SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_E_THAE5_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 PHE A 173
LEU A  70
LEU A  59
 None
 0.62A 1mx1E-1amyA:
1.5		 1mx1E-1amyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		3 PHE B 383
LEU A 103
LEU A  99
 None
 0.54A 1mx1E-1as4B:
undetectable		 1mx1E-1as4B:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 PHE A 148
LEU A 138
LEU A 134
 None
 0.68A 1mx1E-1bdgA:
undetectable		 1mx1E-1bdgA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 PHE A 554
LEU A 129
LEU A 138
 None
 0.60A 1mx1E-1c0aA:
undetectable		 1mx1E-1c0aA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		3 PHE A 107
LEU A 131
LEU A 171
 None
 0.61A 1mx1E-1ci9A:
undetectable		 1mx1E-1ci9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		3 PHE A 303
LEU A 116
LEU A 112
 None
 0.66A 1mx1E-1cjaA:
undetectable		 1mx1E-1cjaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		3 PHE A 737
LEU A 688
LEU A 685
 None
 0.62A 1mx1E-1d2nA:
undetectable		 1mx1E-1d2nA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 PHE A 284
LEU A 353
LEU A 425
 None
 0.64A 1mx1E-1ezvA:
undetectable		 1mx1E-1ezvA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fao DUAL ADAPTOR OF
PHOSPHOTYROSINE AND
3-PHOSPHOINOSITIDES

(Homo sapiens) 		PF00169
(PH) 		3 PHE A 186
LEU A 239
LEU A 230
 None
 0.52A 1mx1E-1faoA:
undetectable		 1mx1E-1faoA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		3 PHE A  63
LEU A  78
LEU A 104
 None
 0.55A 1mx1E-1fbaA:
undetectable		 1mx1E-1fbaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		3 PHE A 264
LEU A 371
LEU A 375
 None
 0.64A 1mx1E-1g38A:
undetectable		 1mx1E-1g38A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 PHE A 667
LEU A 519
LEU A 591
 None
 0.60A 1mx1E-1gqjA:
undetectable		 1mx1E-1gqjA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
6

(Homo sapiens) 		PF00581
(Rhodanese) 		3 PHE A  86
LEU A 122
LEU A 118
 None
 0.60A 1mx1E-1hzmA:
undetectable		 1mx1E-1hzmA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		3 PHE H 199
LEU H 162
LEU H 130
 None
TRS  H 800 ( 4.9A)
TRS  H 800 ( 4.4A)
 0.62A 1mx1E-1id5H:
undetectable		 1mx1E-1id5H:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipi HOLLIDAY JUNCTION
RESOLVASE

(Pyrococcus
furiosus) 		PF01870
(Hjc) 		3 PHE A  21
LEU A 113
LEU A 109
 None
 0.61A 1mx1E-1ipiA:
undetectable		 1mx1E-1ipiA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq7 OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 PHE A 628
LEU A 644
LEU A 608
 None
 0.67A 1mx1E-1iq7A:
undetectable		 1mx1E-1iq7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		3 PHE A 195
LEU A 187
LEU A 243
 None
 0.59A 1mx1E-1iugA:
undetectable		 1mx1E-1iugA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PHE A1045
LEU A1012
LEU A1057
 None
 0.67A 1mx1E-1jqbA:
undetectable		 1mx1E-1jqbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PHE A1045
LEU A1012
LEU A1334
 None
 0.65A 1mx1E-1jqbA:
undetectable		 1mx1E-1jqbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		3 PHE A 738
LEU A 788
LEU A 792
 None
 0.64A 1mx1E-1jqoA:
undetectable		 1mx1E-1jqoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 PHE A 393
LEU A 365
LEU A 432
 None
 0.63A 1mx1E-1jx2A:
undetectable		 1mx1E-1jx2A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		3 PHE A 416
LEU A 517
LEU A 439
 None
 0.60A 1mx1E-1jy1A:
undetectable		 1mx1E-1jy1A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 PHE A 548
LEU A 135
LEU A 144
 None
 0.62A 1mx1E-1l0wA:
undetectable		 1mx1E-1l0wA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		3 PHE A 536
LEU A 595
LEU A 546
 None
 0.49A 1mx1E-1l5jA:
undetectable		 1mx1E-1l5jA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lg4 PRION-LIKE PROTEIN

(Homo sapiens) 		PF00377
(Prion) 		3 PHE A  59
LEU A 132
LEU A 135
 None
 0.66A 1mx1E-1lg4A:
undetectable		 1mx1E-1lg4A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 PHE A 591
LEU A 534
LEU A 540
 None
 0.66A 1mx1E-1lq2A:
undetectable		 1mx1E-1lq2A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		3 PHE A 123
LEU A  75
LEU A 133
 None
 0.66A 1mx1E-1m7jA:
undetectable		 1mx1E-1m7jA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		3 PHE K 199
LEU K 162
LEU K 130
 None
 0.63A 1mx1E-1mkxK:
undetectable		 1mx1E-1mkxK:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		3 PHE A 341
LEU A 144
LEU A 218
 HEM  A 602 ( 4.9A)
None
HEM  A 602 ( 4.9A)
 0.66A 1mx1E-1n97A:
undetectable		 1mx1E-1n97A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		3 PHE A 351
LEU A 402
LEU A 227
 None
 0.65A 1mx1E-1q15A:
undetectable		 1mx1E-1q15A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 PHE A 153
LEU A 197
LEU A 201
 None
 0.68A 1mx1E-1q3bA:
undetectable		 1mx1E-1q3bA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q98 THIOL PEROXIDASE

(Haemophilus
influenzae) 		PF08534
(Redoxin) 		3 PHE A  26
LEU A  48
LEU A 136
 None
 0.47A 1mx1E-1q98A:
undetectable		 1mx1E-1q98A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 PHE A 678
LEU A 728
LEU A 732
 None
 0.56A 1mx1E-1qb4A:
undetectable		 1mx1E-1qb4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN

(Homo sapiens) 		PF00079
(Serpin) 		3 PHE A 387
LEU A 103
LEU A  99
 None
 0.58A 1mx1E-1qmnA:
undetectable		 1mx1E-1qmnA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF04069
(OpuAC) 		3 PHE A 255
LEU A  31
LEU A  34
 None
 0.65A 1mx1E-1r9lA:
undetectable		 1mx1E-1r9lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		3 PHE A  89
LEU A 267
LEU A 288
 None
 0.67A 1mx1E-1ry6A:
undetectable		 1mx1E-1ry6A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9a CHLOROCATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 PHE A 252
LEU A 211
LEU A 233
 None
 0.56A 1mx1E-1s9aA:
undetectable		 1mx1E-1s9aA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		3 PHE A 373
LEU A 421
LEU A 417
 None
 0.60A 1mx1E-1sezA:
undetectable		 1mx1E-1sezA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 PHE A 172
LEU A 215
LEU A 213
 None
 0.67A 1mx1E-1skxA:
1.1		 1mx1E-1skxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3

(Homo sapiens) 		PF01088
(Peptidase_C12) 		3 PHE A  31
LEU A 100
LEU A   7
 None
 0.67A 1mx1E-1uchA:
undetectable		 1mx1E-1uchA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54

(Homo sapiens) 		PF00270
(DEAD) 		3 PHE A 269
LEU A 126
LEU A 264
 None
 0.65A 1mx1E-1vecA:
undetectable		 1mx1E-1vecA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjg PUTATIVE LIPASE FROM
THE G-D-S-L FAMILY

(Nostoc sp. PCC
7120) 		PF13472
(Lipase_GDSL_2) 		3 PHE A 205
LEU A  79
LEU A 121
 None
 0.67A 1mx1E-1vjgA:
3.0		 1mx1E-1vjgA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjx PUTATIVE
FERRITIN-LIKE
DIIRON-CARBOXYLATE
PROTEIN TM1526

(Thermotoga
maritima) 		PF02915
(Rubrerythrin) 		3 PHE A  50
LEU A 110
LEU A 114
 None
 0.67A 1mx1E-1vjxA:
undetectable		 1mx1E-1vjxA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 PHE A 318
LEU A 289
LEU A 302
 None
 0.67A 1mx1E-1vzoA:
undetectable		 1mx1E-1vzoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PHE A 191
LEU B  65
LEU B  69
 PEG  A1369 (-4.8A)
None
None
 0.68A 1mx1E-1w85A:
undetectable		 1mx1E-1w85A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 PHE A 543
LEU A 514
LEU A 503
 None
 0.59A 1mx1E-1xfdA:
14.2		 1mx1E-1xfdA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		3 PHE A 303
LEU A 226
LEU A 230
 None
 0.63A 1mx1E-1ya0A:
undetectable		 1mx1E-1ya0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		3 PHE A  74
LEU A 178
LEU A  24
 None
 0.64A 1mx1E-1yzfA:
2.2		 1mx1E-1yzfA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ziq GAMMA CRYSTALLIN E

(Rattus
norvegicus) 		PF00030
(Crystall) 		3 PHE A1005
LEU A1044
LEU A1057
 None
 0.51A 1mx1E-1ziqA:
undetectable		 1mx1E-1ziqA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1znx GUANYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00625
(Guanylate_kin) 		3 PHE A  77
LEU A  86
LEU A 102
 None
 0.49A 1mx1E-1znxA:
undetectable		 1mx1E-1znxA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 PHE A 240
LEU A 219
LEU A 223
 None
 0.68A 1mx1E-2a9cA:
undetectable		 1mx1E-2a9cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aoq DNA MISMATCH REPAIR
PROTEIN MUTH

(Haemophilus
influenzae) 		PF02976
(MutH) 		3 PHE A 217
LEU A 154
LEU A 117
 None
 0.65A 1mx1E-2aoqA:
undetectable		 1mx1E-2aoqA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azo MUTH

(Escherichia
coli) 		PF02976
(MutH) 		3 PHE A 217
LEU A 154
LEU A 117
 None
 0.66A 1mx1E-2azoA:
undetectable		 1mx1E-2azoA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bba EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		3 PHE A 178
LEU A  90
LEU A 164
 None
 0.67A 1mx1E-2bbaA:
undetectable		 1mx1E-2bbaA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		3 PHE A 333
LEU A 281
LEU A 273
 None
 0.65A 1mx1E-2braA:
undetectable		 1mx1E-2braA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx6 XRP2 PROTEIN

(Homo sapiens) 		PF07986
(TBCC) 		3 PHE A 102
LEU A 112
LEU A 129
 None
 0.56A 1mx1E-2bx6A:
undetectable		 1mx1E-2bx6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 PHE A 154
LEU A 136
LEU A 140
 None
 0.65A 1mx1E-2ca4A:
undetectable		 1mx1E-2ca4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		3 PHE A 381
LEU A 359
LEU A 363
 None
 0.58A 1mx1E-2cfoA:
2.3		 1mx1E-2cfoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3

(Salmonella
enterica) 		PF00669
(Flagellin_N) 		3 PHE A 136
LEU A  80
LEU A 250
 None
 0.58A 1mx1E-2d4xA:
undetectable		 1mx1E-2d4xA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r TOB1 PROTEIN

(Homo sapiens) 		PF07742
(BTG) 		3 PHE B  35
LEU B 114
LEU B 110
 None
 0.60A 1mx1E-2d5rB:
undetectable		 1mx1E-2d5rB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		3 PHE A 238
LEU A 429
LEU A 410
 None
 0.65A 1mx1E-2dc0A:
undetectable		 1mx1E-2dc0A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		3 PHE A 255
LEU A 224
LEU A 228
 None
 0.62A 1mx1E-2dqbA:
0.9		 1mx1E-2dqbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0z VIRUS-LIKE PARTICLE

(Pyrococcus
furiosus) 		PF04454
(Linocin_M18) 		3 PHE A 296
LEU A 134
LEU A 130
 None
 0.50A 1mx1E-2e0zA:
undetectable		 1mx1E-2e0zA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A

(Aquifex
aeolicus) 		PF12804
(NTP_transf_3) 		3 PHE A  54
LEU A 119
LEU A 116
 None
 0.62A 1mx1E-2e8bA:
undetectable		 1mx1E-2e8bA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 PHE A 140
LEU A 159
LEU A 223
 SAH  A 501 (-3.5A)
None
None
 0.66A 1mx1E-2efjA:
1.5		 1mx1E-2efjA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 PHE A 207
LEU A 223
LEU A 375
 None
 0.61A 1mx1E-2efjA:
1.5		 1mx1E-2efjA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 PHE A 208
LEU A 224
LEU A 363
 None
 0.65A 1mx1E-2eg5A:
undetectable		 1mx1E-2eg5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF03822
(NAF)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		3 PHE A  82
LEU D 324
LEU D 327
 None
 0.62A 1mx1E-2ehbA:
1.3		 1mx1E-2ehbA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej9 PUTATIVE BIOTIN
LIGASE

(Methanocaldococcus
jannaschii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		3 PHE A 163
LEU A  58
LEU A  62
 None
 0.67A 1mx1E-2ej9A:
undetectable		 1mx1E-2ej9A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eql HORSE MILK LYSOZYME

(Equus caballus) 		PF00062
(Lys) 		3 PHE A  57
LEU A  12
LEU A   8
 None
 0.62A 1mx1E-2eqlA:
undetectable		 1mx1E-2eqlA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ett SORTING NEXIN-22

(Homo sapiens) 		PF00787
(PX) 		3 PHE A  55
LEU A 109
LEU A 113
 None
 0.62A 1mx1E-2ettA:
undetectable		 1mx1E-2ettA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 PHE A 168
LEU A 102
LEU A 104
 None
 0.67A 1mx1E-2ew2A:
1.6		 1mx1E-2ew2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		3 PHE A 180
LEU A 146
LEU A 374
 None
 0.66A 1mx1E-2frxA:
undetectable		 1mx1E-2frxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 PHE A 229
LEU A 211
LEU A 246
 None
 0.68A 1mx1E-2g3nA:
undetectable		 1mx1E-2g3nA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		3 PHE A 218
LEU A 141
LEU A 175
 None
 0.65A 1mx1E-2g6bA:
undetectable		 1mx1E-2g6bA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gje MITOCHONDRIAL
RNA-BINDING PROTEIN
2

(Trypanosoma
brucei) 		PF09387
(MRP) 		3 PHE A 156
LEU A 205
LEU A 209
 None
 0.66A 1mx1E-2gjeA:
undetectable		 1mx1E-2gjeA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		3 PHE A  51
LEU A 264
LEU A 260
 None
 0.52A 1mx1E-2glfA:
2.8		 1mx1E-2glfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		3 PHE A 160
LEU A  89
LEU A 185
 None
 0.67A 1mx1E-2gzsA:
11.3		 1mx1E-2gzsA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5r MSTRAWBERRY

(Discosoma sp.) 		PF01353
(GFP) 		3 PHE A  56
LEU A  61
LEU A 124
 None
 0.62A 1mx1E-2h5rA:
undetectable		 1mx1E-2h5rA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans) 		PF03069
(FmdA_AmdA) 		3 PHE A 291
LEU A 249
LEU A 263
 None
 0.66A 1mx1E-2ii1A:
undetectable		 1mx1E-2ii1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHO

(Pseudomonas
stutzeri) 		PF04663
(Phenol_monoox) 		3 PHE E  50
LEU E 104
LEU E  80
 None
 0.51A 1mx1E-2inpE:
undetectable		 1mx1E-2inpE:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		3 PHE A 299
LEU A 175
LEU A 171
 None
 0.65A 1mx1E-2j3hA:
1.7		 1mx1E-2j3hA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 PHE A 465
LEU A 486
LEU A 482
 None
 0.68A 1mx1E-2jisA:
undetectable		 1mx1E-2jisA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jks BRADYZOITE SURFACE
ANTIGEN BSR4

(Toxoplasma
gondii) 		PF04092
(SAG) 		3 PHE A 134
LEU A 120
LEU A 122
 None
 0.64A 1mx1E-2jksA:
undetectable		 1mx1E-2jksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kw7 CONSERVED DOMAIN
PROTEIN

(Porphyromonas
gingivalis) 		PF04536
(TPM_phosphatase) 		3 PHE A 126
LEU A  90
LEU A  27
 None
 0.59A 1mx1E-2kw7A:
2.3		 1mx1E-2kw7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n9p LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		PF00240
(ubiquitin) 		3 PHE C  42
LEU C  59
LEU C  84
 None
 0.68A 1mx1E-2n9pC:
undetectable		 1mx1E-2n9pC:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		3 PHE A  32
LEU A 146
LEU A 142
 None
 0.60A 1mx1E-2nrjA:
undetectable		 1mx1E-2nrjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2f APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		3 PHE A 148
LEU A 178
LEU A 182
 None
 0.54A 1mx1E-2o2fA:
undetectable		 1mx1E-2o2fA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		3 PHE A 473
LEU A 522
LEU A 519
 None
 0.66A 1mx1E-2o3eA:
undetectable		 1mx1E-2o3eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		3 PHE A 193
LEU A 203
LEU A 209
 None
 0.62A 1mx1E-2omvA:
undetectable		 1mx1E-2omvA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484

(Clavularia sp.) 		PF01353
(GFP) 		3 PHE A  56
LEU A  61
LEU A 124
 None
 0.66A 1mx1E-2otbA:
undetectable		 1mx1E-2otbA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owy RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Pseudomonas
aeruginosa) 		PF04381
(RdgC) 		3 PHE A 294
LEU A 166
LEU A 248
 None
 0.52A 1mx1E-2owyA:
undetectable		 1mx1E-2owyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		3 PHE B 143
LEU B 163
LEU B 161
 None
 0.68A 1mx1E-2p1nB:
undetectable		 1mx1E-2p1nB:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)

(Nitrosomonas
europaea) 		PF10369
(ALS_ss_C)
PF13710
(ACT_5) 		3 PHE A  23
LEU A  64
LEU A   7
 None
 0.66A 1mx1E-2pc6A:
undetectable		 1mx1E-2pc6A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		3 PHE A 521
LEU A 586
LEU A 575
 None
 0.54A 1mx1E-2pz1A:
undetectable		 1mx1E-2pz1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 PHE A 668
LEU A 509
LEU A 640
 None
 0.63A 1mx1E-2q1fA:
undetectable		 1mx1E-2q1fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm0 BES

(Bacillus cereus) 		PF00756
(Esterase) 		3 PHE A 128
LEU A  51
LEU A 153
 None
 0.52A 1mx1E-2qm0A:
12.9		 1mx1E-2qm0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		3 PHE A 341
LEU A  65
LEU A  62
 None
 0.67A 1mx1E-2qs8A:
undetectable		 1mx1E-2qs8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rql PROBABLE SIGMA-54
MODULATION PROTEIN

(Escherichia
coli) 		PF02482
(Ribosomal_S30AE) 		3 PHE A  24
LEU A  54
LEU A  85
 None
 0.62A 1mx1E-2rqlA:
undetectable		 1mx1E-2rqlA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 PHE G 950
LEU G 995
LEU G 914
 None
 0.64A 1mx1E-2uv8G:
undetectable		 1mx1E-2uv8G:
14.76