SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_C_THAC3

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 GLY A 107
SER A 194
LEU A 285
PHE A 393
HIS A 435
 None
 0.70A 1mx1C-1aqlA:
48.2		 1mx1C-1aqlA:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		5 LEU A 100
LEU A  67
LEU A  59
LEU A  63
LEU A  53
 None
 1.16A 1mx1C-1gm5A:
undetectable		 1mx1C-1gm5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		5 LEU A 115
GLY A 298
VAL A 260
LEU A 261
LEU A 264
 None
 0.96A 1mx1C-1gq7A:
undetectable		 1mx1C-1gq7A:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 LEU A  97
GLY A 142
SER A 221
LEU A 255
HIS A 467
 None
 0.58A 1mx1C-1k4yA:
64.4		 1mx1C-1k4yA:
82.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 341
GLY A 301
THR A 375
LEU A 280
LEU A 392
 None
 1.25A 1mx1C-1ko0A:
undetectable		 1mx1C-1ko0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzj HYPOTHETICAL PROTEIN
YADB

(Escherichia
coli) 		PF00749
(tRNA-synt_1c) 		5 VAL A 267
LEU A 271
LEU A  23
LEU A 247
LEU A  18
 None
 1.14A 1mx1C-1nzjA:
undetectable		 1mx1C-1nzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		5 LEU H  14
GLY H  44
VAL H  87
LEU H 104
LEU H  83
 None
 1.21A 1mx1C-1q5rH:
undetectable		 1mx1C-1q5rH:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 129
GLY A 100
THR A  51
VAL A  54
LEU A 149
 None
 0.84A 1mx1C-1rf5A:
undetectable		 1mx1C-1rf5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		5 LEU A  33
VAL A  94
LEU A  95
LEU A  98
LEU A  67
 None
 0.99A 1mx1C-1s8eA:
undetectable		 1mx1C-1s8eA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 GLY A  12
VAL A  52
LEU A  50
LEU A  54
LEU A  19
 None
 0.88A 1mx1C-1txgA:
undetectable		 1mx1C-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A  76
GLY A  12
LEU A  50
LEU A  54
LEU A  19
 None
 0.82A 1mx1C-1txgA:
undetectable		 1mx1C-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		5 GLY A 128
THR A 173
LEU A 174
LEU A 108
PHE A 168
 None
 1.17A 1mx1C-1u9cA:
undetectable		 1mx1C-1u9cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 THR A 101
LEU A 105
LEU A 187
LEU A 108
LEU A 153
 None
 1.13A 1mx1C-1x2gA:
undetectable		 1mx1C-1x2gA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 THR A 101
VAL A 104
LEU A 187
LEU A 108
LEU A 153
 None
 1.12A 1mx1C-1x2gA:
undetectable		 1mx1C-1x2gA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 LEU A 513
LEU A 312
LEU A 327
LEU A 316
LEU A 328
 None
 1.07A 1mx1C-1x9nA:
undetectable		 1mx1C-1x9nA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a11 RIBONUCLEASE III

(Mycobacterium
tuberculosis) 		PF14622
(Ribonucleas_3_3) 		5 LEU A  16
LEU A 145
LEU A   8
LEU A  91
LEU A   9
 None
 0.74A 1mx1C-2a11A:
undetectable		 1mx1C-2a11A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 THR B 205
VAL B 174
LEU B 134
LEU B 172
LEU B  71
 None
 1.15A 1mx1C-2akaB:
1.9		 1mx1C-2akaB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 5 GLY A  72
VAL A  28
LEU A  48
LEU A 102
LEU A 100
 None
 0.97A 1mx1C-2dstA:
2.2		 1mx1C-2dstA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB

(Escherichia
coli) 		PF13036
(LpoB) 		5 GLY A 150
VAL A 122
LEU A 142
LEU A  88
LEU A 136
 None
 1.17A 1mx1C-2miiA:
undetectable		 1mx1C-2miiA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A 343
VAL A 274
LEU A 273
LEU A 270
LEU A 397
 None
 1.26A 1mx1C-2osaA:
undetectable		 1mx1C-2osaA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 LEU A  21
THR A 118
VAL A  71
LEU A  81
LEU A  28
 None
 1.03A 1mx1C-2ph3A:
4.2		 1mx1C-2ph3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwj TYPE III EXPORT
PROTEIN PSCE
TYPE III EXPORT
PROTEIN PSCG

(Pseudomonas
aeruginosa) 		PF08988
(T3SS_needle_E)
PF09477
(Type_III_YscG) 		5 LEU G   5
THR E  68
LEU E  12
LEU E   8
LEU G   9
 None
 0.89A 1mx1C-2uwjG:
undetectable		 1mx1C-2uwjG:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A  73
GLY A 221
VAL A 235
LEU A 242
LEU A  24
 None
 0.87A 1mx1C-2xecA:
2.5		 1mx1C-2xecA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		5 LEU A 169
THR A  67
LEU A  66
LEU A  58
LEU A  55
 None
 1.25A 1mx1C-2y4fA:
undetectable		 1mx1C-2y4fA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5q INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 LEU A 119
LEU A 110
LEU A 125
LEU A 127
LEU A 141
 None
 1.14A 1mx1C-2y5qA:
undetectable		 1mx1C-2y5qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 LEU A 334
GLY A 150
LEU A 111
LEU A 120
LEU A 103
 None
 1.26A 1mx1C-2z8eA:
undetectable		 1mx1C-2z8eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 LEU A 334
GLY A 150
VAL A 114
LEU A 120
LEU A 103
 None
 1.14A 1mx1C-2z8eA:
undetectable		 1mx1C-2z8eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 THR A 653
LEU A 588
LEU A 551
LEU A 584
PHE A 655
 None
 1.21A 1mx1C-3c2gA:
undetectable		 1mx1C-3c2gA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		5 GLY A 154
THR A 337
VAL A 333
LEU A 336
LEU A 109
 None
 1.09A 1mx1C-3cmnA:
undetectable		 1mx1C-3cmnA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 LEU A 343
THR A 279
VAL A 274
LEU A 270
LEU A 397
 None
 1.25A 1mx1C-3cxlA:
undetectable		 1mx1C-3cxlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE

(Cryptosporidium
parvum) 		PF00300
(His_Phos_1) 		5 VAL A 241
LEU A 235
LEU A 208
LEU A 212
LEU A 205
 None
 1.08A 1mx1C-3d8hA:
undetectable		 1mx1C-3d8hA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 104
LEU A  57
LEU A  77
LEU A 106
LEU A  76
 None
 0.92A 1mx1C-3e7oA:
undetectable		 1mx1C-3e7oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		5 VAL A 306
LEU A 310
LEU A 279
LEU A 346
LEU A 294
 None
 1.23A 1mx1C-3hdoA:
undetectable		 1mx1C-3hdoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htv D-ALLOSE KINASE

(Escherichia
coli) 		PF00480
(ROK) 		5 LEU A  90
VAL A 110
LEU A  67
LEU A 102
LEU A  95
 None
 1.19A 1mx1C-3htvA:
undetectable		 1mx1C-3htvA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 LEU A 457
SER A 258
VAL A 264
LEU A 282
LEU A 251
 None
 1.08A 1mx1C-3k5wA:
undetectable		 1mx1C-3k5wA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A1143
SER A1221
LEU A1363
PHE A1426
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 (-3.8A)
None
None
 0.94A 1mx1C-3k9bA:
62.1		 1mx1C-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		10 LEU A1097
GLY A1142
SER A1221
THR A1252
VAL A1254
LEU A1255
LEU A1363
MET A1425
PHE A1426
HIS A1468
 WW2  A 193 ( 4.9A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
None
WW2  A 193 (-3.8A)
None
None
None
 0.45A 1mx1C-3k9bA:
62.1		 1mx1C-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu ALPHA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		5 THR B 357
VAL B 360
LEU B 361
LEU B 303
LEU B 364
 None
 1.14A 1mx1C-3kmuB:
undetectable		 1mx1C-3kmuB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A 160
THR A  77
LEU A  90
LEU A 118
LEU A 120
 None
 1.11A 1mx1C-3ml5A:
undetectable		 1mx1C-3ml5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 LEU A 281
GLY A 207
VAL A 132
LEU A 125
LEU A 128
 None
 1.26A 1mx1C-3nizA:
undetectable		 1mx1C-3nizA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		5 LEU A 472
SER A 455
VAL A 423
LEU A 433
LEU A 429
 None
 1.02A 1mx1C-3nowA:
undetectable		 1mx1C-3nowA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05721
(PhyH) 		5 LEU A  20
SER A 129
LEU A 132
LEU A 171
LEU A  18
 None
 0.91A 1mx1C-3obzA:
undetectable		 1mx1C-3obzA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU B 437
VAL B 365
LEU B 389
LEU B 410
LEU B 363
 None
 0.95A 1mx1C-3ohmB:
undetectable		 1mx1C-3ohmB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 LEU A 244
GLY A 297
THR A 354
LEU A 348
LEU A 345
 None
 1.19A 1mx1C-3pjxA:
undetectable		 1mx1C-3pjxA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 SER A  99
LEU A 150
LEU A 110
LEU A 127
LEU A 105
 None
 1.14A 1mx1C-3pvcA:
undetectable		 1mx1C-3pvcA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rms UNCHARACTERIZED
PROTEIN

(Saccharomonospora
viridis) 		PF16827
(zf-HC3) 		5 THR A 106
VAL A 102
LEU A 105
LEU A  95
LEU A  32
 None
None
None
None
GOL  A 115 (-4.8A)
 1.23A 1mx1C-3rmsA:
undetectable		 1mx1C-3rmsA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		5 LEU A 206
LEU A 104
LEU A 179
LEU A  35
PHE A 231
 None
 1.07A 1mx1C-3swgA:
undetectable		 1mx1C-3swgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 412
VAL A 374
LEU A 375
LEU A 377
LEU A 385
 None
 0.91A 1mx1C-3u4aA:
undetectable		 1mx1C-3u4aA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 5 VAL A  64
LEU A  51
LEU A  27
LEU A  23
LEU A  32
 None
 1.05A 1mx1C-3u9gA:
undetectable		 1mx1C-3u9gA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		5 LEU A 523
VAL A 464
LEU A 468
LEU A 496
LEU A 452
 None
 1.19A 1mx1C-4aysA:
undetectable		 1mx1C-4aysA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		5 VAL A 412
LEU A 413
LEU A 361
LEU A 416
LEU A 360
 None
 0.85A 1mx1C-4d3yA:
undetectable		 1mx1C-4d3yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edn BETA-PARVIN

(Homo sapiens) 		PF00307
(CH) 		5 THR A 349
VAL A 352
LEU A 353
LEU A 295
LEU A 356
 None
 1.15A 1mx1C-4ednA:
undetectable		 1mx1C-4ednA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A  55
VAL A 105
LEU A 102
LEU A  37
LEU A 110
 None
 0.80A 1mx1C-4epaA:
undetectable		 1mx1C-4epaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 183
LEU A 184
LEU A 208
LEU A 187
LEU A 151
 None
 1.21A 1mx1C-4ev0A:
undetectable		 1mx1C-4ev0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzc EPSIN-2

(Saccharomyces
cerevisiae) 		PF01417
(ENTH) 		5 SER A  46
THR A  19
VAL A  23
LEU A  80
LEU A  59
 None
 1.07A 1mx1C-4gzcA:
undetectable		 1mx1C-4gzcA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A  83
VAL A 156
LEU A 157
LEU A 160
LEU A  93
 None
 1.23A 1mx1C-4j8lA:
undetectable		 1mx1C-4j8lA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 GLY A 471
VAL A 476
LEU A 485
LEU A 481
LEU A 488
 None
 1.11A 1mx1C-4je5A:
undetectable		 1mx1C-4je5A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 LEU A 338
GLY A 390
VAL A 915
LEU A 972
LEU A 989
 None
 1.09A 1mx1C-4k0eA:
2.5		 1mx1C-4k0eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 LEU A 262
VAL B 201
LEU B 220
LEU B 171
LEU B 199
 None
 1.12A 1mx1C-4nfuA:
4.0		 1mx1C-4nfuA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		5 LEU A 148
VAL A 162
LEU A 159
LEU A 167
LEU A 165
 None
 1.26A 1mx1C-4po4A:
undetectable		 1mx1C-4po4A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 GLY A 828
VAL A 730
LEU A 841
LEU A 728
LEU A 753
 None
 0.80A 1mx1C-4qnlA:
undetectable		 1mx1C-4qnlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		6 THR A 371
VAL A 368
LEU A 367
LEU A 471
LEU A 364
LEU A 470
 None
 1.19A 1mx1C-4qreA:
undetectable		 1mx1C-4qreA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  83
LEU A  74
LEU A  89
LEU A  91
LEU A 107
 None
 1.26A 1mx1C-4r5cA:
undetectable		 1mx1C-4r5cA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6j LUCINE RICH REPEATS
DLRR_H

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A  83
LEU A  74
LEU A  89
LEU A  91
LEU A 107
 None
 1.22A 1mx1C-4r6jA:
undetectable		 1mx1C-4r6jA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 5 THR A 242
LEU A 246
LEU A 252
LEU A 249
PHE A 158
 None
 1.14A 1mx1C-4txdA:
undetectable		 1mx1C-4txdA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL B 102
LEU B  55
LEU B  75
LEU B 104
LEU B  74
 None
None
39G  B 401 (-4.3A)
39G  B 401 ( 4.7A)
None
 0.93A 1mx1C-4tyhB:
undetectable		 1mx1C-4tyhB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 133
LEU A 123
LEU A 139
LEU A 141
LEU A 156
 None
 1.09A 1mx1C-4tzhA:
undetectable		 1mx1C-4tzhA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A 137
LEU A 127
LEU A 143
LEU A 145
LEU A 160
 None
 1.13A 1mx1C-4u06A:
undetectable		 1mx1C-4u06A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A 222
LEU A 278
LEU A 260
LEU A 281
LEU A 237
 None
 1.15A 1mx1C-4u06A:
undetectable		 1mx1C-4u06A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A 298
LEU A 288
LEU A 304
LEU A 306
LEU A 321
 None
 1.20A 1mx1C-4u06A:
undetectable		 1mx1C-4u06A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 278
LEU A 268
LEU A 284
LEU A 286
LEU A 301
 None
 1.23A 1mx1C-4u08A:
undetectable		 1mx1C-4u08A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 301
LEU A 291
LEU A 307
LEU A 309
LEU A 324
 None
 1.24A 1mx1C-4u08A:
undetectable		 1mx1C-4u08A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 178
LEU A 168
LEU A 184
LEU A 186
LEU A 201
 None
 1.14A 1mx1C-4u09A:
undetectable		 1mx1C-4u09A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0k FAB FRAGMENT HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 LEU H  48
VAL H  12
LEU H  82
LEU H  82
LEU H  80
 None
 1.16A 1mx1C-4x0kH:
undetectable		 1mx1C-4x0kH:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 5 THR A  72
VAL A  74
LEU A  69
LEU A  85
LEU A 152
 None
 1.00A 1mx1C-4xj6A:
undetectable		 1mx1C-4xj6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 LEU A 155
LEU A 200
LEU A 135
LEU A  78
LEU A 136
 None
 1.17A 1mx1C-5a0kA:
undetectable		 1mx1C-5a0kA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a2g CARBOXYLIC ESTER
HYDROLASE

(Hungatella
hathewayi) 		PF00135
(COesterase) 		5 GLY A 114
SER A 200
LEU A 233
PHE A 379
HIS A 416
 None
 0.90A 1mx1C-5a2gA:
38.3		 1mx1C-5a2gA:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 LEU A 195
GLY A 233
VAL A 644
LEU A 192
LEU A 620
 None
 0.95A 1mx1C-5az4A:
undetectable		 1mx1C-5az4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 270
VAL A 305
LEU A 307
LEU A 293
MET A 340
 4YB  A 502 (-4.4A)
None
None
None
None
 1.25A 1mx1C-5c5hA:
undetectable		 1mx1C-5c5hA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 THR A  80
VAL A  96
LEU A  82
LEU A  94
PHE A 104
 None
 1.03A 1mx1C-5cerA:
undetectable		 1mx1C-5cerA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 THR A 205
VAL A 174
LEU A 134
LEU A 172
LEU A  71
 GDP  A 801 ( 4.8A)
None
None
None
None
 1.18A 1mx1C-5d3qA:
1.9		 1mx1C-5d3qA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Brucella ovis) 		PF13420
(Acetyltransf_4) 		5 THR A 158
VAL A 120
LEU A 160
LEU A  81
LEU A 118
 None
 1.12A 1mx1C-5dwmA:
undetectable		 1mx1C-5dwmA:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		6 GLY A 125
SER A 204
THR A 235
LEU A 238
PHE A 407
HIS A 449
 None
 0.62A 1mx1C-5fv4A:
66.9		 1mx1C-5fv4A:
78.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus) 		PF00067
(p450) 		5 THR A 183
VAL A 186
LEU A 187
LEU A 190
LEU A 466
 None
 0.86A 1mx1C-5fygA:
undetectable		 1mx1C-5fygA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl3 LMO2470 PROTEIN

(Listeria
monocytogenes) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A 240
LEU A 231
LEU A 246
LEU A 248
LEU A 263
 None
 1.26A 1mx1C-5hl3A:
undetectable		 1mx1C-5hl3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 VAL A 246
LEU A 243
LEU A 255
LEU A 251
LEU A 258
 None
 0.98A 1mx1C-5ja1A:
9.9		 1mx1C-5ja1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A  79
THR A  60
VAL A  57
LEU A  92
LEU A  53
 None
 1.09A 1mx1C-5lnqA:
undetectable		 1mx1C-5lnqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m42 PROLINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 LEU A 150
LEU A  80
LEU A 132
LEU A  98
LEU A 146
 None
 1.22A 1mx1C-5m42A:
undetectable		 1mx1C-5m42A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		5 GLY A 277
THR A 210
LEU A 211
LEU A 280
PHE A  61
 None
 1.13A 1mx1C-5mgvA:
undetectable		 1mx1C-5mgvA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 729
THR A 581
LEU A 759
PHE A 495
HIS A 557
 None
 0.87A 1mx1C-5n6uA:
undetectable		 1mx1C-5n6uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		5 GLY A 156
THR A  75
VAL A  72
LEU A 104
LEU A 103
 None
 1.05A 1mx1C-5tgfA:
undetectable		 1mx1C-5tgfA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		5 LEU A  75
VAL A 200
LEU A 171
LEU A 198
LEU A 187
 None
 1.12A 1mx1C-5tjrA:
undetectable		 1mx1C-5tjrA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		5 LEU A 573
VAL A 649
LEU A 617
LEU A 625
LEU A 636
 None
 1.20A 1mx1C-5uj7A:
2.4		 1mx1C-5uj7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		5 LEU A 573
VAL A 649
LEU A 617
LEU A 625
LEU A 636
 None
 1.21A 1mx1C-5ujmA:
2.4		 1mx1C-5ujmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 5 GLY A 282
SER A 286
LEU A 291
LEU A 204
LEU A 294
 None
 0.95A 1mx1C-5v8cA:
undetectable		 1mx1C-5v8cA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 5 GLY A  73
VAL A  43
LEU A  39
LEU A  45
LEU A 229
 None
 1.24A 1mx1C-5x8oA:
undetectable		 1mx1C-5x8oA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 290
VAL A 127
LEU A 111
LEU A 125
LEU A 110
 None
 1.10A 1mx1C-5y2wA:
undetectable		 1mx1C-5y2wA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ

(Aspergillus
nidulans) 		no annotation 5 GLY B 213
LEU B 159
LEU B 124
LEU B 225
HIS B 134
 AKG  B 402 (-2.9A)
AKG  B 402 (-4.4A)
None
None
58K  B 403 (-3.4A)
 1.25A 1mx1C-5y7rB:
undetectable		 1mx1C-5y7rB:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4

(Homo sapiens) 		no annotation 5 VAL A 275
LEU A 287
LEU A 390
LEU A 277
HIS A 356
 None
None
None
None
1PE  A 501 ( 4.3A)
 1.00A 1mx1C-6eubA:
undetectable		 1mx1C-6eubA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 5 THR A 329
VAL A 332
LEU A 333
LEU A 310
LEU A 336
 None
 1.01A 1mx1C-6fcxA:
undetectable		 1mx1C-6fcxA:
11.14