SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_B_THAB2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		5 LEU A 199
VAL A 119
LEU A 206
LEU A  91
LEU A 207
 None
 1.37A 1mx1B-1bsgA:
undetectable		 1mx1B-1bsgA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5
CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR

(Homo sapiens) 		PF00069
(Pkinase)
PF03261
(CDK5_activator) 		5 LEU A  49
LEU D 245
LEU D 249
LEU A  76
HIS A  71
 None
 1.16A 1mx1B-1h4lA:
undetectable		 1mx1B-1h4lA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 LEU A  97
PHE A 101
GLY A 142
SER A 221
HIS A 467
 None
 0.68A 1mx1B-1k4yA:
63.5		 1mx1B-1k4yA:
82.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 PHE A 251
GLY A 277
VAL A 231
LEU A 274
LEU A 236
 None
 1.02A 1mx1B-1lcyA:
undetectable		 1mx1B-1lcyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 LEU A 356
GLY A 354
VAL A 281
LEU A 529
LEU A 346
 None
 1.33A 1mx1B-1m64A:
undetectable		 1mx1B-1m64A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 PHE A  12
LEU A 132
LEU A 106
LEU A 143
LEU A 133
 None
 1.25A 1mx1B-1mb9A:
undetectable		 1mx1B-1mb9A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 260
PHE A 252
LEU A 225
LEU A 278
LEU A 281
 None
 1.33A 1mx1B-1p43A:
undetectable		 1mx1B-1p43A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5r PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		5 LEU H  14
GLY H  44
VAL H  87
LEU H 104
LEU H  83
 None
 1.24A 1mx1B-1q5rH:
undetectable		 1mx1B-1q5rH:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 LEU A 515
PHE A 446
LEU A 466
LEU A 112
LEU A 469
 None
 1.27A 1mx1B-1urjA:
1.4		 1mx1B-1urjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 LEU A  68
GLY A 100
VAL A  20
LEU A 327
LEU A 304
 None
 1.38A 1mx1B-1xa0A:
2.4		 1mx1B-1xa0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		5 LEU A  44
GLY A  42
LEU A  74
LEU A 167
LEU A 171
 None
 1.10A 1mx1B-1xngA:
undetectable		 1mx1B-1xngA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yii ANNEXIN A5

(Gallus gallus) 		PF00191
(Annexin) 		5 LEU A 152
GLY A 199
VAL A 209
LEU A 206
LEU A 237
 None
 1.25A 1mx1B-1yiiA:
undetectable		 1mx1B-1yiiA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 258
PHE A 250
VAL A 288
LEU A 223
LEU A 275
 None
 1.08A 1mx1B-2akzA:
undetectable		 1mx1B-2akzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 LEU X  41
PHE X  45
LEU X  61
LEU X  53
LEU X   9
 None
 1.41A 1mx1B-2b5dX:
undetectable		 1mx1B-2b5dX:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 LEU A  72
LEU A  92
LEU A 120
LEU A  85
LEU A  87
 None
 1.00A 1mx1B-2bnhA:
undetectable		 1mx1B-2bnhA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 VAL A 274
LEU A 258
LEU A 271
LEU A 214
LEU A 229
 None
 1.28A 1mx1B-2bnhA:
undetectable		 1mx1B-2bnhA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A  29
PHE A  92
GLY A 115
VAL A 125
LEU A  19
 None
 1.41A 1mx1B-2fw2A:
undetectable		 1mx1B-2fw2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjm PROTEIN NLRC5

(Mus musculus) 		no annotation 5 LEU A  80
PHE A  76
LEU A  25
LEU A  62
LEU A  22
 None
 1.13A 1mx1B-2mjmA:
2.2		 1mx1B-2mjmA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 LEU A 166
PHE A 162
VAL A  69
LEU A 125
MET A  65
 None
 1.36A 1mx1B-2nwqA:
3.8		 1mx1B-2nwqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 LEU A 197
GLY A 224
VAL A 338
LEU A 357
LEU A 291
 None
 1.33A 1mx1B-2q3zA:
undetectable		 1mx1B-2q3zA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A 296
LEU A 336
LEU A 288
LEU A 309
LEU A 332
 VAL  A 296 ( 0.6A)
LEU  A 336 ( 0.6A)
LEU  A 288 ( 0.6A)
LEU  A 309 ( 0.6A)
LEU  A 332 ( 0.6A)
 1.40A 1mx1B-2qv2A:
undetectable		 1mx1B-2qv2A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 LEU A 548
VAL A 528
LEU A 505
LEU A 539
LEU A 503
 None
 1.35A 1mx1B-2vf8A:
undetectable		 1mx1B-2vf8A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpi GMP SYNTHASE

(Homo sapiens) 		PF00117
(GATase) 		5 LEU A 203
GLY A 199
VAL A 133
LEU A 143
LEU A 101
 None
 1.04A 1mx1B-2vpiA:
undetectable		 1mx1B-2vpiA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 259
PHE A 251
VAL A 289
LEU A 224
LEU A 276
 EDO  A 504 ( 4.7A)
None
None
None
None
 1.13A 1mx1B-2xsxA:
undetectable		 1mx1B-2xsxA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A1006
LEU A1008
LEU A 927
LEU A 883
MET A 970
 None
 1.23A 1mx1B-2xt6A:
undetectable		 1mx1B-2xt6A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		5 LEU A 388
LEU A 378
LEU A 294
LEU A 148
LEU A 381
 None
 1.32A 1mx1B-2z3tA:
undetectable		 1mx1B-2z3tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 LEU A 334
GLY A 150
VAL A 114
LEU A 120
LEU A 103
 None
 1.15A 1mx1B-2z8eA:
undetectable		 1mx1B-2z8eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 258
PHE A 250
VAL A 288
LEU A 223
LEU A 275
 None
 1.07A 1mx1B-3b97A:
undetectable		 1mx1B-3b97A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A  49
PHE A 111
GLY A  81
LEU A  12
LEU A  51
 None
 1.18A 1mx1B-3e97A:
undetectable		 1mx1B-3e97A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exc UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		PF09827
(CRISPR_Cas2) 		5 LEU X  27
GLY X  37
LEU X   4
LEU X  67
LEU X  47
 None
 1.19A 1mx1B-3excX:
undetectable		 1mx1B-3excX:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK

(Escherichia
coli) 		PF00106
(adh_short) 		5 LEU A  16
LEU A 139
LEU A 131
LEU A 135
MET A 175
 None
 1.29A 1mx1B-3f1kA:
4.0		 1mx1B-3f1kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 272
GLY A  96
VAL A  37
LEU A  71
LEU A 278
 None
 1.10A 1mx1B-3gazA:
undetectable		 1mx1B-3gazA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A  89
GLY A  88
LEU A 402
LEU A 431
LEU A 383
 None
 1.32A 1mx1B-3hpaA:
undetectable		 1mx1B-3hpaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Schistosoma
mansoni) 		PF01652
(IF4E) 		5 LEU A 149
LEU A 118
LEU A  63
LEU A 173
LEU A 117
 None
 1.26A 1mx1B-3hxgA:
undetectable		 1mx1B-3hxgA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 LEU A 603
VAL A 713
LEU A 632
LEU A 710
LEU A 631
 None
 1.38A 1mx1B-3hzjA:
2.2		 1mx1B-3hzjA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		5 LEU A  16
LEU A 139
LEU A 131
LEU A 135
MET A 175
 None
 1.33A 1mx1B-3iahA:
3.6		 1mx1B-3iahA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		5 LEU A  16
LEU A 139
LEU A 188
LEU A 131
LEU A 135
 None
 1.28A 1mx1B-3iahA:
3.6		 1mx1B-3iahA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 LEU A 457
SER A 258
VAL A 264
LEU A 282
LEU A 251
 None
 1.12A 1mx1B-3k5wA:
undetectable		 1mx1B-3k5wA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		9 LEU A1097
PHE A1101
GLY A1142
SER A1221
VAL A1254
LEU A1358
LEU A1363
MET A1425
HIS A1468
 WW2  A 193 ( 4.9A)
None
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
WW2  A 193 (-3.8A)
None
None
 0.38A 1mx1B-3k9bA:
62.1		 1mx1B-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 PHE A1101
GLY A1142
LEU A1255
LEU A1358
HIS A1468
 None
WW2  A 193 (-3.4A)
None
None
None
 1.29A 1mx1B-3k9bA:
62.1		 1mx1B-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 PHE A1021
LEU A1037
LEU A1108
LEU A 914
LEU A1036
 None
 1.26A 1mx1B-3mpxA:
undetectable		 1mx1B-3mpxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 LEU A 281
GLY A 207
VAL A 132
LEU A 125
LEU A 128
 None
 1.23A 1mx1B-3nizA:
undetectable		 1mx1B-3nizA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		5 LEU A 472
SER A 455
VAL A 423
LEU A 433
LEU A 429
 None
 1.04A 1mx1B-3nowA:
undetectable		 1mx1B-3nowA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		5 VAL B 309
LEU B 400
LEU B 376
LEU B 441
LEU B 399
 None
 1.43A 1mx1B-3nvnB:
undetectable		 1mx1B-3nvnB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8x ZETA-TOXIN

(Streptococcus
pyogenes) 		PF06414
(Zeta_toxin) 		5 LEU B 185
GLY B  40
SER B  44
LEU B 230
LEU B 226
 None
None
SO4  B 602 (-3.3A)
None
None
 1.22A 1mx1B-3q8xB:
2.1		 1mx1B-3q8xB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woz CLIP-ASSOCIATING
PROTEIN 2

(Mus musculus) 		no annotation 5 LEU A 711
PHE A 707
LEU A 722
LEU A 685
LEU A 729
 None
 1.21A 1mx1B-3wozA:
undetectable		 1mx1B-3wozA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 GLY A 496
LEU A 509
LEU A 467
LEU A 494
HIS A 466
 None
 1.27A 1mx1B-3zgbA:
undetectable		 1mx1B-3zgbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 GLY A 496
VAL A 505
LEU A 509
LEU A 467
LEU A 494
 None
 1.21A 1mx1B-3zgbA:
undetectable		 1mx1B-3zgbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A1006
LEU A1008
LEU A 927
LEU A 883
MET A 970
 None
 1.22A 1mx1B-3zhrA:
undetectable		 1mx1B-3zhrA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		5 LEU A 204
PHE A 182
LEU A 151
LEU A 142
LEU A 150
 None
 1.32A 1mx1B-4a3uA:
3.5		 1mx1B-4a3uA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A  60
PHE A  56
GLY A  59
LEU A  46
LEU A  42
 None
 1.27A 1mx1B-4arxA:
undetectable		 1mx1B-4arxA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		5 PHE A 548
VAL A 407
LEU A 403
LEU A 552
LEU A 501
 None
 1.28A 1mx1B-4fieA:
undetectable		 1mx1B-4fieA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		5 VAL A 131
LEU A 155
LEU A 151
LEU A 121
LEU A 158
 None
None
None
EDO  A 304 (-4.1A)
None
 1.24A 1mx1B-4g1kA:
undetectable		 1mx1B-4g1kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		5 VAL A 115
LEU A  84
LEU A  91
LEU A  54
LEU A  81
 None
 1.06A 1mx1B-4ggjA:
undetectable		 1mx1B-4ggjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i66 UNCHARACTERIZED
PROTEIN HOCH_4089

(Haliangium
ochraceum) 		PF13709
(DUF4159) 		5 LEU A 185
GLY A 178
VAL A 132
LEU A 136
LEU A 228
 None
 0.81A 1mx1B-4i66A:
undetectable		 1mx1B-4i66A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 GLY A 471
VAL A 476
LEU A 485
LEU A 481
LEU A 488
 None
 1.19A 1mx1B-4je5A:
undetectable		 1mx1B-4je5A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 LEU A 338
GLY A 390
VAL A 915
LEU A 972
LEU A 989
 None
 1.11A 1mx1B-4k0eA:
2.4		 1mx1B-4k0eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky9 BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 PHE A 314
VAL A 231
LEU A  61
LEU A 107
LEU A 102
 None
 1.27A 1mx1B-4ky9A:
undetectable		 1mx1B-4ky9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		5 LEU A  28
VAL A 116
LEU A  91
LEU A 118
LEU A  83
 None
 1.24A 1mx1B-4lomA:
undetectable		 1mx1B-4lomA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhl INTERLEUKIN-11

(Homo sapiens) 		PF07400
(IL11) 		5 LEU A 192
GLY A 191
LEU A  90
LEU A 140
LEU A  94
 None
 1.40A 1mx1B-4mhlA:
undetectable		 1mx1B-4mhlA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo3 COAGULATION FACTOR
VIII

(Sus scrofa) 		PF00754
(F5_F8_type_C) 		5 LEU M2306
VAL M2257
LEU M2321
LEU M2319
LEU M2297
 None
 1.19A 1mx1B-4mo3M:
undetectable		 1mx1B-4mo3M:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 LEU A 631
VAL A 741
LEU A 660
LEU A 738
LEU A 659
 None
 1.23A 1mx1B-4nc6A:
undetectable		 1mx1B-4nc6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		5 LEU A  79
LEU A 252
LEU A 256
LEU A  36
LEU A 249
 None
 1.31A 1mx1B-4nmwA:
11.5		 1mx1B-4nmwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 5 LEU A 518
VAL A 467
LEU A 463
LEU A 557
LEU A 523
 None
 1.21A 1mx1B-4nuzA:
undetectable		 1mx1B-4nuzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		5 PHE A 149
LEU A 301
LEU A 186
LEU A 190
HIS A 183
 None
 1.13A 1mx1B-4nz0A:
undetectable		 1mx1B-4nz0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 275
GLY A 252
VAL A 397
LEU A 145
LEU A 266
 None
 1.33A 1mx1B-4oqrA:
undetectable		 1mx1B-4oqrA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 LEU B  72
LEU B  92
LEU B 120
LEU B  85
LEU B  87
 None
 0.88A 1mx1B-4peqB:
undetectable		 1mx1B-4peqB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50

(Saccharomyces
cerevisiae) 		no annotation 5 PHE D 201
VAL D 338
LEU D 351
LEU D 342
LEU D 323
 None
 1.21A 1mx1B-4qqfD:
undetectable		 1mx1B-4qqfD:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r01 PUTATIVE NADH-FLAVIN
REDUCTASE

(Streptococcus
pneumoniae) 		PF13460
(NAD_binding_10) 		5 SER A  63
LEU A 143
LEU A 137
LEU A  55
LEU A  87
 None
 1.38A 1mx1B-4r01A:
3.3		 1mx1B-4r01A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A  60
PHE A  56
GLY A  59
LEU A  46
LEU A  42
 None
 1.24A 1mx1B-4w8jA:
undetectable		 1mx1B-4w8jA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		5 PHE A 548
VAL A 407
LEU A 403
LEU A 552
LEU A 501
 None
 1.34A 1mx1B-4xbrA:
undetectable		 1mx1B-4xbrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 LEU A 498
PHE A 497
VAL A 191
LEU A 137
LEU A 141
 None
 1.03A 1mx1B-5ah5A:
undetectable		 1mx1B-5ah5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 LEU A 195
GLY A 233
VAL A 644
LEU A 192
LEU A 620
 None
 0.98A 1mx1B-5az4A:
undetectable		 1mx1B-5az4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A 671
LEU A 419
LEU A 937
LEU A 614
HIS A 934
 None
 0.85A 1mx1B-5b7iA:
undetectable		 1mx1B-5b7iA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 VAL A 305
LEU A 216
LEU A 249
LEU A  35
HIS A  34
 None
 1.42A 1mx1B-5c54A:
undetectable		 1mx1B-5c54A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhm IMMUNOREACTIVE 32
KDA ANTIGEN

(Porphyromonas
gingivalis) 		no annotation 5 VAL C 222
LEU C  69
LEU C 137
LEU C  66
LEU C  68
 None
 1.42A 1mx1B-5dhmC:
undetectable		 1mx1B-5dhmC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqj TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Saccharomyces
cerevisiae) 		PF04189
(Gcd10p) 		5 VAL A 373
LEU A 396
LEU A 369
LEU A 225
LEU A 442
 None
 1.23A 1mx1B-5eqjA:
undetectable		 1mx1B-5eqjA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 PHE A  84
GLY A 125
LEU A 238
LEU A 340
HIS A 449
 None
 1.30A 1mx1B-5fv4A:
66.4		 1mx1B-5fv4A:
78.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 PHE A  84
GLY A 125
SER A 204
LEU A 340
HIS A 449
 None
 0.17A 1mx1B-5fv4A:
66.4		 1mx1B-5fv4A:
78.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 237
PHE A 239
LEU A 456
LEU A 408
LEU A 434
 None
 1.23A 1mx1B-5h80A:
undetectable		 1mx1B-5h80A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 LEU A 554
VAL A 591
LEU A 492
LEU A 490
MET A 589
 None
 1.28A 1mx1B-5hp5A:
undetectable		 1mx1B-5hp5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2

(Homo sapiens) 		PF00400
(WD40) 		5 LEU A 664
GLY A 658
VAL A 614
LEU A 622
LEU A 716
 None
 1.16A 1mx1B-5igqA:
undetectable		 1mx1B-5igqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 305
VAL A 296
LEU A 326
LEU A 323
LEU A 253
 None
 1.19A 1mx1B-5keiA:
undetectable		 1mx1B-5keiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzd N-ACETYLNEURAMINATE
LYASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		5 LEU A   8
GLY A   7
LEU A 187
LEU A 185
LEU A 194
 None
 1.30A 1mx1B-5kzdA:
undetectable		 1mx1B-5kzdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 LEU A 452
PHE A  43
LEU A 524
LEU A 466
LEU A 522
 None
 1.18A 1mx1B-5la7A:
undetectable		 1mx1B-5la7A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 SER A 117
LEU A 165
LEU A 125
LEU A 137
LEU A 167
 None
 1.23A 1mx1B-5ljoA:
undetectable		 1mx1B-5ljoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		5 LEU A 618
VAL A 631
LEU A 590
LEU A 599
LEU A 558
 None
 1.36A 1mx1B-5tr1A:
undetectable		 1mx1B-5tr1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 5 PHE A 548
VAL A 407
LEU A 403
LEU A 552
LEU A 501
 None
 1.30A 1mx1B-5vefA:
undetectable		 1mx1B-5vefA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wai ZINC FINGER PROTEIN
AEBP2

(Homo sapiens) 		no annotation 5 LEU C 477
LEU C 457
LEU C 415
LEU C 488
HIS C 418
 None
 1.26A 1mx1B-5waiC:
undetectable		 1mx1B-5waiC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve CASPASE

(Homo sapiens) 		PF00619
(CARD) 		5 LEU S  89
LEU S  20
LEU S  25
LEU S   9
LEU S  16
 None
 1.42A 1mx1B-5wveS:
undetectable		 1mx1B-5wveS:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 5 LEU A  35
VAL A  71
LEU A 165
LEU A  18
LEU A  60
 None
 1.33A 1mx1B-5x3hA:
1.7		 1mx1B-5x3hA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x47 3-DEHYDROQUINATE
DEHYDRATASE

(Acinetobacter
baumannii) 		PF01220
(DHquinase_II) 		5 LEU A 103
LEU A  27
LEU A  13
LEU A  16
HIS A   9
 None
 0.77A 1mx1B-5x47A:
undetectable		 1mx1B-5x47A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 VAL C 139
LEU C 148
LEU C 144
LEU C  77
LEU C 151
 None
 1.37A 1mx1B-5xn6C:
undetectable		 1mx1B-5xn6C:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 290
VAL A 127
LEU A 111
LEU A 125
LEU A 110
 None
 1.18A 1mx1B-5y2wA:
undetectable		 1mx1B-5y2wA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus) 		no annotation 5 LEU A 212
GLY A 196
LEU A  33
LEU A 209
LEU A  53
 None
 1.37A 1mx1B-5zfhA:
undetectable		 1mx1B-5zfhA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 5 LEU A  56
PHE A  65
VAL A 295
LEU A  21
LEU A 313
 None
None
None
None
ACT  A 503 ( 4.3A)
 1.11A 1mx1B-6duxA:
undetectable		 1mx1B-6duxA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 5 LEU A 463
LEU A 518
LEU A 485
LEU A 487
MET A 527
 None
 1.21A 1mx1B-6en3A:
undetectable		 1mx1B-6en3A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 5 LEU A 518
VAL A 467
LEU A 463
LEU A 557
LEU A 523
 None
 1.16A 1mx1B-6en3A:
undetectable		 1mx1B-6en3A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		no annotation 5 LEU A 137
VAL A  74
LEU A 119
LEU A  95
LEU A 148
 None
 1.34A 1mx1B-6fg8A:
undetectable		 1mx1B-6fg8A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g96 ACETYLTRANSFERASE

(Salmonella
enterica) 		no annotation 5 VAL B  64
LEU B 111
LEU B  92
LEU B 169
LEU B 112
 None
None
ACO  B 201 (-4.8A)
None
None
 1.17A 1mx1B-6g96B:
undetectable		 1mx1B-6g96B:
9.35