SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_D_THAD4_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 308
GLY A 210
LEU A 227
ILE A 316
LEU A 315
 None
 0.83A 1mx1D-1b41A:
46.4		 1mx1D-1b41A:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 LEU A 308
GLY A 210
LEU A 227
ILE A 316
LEU A 315
 None
 0.91A 1mx1D-1c2oA:
45.9		 1mx1D-1c2oA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		5 LEU A  67
GLY A 106
SER A 189
PHE A 363
HIS A 399
 None
 0.80A 1mx1D-1c7jA:
44.1		 1mx1D-1c7jA:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 LEU A 399
GLY A 331
GLY A 330
LEU A 362
LEU A 323
 None
 0.80A 1mx1D-1cj0A:
undetectable		 1mx1D-1cj0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		6 VAL A 349
LEU A 350
LEU A 372
LEU A 368
LEU A 378
PHE A 342
 None
 1.21A 1mx1D-1cj2A:
undetectable		 1mx1D-1cj2A:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
CLL  A 801 (-4.8A)
 0.49A 1mx1D-1cleA:
40.3		 1mx1D-1cleA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 304
HIS A 449
 None
 0.95A 1mx1D-1crlA:
39.8		 1mx1D-1crlA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
PHE A 415
HIS A 449
 None
 0.66A 1mx1D-1crlA:
39.8		 1mx1D-1crlA:
30.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		6 LEU C 464
GLY C 479
GLY C 480
VAL C 491
LEU C 495
LEU C 460
 None
 1.43A 1mx1D-1d7wC:
undetectable		 1mx1D-1d7wC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dih DIHYDRODIPICOLINATE
REDUCTASE

(Escherichia
coli) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		6 GLY A  15
GLY A  14
VAL A  62
LEU A  44
ILE A  22
LEU A  21
 NDP  A 301 ( 3.5A)
NDP  A 301 ( 4.9A)
None
None
None
None
 1.26A 1mx1D-1dihA:
undetectable		 1mx1D-1dihA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 348
GLY A 172
GLY A 173
LEU A 375
ILE A 244
 None
 0.86A 1mx1D-1ee0A:
undetectable		 1mx1D-1ee0A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		6 GLY A 109
GLY A 110
LEU A  28
LEU A  85
ILE A 115
PHE A  62
 2CP  A 270 ( 3.8A)
2CP  A 270 (-3.4A)
None
None
None
None
 1.30A 1mx1D-1ef9A:
undetectable		 1mx1D-1ef9A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		5 GLY A1521
GLY A1522
VAL A1316
LEU A1485
ILE A1525
 None
 0.94A 1mx1D-1eg7A:
undetectable		 1mx1D-1eg7A:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 122
GLY A 123
LEU A 127
PHE A 345
HIS A 449
 None
 0.92A 1mx1D-1gz7A:
40.3		 1mx1D-1gz7A:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		6 GLY A 122
GLY A 123
SER A 209
VAL A 296
LEU A 127
HIS A 449
 None
 1.32A 1mx1D-1gz7A:
40.3		 1mx1D-1gz7A:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 297
PHE A 415
 None
 0.85A 1mx1D-1gz7A:
40.3		 1mx1D-1gz7A:
31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
PHE A 415
HIS A 449
 None
 0.59A 1mx1D-1gz7A:
40.3		 1mx1D-1gz7A:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		6 LEU B 142
GLY B 197
LEU B 204
LEU B 224
LEU B 223
LEU B 156
 None
 1.34A 1mx1D-1i2mB:
undetectable		 1mx1D-1i2mB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10

(Homo sapiens) 		PF00179
(UQ_con) 		5 GLY A  64
SER A  51
VAL A 128
LEU A 132
LEU A  83
 None
 0.84A 1mx1D-1i7kA:
undetectable		 1mx1D-1i7kA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLY A  89
GLY A  88
VAL A 134
LEU A 105
LEU A 127
LEU A 120
 None
 1.40A 1mx1D-1iy9A:
3.0		 1mx1D-1iy9A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 LEU A 290
GLY A 287
GLY A 286
LEU A 312
ILE A 208
 None
 0.95A 1mx1D-1jcfA:
2.5		 1mx1D-1jcfA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 GLY A 127
GLY A 128
SER A 202
ILE A 260
HIS A 338
 None
 0.60A 1mx1D-1jkmA:
18.6		 1mx1D-1jkmA:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		6 LEU A  97
GLY A 142
GLY A 143
SER A 221
LEU A 255
HIS A 467
 None
 0.53A 1mx1D-1k4yA:
64.0		 1mx1D-1k4yA:
82.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		5 LEU A  68
GLY A  36
GLY A  37
ILE A  42
LEU A  43
 None
SAH  A 401 (-4.1A)
SAH  A 401 (-3.3A)
None
None
 0.94A 1mx1D-1m6yA:
undetectable		 1mx1D-1m6yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 150
GLY A 151
SER A 238
PHE A 440
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.5A)
SO4  A 593 (-4.1A)
 0.51A 1mx1D-1qonA:
47.2		 1mx1D-1qonA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5k AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		5 GLY A  80
VAL A  76
ILE A  97
LEU A  96
PHE A 132
 COA  A 600 ( 3.8A)
None
None
None
None
 0.97A 1mx1D-1s5kA:
undetectable		 1mx1D-1s5kA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		6 LEU A 170
GLY A 213
LEU A 179
LEU A 252
ILE A 223
LEU A 248
 None
 1.32A 1mx1D-1sqhA:
undetectable		 1mx1D-1sqhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLY A 103
LEU A  68
LEU A  43
LEU A  72
ILE A 136
 None
 0.97A 1mx1D-1tuoA:
undetectable		 1mx1D-1tuoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		6 LEU A  76
GLY A  12
VAL A  52
LEU A  50
LEU A  54
LEU A  19
 None
 1.02A 1mx1D-1txgA:
undetectable		 1mx1D-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 GLY A 614
GLY A 615
VAL A 537
LEU A 638
LEU A 619
 None
 0.86A 1mx1D-1u2lA:
undetectable		 1mx1D-1u2lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 LEU A 205
GLY A 265
GLY A 264
LEU A 283
LEU A  64
 None
None
None
FMT  A1212 ( 4.5A)
None
 0.74A 1mx1D-1u60A:
undetectable		 1mx1D-1u60A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 GLY A 127
GLY A 128
SER A 210
PHE A 400
HIS A 440
 EDO  A1902 (-3.6A)
EDO  A1902 (-3.4A)
EDO  A1902 (-2.4A)
None
EDO  A1902 ( 4.9A)
 0.67A 1mx1D-1ukcA:
38.0		 1mx1D-1ukcA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		6 LEU A  82
VAL A 128
LEU A 129
LEU A 144
LEU A 141
LEU A 150
 None
 1.49A 1mx1D-1ukwA:
undetectable		 1mx1D-1ukwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 LEU A  35
GLY A 133
LEU A 161
LEU A 126
ILE A  96
 None
 0.89A 1mx1D-1wnoA:
undetectable		 1mx1D-1wnoA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		6 LEU A  11
VAL A  60
LEU A  64
LEU A  45
ILE A 113
LEU A 115
 None
 1.50A 1mx1D-1ynqA:
undetectable		 1mx1D-1ynqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 323
GLY A 324
LEU A 291
LEU A 175
HIS A 158
 None
None
None
None
NI  A 381 (-3.4A)
 0.95A 1mx1D-1ysjA:
2.6		 1mx1D-1ysjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01544
(CorA) 		5 LEU A  87
GLY A  77
VAL A  50
LEU A  51
LEU A 137
 None
 0.94A 1mx1D-2bbhA:
undetectable		 1mx1D-2bbhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLY A  56
LEU A 182
LEU A 177
LEU A 186
HIS A 189
 None
 0.94A 1mx1D-2bccA:
undetectable		 1mx1D-2bccA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		6 LEU A1319
GLY A1138
VAL A1253
LEU A1315
LEU A1284
PHE A1153
 None
 1.27A 1mx1D-2bruA:
3.8		 1mx1D-2bruA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 VAL A 297
LEU A 266
LEU A 294
ILE A 359
LEU A 333
 None
 0.93A 1mx1D-2d0oA:
undetectable		 1mx1D-2d0oA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 6 GLY A  72
VAL A  28
LEU A  48
LEU A 102
LEU A  26
LEU A 100
 None
 1.19A 1mx1D-2dstA:
5.6		 1mx1D-2dstA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A  21
GLY A  22
VAL A 319
LEU A 316
LEU A  26
 None
 0.90A 1mx1D-2eezA:
2.4		 1mx1D-2eezA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 GLY A 146
GLY A 147
SER A 226
PHE A 425
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
None
TFC  A 600 (-4.2A)
 0.52A 1mx1D-2fj0A:
46.4		 1mx1D-2fj0A:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 LEU A  98
GLY A 146
GLY A 147
SER A 226
HIS A 471
 None
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
 0.92A 1mx1D-2fj0A:
46.4		 1mx1D-2fj0A:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 VAL A 433
LEU A 437
LEU A 417
ILE A 350
LEU A 351
 None
 0.88A 1mx1D-2i4nA:
undetectable		 1mx1D-2i4nA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 LEU A  69
GLY A 128
GLY A 129
LEU A 104
LEU A 133
 None
 0.92A 1mx1D-2iu3A:
undetectable		 1mx1D-2iu3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  55
GLY A  86
GLY A  88
SER A  90
LEU A 117
 None
 0.95A 1mx1D-2l3gA:
undetectable		 1mx1D-2l3gA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3y INTERLEUKIN-6

(Mus musculus) 		PF00489
(IL6) 		5 LEU A  33
LEU A 103
LEU A 180
LEU A 176
ILE A 129
 None
 0.96A 1mx1D-2l3yA:
undetectable		 1mx1D-2l3yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.87A 1mx1D-2o7rA:
18.3		 1mx1D-2o7rA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN

(Homo sapiens) 		PF02545
(Maf) 		5 GLY A 175
GLY A 174
VAL A 121
LEU A 114
LEU A 185
 None
 0.90A 1mx1D-2p5xA:
undetectable		 1mx1D-2p5xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		5 GLY A 160
VAL A  28
LEU A  77
LEU A 173
LEU A 177
 None
 0.77A 1mx1D-2ps3A:
undetectable		 1mx1D-2ps3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 GLY A  17
GLY A  18
VAL A  57
LEU A  55
LEU A  24
 EDO  A 320 (-3.6A)
None
None
None
None
 0.88A 1mx1D-2qytA:
undetectable		 1mx1D-2qytA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x86 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Escherichia
coli) 		PF01370
(Epimerase) 		5 LEU A  42
GLY A   7
GLY A   6
LEU A  33
HIS A 177
 None
None
NAP  A 400 (-3.4A)
None
NAP  A 400 (-4.0A)
 0.91A 1mx1D-2x86A:
undetectable		 1mx1D-2x86A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		5 GLY A  38
LEU A 105
ILE A  99
LEU A 100
PHE A  92
 SFG  A1198 (-4.3A)
None
None
None
None
 0.94A 1mx1D-2xvaA:
undetectable		 1mx1D-2xvaA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE

(Nonomuraea
recticatena) 		PF00067
(p450) 		5 LEU A 285
GLY A 260
VAL A 405
LEU A 382
LEU A 403
 None
 0.94A 1mx1D-2z36A:
undetectable		 1mx1D-2z36A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		6 LEU A 334
GLY A 150
VAL A 114
LEU A 111
LEU A 120
LEU A 103
 None
 1.24A 1mx1D-2z8eA:
undetectable		 1mx1D-2z8eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		6 LEU A  15
GLY A  87
VAL A 136
LEU A 134
LEU A 141
LEU A  93
 None
 1.42A 1mx1D-3bjrA:
17.1		 1mx1D-3bjrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		5 LEU A  67
GLY A  87
VAL A 136
LEU A 134
LEU A 141
 None
 0.95A 1mx1D-3bjrA:
17.1		 1mx1D-3bjrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		6 GLY A 252
GLY A 141
LEU A 226
LEU A 168
ILE A 233
PHE A 260
 None
 1.29A 1mx1D-3cwcA:
2.6		 1mx1D-3cwcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE

(Thermotoga
maritima) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A  35
LEU A   9
LEU A  92
LEU A  98
ILE A  74
 None
 0.80A 1mx1D-3dfyA:
undetectable		 1mx1D-3dfyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli) 		PF02665
(Nitrate_red_gam) 		5 GLY C 104
GLY C 105
LEU C 130
ILE C  59
HIS C  56
 None
None
HEM  C 806 (-3.8A)
HEM  C 806 (-4.3A)
HEM  C 806 (-3.2A)
 0.93A 1mx1D-3egwC:
undetectable		 1mx1D-3egwC:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		6 LEU A 216
GLY A  21
GLY A  22
VAL A 101
LEU A  18
LEU A  29
 None
 1.41A 1mx1D-3g8aA:
3.1		 1mx1D-3g8aA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		6 GLY A 140
VAL A 154
LEU A 182
LEU A 227
LEU A 212
LEU A 143
 None
None
None
None
None
EDO  A   6 ( 4.8A)
 1.32A 1mx1D-3gf6A:
undetectable		 1mx1D-3gf6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 GLY A 104
VAL A  98
LEU A  99
ILE A  55
LEU A  54
 None
 0.95A 1mx1D-3h3eA:
undetectable		 1mx1D-3h3eA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isl PURINE CATABOLISM
PROTEIN PUCG

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		6 GLY A 181
GLY A 180
VAL A 282
LEU A 202
LEU A 290
LEU A  58
 None
 1.32A 1mx1D-3islA:
undetectable		 1mx1D-3islA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		6 GLY A1143
SER A1221
ILE A1359
LEU A1363
PHE A1426
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 ( 4.3A)
WW2  A 193 (-3.8A)
None
None
 0.88A 1mx1D-3k9bA:
62.0		 1mx1D-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		10 LEU A1097
GLY A1142
GLY A1143
SER A1221
VAL A1254
LEU A1255
ILE A1359
LEU A1363
PHE A1426
HIS A1468
 WW2  A 193 ( 4.9A)
WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
WW2  A 193 ( 4.3A)
WW2  A 193 (-3.8A)
None
None
 0.51A 1mx1D-3k9bA:
62.0		 1mx1D-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		6 LEU A  43
GLY A  45
LEU A  11
LEU A 102
ILE A  81
PHE A  23
 None
 1.43A 1mx1D-3lu2A:
undetectable		 1mx1D-3lu2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE

(Thiobacillus
denitrificans) 		PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3) 		5 GLY A  16
GLY A  15
VAL A  76
LEU A   8
LEU A  78
 None
 0.78A 1mx1D-3mtjA:
undetectable		 1mx1D-3mtjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwe ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF16114
(Citrate_bind) 		6 LEU A 195
GLY A  11
VAL A 214
LEU A 200
LEU A 217
ILE A  19
 None
 1.42A 1mx1D-3mweA:
undetectable		 1mx1D-3mweA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		6 LEU A  92
GLY A 130
GLY A 131
VAL A  53
LEU A 135
LEU A  88
 None
 1.45A 1mx1D-3nd0A:
undetectable		 1mx1D-3nd0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		6 GLY A 102
GLY A 105
VAL A  81
LEU A 119
LEU A 108
LEU A  96
 None
 1.42A 1mx1D-3om8A:
13.4		 1mx1D-3om8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ory FLAP ENDONUCLEASE 1

(Desulfurococcus
amylolyticus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 GLY A  64
VAL A 308
LEU A 312
LEU A 142
ILE A  70
 None
 0.83A 1mx1D-3oryA:
undetectable		 1mx1D-3oryA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 256
GLY A 226
VAL A 304
LEU A 330
LEU A 248
 None
 0.83A 1mx1D-3ouuA:
undetectable		 1mx1D-3ouuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		6 GLY A 126
GLY A 127
VAL A 434
LEU A  23
LEU A 448
HIS A  96
 None
None
None
None
None
ZN  A 501 (-3.3A)
 1.14A 1mx1D-3pfeA:
undetectable		 1mx1D-3pfeA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		5 LEU A 147
GLY A 142
LEU A  38
LEU A 331
PHE A  73
 None
None
None
None
URA  A 430 (-3.4A)
 0.83A 1mx1D-3qe7A:
undetectable		 1mx1D-3qe7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkd MONOCLONAL ANTIBODY,
LIGHT CHAIN

(Mus musculus) 		no annotation 5 LEU L  47
VAL L  13
LEU L  78
ILE L  21
LEU L  73
 None
 0.97A 1mx1D-3rkdL:
undetectable		 1mx1D-3rkdL:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		5 LEU A 200
VAL A  62
LEU A  57
LEU A  74
LEU A 223
 None
 0.70A 1mx1D-3sweA:
undetectable		 1mx1D-3sweA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE

(Vibrio cholerae) 		PF00857
(Isochorismatase) 		6 LEU A  15
GLY A 170
GLY A 172
VAL A 146
LEU A  11
LEU A  54
 None
 1.40A 1mx1D-3tb4A:
undetectable		 1mx1D-3tb4A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE

(Sinorhizobium
meliloti) 		PF08013
(Tagatose_6_P_K) 		5 LEU A  96
GLY A  93
GLY A  92
LEU A  49
ILE A 174
 None
 0.90A 1mx1D-3txvA:
undetectable		 1mx1D-3txvA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 GLY A 671
GLY A 672
VAL A 594
LEU A 695
LEU A 676
 None
 0.74A 1mx1D-3ut2A:
undetectable		 1mx1D-3ut2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		5 GLY A  64
VAL A  76
LEU A  10
LEU A 117
LEU A  73
 None
 0.90A 1mx1D-3uxyA:
undetectable		 1mx1D-3uxyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		5 LEU A 349
GLY A 360
GLY A 361
LEU A 362
LEU A 305
 None
CA  A 507 (-4.4A)
CA  A 506 (-4.3A)
None
None
 0.86A 1mx1D-3vi1A:
undetectable		 1mx1D-3vi1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 486
GLY A 397
GLY A 396
LEU A 445
ILE A 522
 None
 0.90A 1mx1D-3vskA:
undetectable		 1mx1D-3vskA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 5 GLY B 262
GLY B 263
LEU B 113
ILE B 268
LEU B 269
 None
 0.87A 1mx1D-3w0lB:
2.3		 1mx1D-3w0lB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		5 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.92A 1mx1D-3wmtA:
10.8		 1mx1D-3wmtA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		5 GLY A 610
GLY A 611
VAL A 533
LEU A 634
LEU A 615
 None
 0.80A 1mx1D-3wxoA:
undetectable		 1mx1D-3wxoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE

(Roseobacter
denitrificans) 		PF00557
(Peptidase_M24) 		5 GLY A  74
VAL A 159
LEU A 163
LEU A 105
ILE A 193
 None
 0.91A 1mx1D-4b28A:
undetectable		 1mx1D-4b28A:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
SER A 220
PHE A 427
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-4.7A)
None
 0.51A 1mx1D-4be9A:
41.3		 1mx1D-4be9A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bph D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 2

(Bacillus
subtilis) 		PF00550
(PP-binding) 		5 VAL A  10
LEU A  43
LEU A  42
ILE A  52
PHE A   3
 None
 0.88A 1mx1D-4bphA:
undetectable		 1mx1D-4bphA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 GLY V 494
VAL V 520
LEU V 392
ILE V 488
LEU V 492
 None
 0.97A 1mx1D-4bxsV:
undetectable		 1mx1D-4bxsV:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI) 		6 LEU C  39
GLY C  57
SER C  31
LEU C  59
LEU C  56
LEU C  62
 None
 1.47A 1mx1D-4d10C:
undetectable		 1mx1D-4d10C:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A  55
VAL A 105
LEU A 102
LEU A  37
LEU A 110
 None
 0.86A 1mx1D-4epaA:
undetectable		 1mx1D-4epaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		5 LEU A 415
GLY A 427
LEU A 355
ILE A 346
LEU A 434
 None
 0.94A 1mx1D-4fajA:
undetectable		 1mx1D-4fajA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		5 GLY A 136
GLY A 137
SER A 218
PHE A 421
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
 0.56A 1mx1D-4fnmA:
37.5		 1mx1D-4fnmA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		6 GLY A  79
GLY A  80
LEU A  76
LEU A  19
LEU A  86
HIS A 185
 None
None
None
None
None
EDO  A 403 (-4.1A)
 1.10A 1mx1D-4gyiA:
undetectable		 1mx1D-4gyiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		6 LEU A   3
GLY A  79
GLY A  80
LEU A  76
LEU A  19
HIS A 185
 None
None
None
None
None
EDO  A 403 (-4.1A)
 1.19A 1mx1D-4gyiA:
undetectable		 1mx1D-4gyiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		6 GLY B 170
VAL B 235
LEU B 232
LEU B 169
ILE B 106
LEU B 105
 None
 1.10A 1mx1D-4hdsB:
undetectable		 1mx1D-4hdsB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 VAL A  59
LEU A  27
LEU A 105
LEU A  57
PHE A  40
 None
 0.97A 1mx1D-4jotA:
2.5		 1mx1D-4jotA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 LEU A3840
VAL A3945
LEU A3929
LEU A3882
LEU A3927
LEU A3881
 None
 1.49A 1mx1D-4kc5A:
undetectable		 1mx1D-4kc5A:
20.59