0A:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha)
PF07859
(Abhydrolase_3)
5 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
0.87A 1mx1F-2o7rA:
18.3
1mx1F-2o7rA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2


(Homo sapiens)
PF00282
(Pyridoxal_deC)
5 GLY A 337
VAL A 384
LEU A 347
LEU A 371
LEU A 381
None
1.07A 1mx1F-2okkA:
undetectable
1mx1F-2okkA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II


(Caldanaerobacter
subterraneus)
PF00753
(Lactamase_B)
5 GLY A 225
GLY A 224
VAL A  15
LEU A  36
LEU A 222
None
0.89A 1mx1F-2p4zA:
undetectable
1mx1F-2p4zA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA


(Escherichia
coli)
PF01297
(ZnuA)
5 GLY A 160
VAL A  28
LEU A  77
LEU A 173
LEU A 177
None
0.91A 1mx1F-2ps3A:
undetectable
1mx1F-2ps3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE


(Vibrio
parahaemolyticus)
PF00282
(Pyridoxal_deC)
5 GLY A 728
VAL A 774
LEU A 738
LEU A 762
LEU A 771
None
0.97A 1mx1F-2qmaA:
undetectable
1mx1F-2qmaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 GLY A 625
VAL A 604
LEU A 642
LEU A 606
LEU A 586
None
1.03A 1mx1F-2vdcA:
undetectable
1mx1F-2vdcA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus)
PF00795
(CN_hydrolase)
5 GLY A 121
GLY A 120
VAL A 110
LEU A 107
LEU A 118
None
1.03A 1mx1F-2w1vA:
undetectable
1mx1F-2w1vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
5 GLY A 132
VAL A  65
LEU A  58
LEU A  60
LEU A  70
None
0.88A 1mx1F-2xvgA:
undetectable
1mx1F-2xvgA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis)
PF07859
(Abhydrolase_3)
5 GLY A  85
GLY A  86
SER A 157
LEU A 213
HIS A 284
None
0.89A 1mx1F-2yh2A:
19.3
1mx1F-2yh2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zd2 ATP12 ATPASE

(Paracoccus
denitrificans)
PF07542
(ATP12)
5 GLY A1097
VAL A1150
LEU A1151
LEU A1154
LEU A1102
None
0.91A 1mx1F-2zd2A:
undetectable
1mx1F-2zd2A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE


(Lactobacillus
plantarum)
PF07859
(Abhydrolase_3)
5 GLY A  87
VAL A 136
LEU A 134
LEU A 141
LEU A  93
None
0.79A 1mx1F-3bjrA:
17.3
1mx1F-3bjrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp7 ALKALINE SERINE
PROTEASE AL20


(Nesterenkonia
aethiopica)
PF13365
(Trypsin_2)
5 GLY A 166
GLY A 167
SER A 169
VAL A  12
HIS A  41
FMT  A 219 (-3.5A)
FMT  A 219 (-3.6A)
FMT  A 219 (-2.6A)
None
FMT  A 219 (-3.9A)
1.00A 1mx1F-3cp7A:
undetectable
1mx1F-3cp7A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3


(Saccharomyces
cerevisiae)
PF03571
(Peptidase_M49)
5 GLY A  71
VAL A  91
LEU A  88
LEU A 707
LEU A 703
None
1.05A 1mx1F-3cskA:
undetectable
1mx1F-3cskA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 104
LEU A  57
LEU A  77
LEU A 106
LEU A  76
None
1.01A 1mx1F-3e7oA:
undetectable
1mx1F-3e7oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fds DNA POLYMERASE
SLIDING CLAMP C


(Sulfolobus
solfataricus)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 GLY D  39
VAL D  19
LEU D  23
LEU D  48
PHE D  71
None
1.07A 1mx1F-3fdsD:
undetectable
1mx1F-3fdsD:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1


(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
6 GLY A  35
GLY A 104
SER A 107
LEU A 201
LEU A 103
LEU A 200
FAD  A 522 (-3.3A)
None
None
None
None
None
1.48A 1mx1F-3gdnA:
undetectable
1mx1F-3gdnA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 102
LEU A  55
LEU A  75
LEU A 104
LEU A  74
None
None
NIL  A   1 ( 4.8A)
NIL  A   1 ( 4.3A)
None
0.94A 1mx1F-3gp0A:
undetectable
1mx1F-3gp0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3he1 MAJOR EXPORTED HCP3
PROTEIN


(Pseudomonas
aeruginosa)
PF05638
(T6SS_HCP)
6 GLY A  15
GLY A  11
VAL A  94
LEU A  91
LEU A  80
MET A   7
None
1.24A 1mx1F-3he1A:
undetectable
1mx1F-3he1A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ils AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE


(Aspergillus
parasiticus)
PF00975
(Thioesterase)
5 GLY A1874
SER A1937
VAL A2014
PHE A2056
HIS A2088
None
1.04A 1mx1F-3ilsA:
10.5
1mx1F-3ilsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II


(Escherichia
coli)
PF00294
(PfkB)
5 GLY A 136
VAL A 148
LEU A 182
LEU A 139
LEU A 186
None
1.04A 1mx1F-3iq0A:
undetectable
1mx1F-3iq0A:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1


(Homo sapiens)
PF00135
(COesterase)
10 GLY A1142
GLY A1143
SER A1221
VAL A1254
LEU A1255
LEU A1363
MET A1364
MET A1425
PHE A1426
HIS A1468
WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
WW2  A 193 (-3.8A)
None
None
None
None
0.52A 1mx1F-3k9bA:
62.0
1mx1F-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lim FRAGACEATOXIN C

(Actinia
fragacea)
PF06369
(Anemone_cytotox)
5 GLY A  36
VAL A  18
LEU A  19
LEU A  71
HIS A 175
None
1.02A 1mx1F-3limA:
undetectable
1mx1F-3limA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE


(Thiobacillus
denitrificans)
PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3)
5 GLY A  16
GLY A  15
VAL A  76
LEU A   8
LEU A  78
None
0.66A 1mx1F-3mtjA:
undetectable
1mx1F-3mtjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE


(Thiobacillus
denitrificans)
PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3)
5 GLY A  17
GLY A  15
VAL A  76
LEU A   8
LEU A  78
None
0.90A 1mx1F-3mtjA:
undetectable
1mx1F-3mtjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula)
PF05721
(PhyH)
5 GLY A 130
LEU A  95
MET A  96
PHE A 123
HIS A  99
None
None
None
None
FMT  A 750 (-4.3A)
1.07A 1mx1F-3nnmA:
undetectable
1mx1F-3nnmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus)
PF00005
(ABC_tran)
5 GLY A 215
GLY A 216
LEU A 243
LEU A 222
MET A 202
None
1.03A 1mx1F-3ozxA:
undetectable
1mx1F-3ozxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe8 ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis)
PF00378
(ECH_1)
5 GLY A 103
GLY A 102
LEU A 136
LEU A 108
PHE A  38
None
ZN  A 254 ( 4.1A)
None
None
None
1.03A 1mx1F-3pe8A:
undetectable
1mx1F-3pe8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Legionella
pneumophila)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
6 GLY A 126
GLY A 127
VAL A 434
LEU A  23
LEU A 448
HIS A  96
None
None
None
None
None
ZN  A 501 (-3.3A)
1.11A 1mx1F-3pfeA:
undetectable
1mx1F-3pfeA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Actinobacillus
succinogenes)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 210
GLY A 209
VAL A 221
LEU A 235
LEU A 207
None
1.07A 1mx1F-3pfrA:
undetectable
1mx1F-3pfrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydomonas
reinhardtii)
PF00155
(Aminotran_1_2)
5 GLY A 330
GLY A 331
VAL A 120
LEU A 335
LEU A 116
None
1.01A 1mx1F-3qguA:
undetectable
1mx1F-3qguA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
6 GLY A  35
GLY A 104
SER A 107
LEU A 201
LEU A 103
LEU A 200
FAD  A 773 (-3.4A)
None
None
None
None
None
1.46A 1mx1F-3redA:
undetectable
1mx1F-3redA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1


(Rattus
norvegicus)
no annotation 5 VAL A  64
LEU A  51
LEU A  27
LEU A  23
LEU A  32
None
1.06A 1mx1F-3u9gA:
undetectable
1mx1F-3u9gA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2


(Magnaporthe
oryzae)
PF00141
(peroxidase)
5 GLY A 671
GLY A 672
VAL A 594
LEU A 695
LEU A 676
None
1.00A 1mx1F-3ut2A:
undetectable
1mx1F-3ut2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
5 GLY A 610
GLY A 611
VAL A 533
LEU A 634
LEU A 615
None
1.05A 1mx1F-3wxoA:
undetectable
1mx1F-3wxoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB


(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 GLY A 151
GLY A 152
VAL A 169
LEU A 170
LEU A 139
None
0.68A 1mx1F-4b3iA:
3.3
1mx1F-4b3iA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae)
PF00135
(COesterase)
5 GLY A 133
GLY A 134
LEU A 138
PHE A 356
HIS A 465
None
PGE  A1554 ( 4.7A)
None
None
None
0.78A 1mx1F-4be9A:
40.8
1mx1F-4be9A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae)
PF00135
(COesterase)
6 GLY A 134
GLY A 135
SER A 220
LEU A 315
PHE A 427
HIS A 465
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-4.3A)
1PE  A1553 (-4.7A)
None
0.67A 1mx1F-4be9A:
40.8
1mx1F-4be9A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis)
PF00089
(Trypsin)
PF14670
(FXa_inhibition)
5 GLY A 364
GLY A 197
VAL A 221
LEU A 187
LEU A 207
None
1.07A 1mx1F-4bxwA:
undetectable
1mx1F-4bxwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius)
PF03512
(Glyco_hydro_52)
5 GLY A  52
GLY A  53
VAL A 268
LEU A  54
PHE A 136
None
1.05A 1mx1F-4c1oA:
undetectable
1mx1F-4c1oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus)
PF01650
(Peptidase_C13)
5 VAL A 412
LEU A 413
LEU A 361
LEU A 416
LEU A 360
None
0.87A 1mx1F-4d3yA:
2.6
1mx1F-4d3yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens)
PF01650
(Peptidase_C13)
5 VAL A 407
LEU A 408
LEU A 356
LEU A 411
LEU A 355
None
0.88A 1mx1F-4fguA:
undetectable
1mx1F-4fguA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE


(Lucilia cuprina)
PF00135
(COesterase)
5 GLY A 136
GLY A 137
SER A 218
PHE A 421
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.48A 1mx1F-4fnmA:
37.3
1mx1F-4fnmA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3


(Pseudomonas
aeruginosa)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 GLY A 136
GLY A 134
VAL A 126
LEU A  82
LEU A 129
None
1.00A 1mx1F-4fsfA:
undetectable
1mx1F-4fsfA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0j NON-STRUCTURAL
PROTEIN 2


(Rotavirus A)
PF02509
(Rota_NS35)
5 GLY A 141
VAL A  93
LEU A  91
LEU A   4
LEU A  88
None
0.99A 1mx1F-4g0jA:
undetectable
1mx1F-4g0jA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum)
PF01163
(RIO1)
PF09202
(Rio2_N)
6 GLY A  79
GLY A  80
LEU A  76
LEU A  19
LEU A  86
HIS A 185
None
None
None
None
None
EDO  A 403 (-4.1A)
1.02A 1mx1F-4gyiA:
undetectable
1mx1F-4gyiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjt ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
5 GLY A 102
GLY A 101
LEU A 135
LEU A 107
PHE A  37
None
GOL  A 301 ( 4.3A)
None
None
None
1.08A 1mx1F-4jjtA:
undetectable
1mx1F-4jjtA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbr GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
PF08718
(GLTP)
5 VAL A  13
LEU A  14
LEU A  43
LEU A  39
LEU A  46
None
1.06A 1mx1F-4kbrA:
undetectable
1mx1F-4kbrA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN


(Burkholderia
thailandensis)
PF00532
(Peripla_BP_1)
5 GLY A 103
GLY A 101
VAL A 133
LEU A 130
LEU A 122
None
1.09A 1mx1F-4kzkA:
3.1
1mx1F-4kzkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5n URACIL-DNA
GLYCOSYLASE


(Human
alphaherpesvirus
1)
PF03167
(UDG)
5 GLY A 133
SER A 102
VAL A 116
LEU A 113
LEU A 117
None
1.06A 1mx1F-4l5nA:
undetectable
1mx1F-4l5nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
5 GLY A 222
SER A 220
VAL A 323
LEU A 327
MET A 258
None
1.01A 1mx1F-4mo9A:
undetectable
1mx1F-4mo9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE


(Kribbella
flavida)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
5 VAL A 301
LEU A 319
LEU A 340
LEU A 303
LEU A 357
None
1.01A 1mx1F-4my0A:
undetectable
1mx1F-4my0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)


(Chaetomium
thermophilum)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
5 GLY A 901
LEU A 859
LEU A 887
LEU A 862
LEU A 886
None
1.07A 1mx1F-4n3nA:
undetectable
1mx1F-4n3nA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE


(Campylobacter
jejuni)
PF00764
(Arginosuc_synth)
5 GLY A 283
LEU A  92
LEU A 247
LEU A 187
LEU A 233
None
1.03A 1mx1F-4nzpA:
undetectable
1mx1F-4nzpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN


(Mycolicibacterium
smegmatis)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
5 GLY A 124
GLY A 123
SER A 121
LEU A  97
PHE A  26
None
None
PAR  A 500 (-3.0A)
None
PAR  A 500 (-3.7A)
0.97A 1mx1F-4qb9A:
undetectable
1mx1F-4qb9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE


(Neurospora
crassa)
PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt)
5 GLY A 237
GLY A 238
VAL A 753
LEU A 419
LEU A 423
FAD  A 902 (-4.5A)
FAD  A 902 ( 3.7A)
None
None
None
0.97A 1mx1F-4qi7A:
2.0
1mx1F-4qi7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C)
no annotation 5 GLY A 828
VAL A 730
LEU A 841
LEU A 728
LEU A 753
None
0.80A 1mx1F-4qnlA:
undetectable
1mx1F-4qnlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14


(Mus musculus)
PF00069
(Pkinase)
5 VAL B 102
LEU B  55
LEU B  75
LEU B 104
LEU B  74
None
None
39G  B 401 (-4.3A)
39G  B 401 ( 4.7A)
None
1.06A 1mx1F-4tyhB:
undetectable
1mx1F-4tyhB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei)
PF07859
(Abhydrolase_3)
5 GLY A  90
GLY A  91
SER A 164
LEU A 217
HIS A 291
None
0.83A 1mx1F-4wy8A:
18.5
1mx1F-4wy8A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens)
PF00135
(COesterase)
5 GLY A 116
GLY A 117
SER A 198
PHE A 398
HIS A 438
40V  A1001 (-3.2A)
40V  A1001 (-3.4A)
40V  A1001 (-3.1A)
40V  A1001 (-4.9A)
40V  A1001 (-3.6A)
0.69A 1mx1F-4xiiA:
51.8
1mx1F-4xiiA:
35.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae)
PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2)
5 GLY A 234
GLY A 233
VAL A  92
LEU A 249
LEU A  94
None
0.76A 1mx1F-4yw5A:
undetectable
1mx1F-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2


(Homo sapiens)
PF00043
(GST_C)
5 VAL B 148
LEU B 183
LEU B 138
LEU B 142
LEU B 135
None
0.96A 1mx1F-5a1nB:
undetectable
1mx1F-5a1nB:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a2g CARBOXYLIC ESTER
HYDROLASE


(Hungatella
hathewayi)
PF00135
(COesterase)
5 GLY A 114
SER A 200
LEU A 233
PHE A 379
HIS A 416
None
0.89A 1mx1F-5a2gA:
38.0
1mx1F-5a2gA:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azy TRANSMEMBRANE EMP24
DOMAIN-CONTAINING
PROTEIN 10


(Rattus
norvegicus)
PF01105
(EMP24_GP25L)
5 GLY A  30
VAL A 107
LEU A  44
LEU A 124
HIS A 128
SO4  A 201 (-3.2A)
None
None
None
SO4  A 201 (-3.6A)
1.08A 1mx1F-5azyA:
undetectable
1mx1F-5azyA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cml OSMC FAMILY PROTEIN

(Rhodothermus
marinus)
PF12146
(Hydrolase_4)
5 GLY A 132
VAL A 240
LEU A 224
LEU A 230
PHE A  34
None
1.07A 1mx1F-5cmlA:
12.9
1mx1F-5cmlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE


(Plasmodium
falciparum)
PF00227
(Proteasome)
5 GLY K   6
VAL K 127
LEU K 115
LEU K 143
HIS K 132
None
0.85A 1mx1F-5fmgK:
undetectable
1mx1F-5fmgK:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE


(Sus scrofa)
PF00135
(COesterase)
7 GLY A 125
GLY A 126
SER A 204
LEU A 238
MET A 345
PHE A 407
HIS A 449
None
0.48A 1mx1F-5fv4A:
66.6
1mx1F-5fv4A:
78.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 GLY A 108
GLY A 109
SER A 188
LEU A  24
HIS A 317
TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
0.60A 1mx1F-5hc4A:
20.5
1mx1F-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899


(Dyadobacter
fermentans)
PF13088
(BNR_2)
5 GLY A 294
GLY A 295
VAL A 252
LEU A 218
LEU A 236
ACT  A 403 (-3.9A)
None
None
ACT  A 403 ( 4.9A)
None
0.67A 1mx1F-5hx0A:
undetectable
1mx1F-5hx0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
5 VAL A 246
LEU A 243
LEU A 255
LEU A 251
LEU A 258
None
1.05A 1mx1F-5ja1A:
9.7
1mx1F-5ja1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei)
PF00141
(peroxidase)
5 GLY A 636
GLY A 637
VAL A 559
LEU A 660
LEU A 641
None
1.07A 1mx1F-5kqiA:
undetectable
1mx1F-5kqiA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
5 GLY A 186
VAL A 256
LEU A 249
LEU A 407
LEU A 271
None
1.07A 1mx1F-5lggA:
undetectable
1mx1F-5lggA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens)
PF04598
(Gasdermin)
5 VAL A 352
LEU A 356
LEU A 479
LEU A 312
LEU A 475
None
1.04A 1mx1F-5nh1A:
undetectable
1mx1F-5nh1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR


(Actinomyces
oris)
no annotation 5 GLY A 282
SER A 286
LEU A 291
LEU A 204
LEU A 294
None
0.93A 1mx1F-5v8cA:
undetectable
1mx1F-5v8cA:
9.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
5 GLY A 109
GLY A 110
SER A 191
PHE A 394
HIS A 442
EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 ( 4.1A)
EPE  A 600 ( 4.0A)
0.47A 1mx1F-5w1uA:
39.2
1mx1F-5w1uA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii)
PF01501
(Glyco_transf_8)
5 GLY A1372
LEU A1261
LEU A1391
LEU A1277
LEU A1377
None
0.98A 1mx1F-5y7fA:
undetectable
1mx1F-5y7fA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C)
no annotation 5 GLY 2 350
VAL 2 281
LEU 2 285
LEU 2 341
LEU 2 260
None
0.93A 1mx1F-5zvs2:
undetectable
1mx1F-5zvs2:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4


(Homo sapiens)
no annotation 5 VAL A 275
LEU A 287
LEU A 390
LEU A 277
HIS A 356
None
None
None
None
1PE  A 501 ( 4.3A)
0.95A 1mx1F-6eubA:
undetectable
1mx1F-6eubA:
7.48