SIMILAR PATTERNS OF AMINO ACIDS FOR 1MT1_K_AG2K7002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 ARG A 308
LEU A  68
ASP A  64
GLY A 217
 None
 0.72A 1mt1H-1agxA:
0.0
1mt1K-1agxA:
0.0		 1mt1H-1agxA:
17.22
1mt1K-1agxA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ARG A 534
LEU A 426
ASP A 550
GLY A 593
 None
 0.91A 1mt1H-1b25A:
0.0
1mt1K-1b25A:
0.0		 1mt1H-1b25A:
13.14
1mt1K-1b25A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		4 GLU A 386
LEU A 382
LEU A 170
GLY A 171
 None
HEM  A 430 (-4.6A)
None
None
 0.80A 1mt1H-1cptA:
0.0
1mt1K-1cptA:
0.0		 1mt1H-1cptA:
14.18
1mt1K-1cptA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1deu PROCATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 ILE A 151
GLU A 139
LEU A   1
GLY A 149
 None
 0.89A 1mt1H-1deuA:
undetectable
1mt1K-1deuA:
undetectable		 1mt1H-1deuA:
15.81
1mt1K-1deuA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.91A 1mt1H-1e6vA:
0.4
1mt1K-1e6vA:
undetectable		 1mt1H-1e6vA:
11.53
1mt1K-1e6vA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ILE A 412
ARG A 410
ASP A 566
GLY A 572
 None
 0.88A 1mt1H-1g0dA:
0.9
1mt1K-1g0dA:
0.0		 1mt1H-1g0dA:
10.62
1mt1K-1g0dA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 ARG 1 248
LEU 1 343
ASP 1 252
LEU 1 188
 None
 0.80A 1mt1H-1gt91:
0.0
1mt1K-1gt91:
0.0		 1mt1H-1gt91:
13.55
1mt1K-1gt91:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iub FUCOSE-SPECIFIC
LECTIN

(Aleuria
aurantia) 		PF07938
(Fungal_lectin) 		4 ILE A  86
LEU A 115
LEU A 102
GLY A 103
 None
 0.83A 1mt1H-1iubA:
0.0
1mt1K-1iubA:
undetectable		 1mt1H-1iubA:
15.02
1mt1K-1iubA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU)
PF02287
(Dehydratase_SU) 		4 ILE A 490
LEU G  38
LEU A 472
GLY A 471
 None
 0.87A 1mt1H-1iwpA:
0.0
1mt1K-1iwpA:
0.0		 1mt1H-1iwpA:
11.05
1mt1K-1iwpA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE F 183
LEU F 103
LEU F 131
GLY F 130
 None
 0.87A 1mt1H-1j8mF:
undetectable
1mt1K-1j8mF:
undetectable		 1mt1H-1j8mF:
15.67
1mt1K-1j8mF:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 GLU A  34
LEU A 377
LEU A 316
GLY A 313
 None
 0.76A 1mt1H-1lwhA:
undetectable
1mt1K-1lwhA:
0.0		 1mt1H-1lwhA:
13.44
1mt1K-1lwhA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 LEU A 534
ASP A  85
LEU A  86
GLY A  83
 None
 0.84A 1mt1H-1mroA:
undetectable
1mt1K-1mroA:
undetectable		 1mt1H-1mroA:
10.79
1mt1K-1mroA:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF01862
(PvlArgDC) 		4 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.19A 1mt1H-1n2mA:
18.1
1mt1K-1n2mA:
3.2		 1mt1H-1n2mA:
67.88
1mt1K-1n2mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 ILE C 409
GLU C 300
LEU C 283
GLY C 441
 None
 0.77A 1mt1H-1n8yC:
undetectable
1mt1K-1n8yC:
undetectable		 1mt1H-1n8yC:
11.95
1mt1K-1n8yC:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 ILE A 607
LEU A 534
LEU A 589
GLY A 590
 None
 0.88A 1mt1H-1o94A:
undetectable
1mt1K-1o94A:
undetectable		 1mt1H-1o94A:
9.45
1mt1K-1o94A:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A   4
LEU A  57
LEU A  92
GLY A  93
 None
 0.69A 1mt1H-1qorA:
undetectable
1mt1K-1qorA:
undetectable		 1mt1H-1qorA:
17.93
1mt1K-1qorA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5

(Glycine max) 		PF13499
(EF-hand_7) 		4 ILE A  27
LEU A  75
LEU A  36
GLY A  35
 None
 0.88A 1mt1H-1s6iA:
undetectable
1mt1K-1s6iA:
undetectable		 1mt1H-1s6iA:
20.00
1mt1K-1s6iA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.89A 1mt1H-1t1eA:
undetectable
1mt1K-1t1eA:
undetectable		 1mt1H-1t1eA:
10.26
1mt1K-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ILE A  82
LEU A  67
ASP A  71
LEU A  74
 None
 0.81A 1mt1H-1u3dA:
undetectable
1mt1K-1u3dA:
undetectable		 1mt1H-1u3dA:
12.57
1mt1K-1u3dA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ARG A 159
LEU A 169
ASP A 165
GLY A 160
 None
 0.88A 1mt1H-1ub3A:
undetectable
1mt1K-1ub3A:
undetectable		 1mt1H-1ub3A:
18.67
1mt1K-1ub3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vaj HYPOTHETICAL PROTEIN
PH0010

(Pyrococcus
horikoshii) 		PF01871
(AMMECR1) 		4 ILE A  66
ARG A  92
LEU A 147
GLY A  64
 None
 0.89A 1mt1H-1vajA:
2.1
1mt1K-1vajA:
undetectable		 1mt1H-1vajA:
21.66
1mt1K-1vajA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi7 HYPOTHETICAL PROTEIN
YIGZ

(Escherichia
coli) 		PF01205
(UPF0029)
PF09186
(DUF1949) 		4 ILE A 165
LEU A 192
LEU A 180
GLY A 163
 None
 0.90A 1mt1H-1vi7A:
undetectable
1mt1K-1vi7A:
undetectable		 1mt1H-1vi7A:
17.89
1mt1K-1vi7A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y88 HYPOTHETICAL PROTEIN
AF1548

(Archaeoglobus
fulgidus) 		PF04471
(Mrr_cat) 		4 ARG A  13
ASP A 153
LEU A 148
GLY A 147
 None
 0.87A 1mt1H-1y88A:
undetectable
1mt1K-1y88A:
undetectable		 1mt1H-1y88A:
19.49
1mt1K-1y88A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zle PTR NECROSIS TOXIN

(Pyrenophora
tritici-repentis) 		PF11584
(Toxin_ToxA) 		4 ILE A 120
LEU A 161
LEU A 108
GLY A 107
 None
 0.92A 1mt1H-1zleA:
undetectable
1mt1K-1zleA:
undetectable		 1mt1H-1zleA:
18.05
1mt1K-1zleA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 ILE A 241
ARG A 216
ASP A 300
GLY A 243
 None
 0.83A 1mt1H-2bihA:
undetectable
1mt1K-2bihA:
undetectable		 1mt1H-2bihA:
12.88
1mt1K-2bihA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 ILE A 241
ARG A 216
ASP A 300
LEU A 301
GLY A 243
 None
 1.05A 1mt1H-2biiA:
undetectable
1mt1K-2biiA:
undetectable		 1mt1H-2biiA:
13.67
1mt1K-2biiA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 186
LEU A 271
LEU A 245
GLY A 184
 None
 0.84A 1mt1H-2cf5A:
undetectable
1mt1K-2cf5A:
undetectable		 1mt1H-2cf5A:
18.28
1mt1K-2cf5A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 GLU A 292
ARG A 338
LEU A 288
GLY A 392
 None
 0.91A 1mt1H-2dc0A:
undetectable
1mt1K-2dc0A:
undetectable		 1mt1H-2dc0A:
13.72
1mt1K-2dc0A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ARG A 191
ASP A 218
LEU A 217
GLY A 202
 None
 0.83A 1mt1H-2djzA:
0.6
1mt1K-2djzA:
undetectable		 1mt1H-2djzA:
16.60
1mt1K-2djzA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ARG A 414
LEU A 441
ASP A 442
GLY A 353
 None
NAD  A5555 (-4.5A)
None
None
 0.63A 1mt1H-2fknA:
undetectable
1mt1K-2fknA:
undetectable		 1mt1H-2fknA:
12.68
1mt1K-2fknA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		4 GLU C 156
LEU C 152
LEU C 142
GLY C 139
 None
 0.91A 1mt1H-2fm8C:
undetectable
1mt1K-2fm8C:
undetectable		 1mt1H-2fm8C:
23.81
1mt1K-2fm8C:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm9 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		4 GLU A 156
LEU A 152
LEU A 142
GLY A 139
 None
 0.90A 1mt1H-2fm9A:
undetectable
1mt1K-2fm9A:
undetectable		 1mt1H-2fm9A:
26.63
1mt1K-2fm9A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g42 HYPOTHETICAL PROTEIN
TM_0693

(Thermotoga
maritima) 		no annotation 4 ARG A  29
LEU A  52
ASP A  48
LEU A  45
 None
 0.75A 1mt1H-2g42A:
undetectable
1mt1K-2g42A:
undetectable		 1mt1H-2g42A:
23.89
1mt1K-2g42A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfp MULTIDRUG RESISTANCE
PROTEIN D

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ILE A  26
ASP A  33
LEU A 238
GLY A 239
 None
 0.90A 1mt1H-2gfpA:
undetectable
1mt1K-2gfpA:
undetectable		 1mt1H-2gfpA:
12.83
1mt1K-2gfpA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583

(Discosoma sp.) 		PF01353
(GFP) 		4 ILE A 180
LEU A 189
LEU A 150
GLY A 159
 None
 0.91A 1mt1H-2h8qA:
undetectable
1mt1K-2h8qA:
undetectable		 1mt1H-2h8qA:
19.20
1mt1K-2h8qA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivy HYPOTHETICAL PROTEIN
SSO1404

(Sulfolobus
solfataricus) 		PF09827
(CRISPR_Cas2) 		4 GLU A  77
ASP A  30
LEU A  29
GLY A  28
 None
 0.85A 1mt1H-2ivyA:
undetectable
1mt1K-2ivyA:
undetectable		 1mt1H-2ivyA:
20.49
1mt1K-2ivyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 ARG A 297
LEU A 467
ASP A 466
LEU A 289
 None
 0.91A 1mt1H-2jgpA:
1.1
1mt1K-2jgpA:
undetectable		 1mt1H-2jgpA:
11.37
1mt1K-2jgpA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 332
LEU A 282
ASP A 283
LEU A 121
GLY A 120
 None
 1.46A 1mt1H-2ongA:
undetectable
1mt1K-2ongA:
undetectable		 1mt1H-2ongA:
10.58
1mt1K-2ongA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.60A 1mt1H-2pbgA:
undetectable
1mt1K-2pbgA:
undetectable		 1mt1H-2pbgA:
13.23
1mt1K-2pbgA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 ILE A 228
ARG A  50
LEU A 322
GLY A  47
 None
FAD  A 401 ( 4.1A)
None
None
 0.89A 1mt1H-2q6uA:
0.7
1mt1K-2q6uA:
undetectable		 1mt1H-2q6uA:
14.07
1mt1K-2q6uA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR

(Geobacillus
stearothermophilus) 		PF01047
(MarR) 		4 ILE A 107
LEU A  73
LEU A  82
GLY A 103
 None
 0.82A 1mt1H-2rdpA:
undetectable
1mt1K-2rdpA:
undetectable		 1mt1H-2rdpA:
21.79
1mt1K-2rdpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		4 GLU A 313
LEU A 309
LEU A 120
GLY A 121
 None
HEM  A 410 ( 4.5A)
None
None
 0.84A 1mt1H-2rfbA:
undetectable
1mt1K-2rfbA:
undetectable		 1mt1H-2rfbA:
14.75
1mt1K-2rfbA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ARG A 418
LEU A 445
ASP A 446
GLY A 357
 None
NAD  A3001 (-4.1A)
None
None
 0.57A 1mt1H-2v7gA:
undetectable
1mt1K-2v7gA:
undetectable		 1mt1H-2v7gA:
13.19
1mt1K-2v7gA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 GLU A 108
LEU A 161
LEU A  92
GLY A 151
 MN  A1005 (-2.5A)
None
None
None
 0.73A 1mt1H-2vqaA:
undetectable
1mt1K-2vqaA:
undetectable		 1mt1H-2vqaA:
13.47
1mt1K-2vqaA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		4 ILE A 222
LEU A 385
LEU A 274
GLY A 275
 None
 0.83A 1mt1H-2yg1A:
undetectable
1mt1K-2yg1A:
undetectable		 1mt1H-2yg1A:
11.40
1mt1K-2yg1A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 ARG A 404
LEU A  40
ASP A  36
LEU A  33
 None
 0.77A 1mt1H-2ynkA:
undetectable
1mt1K-2ynkA:
undetectable		 1mt1H-2ynkA:
13.36
1mt1K-2ynkA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ytw SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A 107
ASP A  70
LEU A  66
GLY A  65
 None
 0.75A 1mt1H-2ytwA:
undetectable
1mt1K-2ytwA:
undetectable		 1mt1H-2ytwA:
18.05
1mt1K-2ytwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		4 ILE A 393
ASP A 355
LEU A 351
GLY A 350
 None
 0.80A 1mt1H-2zleA:
undetectable
1mt1K-2zleA:
undetectable		 1mt1H-2zleA:
13.17
1mt1K-2zleA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1y ACIDIC RIBOSOMAL
PROTEIN P0

(Pyrococcus
horikoshii) 		PF00466
(Ribosomal_L10) 		4 LEU G 192
ASP G 190
LEU G 189
GLY G 188
 None
 0.90A 1mt1H-3a1yG:
undetectable
1mt1K-3a1yG:
undetectable		 1mt1H-3a1yG:
17.44
1mt1K-3a1yG:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 GLU A 362
LEU A 358
LEU A 162
GLY A 163
 HEM  A1430 ( 4.7A)
HEM  A1430 ( 4.8A)
None
None
 0.90A 1mt1H-3abbA:
undetectable
1mt1K-3abbA:
undetectable		 1mt1H-3abbA:
15.02
1mt1K-3abbA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		4 LEU A  43
ASP A  44
LEU A  53
GLY A  50
 None
 0.86A 1mt1H-3bxoA:
undetectable
1mt1K-3bxoA:
undetectable		 1mt1H-3bxoA:
15.56
1mt1K-3bxoA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		5 GLU A  52
LEU A  54
ASP A 275
LEU A 276
GLY A 273
 None
 1.27A 1mt1H-3d9wA:
undetectable
1mt1K-3d9wA:
undetectable		 1mt1H-3d9wA:
15.86
1mt1K-3d9wA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		4 LEU A 287
ASP A 288
LEU A 297
GLY A 294
 None
 0.83A 1mt1H-3dliA:
undetectable
1mt1K-3dliA:
undetectable		 1mt1H-3dliA:
20.09
1mt1K-3dliA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		4 ARG A 226
ASP A 139
LEU A 142
GLY A 143
 None
 0.76A 1mt1H-3dpiA:
undetectable
1mt1K-3dpiA:
undetectable		 1mt1H-3dpiA:
17.50
1mt1K-3dpiA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		4 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.82A 1mt1H-3e8sA:
undetectable
1mt1K-3e8sA:
undetectable		 1mt1H-3e8sA:
17.39
1mt1K-3e8sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gx1 LIN1832 PROTEIN

(Listeria
innocua) 		PF03610
(EIIA-man) 		4 ILE A 653
LEU A 566
LEU A 646
GLY A 647
 None
None
SO4  A 709 ( 4.2A)
None
 0.83A 1mt1H-3gx1A:
undetectable
1mt1K-3gx1A:
undetectable		 1mt1H-3gx1A:
21.43
1mt1K-3gx1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ILE A  82
ARG A  85
ASP A 141
GLY A 132
 None
 0.71A 1mt1H-3h55A:
undetectable
1mt1K-3h55A:
undetectable		 1mt1H-3h55A:
14.18
1mt1K-3h55A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		4 ILE A 390
GLU A 457
LEU A 467
GLY A 428
 None
 0.87A 1mt1H-3icjA:
undetectable
1mt1K-3icjA:
undetectable		 1mt1H-3icjA:
11.86
1mt1K-3icjA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 ILE B 219
LEU B1061
LEU B 251
GLY B 250
 None
 0.89A 1mt1H-3iz3B:
undetectable
1mt1K-3iz3B:
undetectable		 1mt1H-3iz3B:
6.67
1mt1K-3iz3B:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		4 ILE D 552
LEU D 565
LEU D 444
GLY D 450
 None
 0.89A 1mt1H-3k70D:
undetectable
1mt1K-3k70D:
undetectable		 1mt1H-3k70D:
10.89
1mt1K-3k70D:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ILE A  24
GLU A 323
LEU A 344
ASP A 401
 None
 0.91A 1mt1H-3k92A:
undetectable
1mt1K-3k92A:
undetectable		 1mt1H-3k92A:
14.77
1mt1K-3k92A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 ILE A 181
LEU A 101
LEU A 129
GLY A 128
 None
 0.90A 1mt1H-3kl4A:
undetectable
1mt1K-3kl4A:
undetectable		 1mt1H-3kl4A:
14.55
1mt1K-3kl4A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Salmonella
enterica) 		PF00926
(DHBP_synthase) 		4 GLU A  40
ARG A 150
LEU A 140
GLY A  94
 5SP  A 500 (-3.9A)
5SP  A 500 (-2.8A)
5SP  A 500 ( 4.8A)
None
 0.87A 1mt1H-3lquA:
undetectable
1mt1K-3lquA:
undetectable		 1mt1H-3lquA:
21.66
1mt1K-3lquA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m05 UNCHARACTERIZED
PROTEIN PEPE_1480

(Pediococcus
pentosaceus) 		PF06153
(CdAMP_rec) 		4 ARG A  69
LEU A  18
ASP A  14
GLY A  96
 None
 0.86A 1mt1H-3m05A:
undetectable
1mt1K-3m05A:
undetectable		 1mt1H-3m05A:
19.67
1mt1K-3m05A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)

(Rhodobacter
sphaeroides) 		PF00588
(SpoU_methylase) 		5 ARG A  11
LEU A 129
ASP A 126
LEU A 122
GLY A 116
 None
None
None
None
ACY  A 250 (-4.5A)
 1.36A 1mt1H-3onpA:
undetectable
1mt1K-3onpA:
undetectable		 1mt1H-3onpA:
19.68
1mt1K-3onpA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		4 ARG A 233
LEU A 349
ASP A 177
GLY A 175
 None
 0.89A 1mt1H-3pg5A:
undetectable
1mt1K-3pg5A:
undetectable		 1mt1H-3pg5A:
16.43
1mt1K-3pg5A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 ILE L 266
LEU L 188
LEU L 181
GLY L 225
 None
 0.91A 1mt1H-3rkoL:
undetectable
1mt1K-3rkoL:
undetectable		 1mt1H-3rkoL:
10.42
1mt1K-3rkoL:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 4 ILE A 207
LEU A  62
LEU A 212
GLY A 209
 None
 0.88A 1mt1H-3s4lA:
undetectable
1mt1K-3s4lA:
undetectable		 1mt1H-3s4lA:
20.99
1mt1K-3s4lA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ILE B 118
GLU B 220
LEU B 187
GLY B 125
 None
 0.88A 1mt1H-3sqgB:
undetectable
1mt1K-3sqgB:
undetectable		 1mt1H-3sqgB:
13.79
1mt1K-3sqgB:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 ARG A 265
ASP A 303
LEU A 273
GLY A 272
 None
None
None
SO4  A 543 ( 3.8A)
 0.80A 1mt1H-3sqlA:
undetectable
1mt1K-3sqlA:
undetectable		 1mt1H-3sqlA:
12.52
1mt1K-3sqlA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 248
LEU A  23
ASP A 289
GLY A 256
 None
 0.89A 1mt1H-3u4aA:
undetectable
1mt1K-3u4aA:
undetectable		 1mt1H-3u4aA:
7.93
1mt1K-3u4aA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1

(Actinomyces
oris) 		no annotation 4 ILE A 208
LEU A 278
LEU A 323
GLY A 322
 None
 0.86A 1mt1H-3uxfA:
undetectable
1mt1K-3uxfA:
undetectable		 1mt1H-3uxfA:
11.91
1mt1K-3uxfA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		4 ILE A 262
LEU A 360
LEU A 299
GLY A 260
 None
 0.86A 1mt1H-3wq8A:
undetectable
1mt1K-3wq8A:
undetectable		 1mt1H-3wq8A:
14.22
1mt1K-3wq8A:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a29 ENGINEERED
RETRO-ALDOL ENZYME
RA95.0

(synthetic
construct) 		PF00218
(IGPS) 		4 ARG A  28
LEU A  33
ASP A 128
GLY A 126
 None
 0.60A 1mt1H-4a29A:
undetectable
1mt1K-4a29A:
undetectable		 1mt1H-4a29A:
19.51
1mt1K-4a29A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		4 GLU A  12
ARG A 172
LEU A  35
GLY A 170
 None
 0.86A 1mt1H-4a9aA:
undetectable
1mt1K-4a9aA:
undetectable		 1mt1H-4a9aA:
14.81
1mt1K-4a9aA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cd8 ENDO-BETA-1,4-MANNAN
ASE

(Alicyclobacillus
acidocaldarius) 		no annotation 4 ARG A 170
ASP A 196
LEU A 176
GLY A 175
 None
 0.79A 1mt1H-4cd8A:
undetectable
1mt1K-4cd8A:
undetectable		 1mt1H-4cd8A:
17.43
1mt1K-4cd8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epz TRANSCRIPTION
ANTI-TERMINATOR
ANTAGONIST UPXZ

(Bacteroides
uniformis) 		PF06603
(UpxZ) 		4 ILE A  93
GLU A 122
LEU A 107
GLY A  59
 None
 0.84A 1mt1H-4epzA:
undetectable
1mt1K-4epzA:
undetectable		 1mt1H-4epzA:
20.75
1mt1K-4epzA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE

(Burkholderia
thailandensis) 		PF01208
(URO-D) 		4 ARG A 242
LEU A  14
ASP A 271
GLY A 269
 None
 0.90A 1mt1H-4exqA:
undetectable
1mt1K-4exqA:
undetectable		 1mt1H-4exqA:
15.20
1mt1K-4exqA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
no annotation 		4 GLU A 653
ARG B 518
ASP A 550
GLY B 515
 None
 0.92A 1mt1H-4fddA:
undetectable
1mt1K-4fddA:
undetectable		 1mt1H-4fddA:
8.42
1mt1K-4fddA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is7 CASKIN-2

(Homo sapiens) 		PF00536
(SAM_1) 		4 ARG A 156
ASP A 125
LEU A 122
GLY A 121
 None
 0.83A 1mt1H-4is7A:
undetectable
1mt1K-4is7A:
undetectable		 1mt1H-4is7A:
21.43
1mt1K-4is7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A  38
LEU A  73
ASP A 234
GLY A  52
 None
 0.87A 1mt1H-4jb6A:
undetectable
1mt1K-4jb6A:
0.0		 1mt1H-4jb6A:
15.03
1mt1K-4jb6A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		4 ILE A  75
GLU A  79
LEU A 108
LEU A 116
 None
 0.92A 1mt1H-4mmpA:
undetectable
1mt1K-4mmpA:
undetectable		 1mt1H-4mmpA:
13.64
1mt1K-4mmpA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaq R-SPECIFIC CARBONYL
REDUCTASE

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A  55
ASP A  51
LEU A  47
GLY A  46
 None
 0.82A 1mt1H-4oaqA:
undetectable
1mt1K-4oaqA:
undetectable		 1mt1H-4oaqA:
13.90
1mt1K-4oaqA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 GLU A 357
LEU A 353
LEU A 162
GLY A 163
 HEM  A 501 ( 4.9A)
None
None
None
 0.89A 1mt1H-4oqrA:
undetectable
1mt1K-4oqrA:
undetectable		 1mt1H-4oqrA:
14.88
1mt1K-4oqrA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		4 ILE A 189
LEU A 334
LEU A 373
GLY A 376
 None
 0.82A 1mt1H-4pj1A:
undetectable
1mt1K-4pj1A:
undetectable		 1mt1H-4pj1A:
11.71
1mt1K-4pj1A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 ARG A 328
LEU A 269
ASP A 272
LEU A 318
 None
 0.89A 1mt1H-4umvA:
undetectable
1mt1K-4umvA:
undetectable		 1mt1H-4umvA:
8.95
1mt1K-4umvA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		4 ILE A 287
ARG A 288
ASP A 259
GLY A 289
 None
 0.91A 1mt1H-4uwqA:
undetectable
1mt1K-4uwqA:
undetectable		 1mt1H-4uwqA:
11.84
1mt1K-4uwqA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE

(Burkholderia
pseudomallei) 		PF01063
(Aminotran_4) 		4 GLU A 199
LEU A 132
ASP A 182
GLY A 180
 None
 0.85A 1mt1H-4whxA:
undetectable
1mt1K-4whxA:
undetectable		 1mt1H-4whxA:
18.39
1mt1K-4whxA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 GLU A 362
LEU A 358
LEU A 157
GLY A 158
 HEM  A 503 ( 4.5A)
None
None
None
 0.91A 1mt1H-4wpzA:
undetectable
1mt1K-4wpzA:
undetectable		 1mt1H-4wpzA:
15.27
1mt1K-4wpzA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe3 CYTOCHROME P-450

(Streptomyces
antibioticus) 		PF00067
(p450) 		4 GLU A 365
LEU A 361
LEU A 161
GLY A 162
 HEM  A 501 ( 4.8A)
None
None
None
 0.90A 1mt1H-4xe3A:
undetectable
1mt1K-4xe3A:
undetectable		 1mt1H-4xe3A:
14.80
1mt1K-4xe3A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF03734
(YkuD) 		4 LEU A 184
ASP A 188
LEU A 191
GLY A 193
 None
 0.51A 1mt1H-4y4vA:
undetectable
1mt1K-4y4vA:
undetectable		 1mt1H-4y4vA:
14.41
1mt1K-4y4vA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycz FUSION PROTEIN OF
SEC13 AND NUP145C

(Thermothelomyces
thermophila) 		PF00400
(WD40)
PF12110
(Nup96) 		4 LEU A1731
ASP A1725
LEU A1724
GLY A1723
 None
 0.75A 1mt1H-4yczA:
undetectable
1mt1K-4yczA:
undetectable		 1mt1H-4yczA:
8.23
1mt1K-4yczA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		5 ARG A 296
LEU A  70
ASP A 339
LEU A 308
GLY A 307
 None
 0.96A 1mt1H-4yyfA:
undetectable
1mt1K-4yyfA:
undetectable		 1mt1H-4yyfA:
13.61
1mt1K-4yyfA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT A

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV) 		4 ILE A 464
ARG A 460
LEU A 447
ASP A 450
 None
 0.87A 1mt1H-4z2eA:
undetectable
1mt1K-4z2eA:
undetectable		 1mt1H-4z2eA:
14.88
1mt1K-4z2eA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5q CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		4 GLU A 361
LEU A 357
LEU A 157
GLY A 158
 HEM  A 401 ( 4.8A)
HEM  A 401 (-4.6A)
None
None
 0.91A 1mt1H-4z5qA:
undetectable
1mt1K-4z5qA:
undetectable		 1mt1H-4z5qA:
14.42
1mt1K-4z5qA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		4 ILE A 402
LEU A 422
LEU A 273
GLY A 274
 ILE  A 402 ( 0.7A)
LEU  A 422 ( 0.6A)
LEU  A 273 ( 0.6A)
GLY  A 274 ( 0.0A)
 0.84A 1mt1H-4zkeA:
undetectable
1mt1K-4zkeA:
undetectable		 1mt1H-4zkeA:
11.55
1mt1K-4zkeA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 ARG A 256
LEU A  16
ASP A 294
GLY A 263
 None
 0.80A 1mt1H-4zm6A:
undetectable
1mt1K-4zm6A:
undetectable		 1mt1H-4zm6A:
9.20
1mt1K-4zm6A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		5 ILE F 272
GLU H 217
LEU F 119
LEU H  44
GLY H  43
 None
 1.49A 1mt1H-5a5tF:
undetectable
1mt1K-5a5tF:
undetectable		 1mt1H-5a5tF:
14.72
1mt1K-5a5tF:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 LEU A 536
ASP A  88
LEU A  89
GLY A  86
 None
 0.84A 1mt1H-5a8rA:
undetectable
1mt1K-5a8rA:
undetectable		 1mt1H-5a8rA:
12.84
1mt1K-5a8rA:
8.49