SIMILAR PATTERNS OF AMINO ACIDS FOR 1MX1_A_THAA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		5 LEU A  44
PHE A  60
GLY A 200
SER A 203
HIS A 231
 None
 1.14A 1mx1A-1c8uA:
undetectable		 1mx1A-1c8uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 LEU A 362
GLY A 330
GLY A 331
LEU A 399
LEU A 337
 None
 1.13A 1mx1A-1cj0A:
undetectable		 1mx1A-1cj0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		6 LEU C 464
GLY C 479
GLY C 480
VAL C 491
LEU C 495
LEU C 460
 None
 1.44A 1mx1A-1d7wC:
undetectable		 1mx1A-1d7wC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 LEU A1198
PHE A1175
GLY A1210
LEU A1257
LEU A1255
 None
 1.03A 1mx1A-1dllA:
undetectable		 1mx1A-1dllA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ete FLT3 LIGAND

(Homo sapiens) 		PF02947
(Flt3_lig) 		5 LEU A  38
GLY A  45
GLY A  46
LEU A 115
LEU A  52
 None
 1.02A 1mx1A-1eteA:
undetectable		 1mx1A-1eteA:
13.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 122
GLY A 123
SER A 209
VAL A 296
HIS A 449
 None
 1.11A 1mx1A-1gz7A:
40.1		 1mx1A-1gz7A:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		5 LEU A 356
PHE A 355
GLY A  17
VAL A 319
LEU A 349
 None
 1.15A 1mx1A-1j2bA:
undetectable		 1mx1A-1j2bA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		5 LEU A  76
PHE A  72
GLY A  59
GLY A  89
LEU A 115
 None
 0.92A 1mx1A-1j6oA:
undetectable		 1mx1A-1j6oA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		6 LEU A 132
GLY A 127
GLY A 128
SER A 202
LEU A 268
HIS A 338
 None
 1.35A 1mx1A-1jkmA:
19.2		 1mx1A-1jkmA:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		7 LEU A  97
PHE A 101
GLY A 142
GLY A 143
SER A 221
LEU A 255
HIS A 467
 None
 0.62A 1mx1A-1k4yA:
64.8		 1mx1A-1k4yA:
82.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		5 PHE A 122
GLY A 205
LEU A  67
MET A  64
HIS A 188
 None
 1.11A 1mx1A-1l8tA:
undetectable		 1mx1A-1l8tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 276
GLY A 248
GLY A 246
VAL A 143
LEU A 139
 None
 1.11A 1mx1A-1lgfA:
undetectable		 1mx1A-1lgfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		5 GLY A  37
GLY A  36
VAL A  75
LEU A  68
LEU A 101
 SAH  A 401 (-3.3A)
SAH  A 401 (-4.1A)
None
None
None
 1.13A 1mx1A-1m6yA:
2.3		 1mx1A-1m6yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		5 LEU A 129
PHE A 133
GLY A 119
LEU A  24
LEU A 177
 None
 1.01A 1mx1A-1nrkA:
undetectable		 1mx1A-1nrkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F
CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF08802
(CytB6-F_Fe-S)
PF16639
(Apocytochr_F_N) 		5 GLY R  51
GLY R  52
LEU A 264
LEU R  49
MET R  45
 None
None
None
SQD  R 950 ( 4.6A)
None
 1.16A 1mx1A-1q90R:
undetectable		 1mx1A-1q90R:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		5 LEU A 310
GLY A 233
GLY A 234
LEU A  75
HIS A  70
 None
 1.08A 1mx1A-1qlmA:
undetectable		 1mx1A-1qlmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		5 LEU A 331
VAL A 181
LEU A 135
LEU A 125
LEU A 124
 None
 1.16A 1mx1A-1tjrA:
undetectable		 1mx1A-1tjrA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A  76
GLY A  12
VAL A  52
LEU A  50
LEU A  19
 None
 0.79A 1mx1A-1txgA:
undetectable		 1mx1A-1txgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 LEU A 205
GLY A 265
GLY A 264
LEU A 283
LEU A  64
 None
None
None
FMT  A1212 ( 4.5A)
None
 0.73A 1mx1A-1u60A:
undetectable		 1mx1A-1u60A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 GLY A  96
GLY A  99
LEU A  53
LEU A  55
HIS A 169
 None
 0.86A 1mx1A-1uchA:
undetectable		 1mx1A-1uchA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		6 LEU A 148
PHE A 152
GLY A 257
VAL A 281
LEU A 285
LEU A 380
 None
 1.36A 1mx1A-1uedA:
undetectable		 1mx1A-1uedA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		5 LEU B 871
GLY A  33
SER A  38
VAL B 853
HIS A  14
 None
 1.14A 1mx1A-1us8B:
undetectable		 1mx1A-1us8B:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		5 LEU A  23
VAL A 294
LEU A 297
LEU A 254
LEU A 253
 None
 1.06A 1mx1A-1vhnA:
2.7		 1mx1A-1vhnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 LEU A  69
GLY A  21
SER A   4
VAL A  32
LEU A  43
 None
 1.10A 1mx1A-1x9sA:
undetectable		 1mx1A-1x9sA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yud HYPOTHETICAL PROTEIN
SO0799

(Shewanella
oneidensis) 		PF06172
(Cupin_5) 		5 GLY A  19
GLY A  20
SER A  52
LEU A  46
HIS A  55
 None
 1.06A 1mx1A-1yudA:
undetectable		 1mx1A-1yudA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 370
GLY A 431
VAL A 483
LEU A 484
LEU A 357
 None
 1.06A 1mx1A-1zrzA:
undetectable		 1mx1A-1zrzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 LEU A 219
PHE A 114
GLY A 221
VAL A 261
LEU A 317
 None
None
None
TYR  A 888 (-4.7A)
None
 1.15A 1mx1A-2amcA:
undetectable		 1mx1A-2amcA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01544
(CorA) 		5 LEU A  87
GLY A  77
VAL A  50
LEU A  51
LEU A 137
 None
 0.83A 1mx1A-2bbhA:
undetectable		 1mx1A-2bbhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 226
GLY A 251
GLY A 250
VAL A 327
LEU A 328
 None
 1.14A 1mx1A-2bi0A:
undetectable		 1mx1A-2bi0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		5 LEU A 290
PHE A 131
GLY A 268
LEU A 418
LEU A 294
 None
 1.16A 1mx1A-2canA:
undetectable		 1mx1A-2canA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 5 GLY A  72
VAL A  28
LEU A  48
LEU A 102
LEU A 100
 None
 1.06A 1mx1A-2dstA:
undetectable		 1mx1A-2dstA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Thermus
thermophilus) 		PF00106
(adh_short) 		5 PHE A 144
GLY A 140
GLY A 181
SER A 137
VAL A 203
 None
 1.11A 1mx1A-2ehdA:
3.6		 1mx1A-2ehdA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE

(Aquifex
aeolicus) 		PF02441
(Flavoprotein) 		5 LEU A  24
PHE A  29
VAL A 147
LEU A 173
LEU A 174
 None
 1.10A 1mx1A-2ejbA:
undetectable		 1mx1A-2ejbA:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 LEU A  98
GLY A 146
GLY A 147
SER A 226
HIS A 471
 None
TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
 0.93A 1mx1A-2fj0A:
49.2		 1mx1A-2fj0A:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 194
GLY A 195
VAL A 482
LEU A 479
LEU A 158
 None
 1.10A 1mx1A-2ipiA:
undetectable		 1mx1A-2ipiA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  55
GLY A  86
GLY A  88
SER A  90
LEU A 117
 None
 1.03A 1mx1A-2l3gA:
undetectable		 1mx1A-2l3gA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN

(Homo sapiens) 		PF02545
(Maf) 		5 GLY A 175
GLY A 174
VAL A 121
LEU A 114
LEU A 185
 None
 0.80A 1mx1A-2p5xA:
undetectable		 1mx1A-2p5xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 LEU A 205
GLY A 265
GLY A 264
LEU A 283
LEU A  63
 None
 0.99A 1mx1A-2pbyA:
undetectable		 1mx1A-2pbyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		5 GLY A 160
VAL A  28
LEU A  77
LEU A 173
LEU A 177
 None
 0.82A 1mx1A-2ps3A:
undetectable		 1mx1A-2ps3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rir DIPICOLINATE
SYNTHASE, A CHAIN

(Bacillus
subtilis) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		5 LEU A  17
GLY A  12
GLY A  11
VAL A  83
LEU A  38
 None
 1.15A 1mx1A-2rirA:
undetectable		 1mx1A-2rirA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 215
GLY A 216
VAL A 505
LEU A 502
LEU A 179
 None
 1.12A 1mx1A-2wdwA:
undetectable		 1mx1A-2wdwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x86 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Escherichia
coli) 		PF01370
(Epimerase) 		5 LEU A  42
GLY A   7
GLY A   6
LEU A  33
HIS A 177
 None
None
NAP  A 400 (-3.4A)
None
NAP  A 400 (-4.0A)
 0.95A 1mx1A-2x86A:
2.9		 1mx1A-2x86A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 186
GLY A 187
VAL A 479
LEU A 476
LEU A 150
 None
 1.13A 1mx1A-2y3sA:
undetectable		 1mx1A-2y3sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 GLY A  85
GLY A  86
SER A 157
LEU A 213
HIS A 284
 None
 0.95A 1mx1A-2yh2A:
19.4		 1mx1A-2yh2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 LEU A  58
GLY A  72
VAL A 421
LEU A 110
LEU A 115
 None
 1.16A 1mx1A-2z00A:
undetectable		 1mx1A-2z00A:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze3 DFA0005

(Deinococcus
ficus) 		PF13714
(PEP_mutase) 		5 LEU A 125
GLY A 174
VAL A 205
LEU A 203
LEU A 129
 None
 1.04A 1mx1A-2ze3A:
undetectable		 1mx1A-2ze3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		6 LEU A 145
PHE A 149
GLY A 255
VAL A 279
LEU A 283
LEU A 377
 None
 1.42A 1mx1A-3abbA:
undetectable		 1mx1A-3abbA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp7 ALKALINE SERINE
PROTEASE AL20

(Nesterenkonia
aethiopica) 		PF13365
(Trypsin_2) 		5 GLY A 166
GLY A 167
SER A 169
VAL A  12
HIS A  41
 FMT  A 219 (-3.5A)
FMT  A 219 (-3.6A)
FMT  A 219 (-2.6A)
None
FMT  A 219 (-3.9A)
 1.10A 1mx1A-3cp7A:
undetectable		 1mx1A-3cp7A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cy5 HEMOGLOBIN SUBUNIT
BETA

(Bubalus bubalis) 		PF00042
(Globin) 		5 LEU B  68
GLY B  24
GLY B  25
LEU B 110
HIS B 117
 None
 1.15A 1mx1A-3cy5B:
undetectable		 1mx1A-3cy5B:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		5 LEU A 122
GLY A  87
LEU A  69
LEU A  93
HIS A  45
 None
 1.05A 1mx1A-3d9wA:
undetectable		 1mx1A-3d9wA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		5 PHE A 145
GLY A 209
GLY A 207
LEU A  15
LEU A 186
 None
 1.00A 1mx1A-3e8jA:
undetectable		 1mx1A-3e8jA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		5 LEU A1622
GLY A1550
VAL A1524
LEU A1508
LEU A1620
 None
 1.02A 1mx1A-3hrrA:
undetectable		 1mx1A-3hrrA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		10 LEU A1097
PHE A1101
GLY A1142
GLY A1143
SER A1221
VAL A1254
LEU A1255
LEU A1363
MET A1364
HIS A1468
 WW2  A 193 ( 4.9A)
None
WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
WW2  A 193 (-3.8A)
None
None
 0.46A 1mx1A-3k9bA:
67.2		 1mx1A-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lft UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF04392
(ABC_sub_bind) 		5 LEU A 106
VAL A 298
LEU A 299
LEU A 132
LEU A 125
 None
 1.02A 1mx1A-3lftA:
2.4		 1mx1A-3lftA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg0 ORNITHINE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00202
(Aminotran_3) 		5 LEU A 260
PHE A 101
GLY A 238
LEU A 389
LEU A 264
 None
 1.05A 1mx1A-3lg0A:
undetectable		 1mx1A-3lg0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 LEU A 352
GLY A 364
LEU A 456
LEU A 153
LEU A 130
 None
 1.13A 1mx1A-3m6xA:
undetectable		 1mx1A-3m6xA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 LEU X  56
GLY X 171
GLY X 170
LEU X 203
LEU X   9
 None
 1.06A 1mx1A-3m7mX:
undetectable		 1mx1A-3m7mX:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
PRE3

(Saccharomyces
cerevisiae) 		no annotation 5 PHE N  83
GLY N 103
VAL N 184
LEU N 178
LEU N  63
 None
 1.13A 1mx1A-3mg6N:
undetectable		 1mx1A-3mg6N:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		5 LEU A  14
GLY A   9
GLY A   8
VAL A  81
HIS A  76
 None
FAD  A 501 (-4.5A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.9A)
None
 0.99A 1mx1A-3r9uA:
undetectable		 1mx1A-3r9uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF16823
(PilZ_2) 		5 LEU A  96
GLY A  29
LEU A 156
LEU A 126
LEU A 135
 None
 1.09A 1mx1A-3rqaA:
undetectable		 1mx1A-3rqaA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 626
GLY A 461
GLY A 462
VAL A 426
LEU A 467
 None
 1.07A 1mx1A-3u9sA:
2.2		 1mx1A-3u9sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 LEU A 412
GLY A 415
GLY A 416
LEU A 459
MET A 462
 None
 1.13A 1mx1A-3ua4A:
undetectable		 1mx1A-3ua4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		5 LEU A 116
GLY A 156
VAL A 169
LEU A 168
LEU A  10
 None
None
EDO  A 402 ( 4.4A)
None
None
 1.14A 1mx1A-3wczA:
undetectable		 1mx1A-3wczA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  58
GLY A  30
GLY A  33
VAL A  95
LEU A  51
 None
 1.15A 1mx1A-4a73A:
2.2		 1mx1A-4a73A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei) 		PF00656
(Peptidase_C14) 		5 LEU A 336
PHE A 152
GLY A 107
LEU A 292
MET A 293
 None
 1.16A 1mx1A-4afrA:
undetectable		 1mx1A-4afrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A  12
GLY A  13
VAL A  49
LEU A  47
LEU A 130
 None
 1.16A 1mx1A-4b45A:
3.0		 1mx1A-4b45A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 135
SER A 220
VAL A 256
LEU A 315
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 ( 4.4A)
1PE  A1553 (-4.3A)
None
 0.94A 1mx1A-4be9A:
41.2		 1mx1A-4be9A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 5 LEU A 409
GLY A 454
VAL A 490
LEU A 491
LEU A 396
 None
 1.08A 1mx1A-4bwkA:
undetectable		 1mx1A-4bwkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU A   3
GLY A 205
VAL A 189
LEU A 215
LEU A 174
 None
 1.12A 1mx1A-4d8uA:
undetectable		 1mx1A-4d8uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g41 MTA/SAH NUCLEOSIDASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		5 LEU A 222
GLY A   4
LEU A  62
LEU A  43
LEU A  16
 LEU  A 222 ( 0.6A)
GLY  A   4 ( 0.0A)
LEU  A  62 ( 0.6A)
LEU  A  43 ( 0.6A)
LEU  A  16 ( 0.6A)
 1.13A 1mx1A-4g41A:
undetectable		 1mx1A-4g41A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		6 LEU A   3
GLY A  79
GLY A  80
LEU A  76
LEU A  86
HIS A 185
 None
None
None
None
None
EDO  A 403 (-4.1A)
 1.12A 1mx1A-4gyiA:
undetectable		 1mx1A-4gyiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		6 LEU N 148
GLY N 150
VAL N 226
LEU N 104
LEU N 108
MET N 107
 None
 1.31A 1mx1A-4heaN:
undetectable		 1mx1A-4heaN:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 5 LEU A 237
PHE A 242
GLY A 190
VAL A  56
LEU A 195
 None
 1.05A 1mx1A-4i4nA:
2.3		 1mx1A-4i4nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 LEU A 345
PHE A 348
GLY A 358
VAL A 419
LEU A 416
 None
 1.03A 1mx1A-4lz6A:
undetectable		 1mx1A-4lz6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 LEU A 802
GLY A 801
VAL A 769
LEU A 778
LEU A 806
 None
 1.14A 1mx1A-4ncjA:
undetectable		 1mx1A-4ncjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		5 GLY A  21
SER A  82
LEU A 183
LEU A 161
HIS A 235
 CL  A 301 ( 4.0A)
CL  A 301 (-2.8A)
None
None
None
 1.10A 1mx1A-4nmwA:
11.5		 1mx1A-4nmwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 126
GLY A 111
LEU A 134
LEU A  75
LEU A  82
 None
 1.10A 1mx1A-4up7A:
undetectable		 1mx1A-4up7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		5 GLY A  90
GLY A  91
SER A 164
LEU A 217
HIS A 291
 None
 0.88A 1mx1A-4wy8A:
18.7		 1mx1A-4wy8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yii ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
UBIQUITIN-CONJUGATIN
G ENZYME E2 C

(Homo sapiens) 		PF00179
(UQ_con)
PF08672
(ANAPC2) 		5 LEU U 132
GLY U  64
LEU A 765
LEU U  42
MET U  43
 None
 1.01A 1mx1A-4yiiU:
undetectable		 1mx1A-4yiiU:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoc ESTERASE

(Thermogutta
terrifontis) 		PF07859
(Abhydrolase_3) 		5 LEU A 159
GLY A 129
GLY A 128
VAL A  92
LEU A 164
 None
None
None
PEG  A1293 ( 4.9A)
None
 1.10A 1mx1A-5aocA:
18.7		 1mx1A-5aocA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A 193
GLY A 191
GLY A 331
VAL A 245
LEU A 242
 None
 1.02A 1mx1A-5cnxA:
undetectable		 1mx1A-5cnxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		5 LEU A 279
GLY A 278
GLY A 277
LEU A 310
LEU A  83
 None
 1.15A 1mx1A-5d8gA:
undetectable		 1mx1A-5d8gA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A1063
GLY A 979
GLY A 978
LEU A1019
LEU A1026
 None
 1.15A 1mx1A-5fkuA:
undetectable		 1mx1A-5fkuA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 GLY K   6
VAL K 127
LEU K 115
LEU K 143
HIS K 132
 None
 0.98A 1mx1A-5fmgK:
undetectable		 1mx1A-5fmgK:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		7 PHE A  84
GLY A 125
GLY A 126
SER A 204
LEU A 238
MET A 345
HIS A 449
 None
 0.43A 1mx1A-5fv4A:
67.0		 1mx1A-5fv4A:
78.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 108
GLY A 109
SER A 188
LEU A  24
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.58A 1mx1A-5hc4A:
20.5		 1mx1A-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		5 LEU A 448
SER A 407
LEU A 409
LEU A 495
MET A 444
 None
 1.14A 1mx1A-5hmqA:
undetectable		 1mx1A-5hmqA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		6 LEU A 630
GLY A 645
GLY A 646
VAL A 657
LEU A 661
LEU A 626
 None
 1.41A 1mx1A-5mfaA:
undetectable		 1mx1A-5mfaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 LEU A1198
PHE A1175
GLY A1210
LEU A1257
LEU A1255
 None
 1.11A 1mx1A-5n0cA:
undetectable		 1mx1A-5n0cA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 LEU A 130
PHE A 122
GLY A 101
LEU A 132
MET A 133
 None
 1.08A 1mx1A-5n6vA:
undetectable		 1mx1A-5n6vA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7z LIPOPOLYSACCHARIDE
1,6-GALACTOSYLTRANSF
ERASE

(Salmonella
enterica) 		no annotation 5 GLY A 292
LEU A 305
LEU A 274
LEU A 275
MET A 278
 None
 1.04A 1mx1A-5n7zA:
undetectable		 1mx1A-5n7zA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 LEU A 645
PHE A 746
GLY A 628
LEU A 624
LEU A 634
 None
 1.12A 1mx1A-5n94A:
undetectable		 1mx1A-5n94A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 LEU A 108
PHE A  88
GLY A  46
VAL A  15
LEU A  18
 None
 1.06A 1mx1A-5nz7A:
undetectable		 1mx1A-5nz7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue0 CT622 PROTEIN

(Chlamydia
trachomatis) 		no annotation 5 LEU A 465
GLY A 485
LEU A 639
LEU A 548
LEU A 515
 None
 1.05A 1mx1A-5ue0A:
undetectable		 1mx1A-5ue0A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A

(Homo sapiens) 		PF00628
(PHD)
PF01388
(ARID)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
PF08429
(PLU-1) 		5 LEU A 514
GLY A 505
SER A 572
LEU A 545
MET A 546
 None
 1.11A 1mx1A-5v9pA:
undetectable		 1mx1A-5v9pA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 5 PHE A 312
GLY A 305
VAL A  15
LEU A  18
LEU A 330
 None
 1.00A 1mx1A-5w1eA:
undetectable		 1mx1A-5w1eA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A  35
GLY A 103
VAL A 139
LEU A 134
LEU A 179
 None
 1.13A 1mx1A-5wi5A:
undetectable		 1mx1A-5wi5A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 6 LEU A 630
GLY A 645
GLY A 646
VAL A 657
LEU A 661
LEU A 626
 None
 1.44A 1mx1A-6azpA:
undetectable		 1mx1A-6azpA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 5 LEU A 324
PHE A 317
GLY A 276
LEU A 228
LEU A 285
 None
 1.07A 1mx1A-6bwmA:
undetectable		 1mx1A-6bwmA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 5 LEU A 636
GLY A 813
VAL A 843
LEU A 847
LEU A 994
 None
 1.08A 1mx1A-6d6yA:
undetectable		 1mx1A-6d6yA:
8.50