SIMILAR PATTERNS OF AMINO ACIDS FOR 1MUO_A_ADNA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE


(Salmonella
enterica)
PF00291
(PALP)
6 LEU A 181
GLY A 178
VAL A 175
ALA A 201
LEU A 214
LEU A 240
None
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.1A)
None
None
None
0.99A 1muoA-1d6sA:
undetectable
1muoA-1d6sA:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 LEU A  93
GLY A  94
VAL A 101
ALA A 114
TYR A 166
None
0.43A 1muoA-1fotA:
23.2
1muoA-1fotA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A  70
GLY A  71
VAL A  78
ALA A  91
LEU A 193
STU  A 401 (-3.9A)
STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-4.7A)
0.51A 1muoA-1nxkA:
7.8
1muoA-1nxkA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
6 GLY A 212
VAL A 219
ALA A 230
LEU A 260
TYR A 282
LEU A 340
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.2A)
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
0.81A 1muoA-1py5A:
16.7
1muoA-1py5A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
6 LEU A 164
GLY A 165
VAL A 172
ALA A 185
LEU A 226
LEU A 301
ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
ADP  A 810 (-4.7A)
0.82A 1muoA-1q8yA:
6.8
1muoA-1q8yA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 616
GLY A 617
VAL A 624
ALA A 642
TYR A 693
LEU A 818
None
0.67A 1muoA-1rjbA:
17.2
1muoA-1rjbA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 595
GLY A 596
VAL A 603
ALA A 621
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.76A 1muoA-1t46A:
7.7
1muoA-1t46A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
LEU A 468
STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.7A)
STU  A 100 (-4.5A)
0.60A 1muoA-1u59A:
7.6
1muoA-1u59A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A  86
LEU A 137
HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
0.71A 1muoA-1zltA:
7.0
1muoA-1zltA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LEU A  78
LEU A 155
STU  A1301 (-4.2A)
STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 ( 4.8A)
1.05A 1muoA-2bujA:
8.2
1muoA-2bujA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL


(Homo sapiens)
PF00682
(HMGL-like)
6 LEU A 263
GLY A  43
ALA A 261
LEU A 299
ALA A 302
LEU A  63
None
1.13A 1muoA-2cw6A:
undetectable
1muoA-2cw6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU X  17
GLY X  18
VAL X  25
ALA X  37
TYR X  84
LEU X 137
STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
0.69A 1muoA-2dq7X:
8.4
1muoA-2dq7X:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
LEU A 393
H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
0.89A 1muoA-2h8hA:
7.8
1muoA-2h8hA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
5 VAL A  67
ALA A  80
TYR A 131
ALA A 132
LEU A 182
None
0.45A 1muoA-2hakA:
13.9
1muoA-2hakA:
29.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  55
GLY A  56
VAL A  63
ALA A  76
LEU A 108
LEU A 177
None
0.78A 1muoA-2hw6A:
24.3
1muoA-2hw6A:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 251
GLY A 252
VAL A 259
ALA A 271
LEU A 371
TYR A 318
None
None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.7A)
1.03A 1muoA-2og8A:
8.7
1muoA-2og8A:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 588
GLY A 589
VAL A 596
ALA A 614
TYR A 665
LEU A 785
None
0.77A 1muoA-2ogvA:
17.0
1muoA-2ogvA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
6 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
LEU A 468
ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
ANP  A 615 (-4.7A)
0.69A 1muoA-2ozoA:
9.6
1muoA-2ozoA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 487
GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
None
0.78A 1muoA-2psqA:
7.9
1muoA-2psqA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwj MITOCHONDRIAL
PEROXIREDOXIN


(Pisum sativum)
PF08534
(Redoxin)
6 GLY A 145
VAL A 142
ALA A 140
LEU A 122
ALA A  12
LEU A 120
None
1.29A 1muoA-2pwjA:
undetectable
1muoA-2pwjA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  83
VAL A  90
ALA A 103
TYR A 155
LEU A 205
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
0.51A 1muoA-2v55A:
9.7
1muoA-2v55A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LEU A 171
DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.9A)
0.50A 1muoA-2w4oA:
24.4
1muoA-2w4oA:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
6 LEU C  55
GLY C  56
VAL C  63
ALA C  76
TYR C 131
LEU C 183
ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
0.80A 1muoA-2wtkC:
9.9
1muoA-2wtkC:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A 112
GLY A 113
VAL A 120
ALA A 133
TYR A 182
LEU A 234
16X  A1374 (-4.1A)
16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.1A)
16X  A1374 ( 4.8A)
0.92A 1muoA-2x4fA:
11.2
1muoA-2x4fA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 487
GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
0.69A 1muoA-3b2tA:
7.7
1muoA-3b2tA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 484
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
0.64A 1muoA-3c4fA:
8.1
1muoA-3c4fA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Cryptosporidium
parvum)
PF00069
(Pkinase)
6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LEU A 173
TYR A 119
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
1.39A 1muoA-3eb0A:
18.7
1muoA-3eb0A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Cryptosporidium
parvum)
PF00069
(Pkinase)
6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A 119
LEU A 173
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.99A 1muoA-3eb0A:
18.7
1muoA-3eb0A:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
6 GLY A  63
VAL A  70
ALA A  83
TYR A 134
ALA A 135
LEU A 185
None
0.70A 1muoA-3fe3A:
23.8
1muoA-3fe3A:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 833
GLY A 834
VAL A 841
ALA A 859
TYR A 911
LEU A1029
8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
None
0.56A 1muoA-3hngA:
18.2
1muoA-3hngA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
6 GLY A  60
VAL A  67
ALA A  80
TYR A 131
ALA A 132
LEU A 182
None
0.51A 1muoA-3iecA:
10.5
1muoA-3iecA:
29.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
0.71A 1muoA-3lm5A:
15.1
1muoA-3lm5A:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS)
6 GLY A 211
VAL A 218
ALA A 229
LEU A 259
TYR A 281
LEU A 339
LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
0.85A 1muoA-3mdyA:
7.8
1muoA-3mdyA:
26.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
6 LEU A  61
VAL A  69
ALA A  82
TYR A 134
ALA A 135
LEU A 184
None
0.90A 1muoA-3mn3A:
22.9
1muoA-3mn3A:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A 171
GLY A 172
VAL A 179
ALA A 192
TYR A 242
LEU A 293
FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
0.76A 1muoA-3mtlA:
10.4
1muoA-3mtlA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  49
GLY A  50
VAL A  57
ALA A  70
TYR A 122
LEU A 173
XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
0.73A 1muoA-3mvjA:
9.8
1muoA-3mvjA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLY A 209
VAL A 216
ALA A 227
LEU A 257
TYR A 279
LEU A 337
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
0.97A 1muoA-3my0A:
16.3
1muoA-3my0A:
28.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nuu PKB-LIKE

(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  88
GLY A  89
VAL A  96
ALA A 109
TYR A 161
ALA A 162
LEU A 212
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
JOZ  A 361 (-3.8A)
None
0.61A 1muoA-3nuuA:
10.9
1muoA-3nuuA:
33.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 423
GLY A 424
VAL A 431
ALA A 443
TYR A 491
LEU A 543
PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
0.70A 1muoA-3sxsA:
8.8
1muoA-3sxsA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
0.52A 1muoA-3tt0A:
7.8
1muoA-3tt0A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
7 LEU A 295
GLY A 296
VAL A 303
ALA A 315
LEU A 347
TYR A 365
LEU A 423
None
0.98A 1muoA-3ulzA:
18.8
1muoA-3ulzA:
28.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w18 AURORA KINASE A

(Homo sapiens)
PF00069
(Pkinase)
8 LEU A 139
GLY A 140
VAL A 147
ALA A 160
LEU A 194
TYR A 212
ALA A 213
LEU A 263
N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
0.74A 1muoA-3w18A:
16.6
1muoA-3w18A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LEU A 198
ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-4.8A)
0.52A 1muoA-3wigA:
19.5
1muoA-3wigA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A1951
GLY A1952
VAL A1959
ALA A1978
LEU A2010
LEU A2086
VGH  A3000 ( 4.4A)
None
None
VGH  A3000 (-3.4A)
VGH  A3000 (-4.8A)
VGH  A3000 (-4.3A)
1.06A 1muoA-3zbfA:
18.8
1muoA-3zbfA:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af3 AURORA KINASE B

(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  83
GLY A  84
VAL A  91
ALA A 104
LEU A 138
TYR A 156
ALA A 157
LEU A 207
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
None
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-4.6A)
0.47A 1muoA-4af3A:
9.1
1muoA-4af3A:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 560
GLY A 561
VAL A 568
ALA A 586
TYR A 635
LEU A 699
LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
LTI  A1839 (-4.2A)
0.88A 1muoA-4at3A:
8.8
1muoA-4at3A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
6 GLY A 215
VAL A 222
ALA A 233
LEU A 263
TYR A 285
LEU A 343
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-4.7A)
0.88A 1muoA-4c02A:
7.8
1muoA-4c02A:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE


(Candida
albicans)
PF00069
(Pkinase)
7 LEU A 246
GLY A 247
VAL A 254
ALA A 267
TYR A 320
ALA A 321
LEU A 371
None
0.44A 1muoA-4c0tA:
10.8
1muoA-4c0tA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 616
GLY A 617
VAL A 624
ALA A 653
LEU A 773
TYR A 703
None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
0.98A 1muoA-4ckrA:
7.6
1muoA-4ckrA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
6 LEU A 663
VAL A 671
ALA A 684
TYR A 739
ALA A 740
LEU A 789
AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
0.53A 1muoA-4crsA:
20.6
1muoA-4crsA:
29.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eqm PROTEIN KINASE

(Staphylococcus
aureus)
PF00069
(Pkinase)
6 LEU A  16
GLY A  17
VAL A  24
ALA A  37
TYR A  89
LEU A 140
ANP  A 300 (-4.7A)
ANP  A 300 ( 4.4A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-4.3A)
ANP  A 300 (-4.7A)
0.64A 1muoA-4eqmA:
12.5
1muoA-4eqmA:
30.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 377
GLY A 378
VAL A 385
ALA A 400
ALA A 451
LEU A 501
0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-4.0A)
0SB  A 701 (-4.4A)
0.94A 1muoA-4f4pA:
7.6
1muoA-4f4pA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
6 LEU A 377
GLY A 378
VAL A 385
ALA A 400
ALA A 451
LEU A 501
ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
0.73A 1muoA-4fl3A:
8.9
1muoA-4fl3A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 LEU A 855
GLY A 856
VAL A 863
ALA A 880
TYR A 931
LEU A 983
IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
None
IZA  A2001 ( 4.7A)
0.74A 1muoA-4gl9A:
7.4
1muoA-4gl9A:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
6 LEU A 156
GLY A 157
VAL A 164
ALA A 177
TYR A 229
ALA A 230
0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
0.59A 1muoA-4gv1A:
9.6
1muoA-4gv1A:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 828
GLY A 829
VAL A 836
ALA A 853
TYR A 904
LEU A 956
19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
0.65A 1muoA-4hviA:
18.3
1muoA-4hviA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14604
(SH3_9)
6 LEU A 132
GLY A 133
VAL A 140
ALA A 156
ALA A 208
LEU A 259
None
0.63A 1muoA-4hzsA:
16.5
1muoA-4hzsA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 132
GLY A 133
VAL A 140
ALA A 156
ALA A 208
LEU A 259
1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 (-4.6A)
0.63A 1muoA-4id7A:
7.8
1muoA-4id7A:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN


(Toxoplasma
gondii)
PF14531
(Kinase-like)
6 LEU A 258
GLY A 259
VAL A 266
ALA A 279
ALA A 359
LEU A 416
ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.5A)
ANP  A 601 ( 4.9A)
0.86A 1muoA-4jrnA:
6.0
1muoA-4jrnA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
LEU A 393
0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0.84A 1muoA-4k11A:
7.7
1muoA-4k11A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 478
GLY A 479
VAL A 486
ALA A 506
TYR A 557
ALA A 558
LEU A 624
ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 (-3.7A)
ACP  A 801 (-4.4A)
0.73A 1muoA-4k33A:
18.3
1muoA-4k33A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLY A  43
VAL A  50
ALA A  61
TYR A 106
ALA A 107
LEU A 163
1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.3A)
0.75A 1muoA-4l52A:
18.7
1muoA-4l52A:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  33
GLY A  34
VAL A  41
ALA A  54
TYR A 101
LEU A 153
GOL  A 404 ( 3.6A)
None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.9A)
GOL  A 403 ( 4.4A)
0.78A 1muoA-4lg4A:
21.7
1muoA-4lg4A:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
6 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
LEU A 393
VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
0.80A 1muoA-4lggA:
7.0
1muoA-4lggA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2


(Plasmodium
falciparum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
5 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LEU A 199
STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.7A)
0.49A 1muoA-4mvfA:
6.0
1muoA-4mvfA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
0.75A 1muoA-4oliA:
7.8
1muoA-4oliA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
6 LEU A 627
GLY A 628
VAL A 635
ALA A 648
TYR A 703
LEU A 753
None
0.73A 1muoA-4otdA:
9.3
1muoA-4otdA:
29.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q9z HUMAN PROTEIN KINASE
C THETA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
6 LEU A 386
GLY A 387
VAL A 394
ALA A 407
TYR A 460
LEU A 511
PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
0.70A 1muoA-4q9zA:
9.4
1muoA-4q9zA:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 616
GLY A 617
VAL A 624
ALA A 642
TYR A 693
LEU A 818
P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
0.68A 1muoA-4rt7A:
8.1
1muoA-4rt7A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
6 LEU A  14
GLY A  15
VAL A  22
ALA A  35
LEU A 136
TYR A  83
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.8A)
ACP  A1264 ( 4.5A)
1.18A 1muoA-4ueuA:
12.1
1muoA-4ueuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
6 LEU A  14
GLY A  15
VAL A  22
ALA A  35
TYR A  83
LEU A 136
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
0.93A 1muoA-4ueuA:
12.1
1muoA-4ueuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
PF00226
(DnaJ)
6 LEU A 104
GLY A 105
VAL A 112
ALA A 125
TYR A 177
LEU A 228
ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.5A)
0.70A 1muoA-4wb7A:
10.2
1muoA-4wb7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 473
GLY A 474
VAL A 481
ALA A 501
ALA A 553
LEU A 619
40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.5A)
0.61A 1muoA-4xcuA:
8.4
1muoA-4xcuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00106
(adh_short)
6 GLY A 114
VAL A  58
ALA A  64
LEU A   9
ALA A 122
LEU A  80
None
NAD  A 300 (-3.6A)
None
None
None
None
1.19A 1muoA-4xgnA:
undetectable
1muoA-4xgnA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 LEU A 408
GLY A 409
VAL A 416
ALA A 428
TYR A 476
LEU A 528
None
0.99A 1muoA-4xi2A:
18.3
1muoA-4xi2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 616
GLY A 617
VAL A 624
ALA A 642
TYR A 693
LEU A 818
P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
0.81A 1muoA-4xufA:
23.5
1muoA-4xufA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
6 LEU A 408
GLY A 409
VAL A 416
ALA A 428
TYR A 476
LEU A 528
746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 (-4.4A)
0.71A 1muoA-4y93A:
11.6
1muoA-4y93A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2


(Mus musculus)
PF00069
(Pkinase)
6 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LEU A  80
LEU A 149
None
0.70A 1muoA-4ynzA:
15.9
1muoA-4ynzA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
0.67A 1muoA-5a46A:
7.8
1muoA-5a46A:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
6 GLY A  63
VAL A  70
ALA A  83
TYR A 134
ALA A 135
LEU A 185
5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
0.57A 1muoA-5es1A:
25.4
1muoA-5es1A:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eyk AURORA KINASE B-A

(Xenopus laevis)
PF00069
(Pkinase)
7 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LEU A 154
ALA A 173
LEU A 223
5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.8A)
5U5  A 401 (-3.9A)
5U5  A 401 (-4.7A)
0.51A 1muoA-5eykA:
28.0
1muoA-5eykA:
67.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
0.63A 1muoA-5f1zA:
7.7
1muoA-5f1zA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 730
GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
LEU A 881
PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 (-4.6A)
0.80A 1muoA-5fm2A:
8.5
1muoA-5fm2A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 599
GLY A 600
VAL A 607
ALA A 625
TYR A 676
LEU A 825
748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
0.70A 1muoA-5grnA:
18.0
1muoA-5grnA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A  28
VAL A  35
ALA A  50
TYR A  99
ALA A 100
LEU A 158
6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
0.72A 1muoA-5idnA:
9.6
1muoA-5idnA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2


(Homo sapiens)
PF00069
(Pkinase)
PF16579
(AdenylateSensor)
6 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
0.57A 1muoA-5isoA:
10.9
1muoA-5isoA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
6 LEU A  18
GLY A  19
VAL A  26
ALA A  39
LEU A  73
TYR A  91
None
0.73A 1muoA-5m09A:
6.0
1muoA-5m09A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE


(Homo sapiens)
no annotation 5 GLY A  18
VAL A  25
ALA A  38
TYR A  88
LEU A 139
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
0.49A 1muoA-5tvtA:
11.3
1muoA-5tvtA:
28.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  99
VAL A 106
ALA A 119
TYR A 171
LEU A 221
None
0.51A 1muoA-5u7qA:
10.0
1muoA-5u7qA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
no annotation 6 LEU A  24
VAL A  32
ALA A  45
LEU A  79
TYR A  97
LEU A 153
9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
9WS  A 401 (-4.6A)
0.82A 1muoA-5w5jA:
8.2
1muoA-5w5jA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4


(Mus musculus)
no annotation 6 GLY A  29
VAL A  36
ALA A  49
LEU A  82
TYR A  98
LEU A 150
VX6  A 402 ( 4.2A)
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 ( 4.8A)
VX6  A 402 (-4.3A)
VX6  A 402 (-4.4A)
0.65A 1muoA-5wnmA:
8.4
1muoA-5wnmA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 7 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LEU A 947
TYR A 965
LEU A1017
ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
0.74A 1muoA-5wnoA:
9.3
1muoA-5wnoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 6 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LEU A1017
TYR A 965
ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-4.4A)
0.94A 1muoA-5wnoA:
9.3
1muoA-5wnoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN


(Arabidopsis
thaliana)
no annotation 6 GLY A  76
VAL A  83
ALA A  95
TYR A 143
ALA A 144
LEU A 206
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
ANP  A1000 (-3.5A)
ANP  A1000 (-4.5A)
0.76A 1muoA-5xd6A:
19.7
1muoA-5xd6A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 6 LEU A  33
GLY A  34
VAL A  41
ALA A  54
TYR A 101
LEU A 153
ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.2A)
ANP  A 501 (-4.6A)
0.74A 1muoA-6ao5A:
21.1
1muoA-6ao5A:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2


(Homo sapiens)
no annotation 6 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 4.5A)
0.67A 1muoA-6bx6A:
20.7
1muoA-6bx6A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP)
no annotation 6 LEU A 187
GLY A 186
VAL A 412
LEU A 248
TYR A 223
ALA A 220
None
1.49A 1muoA-6c62A:
undetectable
1muoA-6c62A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1


(Homo sapiens)
no annotation 6 GLY A  67
VAL A  74
ALA A  87
TYR A 138
ALA A 139
LEU A 189
None
0.66A 1muoA-6c9dA:
10.4
1muoA-6c9dA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 6 LEU A 197
GLY A 198
VAL A 205
ALA A 217
LEU A 248
LEU A 319
FKY  A9001 (-4.1A)
FKY  A9001 ( 4.0A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 ( 4.9A)
0.78A 1muoA-6cz4A:
11.6
1muoA-6cz4A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
no annotation 7 LEU A 730
GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
LEU A 881
ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-4.3A)
0.73A 1muoA-6fekA:
7.7
1muoA-6fekA:
15.22