SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_D_THAD4_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw5 INSULIN GENE
ENHANCER PROTEIN
ISL-1

(Rattus
norvegicus) 		PF00046
(Homeobox) 		3 PHE A  51
LEU A  18
MET A  39
 None
 0.86A 1mx1D-1bw5A:
undetectable		 1mx1D-1bw5A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 PHE A 277
LEU A 246
MET A 387
 None
 0.91A 1mx1D-1hcyA:
undetectable		 1mx1D-1hcyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hy5 YERSINIA PESTIS
VIRULENCE PROTEIN
YOPE

(Yersinia pestis) 		PF03545
(YopE)
PF09020
(YopE_N) 		3 PHE A1178
LEU A1143
MET A1128
 None
 0.84A 1mx1D-1hy5A:
undetectable		 1mx1D-1hy5A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdp ATRIAL NATRIURETIC
PEPTIDE CLEARANCE
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 PHE A 312
LEU A 115
MET A 139
 None
 0.69A 1mx1D-1jdpA:
2.8		 1mx1D-1jdpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhn CALNEXIN

(Canis lupus) 		PF00262
(Calreticulin) 		3 PHE A 436
LEU A 425
MET A 189
 None
 0.68A 1mx1D-1jhnA:
undetectable		 1mx1D-1jhnA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr9 MANGANESE SUPEROXIDE
DISMUTASE

(Virgibacillus
halodenitrificans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 PHE A 119
LEU A 161
MET A  89
 None
 0.90A 1mx1D-1jr9A:
undetectable		 1mx1D-1jr9A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 PHE A  19
LEU A 165
MET A 252
 None
 0.90A 1mx1D-1kp0A:
undetectable		 1mx1D-1kp0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 PHE A 825
LEU A 430
MET A 425
 None
 0.78A 1mx1D-1kqfA:
undetectable		 1mx1D-1kqfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 PHE A 255
LEU A 170
MET A 194
 None
 0.91A 1mx1D-1lrwA:
undetectable		 1mx1D-1lrwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 PHE A  68
LEU A 100
MET A  97
 None
 0.63A 1mx1D-1m0uA:
undetectable		 1mx1D-1m0uA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 PHE A 223
LEU A 290
MET A 294
 None
 0.90A 1mx1D-1muuA:
undetectable		 1mx1D-1muuA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		3 PHE A 430
LEU A 307
MET A 338
 None
 0.80A 1mx1D-1o0sA:
undetectable		 1mx1D-1o0sA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 PHE A  48
LEU A 236
MET A  21
 None
 0.87A 1mx1D-1olpA:
undetectable		 1mx1D-1olpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		3 PHE B 945
LEU B 926
MET B 975
 None
 0.85A 1mx1D-1uw4B:
undetectable		 1mx1D-1uw4B:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 PHE A  22
LEU A 299
MET A 307
 None
 0.86A 1mx1D-1vkzA:
3.2		 1mx1D-1vkzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 PHE A   6
LEU A 121
MET A 102
 None
 0.76A 1mx1D-1wn1A:
undetectable		 1mx1D-1wn1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A1091
LEU A1076
MET A1001
 None
 0.89A 1mx1D-1wufA:
undetectable		 1mx1D-1wufA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpj HYPOTHETICAL PROTEIN

(Vibrio cholerae) 		PF08282
(Hydrolase_3) 		3 PHE A  41
LEU A 112
MET A 110
 None
 0.90A 1mx1D-1xpjA:
undetectable		 1mx1D-1xpjA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 PHE A1321
LEU A1381
MET A1178
 None
 0.88A 1mx1D-1xv5A:
2.7		 1mx1D-1xv5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		3 PHE A  18
LEU A  46
MET A 251
 None
 0.86A 1mx1D-1yb2A:
undetectable		 1mx1D-1yb2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		3 PHE A  44
LEU A  50
MET A  30
 None
 0.83A 1mx1D-1yobA:
2.0		 1mx1D-1yobA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 PHE A 511
LEU A 623
MET A 483
 None
 0.88A 1mx1D-1zcjA:
2.0		 1mx1D-1zcjA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		3 PHE A  65
LEU A  90
MET A   6
 None
 0.76A 1mx1D-1zypA:
undetectable		 1mx1D-1zypA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		3 PHE A 282
LEU A 256
MET A 251
 None
 0.90A 1mx1D-2bwsA:
undetectable		 1mx1D-2bwsA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		3 PHE A 200
LEU A 216
MET A 261
 None
 0.80A 1mx1D-2dqwA:
undetectable		 1mx1D-2dqwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		3 PHE A 224
LEU A 216
MET A 242
 None
 0.82A 1mx1D-2g37A:
2.1		 1mx1D-2g37A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		3 PHE A  23
LEU A  78
MET A  58
 None
 0.89A 1mx1D-2g9bA:
2.8		 1mx1D-2g9bA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		3 PHE A 249
LEU A 265
MET A  57
 None
 0.87A 1mx1D-2hzkA:
undetectable		 1mx1D-2hzkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6g PUTATIVE
METHYLTRANSFERASE

(Salmonella
enterica) 		PF03848
(TehB) 		3 PHE A  92
LEU A  37
MET A 105
 None
 0.62A 1mx1D-2i6gA:
undetectable		 1mx1D-2i6gA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7p PANTOTHENATE KINASE
3

(Homo sapiens) 		PF03630
(Fumble) 		3 PHE A 323
LEU A 294
MET A 237
 None
 0.91A 1mx1D-2i7pA:
undetectable		 1mx1D-2i7pA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdc GLYPHOSATE
N-ACETYLTRANSFERASE

(Bacillus
licheniformis) 		PF00583
(Acetyltransf_1) 		3 PHE A  56
LEU A 106
MET A 141
 None
 0.91A 1mx1D-2jdcA:
undetectable		 1mx1D-2jdcA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8q PROTEIN SHQ1

(Saccharomyces
cerevisiae) 		no annotation 3 PHE A   6
LEU A  96
MET A  39
 None
 0.84A 1mx1D-2k8qA:
undetectable		 1mx1D-2k8qA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kts HEAT SHOCK PROTEIN
HSLJ

(Escherichia
coli) 		PF03724
(META) 		3 PHE A  33
LEU A  58
MET A  85
 None
 0.82A 1mx1D-2ktsA:
undetectable		 1mx1D-2ktsA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 PHE A 598
LEU A 558
MET A 541
 None
 0.82A 1mx1D-2o1vA:
undetectable		 1mx1D-2o1vA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		3 PHE A 195
LEU A   9
MET A  42
 None
 0.86A 1mx1D-2ow4A:
undetectable		 1mx1D-2ow4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		3 PHE B 402
LEU B 364
MET B 369
 None
 0.79A 1mx1D-2p1nB:
undetectable		 1mx1D-2p1nB:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8b UNCHARACTERIZED
PROTEIN ATU2452

(Agrobacterium
fabrum) 		PF01738
(DLH) 		3 PHE A 164
LEU A 153
MET A 170
 None
 0.82A 1mx1D-2r8bA:
11.6		 1mx1D-2r8bA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PHE A 318
LEU A 303
MET A 300
 PHE  A 318 ( 1.3A)
LEU  A 303 ( 0.6A)
MET  A 300 ( 0.0A)
 0.77A 1mx1D-2vbfA:
undetectable		 1mx1D-2vbfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w58 PRIMOSOME COMPONENT
(HELICASE LOADER)

(Geobacillus
kaustophilus) 		PF01695
(IstB_IS21) 		3 PHE A 245
LEU A 231
MET A 267
 None
 0.77A 1mx1D-2w58A:
undetectable		 1mx1D-2w58A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		3 PHE A  45
LEU A  51
MET A  31
 None
 0.83A 1mx1D-2wc1A:
2.0		 1mx1D-2wc1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		3 PHE A 238
LEU A  93
MET A  88
 None
 0.56A 1mx1D-2wk8A:
1.9		 1mx1D-2wk8A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyo GLUTATHIONE
SYNTHETASE

(Trypanosoma
brucei) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		3 PHE A  18
LEU A   6
MET A   1
 None
 0.76A 1mx1D-2wyoA:
undetectable		 1mx1D-2wyoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 PHE A 511
LEU A 623
MET A 483
 None
 0.90A 1mx1D-2x58A:
undetectable		 1mx1D-2x58A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 PHE A 186
LEU A  39
MET A 178
 None
 0.89A 1mx1D-2x7jA:
undetectable		 1mx1D-2x7jA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8e RAB-PROTEIN 6

(Drosophila
melanogaster) 		PF00071
(Ras) 		3 PHE A  17
LEU A 165
MET A 150
 None
 0.89A 1mx1D-2y8eA:
2.0		 1mx1D-2y8eA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z99 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF04079
(SMC_ScpB) 		3 PHE A 173
LEU A 118
MET A 144
 None
 0.90A 1mx1D-2z99A:
undetectable		 1mx1D-2z99A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Aeropyrum
pernix) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 PHE A 120
LEU A  37
MET A  79
 None
 0.82A 1mx1D-3agkA:
undetectable		 1mx1D-3agkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 PHE A 296
LEU A  74
MET A  93
 None
 0.83A 1mx1D-3ahiA:
2.5		 1mx1D-3ahiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 PHE A 296
LEU A  74
MET A  93
 None
 0.86A 1mx1D-3ai7A:
undetectable		 1mx1D-3ai7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byi RHO GTPASE
ACTIVATING PROTEIN
15

(Homo sapiens) 		PF00620
(RhoGAP) 		3 PHE A 359
LEU A 409
MET A 462
 None
 0.85A 1mx1D-3byiA:
undetectable		 1mx1D-3byiA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		3 PHE A 128
LEU A 173
MET A 193
 None
 0.91A 1mx1D-3eckA:
undetectable		 1mx1D-3eckA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		3 PHE A 216
LEU A 227
MET A 205
 None
 0.85A 1mx1D-3fdgA:
undetectable		 1mx1D-3fdgA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0m CYSTEINE
DESULFURATION
PROTEIN SUFE

(Salmonella
enterica) 		PF02657
(SufE) 		3 PHE A  14
LEU A  30
MET A   1
 None
 0.87A 1mx1D-3g0mA:
undetectable		 1mx1D-3g0mA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		3 PHE A 330
LEU A 357
MET A  36
 None
 0.80A 1mx1D-3h14A:
1.5		 1mx1D-3h14A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 PHE A 158
LEU A  55
MET A 333
 None
 0.85A 1mx1D-3hq9A:
undetectable		 1mx1D-3hq9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 3 PHE A 255
LEU A 201
MET A 199
 None
 0.79A 1mx1D-3hwpA:
undetectable		 1mx1D-3hwpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		3 PHE A 430
LEU A 435
MET A 415
 None
 0.88A 1mx1D-3i3lA:
undetectable		 1mx1D-3i3lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ira CONSERVED PROTEIN

(Methanosarcina
mazei) 		PF03190
(Thioredox_DsbH) 		3 PHE A 118
LEU A 137
MET A  70
 None
 0.87A 1mx1D-3iraA:
undetectable		 1mx1D-3iraA:
14.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		3 PHE A1101
LEU A1358
MET A1364
 None
 0.23A 1mx1D-3k9bA:
62.0		 1mx1D-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 PHE A 113
LEU A 108
MET A   1
 None
 0.83A 1mx1D-3kzwA:
2.7		 1mx1D-3kzwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS

(Vibrio
parahaemolyticus) 		PF02661
(Fic) 		3 PHE A 104
LEU A 137
MET A 142
 None
 0.62A 1mx1D-3letA:
3.3		 1mx1D-3letA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		3 PHE A 220
LEU A 352
MET A 230
 None
 0.80A 1mx1D-3mx3A:
undetectable		 1mx1D-3mx3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njn PEPTIDASE

(Shewanella
oneidensis) 		PF08985
(DP-EP) 		3 PHE A  24
LEU A 103
MET A  83
 None
 0.87A 1mx1D-3njnA:
undetectable		 1mx1D-3njnA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		3 PHE A   7
LEU A  19
MET A 157
 None
 0.87A 1mx1D-3o7jA:
undetectable		 1mx1D-3o7jA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouo NUCLEOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF05733
(Tenui_N) 		3 PHE A 149
LEU A 223
MET A 235
 None
 0.84A 1mx1D-3ouoA:
undetectable		 1mx1D-3ouoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		3 PHE A 167
LEU A 188
MET A 291
 None
 0.86A 1mx1D-3p54A:
undetectable		 1mx1D-3p54A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 PHE A 330
LEU A 493
MET A 361
 None
 0.65A 1mx1D-3qfkA:
undetectable		 1mx1D-3qfkA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 PHE N 169
LEU K  19
MET K  31
 None
 0.88A 1mx1D-3rkoN:
undetectable		 1mx1D-3rkoN:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rst SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		3 PHE A  89
LEU A 107
MET A 141
 None
 0.89A 1mx1D-3rstA:
undetectable		 1mx1D-3rstA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 PHE A 209
LEU A 129
MET A 169
 None
 0.76A 1mx1D-3sghA:
undetectable		 1mx1D-3sghA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		3 PHE A 196
LEU A  38
MET A  43
 None
 0.77A 1mx1D-3tc1A:
undetectable		 1mx1D-3tc1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti2 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		3 PHE A  82
LEU A  34
MET A 179
 None
 0.78A 1mx1D-3ti2A:
undetectable		 1mx1D-3ti2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		3 PHE A 259
LEU A 285
MET A 279
 None
 0.77A 1mx1D-3ubdA:
undetectable		 1mx1D-3ubdA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		3 PHE A 240
LEU A 146
MET A 285
 None
 0.89A 1mx1D-3wstA:
undetectable		 1mx1D-3wstA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		3 PHE A 430
LEU A 211
MET A 441
 None
 0.66A 1mx1D-3zx2A:
undetectable		 1mx1D-3zx2A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 PHE A 149
LEU A 269
MET A 547
 None
 0.79A 1mx1D-4byfA:
undetectable		 1mx1D-4byfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		3 PHE A 216
LEU A 138
MET A 179
 None
 0.74A 1mx1D-4f53A:
undetectable		 1mx1D-4f53A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbo PSEUDOMONAS
FLUORESCENS
AGGLUTININ

(Pseudomonas
fluorescens) 		no annotation 3 PHE A 128
LEU A 103
MET A  51
 None
 0.86A 1mx1D-4fboA:
undetectable		 1mx1D-4fboA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		3 PHE A 164
LEU A  34
MET A  99
 None
 0.67A 1mx1D-4iq4A:
12.7		 1mx1D-4iq4A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j80 CHAPERONE PROTEIN
DNAJ 2

(Thermus
thermophilus) 		PF00226
(DnaJ)
PF01556
(DnaJ_C) 		3 PHE A 179
LEU A 242
MET A 226
 None
 0.87A 1mx1D-4j80A:
undetectable		 1mx1D-4j80A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		3 PHE A 418
LEU A 270
MET A 275
 PHE  A 418 ( 1.3A)
LEU  A 270 ( 0.6A)
MET  A 275 ( 0.0A)
 0.84A 1mx1D-4kqnA:
undetectable		 1mx1D-4kqnA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw2 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		3 PHE A 101
LEU A  75
MET A  43
 None
 0.82A 1mx1D-4kw2A:
undetectable		 1mx1D-4kw2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		3 PHE A  89
LEU A 107
MET A 141
 None
 0.88A 1mx1D-4kwbA:
undetectable		 1mx1D-4kwbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		3 PHE A 278
LEU A 263
MET A 146
 None
 0.76A 1mx1D-4lb0A:
undetectable		 1mx1D-4lb0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING

(Bacteroides
vulgatus) 		PF12771
(SusD-like_2) 		3 PHE A 217
LEU A 348
MET A 227
 None
 0.80A 1mx1D-4lerA:
undetectable		 1mx1D-4lerA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 PHE A 913
LEU A 898
MET A 903
 None
 0.88A 1mx1D-4mz0A:
undetectable		 1mx1D-4mz0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12

(Aspergillus
niveus) 		PF01670
(Glyco_hydro_12) 		3 PHE A 196
LEU A 122
MET A 174
 None
 0.65A 1mx1D-4nprA:
undetectable		 1mx1D-4nprA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		3 PHE A  93
LEU A 239
MET A 241
 None
 0.83A 1mx1D-4nq3A:
undetectable		 1mx1D-4nq3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 3 PHE A 227
LEU A  10
MET A 269
 None
 0.88A 1mx1D-4okmA:
undetectable		 1mx1D-4okmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 PHE A 126
LEU A  37
MET A 134
 None
 0.74A 1mx1D-4ox2A:
undetectable		 1mx1D-4ox2A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2)
PF17047
(SMP_LBD) 		3 PHE A 363
LEU A 471
MET A 445
 None
 0.90A 1mx1D-4p42A:
undetectable		 1mx1D-4p42A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 PHE A 473
LEU A 534
MET A 539
 None
 0.77A 1mx1D-4p7hA:
undetectable		 1mx1D-4p7hA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis) 		PF11477
(PM0188) 		3 PHE A  34
LEU A  16
MET A 315
 None
 0.78A 1mx1D-4v39A:
undetectable		 1mx1D-4v39A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C

(Homo sapiens) 		PF00179
(UQ_con) 		3 PHE U  53
LEU U  39
MET U  44
 None
 0.86A 1mx1D-4yiiU:
undetectable		 1mx1D-4yiiU:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN

(Gallus gallus) 		PF03828
(PAP_assoc) 		3 PHE A 474
LEU A 393
MET A 379
 None
 0.88A 1mx1D-5a30A:
1.8		 1mx1D-5a30A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		3 PHE A1474
LEU A1585
MET A1304
 None
 0.89A 1mx1D-5a31A:
undetectable		 1mx1D-5a31A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC

(Escherichia
coli) 		PF00005
(ABC_tran) 		3 PHE C 120
LEU C 138
MET C 133
 None
 0.91A 1mx1D-5awfC:
undetectable		 1mx1D-5awfC:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		3 PHE A 771
LEU A 688
MET A 756
 None
 0.86A 1mx1D-5cjuA:
2.4		 1mx1D-5cjuA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		3 PHE B 105
LEU B 268
MET B 415
 None
 0.80A 1mx1D-5d9aB:
undetectable		 1mx1D-5d9aB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		3 PHE A 278
LEU A 350
MET A  63
 None
 0.64A 1mx1D-5ds0A:
2.9		 1mx1D-5ds0A:
20.82