SIMILAR PATTERNS OF AMINO ACIDS FOR 1MUO_A_ADNA1_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6s | O-ACETYLSERINESULFHYDRYLASE (Salmonellaenterica) |
PF00291(PALP) | 6 | LEU A 181GLY A 178VAL A 175ALA A 201LEU A 214LEU A 240 | NonePLP A 501 (-3.6A)PLP A 501 ( 4.1A)NoneNoneNone | 0.99A | 1muoA-1d6sA:undetectable | 1muoA-1d6sA:22.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fot | CAMP-DEPENDENTPROTEIN KINASE TYPE1 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | LEU A 93GLY A 94VAL A 101ALA A 114TYR A 166 | None | 0.43A | 1muoA-1fotA:23.2 | 1muoA-1fotA:33.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nxk | MAP KINASE-ACTIVATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 70GLY A 71VAL A 78ALA A 91LEU A 193 | STU A 401 (-3.9A)STU A 401 (-3.6A)STU A 401 (-4.7A)STU A 401 (-3.4A)STU A 401 (-4.7A) | 0.51A | 1muoA-1nxkA:7.8 | 1muoA-1nxkA:28.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1py5 | TGF-BETA RECEPTORTYPE I (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 6 | GLY A 212VAL A 219ALA A 230LEU A 260TYR A 282LEU A 340 | NonePY1 A 700 ( 4.7A)PY1 A 700 (-3.5A)PY1 A 700 (-4.2A)PY1 A 700 (-4.6A)PY1 A 700 (-4.4A) | 0.81A | 1muoA-1py5A:16.7 | 1muoA-1py5A:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8y | SR PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | LEU A 164GLY A 165VAL A 172ALA A 185LEU A 226LEU A 301 | ADP A 810 ( 4.3A)ADP A 810 (-3.3A)ADP A 810 (-4.1A)ADP A 810 (-3.3A)ADP A 810 (-4.4A)ADP A 810 (-4.7A) | 0.82A | 1muoA-1q8yA:6.8 | 1muoA-1q8yA:25.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616GLY A 617VAL A 624ALA A 642TYR A 693LEU A 818 | None | 0.67A | 1muoA-1rjbA:17.2 | 1muoA-1rjbA:27.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 595GLY A 596VAL A 603ALA A 621TYR A 672LEU A 799 | STI A 3 ( 3.8A)NoneSTI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 ( 4.0A)STI A 3 (-4.4A) | 0.76A | 1muoA-1t46A:7.7 | 1muoA-1t46A:27.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u59 | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 344GLY A 345VAL A 352ALA A 367ALA A 417LEU A 468 | STU A 100 (-3.8A)STU A 100 (-3.3A)STU A 100 (-4.8A)STU A 100 (-3.2A)STU A 100 (-3.7A)STU A 100 (-4.5A) | 0.60A | 1muoA-1u59A:7.6 | 1muoA-1u59A:29.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 15GLY A 16VAL A 23ALA A 36TYR A 86LEU A 137 | HYM A 400 (-4.2A)HYM A 400 ( 3.8A)HYM A 400 (-4.3A)HYM A 400 (-3.5A)HYM A 400 (-4.7A)HYM A 400 (-4.5A) | 0.71A | 1muoA-1zltA:7.0 | 1muoA-1zltA:29.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buj | SERINE/THREONINE-PROTEIN KINASE 16 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 26GLY A 27VAL A 34ALA A 47LEU A 78LEU A 155 | STU A1301 (-4.2A)STU A1301 ( 3.8A)STU A1301 (-4.8A)STU A1301 (-3.6A)NoneSTU A1301 ( 4.8A) | 1.05A | 1muoA-2bujA:8.2 | 1muoA-2bujA:26.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cw6 | HYDROXYMETHYLGLUTARYL-COA LYASE,MITOCHONDRIAL (Homo sapiens) |
PF00682(HMGL-like) | 6 | LEU A 263GLY A 43ALA A 261LEU A 299ALA A 302LEU A 63 | None | 1.13A | 1muoA-2cw6A:undetectable | 1muoA-2cw6A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU X 17GLY X 18VAL X 25ALA X 37TYR X 84LEU X 137 | STU X 902 (-3.8A)STU X 902 ( 3.7A)STU X 902 ( 4.8A)STU X 902 (-3.1A)STU X 902 (-4.6A)STU X 902 (-4.4A) | 0.69A | 1muoA-2dq7X:8.4 | 1muoA-2dq7X:26.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | LEU A 273GLY A 274VAL A 281ALA A 293TYR A 340LEU A 393 | H8H A 534 (-3.8A)H8H A 534 ( 3.8A)H8H A 534 (-4.4A)H8H A 534 (-3.2A)H8H A 534 (-4.3A)H8H A 534 (-4.5A) | 0.89A | 1muoA-2h8hA:7.8 | 1muoA-2h8hA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hak | SERINE/THREONINE-PROTEIN KINASE MARK1 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 5 | VAL A 67ALA A 80TYR A 131ALA A 132LEU A 182 | None | 0.45A | 1muoA-2hakA:13.9 | 1muoA-2hakA:29.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hw6 | MAPKINASE-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 55GLY A 56VAL A 63ALA A 76LEU A 108LEU A 177 | None | 0.78A | 1muoA-2hw6A:24.3 | 1muoA-2hw6A:30.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 251GLY A 252VAL A 259ALA A 271LEU A 371TYR A 318 | NoneNoneNone1N8 A 501 ( 3.4A)1N8 A 501 ( 4.3A)1N8 A 501 ( 3.7A) | 1.03A | 1muoA-2og8A:8.7 | 1muoA-2og8A:28.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 588GLY A 589VAL A 596ALA A 614TYR A 665LEU A 785 | None | 0.77A | 1muoA-2ogvA:17.0 | 1muoA-2ogvA:27.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ozo | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 6 | LEU A 344GLY A 345VAL A 352ALA A 367ALA A 417LEU A 468 | ANP A 615 (-4.4A)ANP A 615 ( 4.4A)ANP A 615 (-4.5A)ANP A 615 (-3.3A)ANP A 615 (-3.9A)ANP A 615 (-4.7A) | 0.69A | 1muoA-2ozoA:9.6 | 1muoA-2ozoA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 487GLY A 488VAL A 495ALA A 515TYR A 566ALA A 567LEU A 633 | None | 0.78A | 1muoA-2psqA:7.9 | 1muoA-2psqA:27.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwj | MITOCHONDRIALPEROXIREDOXIN (Pisum sativum) |
PF08534(Redoxin) | 6 | GLY A 145VAL A 142ALA A 140LEU A 122ALA A 12LEU A 120 | None | 1.29A | 1muoA-2pwjA:undetectable | 1muoA-2pwjA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v55 | RHO-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | GLY A 83VAL A 90ALA A 103TYR A 155LEU A 205 | ANP A1480 ( 4.3A)NoneANP A1480 ( 3.9A)ANP A1480 ( 4.9A)ANP A1480 ( 4.7A) | 0.51A | 1muoA-2v55A:9.7 | 1muoA-2v55A:27.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w4o | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE IV (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 52GLY A 53VAL A 60ALA A 73LEU A 171 | DKI A1338 (-3.8A)DKI A1338 (-3.3A)DKI A1338 (-4.2A)DKI A1338 ( 3.7A)DKI A1338 (-4.9A) | 0.50A | 1muoA-2w4oA:24.4 | 1muoA-2w4oA:31.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtk | SERINE/THREONINE-PROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU C 55GLY C 56VAL C 63ALA C 76TYR C 131LEU C 183 | ANP C 2 ( 4.4A)ANP C 2 (-3.3A)ANP C 2 (-4.2A)ANP C 2 (-3.4A)NoneNone | 0.80A | 1muoA-2wtkC:9.9 | 1muoA-2wtkC:27.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4f | MYOSIN LIGHT CHAINKINASE FAMILY MEMBER4 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 112GLY A 113VAL A 120ALA A 133TYR A 182LEU A 234 | 16X A1374 (-4.1A)16X A1374 (-3.4A)16X A1374 (-4.8A)16X A1374 ( 3.8A)16X A1374 (-4.1A)16X A1374 ( 4.8A) | 0.92A | 1muoA-2x4fA:11.2 | 1muoA-2x4fA:28.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 487GLY A 488VAL A 495ALA A 515TYR A 566ALA A 567LEU A 633 | M33 A1996 (-4.0A)M33 A1996 ( 3.8A)M33 A1996 ( 4.7A)M33 A1996 (-3.3A)M33 A1996 ( 4.7A)M33 A1996 (-3.8A)M33 A1996 (-4.5A) | 0.69A | 1muoA-3b2tA:7.7 | 1muoA-3b2tA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 484VAL A 492ALA A 512TYR A 563ALA A 564LEU A 630 | C4F A 1 ( 3.9A)NoneC4F A 1 (-3.3A)NoneC4F A 1 (-3.5A)C4F A 1 (-4.6A) | 0.64A | 1muoA-3c4fA:8.1 | 1muoA-3c4fA:28.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eb0 | PUTATIVEUNCHARACTERIZEDPROTEIN (Cryptosporidiumparvum) |
PF00069(Pkinase) | 6 | LEU A 15GLY A 16VAL A 23ALA A 36LEU A 173TYR A 119 | DRK A 384 (-3.8A)DRK A 384 ( 4.4A)NoneDRK A 384 (-3.5A)DRK A 384 (-4.4A)DRK A 384 (-4.4A) | 1.39A | 1muoA-3eb0A:18.7 | 1muoA-3eb0A:26.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eb0 | PUTATIVEUNCHARACTERIZEDPROTEIN (Cryptosporidiumparvum) |
PF00069(Pkinase) | 6 | LEU A 15GLY A 16VAL A 23ALA A 36TYR A 119LEU A 173 | DRK A 384 (-3.8A)DRK A 384 ( 4.4A)NoneDRK A 384 (-3.5A)DRK A 384 (-4.4A)DRK A 384 (-4.4A) | 0.99A | 1muoA-3eb0A:18.7 | 1muoA-3eb0A:26.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fe3 | MAP/MICROTUBULEAFFINITY-REGULATINGKINASE 3 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 6 | GLY A 63VAL A 70ALA A 83TYR A 134ALA A 135LEU A 185 | None | 0.70A | 1muoA-3fe3A:23.8 | 1muoA-3fe3A:30.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 833GLY A 834VAL A 841ALA A 859TYR A 911LEU A1029 | 8ST A2001 ( 4.7A)None8ST A2001 ( 4.6A)8ST A2001 ( 3.8A)8ST A2001 (-4.9A)None | 0.56A | 1muoA-3hngA:18.2 | 1muoA-3hngA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 6 | GLY A 60VAL A 67ALA A 80TYR A 131ALA A 132LEU A 182 | None | 0.51A | 1muoA-3iecA:10.5 | 1muoA-3iecA:29.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lm5 | SERINE/THREONINE-PROTEIN KINASE 17B (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 39GLY A 40VAL A 47ALA A 60TYR A 112ALA A 113LEU A 165 | QUE A 1 ( 3.8A)NoneQUE A 1 ( 4.6A)QUE A 1 (-3.2A)QUE A 1 (-4.9A)QUE A 1 (-3.9A)None | 0.71A | 1muoA-3lm5A:15.1 | 1muoA-3lm5A:30.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 6 | GLY A 211VAL A 218ALA A 229LEU A 259TYR A 281LEU A 339 | LDN A 1 ( 4.7A)LDN A 1 ( 4.8A)LDN A 1 (-3.6A)NoneLDN A 1 ( 4.8A)LDN A 1 (-4.5A) | 0.85A | 1muoA-3mdyA:7.8 | 1muoA-3mdyA:26.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mn3 | CARBONCATABOLITE-DEREPRESSING PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | LEU A 61VAL A 69ALA A 82TYR A 134ALA A 135LEU A 184 | None | 0.90A | 1muoA-3mn3A:22.9 | 1muoA-3mn3A:32.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mtl | CELL DIVISIONPROTEIN KINASE 16 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 171GLY A 172VAL A 179ALA A 192TYR A 242LEU A 293 | FEF A 668 ( 3.8A)FEF A 668 ( 4.2A)FEF A 668 (-4.9A)FEF A 668 (-3.3A)FEF A 668 (-4.7A)FEF A 668 (-4.2A) | 0.76A | 1muoA-3mtlA:10.4 | 1muoA-3mtlA:27.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvj | CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 49GLY A 50VAL A 57ALA A 70TYR A 122LEU A 173 | XFE A 351 (-4.2A)XFE A 351 ( 4.0A)XFE A 351 ( 4.5A)XFE A 351 (-3.2A)NoneXFE A 351 (-4.6A) | 0.73A | 1muoA-3mvjA:9.8 | 1muoA-3mvjA:28.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | GLY A 209VAL A 216ALA A 227LEU A 257TYR A 279LEU A 337 | NoneLDN A 600 (-4.5A)LDN A 600 (-3.2A)NoneLDN A 600 (-4.7A)LDN A 600 (-4.6A) | 0.97A | 1muoA-3my0A:16.3 | 1muoA-3my0A:28.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 88GLY A 89VAL A 96ALA A 109TYR A 161ALA A 162LEU A 212 | JOZ A 361 (-4.1A)JOZ A 361 ( 4.3A)JOZ A 361 ( 4.7A)JOZ A 361 (-3.4A)NoneJOZ A 361 (-3.8A)None | 0.61A | 1muoA-3nuuA:10.9 | 1muoA-3nuuA:33.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxs | CYTOPLASMICTYROSINE-PROTEINKINASE BMX (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 423GLY A 424VAL A 431ALA A 443TYR A 491LEU A 543 | PP2 A 1 (-4.1A)PP2 A 1 ( 4.1A)PP2 A 1 (-4.5A)PP2 A 1 (-3.2A)PP2 A 1 ( 4.9A)PP2 A 1 (-4.6A) | 0.70A | 1muoA-3sxsA:8.8 | 1muoA-3sxsA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 484GLY A 485VAL A 492ALA A 512TYR A 563ALA A 564LEU A 630 | 07J A 1 ( 4.3A)07J A 1 ( 4.9A)07J A 1 (-4.0A)07J A 1 (-3.5A)07J A 1 (-4.7A)07J A 1 (-3.8A)07J A 1 ( 4.4A) | 0.52A | 1muoA-3tt0A:7.8 | 1muoA-3tt0A:26.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulz | BRASSINOSTEROIDINSENSITIVE1-ASSOCIATEDRECEPTOR KINASE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 7 | LEU A 295GLY A 296VAL A 303ALA A 315LEU A 347TYR A 365LEU A 423 | None | 0.98A | 1muoA-3ulzA:18.8 | 1muoA-3ulzA:28.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w18 | AURORA KINASE A (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 139GLY A 140VAL A 147ALA A 160LEU A 194TYR A 212ALA A 213LEU A 263 | N13 A 501 (-3.7A)NoneN13 A 501 ( 4.7A)N13 A 501 ( 4.1A)N13 A 501 (-4.9A)N13 A 501 (-4.4A)N13 A 501 (-3.7A)N13 A 501 (-4.5A) | 0.74A | 1muoA-3w18A:16.6 | 1muoA-3w18A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wig | DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 75GLY A 76VAL A 83ALA A 96LEU A 198 | ANP A 401 (-3.8A)ANP A 401 ( 3.7A)ANP A 401 ( 4.3A)ANP A 401 (-3.2A)ANP A 401 (-4.8A) | 0.52A | 1muoA-3wigA:19.5 | 1muoA-3wigA:28.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A1951GLY A1952VAL A1959ALA A1978LEU A2010LEU A2086 | VGH A3000 ( 4.4A)NoneNoneVGH A3000 (-3.4A)VGH A3000 (-4.8A)VGH A3000 (-4.3A) | 1.06A | 1muoA-3zbfA:18.8 | 1muoA-3zbfA:26.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4af3 | AURORA KINASE B (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 83GLY A 84VAL A 91ALA A 104LEU A 138TYR A 156ALA A 157LEU A 207 | VX6 A 500 (-3.8A)VX6 A 500 ( 4.1A)VX6 A 500 ( 4.8A)VX6 A 500 (-3.4A)NoneVX6 A 500 (-4.2A)VX6 A 500 (-3.7A)VX6 A 500 (-4.6A) | 0.47A | 1muoA-4af3A:9.1 | 1muoA-4af3A:66.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 560GLY A 561VAL A 568ALA A 586TYR A 635LEU A 699 | LTI A1839 ( 4.2A)LTI A1839 ( 4.3A)NoneLTI A1839 (-3.3A)LTI A1839 (-4.7A)LTI A1839 (-4.2A) | 0.88A | 1muoA-4at3A:8.8 | 1muoA-4at3A:27.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c02 | ACTIVIN RECEPTORTYPE-1 (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 6 | GLY A 215VAL A 222ALA A 233LEU A 263TYR A 285LEU A 343 | NoneTAK A1507 (-4.7A)TAK A1507 (-3.3A)FLC A1503 ( 4.5A)TAK A1507 ( 4.6A)TAK A1507 (-4.7A) | 0.88A | 1muoA-4c02A:7.8 | 1muoA-4c02A:26.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0t | LIKELY PROTEINKINASE (Candidaalbicans) |
PF00069(Pkinase) | 7 | LEU A 246GLY A 247VAL A 254ALA A 267TYR A 320ALA A 321LEU A 371 | None | 0.44A | 1muoA-4c0tA:10.8 | 1muoA-4c0tA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616GLY A 617VAL A 624ALA A 653LEU A 773TYR A 703 | NoneNoneDI1 A1000 (-4.8A)DI1 A1000 (-3.6A)DI1 A1000 (-4.5A)DI1 A1000 (-4.0A) | 0.98A | 1muoA-4ckrA:7.6 | 1muoA-4ckrA:25.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 663VAL A 671ALA A 684TYR A 739ALA A 740LEU A 789 | AGS A1985 (-4.2A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)NoneAGS A1985 (-3.9A)AGS A1985 (-4.8A) | 0.53A | 1muoA-4crsA:20.6 | 1muoA-4crsA:29.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4eqm | PROTEIN KINASE (Staphylococcusaureus) |
PF00069(Pkinase) | 6 | LEU A 16GLY A 17VAL A 24ALA A 37TYR A 89LEU A 140 | ANP A 300 (-4.7A)ANP A 300 ( 4.4A)ANP A 300 ( 4.7A)ANP A 300 ( 3.8A)ANP A 300 (-4.3A)ANP A 300 (-4.7A) | 0.64A | 1muoA-4eqmA:12.5 | 1muoA-4eqmA:30.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4p | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 377GLY A 378VAL A 385ALA A 400ALA A 451LEU A 501 | 0SB A 701 ( 3.9A)0SB A 701 (-3.6A)0SB A 701 (-4.0A)0SB A 701 (-3.3A)0SB A 701 (-4.0A)0SB A 701 (-4.4A) | 0.94A | 1muoA-4f4pA:7.6 | 1muoA-4f4pA:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl3 | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 6 | LEU A 377GLY A 378VAL A 385ALA A 400ALA A 451LEU A 501 | ANP A 701 ( 4.6A)ANP A 701 ( 4.0A)ANP A 701 (-4.1A)ANP A 701 (-3.3A)ANP A 701 (-4.1A)ANP A 701 (-4.5A) | 0.73A | 1muoA-4fl3A:8.9 | 1muoA-4fl3A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl9 | TYROSINE-PROTEINKINASE (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | LEU A 855GLY A 856VAL A 863ALA A 880TYR A 931LEU A 983 | IZA A2001 (-3.7A)IZA A2001 ( 4.9A)NoneIZA A2001 (-3.4A)NoneIZA A2001 ( 4.7A) | 0.74A | 1muoA-4gl9A:7.4 | 1muoA-4gl9A:27.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gv1 | RAC-ALPHASERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 156GLY A 157VAL A 164ALA A 177TYR A 229ALA A 230 | 0XZ A 501 ( 4.1A)GOL A 505 ( 3.4A)0XZ A 501 (-4.5A)0XZ A 501 (-3.3A)0XZ A 501 ( 4.9A)0XZ A 501 (-3.7A) | 0.59A | 1muoA-4gv1A:9.6 | 1muoA-4gv1A:31.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 828GLY A 829VAL A 836ALA A 853TYR A 904LEU A 956 | 19S A1201 (-3.9A)19S A1201 (-3.7A)19S A1201 (-4.4A)19S A1201 (-3.3A)19S A1201 (-4.7A)19S A1201 (-4.5A) | 0.65A | 1muoA-4hviA:18.3 | 1muoA-4hviA:26.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzs | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14604(SH3_9) | 6 | LEU A 132GLY A 133VAL A 140ALA A 156ALA A 208LEU A 259 | None | 0.63A | 1muoA-4hzsA:16.5 | 1muoA-4hzsA:26.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4id7 | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 132GLY A 133VAL A 140ALA A 156ALA A 208LEU A 259 | 1G0 A 401 ( 4.5A)1G0 A 401 ( 4.2A)1G0 A 401 (-4.4A)1G0 A 401 (-3.6A)1G0 A 401 (-3.8A)1G0 A 401 (-4.6A) | 0.63A | 1muoA-4id7A:7.8 | 1muoA-4id7A:26.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrn | RHOPTRY KINASEFAMILY PROTEIN (Toxoplasmagondii) |
PF14531(Kinase-like) | 6 | LEU A 258GLY A 259VAL A 266ALA A 279ALA A 359LEU A 416 | ANP A 601 ( 4.6A)ANP A 601 (-3.4A)ANP A 601 (-4.1A)ANP A 601 ( 3.9A)ANP A 601 (-3.5A)ANP A 601 ( 4.9A) | 0.86A | 1muoA-4jrnA:6.0 | 1muoA-4jrnA:26.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | LEU A 273GLY A 274VAL A 281ALA A 293TYR A 340LEU A 393 | 0J9 A 601 (-4.0A)0J9 A 601 ( 4.0A)0J9 A 601 (-4.4A)0J9 A 601 (-3.3A)0J9 A 601 ( 4.7A)0J9 A 601 (-4.5A) | 0.84A | 1muoA-4k11A:7.7 | 1muoA-4k11A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 478GLY A 479VAL A 486ALA A 506TYR A 557ALA A 558LEU A 624 | ACP A 801 (-3.8A)ACP A 801 (-3.4A)ACP A 801 (-4.2A)ACP A 801 (-3.3A)NoneACP A 801 (-3.7A)ACP A 801 (-4.4A) | 0.73A | 1muoA-4k33A:18.3 | 1muoA-4k33A:28.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l52 | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 7,TGF-BETA-ACTIVATEDKINASE 1 ANDMAP3K7-BINDINGPROTEIN 1 CHIMERA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | GLY A 43VAL A 50ALA A 61TYR A 106ALA A 107LEU A 163 | 1UL A 501 ( 4.1A)1UL A 501 ( 4.9A)1UL A 501 (-3.1A)1UL A 501 (-4.1A)1UL A 501 (-3.6A)1UL A 501 (-4.3A) | 0.75A | 1muoA-4l52A:18.7 | 1muoA-4l52A:28.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg4 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 33GLY A 34VAL A 41ALA A 54TYR A 101LEU A 153 | GOL A 404 ( 3.6A)NoneGOL A 404 (-4.5A)GOL A 404 ( 3.1A)GOL A 404 ( 4.9A)GOL A 403 ( 4.4A) | 0.78A | 1muoA-4lg4A:21.7 | 1muoA-4lg4A:28.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 6 | LEU A 273GLY A 274VAL A 281ALA A 293TYR A 340LEU A 393 | VGG A 601 (-3.2A)VGG A 601 ( 3.8A)VGG A 601 ( 3.5A)VGG A 601 (-3.5A)VGG A 601 ( 4.0A)VGG A 601 (-4.5A) | 0.80A | 1muoA-4lggA:7.0 | 1muoA-4lggA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mvf | CALCIUM-DEPENDENTPROTEIN KINASE 2 (Plasmodiumfalciparum) |
PF00069(Pkinase)PF13499(EF-hand_7) | 5 | LEU A 78GLY A 79VAL A 86ALA A 99LEU A 199 | STU A 601 ( 4.0A)STU A 601 (-3.6A)STU A 601 (-4.8A)STU A 601 (-3.3A)STU A 601 (-4.7A) | 0.49A | 1muoA-4mvfA:6.0 | 1muoA-4mvfA:25.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oli | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 903GLY A 904VAL A 911ALA A 928TYR A 980LEU A1030 | 2TT A1202 (-3.5A)2TT A1202 ( 4.2A)2TT A1202 (-4.5A)2TT A1202 ( 3.9A)2TT A1202 (-4.6A)2TT A1202 (-4.4A) | 0.75A | 1muoA-4oliA:7.8 | 1muoA-4oliA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 627GLY A 628VAL A 635ALA A 648TYR A 703LEU A 753 | None | 0.73A | 1muoA-4otdA:9.3 | 1muoA-4otdA:29.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4q9z | HUMAN PROTEIN KINASEC THETA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 386GLY A 387VAL A 394ALA A 407TYR A 460LEU A 511 | PZW A 801 (-3.9A)PZW A 801 ( 3.8A)PZW A 801 (-4.6A)PZW A 801 (-3.5A)NonePZW A 801 (-4.8A) | 0.70A | 1muoA-4q9zA:9.4 | 1muoA-4q9zA:31.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616GLY A 617VAL A 624ALA A 642TYR A 693LEU A 818 | P30 A1001 (-3.8A)NoneNoneP30 A1001 (-3.4A)P30 A1001 (-4.1A)P30 A1001 (-4.6A) | 0.68A | 1muoA-4rt7A:8.1 | 1muoA-4rt7A:26.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 6 | LEU A 14GLY A 15VAL A 22ALA A 35LEU A 136TYR A 83 | ACP A1264 ( 4.5A)ACP A1264 ( 4.2A)ACP A1264 (-4.7A)ACP A1264 (-2.9A)ACP A1264 ( 4.8A)ACP A1264 ( 4.5A) | 1.18A | 1muoA-4ueuA:12.1 | 1muoA-4ueuA:28.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 6 | LEU A 14GLY A 15VAL A 22ALA A 35TYR A 83LEU A 136 | ACP A1264 ( 4.5A)ACP A1264 ( 4.2A)ACP A1264 (-4.7A)ACP A1264 (-2.9A)ACP A1264 ( 4.5A)ACP A1264 ( 4.8A) | 0.93A | 1muoA-4ueuA:12.1 | 1muoA-4ueuA:28.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 6 | LEU A 104GLY A 105VAL A 112ALA A 125TYR A 177LEU A 228 | ATP A 501 ( 4.3A)ATP A 501 (-3.5A)ATP A 501 (-4.0A)ATP A 501 (-3.4A)NoneATP A 501 (-4.5A) | 0.70A | 1muoA-4wb7A:10.2 | 1muoA-4wb7A:27.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 473GLY A 474VAL A 481ALA A 501ALA A 553LEU A 619 | 40M A1002 ( 4.6A)None40M A1002 ( 4.5A)40M A1002 ( 4.1A)40M A1002 (-3.7A)40M A1002 (-4.5A) | 0.61A | 1muoA-4xcuA:8.4 | 1muoA-4xcuA:27.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgn | 3-HYDROXYACYL-COADEHYDROGENASE (Burkholderiathailandensis) |
PF00106(adh_short) | 6 | GLY A 114VAL A 58ALA A 64LEU A 9ALA A 122LEU A 80 | NoneNAD A 300 (-3.6A)NoneNoneNoneNone | 1.19A | 1muoA-4xgnA:undetectable | 1muoA-4xgnA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xi2 | TYROSINE-PROTEINKINASE BTK (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | LEU A 408GLY A 409VAL A 416ALA A 428TYR A 476LEU A 528 | None | 0.99A | 1muoA-4xi2A:18.3 | 1muoA-4xi2A:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 616GLY A 617VAL A 624ALA A 642TYR A 693LEU A 818 | P30 A1001 (-4.0A)NoneP30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 ( 4.4A)P30 A1001 (-4.3A) | 0.81A | 1muoA-4xufA:23.5 | 1muoA-4xufA:27.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 6 | LEU A 408GLY A 409VAL A 416ALA A 428TYR A 476LEU A 528 | 746 A 702 (-3.8A)746 A 702 ( 3.5A)746 A 702 ( 4.3A)746 A 702 (-2.4A)746 A 702 (-4.4A)746 A 702 (-4.4A) | 0.71A | 1muoA-4y93A:11.6 | 1muoA-4y93A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynz | SERINE/THREONINE-PROTEIN KINASE BRSK2 (Mus musculus) |
PF00069(Pkinase) | 6 | LEU A 26GLY A 27VAL A 34ALA A 47LEU A 80LEU A 149 | None | 0.70A | 1muoA-4ynzA:15.9 | 1muoA-4ynzA:29.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 484GLY A 485VAL A 492ALA A 512TYR A 563ALA A 564LEU A 630 | 38O A1769 (-3.2A)38O A1769 ( 4.7A)38O A1769 (-4.5A)38O A1769 (-3.6A)38O A1769 (-4.2A)38O A1769 (-3.9A)38O A1769 (-4.6A) | 0.67A | 1muoA-5a46A:7.8 | 1muoA-5a46A:26.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5es1 | MAP/MICROTUBULEAFFINITY-REGULATINGKINASE 4 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 6 | GLY A 63VAL A 70ALA A 83TYR A 134ALA A 135LEU A 185 | 5RC A4000 ( 4.3A)5RC A4000 (-4.6A)5RC A4000 (-3.6A)5RC A4000 (-4.5A)5RC A4000 (-3.7A)None | 0.57A | 1muoA-5es1A:25.4 | 1muoA-5es1A:30.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eyk | AURORA KINASE B-A (Xenopus laevis) |
PF00069(Pkinase) | 7 | LEU A 99GLY A 100VAL A 107ALA A 120LEU A 154ALA A 173LEU A 223 | 5U5 A 401 (-3.8A)5U5 A 401 (-3.8A)5U5 A 401 ( 4.3A)5U5 A 401 (-3.5A)5U5 A 401 (-4.8A)5U5 A 401 (-3.9A)5U5 A 401 (-4.7A) | 0.51A | 1muoA-5eykA:28.0 | 1muoA-5eykA:67.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f1z | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 903GLY A 904VAL A 911ALA A 928TYR A 980LEU A1030 | 5U3 A1200 (-3.8A)5U3 A1200 ( 3.7A)5U3 A1200 ( 4.4A)5U3 A1200 (-3.5A)5U3 A1200 (-4.5A)5U3 A1200 (-4.4A) | 0.63A | 1muoA-5f1zA:7.7 | 1muoA-5f1zA:27.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 730GLY A 731VAL A 738ALA A 756TYR A 806ALA A 807LEU A 881 | PP1 A2012 (-4.6A)PP1 A2012 ( 3.9A)PP1 A2012 (-4.4A)PP1 A2012 (-3.2A)NonePP1 A2012 ( 3.5A)PP1 A2012 (-4.6A) | 0.80A | 1muoA-5fm2A:8.5 | 1muoA-5fm2A:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 599GLY A 600VAL A 607ALA A 625TYR A 676LEU A 825 | 748 A1001 (-3.8A)None748 A1001 ( 4.7A)748 A1001 (-3.7A)748 A1001 (-4.0A)748 A1001 (-4.3A) | 0.70A | 1muoA-5grnA:18.0 | 1muoA-5grnA:25.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idn | CYCLIN-DEPENDENTKINASE 8 (Homo sapiens) |
PF00069(Pkinase) | 6 | GLY A 28VAL A 35ALA A 50TYR A 99ALA A 100LEU A 158 | 6A7 A 401 (-3.6A)6A7 A 401 ( 4.5A)6A7 A 401 (-3.3A)6A7 A 401 (-4.9A)6A7 A 401 (-3.7A)6A7 A 401 (-4.8A) | 0.72A | 1muoA-5idnA:9.6 | 1muoA-5idnA:26.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iso | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-2 (Homo sapiens) |
PF00069(Pkinase)PF16579(AdenylateSensor) | 6 | LEU A 22GLY A 23VAL A 30ALA A 43TYR A 95LEU A 146 | STU A 601 (-4.1A)STU A 601 (-3.4A)STU A 601 (-4.8A)STU A 601 (-3.3A)STU A 601 (-4.3A)STU A 601 (-4.5A) | 0.57A | 1muoA-5isoA:10.9 | 1muoA-5isoA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m09 | SERINE/THREONINE-PROTEIN KINASE PKNI (Mycobacteriumtuberculosis) |
PF00069(Pkinase) | 6 | LEU A 18GLY A 19VAL A 26ALA A 39LEU A 73TYR A 91 | None | 0.73A | 1muoA-5m09A:6.0 | 1muoA-5m09A:25.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tvt | MATERNAL EMBRYONICLEUCINE ZIPPERKINASE (Homo sapiens) |
no annotation | 5 | GLY A 18VAL A 25ALA A 38TYR A 88LEU A 139 | 7LV A 401 ( 3.9A)7LV A 401 ( 4.6A)7LV A 401 (-3.4A)7LV A 401 (-4.6A)7LV A 401 (-4.9A) | 0.49A | 1muoA-5tvtA:11.3 | 1muoA-5tvtA:28.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u7q | RHO-ASSOCIATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | GLY A 99VAL A 106ALA A 119TYR A 171LEU A 221 | None | 0.51A | 1muoA-5u7qA:10.0 | 1muoA-5u7qA:30.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w5j | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) |
no annotation | 6 | LEU A 24VAL A 32ALA A 45LEU A 79TYR A 97LEU A 153 | 9WS A 401 ( 4.2A)9WS A 401 ( 4.6A)9WS A 401 (-3.3A)9WS A 401 (-4.9A)None9WS A 401 (-4.6A) | 0.82A | 1muoA-5w5jA:8.2 | 1muoA-5w5jA:28.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wnm | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 4 (Mus musculus) |
no annotation | 6 | GLY A 29VAL A 36ALA A 49LEU A 82TYR A 98LEU A 150 | VX6 A 402 ( 4.2A)VX6 A 402 (-4.6A)VX6 A 402 (-3.2A)VX6 A 402 ( 4.8A)VX6 A 402 (-4.3A)VX6 A 402 (-4.4A) | 0.65A | 1muoA-5wnmA:8.4 | 1muoA-5wnmA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wno | RECEPTORTYROSINE-PROTEINKINASE LET-23 (Caenorhabditiselegans) |
no annotation | 7 | LEU A 891GLY A 892VAL A 899ALA A 917LEU A 947TYR A 965LEU A1017 | ANP A1201 (-4.1A)ANP A1201 ( 3.8A)ANP A1201 (-4.4A)ANP A1201 (-3.3A)ANP A1201 (-4.7A)ANP A1201 (-4.4A)ANP A1201 (-4.7A) | 0.74A | 1muoA-5wnoA:9.3 | 1muoA-5wnoA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wno | RECEPTORTYROSINE-PROTEINKINASE LET-23 (Caenorhabditiselegans) |
no annotation | 6 | LEU A 891GLY A 892VAL A 899ALA A 917LEU A1017TYR A 965 | ANP A1201 (-4.1A)ANP A1201 ( 3.8A)ANP A1201 (-4.4A)ANP A1201 (-3.3A)ANP A1201 (-4.7A)ANP A1201 (-4.4A) | 0.94A | 1muoA-5wnoA:9.3 | 1muoA-5wnoA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xd6 | PROTEIN KINASESUPERFAMILY PROTEIN (Arabidopsisthaliana) |
no annotation | 6 | GLY A 76VAL A 83ALA A 95TYR A 143ALA A 144LEU A 206 | ANP A1000 ( 3.8A)ANP A1000 (-4.1A)ANP A1000 (-3.2A)ANP A1000 (-4.3A)ANP A1000 (-3.5A)ANP A1000 (-4.5A) | 0.76A | 1muoA-5xd6A:19.7 | 1muoA-5xd6A:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao5 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
no annotation | 6 | LEU A 33GLY A 34VAL A 41ALA A 54TYR A 101LEU A 153 | ANP A 501 ( 3.8A)ANP A 501 ( 3.9A)ANP A 501 (-4.4A)ANP A 501 ( 3.7A)ANP A 501 ( 4.2A)ANP A 501 (-4.6A) | 0.74A | 1muoA-6ao5A:21.1 | 1muoA-6ao5A:26.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bx6 | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-2 (Homo sapiens) |
no annotation | 6 | LEU A 22GLY A 23VAL A 30ALA A 43TYR A 95LEU A 146 | EDJ A 301 (-3.9A)EDJ A 301 (-3.4A)NoneEDJ A 301 (-3.4A)EDJ A 301 ( 4.8A)EDJ A 301 ( 4.5A) | 0.67A | 1muoA-6bx6A:20.7 | 1muoA-6bx6A:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c62 | BIURET HYDROLASE (Pseudomonas sp.ADP) |
no annotation | 6 | LEU A 187GLY A 186VAL A 412LEU A 248TYR A 223ALA A 220 | None | 1.49A | 1muoA-6c62A:undetectable | 1muoA-6c62A:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c9d | SERINE/THREONINE-PROTEIN KINASEMARK1,SERINE/THREONINE-PROTEIN KINASEMARK1 (Homo sapiens) |
no annotation | 6 | GLY A 67VAL A 74ALA A 87TYR A 138ALA A 139LEU A 189 | None | 0.66A | 1muoA-6c9dA:10.4 | 1muoA-6c9dA:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cz4 | PROTEIN-TYROSINEKINASE 6 (Homo sapiens) |
no annotation | 6 | LEU A 197GLY A 198VAL A 205ALA A 217LEU A 248LEU A 319 | FKY A9001 (-4.1A)FKY A9001 ( 4.0A)FKY A9001 ( 4.6A)FKY A9001 (-3.3A)FKY A9001 (-4.2A)FKY A9001 ( 4.9A) | 0.78A | 1muoA-6cz4A:11.6 | 1muoA-6cz4A:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fek | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
no annotation | 7 | LEU A 730GLY A 731VAL A 738ALA A 756TYR A 806ALA A 807LEU A 881 | ADN A1104 ( 4.0A)ADN A1104 ( 3.9A)ADN A1104 (-4.4A)ADN A1104 (-3.4A)ADN A1104 ( 4.1A)ADN A1104 (-3.6A)ADN A1104 (-4.3A) | 0.73A | 1muoA-6fekA:7.7 | 1muoA-6fekA:15.22 |