SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_E_THAE5_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		5 VAL A 209
VAL A  80
LEU A 126
LEU A 104
LEU A  76
 None
 1.14A 1mx1E-1a59A:
undetectable		 1mx1E-1a59A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 GLY A 107
SER A 194
LEU A 285
PHE A 393
HIS A 435
 None
 0.82A 1mx1E-1aqlA:
48.4		 1mx1E-1aqlA:
35.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
VAL A 127
SER A 209
PHE A 415
HIS A 449
 None
 0.47A 1mx1E-1crlA:
40.0		 1mx1E-1crlA:
30.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A 331
GLY A 304
VAL A 467
LEU A 464
LEU A 496
 None
 1.36A 1mx1E-1ct9A:
undetectable		 1mx1E-1ct9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		5 VAL A 416
VAL A 449
LEU A 442
LEU A 373
LEU A 470
 None
 0.97A 1mx1E-1e0tA:
2.0		 1mx1E-1e0tA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 LEU A  97
GLY A 142
VAL A 146
SER A 221
HIS A 467
 None
 0.72A 1mx1E-1k4yA:
63.9		 1mx1E-1k4yA:
82.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		5 GLY F  81
VAL F  84
VAL F  66
LEU F  93
LEU F  63
 None
 1.28A 1mx1E-1ka9F:
2.2		 1mx1E-1ka9F:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 223
VAL A 289
LEU A 236
LEU A 242
LEU A 286
 None
None
NAD  A1403 ( 4.4A)
SO4  A1003 (-4.5A)
None
 1.17A 1mx1E-1kolA:
undetectable		 1mx1E-1kolA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mum 2-METHYLISOCITRATE
LYASE

(Escherichia
coli) 		PF13714
(PEP_mutase) 		5 GLY A  46
VAL A  49
LEU A 237
PHE A 186
HIS A 113
 None
 1.14A 1mx1E-1mumA:
undetectable		 1mx1E-1mumA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf9 PHENAZINE
BIOSYNTHESIS PROTEIN
PHZD

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		5 VAL A 205
VAL A  36
LEU A  34
LEU A 111
MET A  39
 None
 1.44A 1mx1E-1nf9A:
undetectable		 1mx1E-1nf9A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq4 OXYTETRACYCLINE
POLYKETIDE SYNTHASE
ACYL CARRIER PROTEIN

(Streptomyces
rimosus) 		PF00550
(PP-binding) 		5 LEU A  37
VAL A  29
LEU A  10
LEU A   6
LEU A   4
 None
 1.33A 1mx1E-1nq4A:
2.1		 1mx1E-1nq4A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		5 LEU H  14
GLY H  44
VAL H  87
LEU H 104
LEU H  83
 None
 1.19A 1mx1E-1q5rH:
undetectable		 1mx1E-1q5rH:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqj FUMARYLACETOACETATE
HYDROLASE

(Mus musculus) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 GLY A 387
VAL A 412
VAL A 375
LEU A 384
LEU A 303
 None
 1.02A 1mx1E-1qqjA:
undetectable		 1mx1E-1qqjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 122
GLY A  71
VAL A 108
LEU A 113
LEU A  94
 None
 1.34A 1mx1E-1tt7A:
undetectable		 1mx1E-1tt7A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 LEU A  79
VAL A  83
VAL A 250
LEU A  35
PHE A  19
 None
 1.39A 1mx1E-1uasA:
undetectable		 1mx1E-1uasA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 LEU A  68
GLY A 100
VAL A  20
LEU A 327
LEU A 304
 None
 1.38A 1mx1E-1xa0A:
2.4		 1mx1E-1xa0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 GLY A 548
VAL A 615
LEU A 446
MET A 449
PHE A 385
 None
None
None
None
PGR  A 803 ( 4.3A)
 1.43A 1mx1E-1yiqA:
undetectable		 1mx1E-1yiqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A 374
GLY A 581
VAL A 584
LEU A 477
LEU A 462
 None
 1.27A 1mx1E-1z8lA:
2.4		 1mx1E-1z8lA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bh5 CYTOCHROME C-550

(Paracoccus
versutus) 		no annotation 5 GLY X  44
VAL X  70
SER X 119
VAL X 112
LEU X  76
 None
 1.43A 1mx1E-2bh5X:
undetectable		 1mx1E-2bh5X:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A  96
VAL A 101
VAL A 121
LEU A 119
LEU A 125
 None
None
FAD  A 301 (-3.8A)
None
None
 1.28A 1mx1E-2culA:
undetectable		 1mx1E-2culA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 223
VAL A 288
LEU A 236
LEU A 242
LEU A 285
 None
None
NAD  A1403 (-4.7A)
None
None
 1.09A 1mx1E-2dphA:
undetectable		 1mx1E-2dphA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 GLY A 108
VAL A 127
LEU A 129
LEU A 327
PHE A 145
 GOL  A2003 ( 3.8A)
None
None
None
None
 1.21A 1mx1E-2elcA:
undetectable		 1mx1E-2elcA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLY A1912
VAL A1947
VAL A1884
LEU A1956
LEU A1921
 None
 1.19A 1mx1E-2h03A:
undetectable		 1mx1E-2h03A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		5 LEU A  75
VAL A 115
VAL A 125
LEU A 122
LEU A 127
 None
 1.11A 1mx1E-2hf0A:
undetectable		 1mx1E-2hf0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 271
VAL A 266
VAL A 384
LEU A 239
LEU A 438
 None
 1.28A 1mx1E-2jgdA:
undetectable		 1mx1E-2jgdA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00550
(PP-binding) 		5 LEU A  31
VAL A  20
VAL A   8
LEU A  78
LEU A  83
 None
 1.13A 1mx1E-2kr5A:
undetectable		 1mx1E-2kr5A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922

(Mycobacterium
tuberculosis) 		PF00691
(OmpA)
PF04972
(BON) 		5 VAL A 160
SER A 132
LEU A 153
LEU A  93
PHE A  97
 None
 1.15A 1mx1E-2l26A:
undetectable		 1mx1E-2l26A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 LEU A  74
VAL A  78
SER A  13
LEU A  88
LEU A 246
 None
 1.24A 1mx1E-2ntjA:
3.7		 1mx1E-2ntjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 317
GLY A  54
VAL A   9
VAL A  63
LEU A  88
 None
 1.06A 1mx1E-2q50A:
undetectable		 1mx1E-2q50A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm0 BES

(Bacillus cereus) 		PF00756
(Esterase) 		5 LEU A 242
VAL A 211
VAL A 191
LEU A 164
LEU A 192
 None
 1.37A 1mx1E-2qm0A:
12.9		 1mx1E-2qm0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xci 3-DEOXY-D-MANNO-2-OC
TULOSONIC ACID
TRANSFERASE

(Aquifex
aeolicus) 		PF04413
(Glycos_transf_N) 		5 GLY A 271
VAL A 293
LEU A 274
LEU A 250
HIS A 184
 None
None
None
None
GOL  A1357 (-3.9A)
 1.50A 1mx1E-2xciA:
2.6		 1mx1E-2xciA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xko GLOBAL NITROGEN
REGULATOR

(Synechococcus
elongatus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 189
VAL A 211
LEU A 148
LEU A 152
LEU A 217
 None
 1.31A 1mx1E-2xkoA:
undetectable		 1mx1E-2xkoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysk HYPOTHETICAL PROTEIN
TTHA1432

(Thermus
thermophilus) 		PF10025
(DUF2267) 		5 LEU A  50
VAL A 130
VAL A 114
LEU A 118
LEU A  39
 None
 1.30A 1mx1E-2yskA:
undetectable		 1mx1E-2yskA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		5 LEU A 539
VAL A 556
VAL A 619
LEU A 577
LEU A 626
 None
 1.23A 1mx1E-3a6pA:
undetectable		 1mx1E-3a6pA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B

(Homo sapiens) 		PF01419
(Jacalin) 		5 LEU A 148
GLY A 132
VAL A  89
MET A 135
LEU A  77
 None
 1.35A 1mx1E-3aqgA:
undetectable		 1mx1E-3aqgA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 527
VAL A 525
VAL A 495
LEU A 498
LEU A 465
 None
 1.19A 1mx1E-3b2dA:
undetectable		 1mx1E-3b2dA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu8 TELOMERIC
REPEAT-BINDING
FACTOR 2

(Homo sapiens) 		PF08558
(TRF) 		5 LEU A 145
VAL A 150
SER A 227
LEU A 136
LEU A 107
 None
 1.16A 1mx1E-3bu8A:
undetectable		 1mx1E-3bu8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 VAL A 215
SER A 240
LEU A 230
LEU A 235
PHE A 267
 None
 1.10A 1mx1E-3e7wA:
undetectable		 1mx1E-3e7wA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq5 SKI-LIKE PROTEIN

(Homo sapiens) 		PF02437
(Ski_Sno) 		5 VAL A 186
VAL A 170
LEU A 233
LEU A 175
LEU A 149
 None
 1.21A 1mx1E-3eq5A:
undetectable		 1mx1E-3eq5A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 LEU A 294
VAL A 259
SER A 255
VAL A 219
LEU A 208
 None
 1.28A 1mx1E-3fdgA:
undetectable		 1mx1E-3fdgA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fds DNA POLYMERASE
SLIDING CLAMP C

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU D 225
VAL D 202
VAL D 176
LEU D 154
LEU D 147
 None
 1.45A 1mx1E-3fdsD:
undetectable		 1mx1E-3fdsD:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffu PROBABLE
PYROPHOSPHOHYDROLASE

(Bdellovibrio
bacteriovorus) 		PF00293
(NUDIX) 		5 GLY A  55
VAL A  24
LEU A  67
LEU A  29
HIS A 116
 GTP  A4033 (-2.8A)
GTP  A4033 (-4.4A)
None
None
None
 1.17A 1mx1E-3ffuA:
undetectable		 1mx1E-3ffuA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 VAL A 476
VAL A 523
LEU A 508
LEU A 518
LEU A 527
 None
 1.00A 1mx1E-3ifqA:
undetectable		 1mx1E-3ifqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 LEU A  68
GLY A 203
VAL A 202
LEU A 540
LEU A 521
 FAD  A 541 (-4.1A)
FAD  A 541 ( 3.7A)
None
None
None
 1.45A 1mx1E-3js8A:
undetectable		 1mx1E-3js8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2m PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF00017
(SH2) 		5 LEU A 160
VAL A 218
LEU A 184
LEU A 232
HIS A 148
 None
 1.32A 1mx1E-3k2mA:
undetectable		 1mx1E-3k2mA:
12.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A1143
SER A1221
MET A1364
PHE A1426
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
None
 0.91A 1mx1E-3k9bA:
62.0		 1mx1E-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		10 LEU A1097
GLY A1142
VAL A1146
SER A1221
VAL A1254
MET A1364
LEU A1388
MET A1425
PHE A1426
HIS A1468
 WW2  A 193 ( 4.9A)
WW2  A 193 (-3.4A)
None
WW2  A 193 (-1.4A)
None
None
None
None
None
None
 0.47A 1mx1E-3k9bA:
62.0		 1mx1E-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf9 4E10_D0_1IS1A_001_C
(T161)

(synthetic
construct) 		PF01765
(RRF) 		5 GLY A  47
VAL A  27
LEU A 103
LEU A  24
LEU A 110
 None
 1.45A 1mx1E-3lf9A:
undetectable		 1mx1E-3lf9A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 261
VAL A 257
LEU A 255
LEU A 385
PHE A 279
 None
None
None
None
XUL  A7778 (-4.5A)
 1.31A 1mx1E-3ll3A:
undetectable		 1mx1E-3ll3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mds MANGANESE SUPEROXIDE
DISMUTASE

(Thermus
thermophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 164
VAL A 163
LEU A 191
LEU A  16
MET A  25
 None
 1.25A 1mx1E-3mdsA:
undetectable		 1mx1E-3mdsA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 LEU A 281
GLY A 207
VAL A 132
LEU A 125
LEU A 128
 None
 1.25A 1mx1E-3nizA:
undetectable		 1mx1E-3nizA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		5 LEU A 472
SER A 455
VAL A 423
LEU A 433
LEU A 429
 None
 1.09A 1mx1E-3nowA:
undetectable		 1mx1E-3nowA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2u NEDD8-CONJUGATING
ENZYME UBC12

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		5 LEU A1041
VAL A1097
LEU A1129
LEU A1084
LEU A1119
 None
 1.13A 1mx1E-3o2uA:
undetectable		 1mx1E-3o2uA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p06 VP4 PROTEIN

(Tellina virus) 		no annotation 5 LEU A 706
VAL A 763
VAL A 809
LEU A 802
LEU A 805
 None
 1.00A 1mx1E-3p06A:
undetectable		 1mx1E-3p06A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 LEU A 518
VAL A 514
LEU A 500
LEU A 505
LEU A 543
 None
 1.29A 1mx1E-3pjxA:
undetectable		 1mx1E-3pjxA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r77 PROBABLE
ISOCHORISMATASE

(Pseudomonas
fluorescens) 		PF00857
(Isochorismatase) 		5 VAL A 205
VAL A  36
LEU A  34
LEU A 111
MET A  39
 None
 1.49A 1mx1E-3r77A:
undetectable		 1mx1E-3r77A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 425
VAL A 427
LEU A 452
LEU A 457
LEU A 491
 None
 1.43A 1mx1E-3rg1A:
undetectable		 1mx1E-3rg1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 LEU A 235
VAL A 190
VAL A 181
LEU A 183
LEU A 245
 None
 1.14A 1mx1E-3rrwA:
undetectable		 1mx1E-3rrwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 LEU A 204
GLY A 260
LEU A 329
MET A 333
PHE A 337
 None
 1.24A 1mx1E-3v8vA:
undetectable		 1mx1E-3v8vA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		5 VAL A 199
VAL A 154
LEU A 197
LEU A 186
LEU A 158
 None
 1.29A 1mx1E-3wy7A:
undetectable		 1mx1E-3wy7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 302
VAL A 267
LEU A 284
LEU A 262
LEU A 291
 None
 1.32A 1mx1E-3zynA:
undetectable		 1mx1E-3zynA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbk FERMITIN FAMILY
HOMOLOG 1

(Mus musculus) 		PF00169
(PH) 		5 LEU A 490
VAL A 486
LEU A 372
LEU A 376
HIS A 457
 None
 1.22A 1mx1E-4bbkA:
undetectable		 1mx1E-4bbkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE

(Acinetobacter
baumannii) 		no annotation 5 VAL A 308
VAL A 384
LEU A 261
LEU A 257
LEU A 388
 None
 1.42A 1mx1E-4bfcA:
undetectable		 1mx1E-4bfcA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		5 LEU A 121
VAL A 117
VAL A 195
LEU A  96
LEU A 100
 None
 1.33A 1mx1E-4bvxA:
undetectable		 1mx1E-4bvxA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		5 LEU A 204
GLY A  40
VAL A 208
VAL A  27
LEU A  29
 None
 1.16A 1mx1E-4dolA:
undetectable		 1mx1E-4dolA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		5 LEU A 285
VAL A 279
LEU A 250
LEU A 236
LEU A 217
 None
 1.26A 1mx1E-4f1hA:
undetectable		 1mx1E-4f1hA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffj RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Streptococcus
pneumoniae) 		PF00926
(DHBP_synthase) 		5 GLY A 104
VAL A  45
VAL A 111
LEU A 160
PHE A 120
 None
 1.27A 1mx1E-4ffjA:
undetectable		 1mx1E-4ffjA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Methylobacillus
flagellatus) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 LEU A  33
VAL A  31
SER A   9
VAL A  15
LEU A   3
 GSH  A 301 (-4.9A)
None
GSH  A 301 (-2.7A)
None
None
 0.85A 1mx1E-4gltA:
undetectable		 1mx1E-4gltA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 LEU A 462
VAL A 474
VAL A 516
LEU A 501
HIS A 507
 None
 1.40A 1mx1E-4iglA:
undetectable		 1mx1E-4iglA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		5 LEU A  68
GLY A 233
LEU A  90
LEU A 163
MET A 181
 None
 1.17A 1mx1E-4iqqA:
undetectable		 1mx1E-4iqqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 132
VAL A 109
LEU A 326
LEU A  49
MET A  36
 None
 1.26A 1mx1E-4iv5A:
undetectable		 1mx1E-4iv5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 241
VAL A 259
LEU A 197
MET A 200
LEU A 142
 None
 1.25A 1mx1E-4jxfA:
undetectable		 1mx1E-4jxfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 LEU A 338
GLY A 390
VAL A 915
LEU A 972
LEU A 989
 None
 1.13A 1mx1E-4k0eA:
2.4		 1mx1E-4k0eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kun HYPOTHETICAL PROTEIN
LPP1115

(Legionella
pneumophila) 		PF07689
(KaiB) 		5 VAL A  10
VAL A  83
LEU A   8
LEU A  77
LEU A  87
 None
 1.35A 1mx1E-4kunA:
undetectable		 1mx1E-4kunA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liz ACTIN-BINDING
PROTEIN,
COFILIN/TROPOMYOSIN
FAMILY PROTEIN,
PUTATIVE

(Entamoeba
histolytica) 		PF00241
(Cofilin_ADF) 		5 VAL A 108
SER A   2
VAL A  31
LEU A  38
LEU A  60
 None
 1.38A 1mx1E-4lizA:
undetectable		 1mx1E-4lizA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 395
GLY A 250
VAL A 392
LEU A 279
LEU A 328
 None
 1.09A 1mx1E-4oqrA:
undetectable		 1mx1E-4oqrA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ps6 INHIBITOR OF
VERTEBRATE LYSOZYME

(Pseudomonas
aeruginosa) 		PF08816
(Ivy) 		5 LEU A 142
GLY A 106
VAL A  95
VAL A  53
LEU A  93
 None
 1.44A 1mx1E-4ps6A:
undetectable		 1mx1E-4ps6A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 LEU A  38
VAL A 106
VAL A 261
LEU A 126
LEU A 265
 None
 1.07A 1mx1E-4q0cA:
undetectable		 1mx1E-4q0cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qzv SPIKE PROTEIN S1

(Tylonycteris
bat coronavirus
HKU4) 		PF09408
(Spike_rec_bind) 		5 LEU B 201
VAL B 118
VAL B  77
LEU B  23
LEU B  36
 None
 1.08A 1mx1E-4qzvB:
undetectable		 1mx1E-4qzvB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 GLY A 241
VAL A 244
VAL A 232
LEU A 205
LEU A 201
 None
 1.34A 1mx1E-4r3aA:
undetectable		 1mx1E-4r3aA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		5 LEU A  69
VAL A 245
VAL A  23
LEU A  40
LEU A  37
 None
 1.40A 1mx1E-4rgpA:
undetectable		 1mx1E-4rgpA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A2316
SER A2324
VAL A2381
LEU A2356
LEU A2397
 None
 1.47A 1mx1E-4rh7A:
undetectable		 1mx1E-4rh7A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1

(Populus tremula
x Populus
tremuloides) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 GLY A 115
VAL A 118
VAL A 143
LEU A 176
LEU A 140
 None
 1.09A 1mx1E-4ri6A:
undetectable		 1mx1E-4ri6A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		5 VAL A 228
LEU A 209
LEU A 235
MET A 213
LEU A 173
 None
 1.27A 1mx1E-4u2mA:
undetectable		 1mx1E-4u2mA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 330
VAL A 355
LEU A 258
LEU A 260
LEU A 359
 None
 1.39A 1mx1E-4w7sA:
undetectable		 1mx1E-4w7sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 VAL A 192
VAL A 367
LEU A 229
LEU A 220
LEU A 236
 FAD  A 500 (-3.8A)
None
FAD  A 500 ( 4.9A)
None
None
 1.36A 1mx1E-4wctA:
undetectable		 1mx1E-4wctA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbz EVDO1

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		5 LEU A 118
VAL A 114
VAL A  39
LEU A 216
LEU A  42
 None
 1.07A 1mx1E-4xbzA:
undetectable		 1mx1E-4xbzA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		6 GLY A 125
VAL A 128
SER A 204
MET A 345
PHE A 407
HIS A 449
 None
 1.26A 1mx1E-5fv4A:
67.2		 1mx1E-5fv4A:
78.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		6 GLY A 125
VAL A 129
SER A 204
MET A 345
PHE A 407
HIS A 449
 None
 0.35A 1mx1E-5fv4A:
67.2		 1mx1E-5fv4A:
78.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 126
VAL A 128
SER A 204
MET A 345
HIS A 449
 None
 0.92A 1mx1E-5fv4A:
67.2		 1mx1E-5fv4A:
78.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN

(Thermococcus
kodakarensis) 		PF02900
(LigB) 		5 VAL A 169
VAL A  89
LEU A 167
LEU A 154
LEU A  85
 None
 1.21A 1mx1E-5heeA:
undetectable		 1mx1E-5heeA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 VAL A  36
VAL A 155
LEU A  59
LEU A  55
LEU A 159
 None
 1.40A 1mx1E-5jjuA:
1.6		 1mx1E-5jjuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE

(Bdellovibrio
bacteriovorus) 		PF01522
(Polysacc_deac_1) 		5 VAL A  30
VAL A 117
LEU A  82
LEU A  90
LEU A 114
 None
 1.16A 1mx1E-5jp6A:
undetectable		 1mx1E-5jp6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 5 VAL A  12
VAL A  87
LEU A  81
LEU A  83
LEU A  91
 None
 1.37A 1mx1E-5o8fA:
undetectable		 1mx1E-5o8fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 194
VAL A 153
VAL A 246
LEU A 232
MET A 226
 None
 1.49A 1mx1E-5tx7A:
undetectable		 1mx1E-5tx7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5g BETA-LACTAMASE

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 LEU A 128
GLY A 124
SER A 115
LEU A  88
LEU A 105
 None
 1.34A 1mx1E-5x5gA:
undetectable		 1mx1E-5x5gA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 5 VAL A  46
VAL A  33
LEU A 155
LEU A  37
LEU A 147
 None
 1.12A 1mx1E-5zbyA:
undetectable		 1mx1E-5zbyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2

(Homo sapiens) 		no annotation 5 VAL A  12
VAL A  87
LEU A  81
LEU A  83
LEU A  91
 None
 1.07A 1mx1E-6d6uA:
undetectable		 1mx1E-6d6uA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6deg BETA SLIDING CLAMP

(Bartonella
birtlesii) 		no annotation 5 VAL A  53
VAL A 221
LEU A 212
LEU A 234
LEU A 137
 None
 0.97A 1mx1E-6degA:
undetectable		 1mx1E-6degA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 5 VAL E  12
VAL E  87
LEU E  81
LEU E  83
LEU E  91
 None
 1.18A 1mx1E-6dw1E:
undetectable		 1mx1E-6dw1E:
undetectable