SIMILAR PATTERNS OF AMINO ACIDS FOR 1MT1_G_AG2G7003

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  66
ASP A  62
LEU A  29
GLY A  30
 None
None
None
NAD  A 352 (-2.6A)
 0.91A 1mt1G-1a5zA:
undetectable
1mt1J-1a5zA:
0.0		 1mt1G-1a5zA:
11.49
1mt1J-1a5zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 LEU A  68
ASP A  64
GLY A 217
ARG A 308
 None
 0.71A 1mt1G-1agxA:
0.0
1mt1J-1agxA:
0.0		 1mt1G-1agxA:
12.68
1mt1J-1agxA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 LEU A 426
ASP A 550
GLY A 593
ARG A 534
 None
 0.89A 1mt1G-1b25A:
0.0
1mt1J-1b25A:
undetectable		 1mt1G-1b25A:
12.02
1mt1J-1b25A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.90A 1mt1G-1e6vA:
undetectable
1mt1J-1e6vA:
0.7		 1mt1G-1e6vA:
6.70
1mt1J-1e6vA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ASP A 566
GLY A 572
ILE A 412
ARG A 410
 None
 0.90A 1mt1G-1g0dA:
0.0
1mt1J-1g0dA:
0.9		 1mt1G-1g0dA:
5.35
1mt1J-1g0dA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 LEU 1 343
ASP 1 252
LEU 1 188
ARG 1 248
 None
 0.79A 1mt1G-1gt91:
0.0
1mt1J-1gt91:
0.0		 1mt1G-1gt91:
9.86
1mt1J-1gt91:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iub FUCOSE-SPECIFIC
LECTIN

(Aleuria
aurantia) 		PF07938
(Fungal_lectin) 		4 LEU A 115
LEU A 102
GLY A 103
ILE A  86
 None
 0.83A 1mt1G-1iubA:
undetectable
1mt1J-1iubA:
0.0		 1mt1G-1iubA:
11.56
1mt1J-1iubA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU)
PF02287
(Dehydratase_SU) 		4 LEU G  38
LEU A 472
GLY A 471
ILE A 490
 None
 0.88A 1mt1G-1iwpG:
undetectable
1mt1J-1iwpG:
undetectable		 1mt1G-1iwpG:
12.77
1mt1J-1iwpG:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU F 103
LEU F 131
GLY F 130
ILE F 183
 None
 0.88A 1mt1G-1j8mF:
0.0
1mt1J-1j8mF:
0.0		 1mt1G-1j8mF:
11.03
1mt1J-1j8mF:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 LEU A 534
ASP A  85
LEU A  86
GLY A  83
 None
 0.84A 1mt1G-1mroA:
undetectable
1mt1J-1mroA:
undetectable		 1mt1G-1mroA:
9.29
1mt1J-1mroA:
10.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF01862
(PvlArgDC) 		4 LEU A  31
ASP A  35
LEU A  38
GLY A  44
 MRD  A7006 ( 4.2A)
None
None
None
 0.15A 1mt1G-1n2mA:
3.4
1mt1J-1n2mA:
18.3		 1mt1G-1n2mA:
100.00
1mt1J-1n2mA:
67.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		4 LEU A 182
LEU A  78
GLY A 241
ILE A 238
 None
 0.89A 1mt1G-1nxzA:
undetectable
1mt1J-1nxzA:
undetectable		 1mt1G-1nxzA:
13.30
1mt1J-1nxzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF08992
(QH-AmDH_gamma)
no annotation 		4 LEU C  51
ASP C  39
LEU B 327
ARG B   9
 None
None
TRW  C  43 ( 4.2A)
None
 0.91A 1mt1G-1pbyC:
undetectable
1mt1J-1pbyC:
undetectable		 1mt1G-1pbyC:
22.67
1mt1J-1pbyC:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A  57
LEU A  92
GLY A  93
ARG A   4
 None
 0.69A 1mt1G-1qorA:
undetectable
1mt1J-1qorA:
undetectable		 1mt1G-1qorA:
13.96
1mt1J-1qorA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5

(Glycine max) 		PF13499
(EF-hand_7) 		4 LEU A  75
LEU A  36
GLY A  35
ILE A  27
 None
 0.85A 1mt1G-1s6iA:
undetectable
1mt1J-1s6iA:
undetectable		 1mt1G-1s6iA:
16.85
1mt1J-1s6iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.87A 1mt1G-1t1eA:
undetectable
1mt1J-1t1eA:
undetectable		 1mt1G-1t1eA:
7.32
1mt1J-1t1eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A  67
ASP A  71
LEU A  74
ILE A  82
 None
 0.82A 1mt1G-1u3dA:
undetectable
1mt1J-1u3dA:
undetectable		 1mt1G-1u3dA:
7.71
1mt1J-1u3dA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 LEU A 169
ASP A 165
GLY A 160
ARG A 159
 None
 0.87A 1mt1G-1ub3A:
undetectable
1mt1J-1ub3A:
undetectable		 1mt1G-1ub3A:
14.08
1mt1J-1ub3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi7 HYPOTHETICAL PROTEIN
YIGZ

(Escherichia
coli) 		PF01205
(UPF0029)
PF09186
(DUF1949) 		4 LEU A 192
LEU A 180
GLY A 163
ILE A 165
 None
 0.89A 1mt1G-1vi7A:
undetectable
1mt1J-1vi7A:
undetectable		 1mt1G-1vi7A:
13.57
1mt1J-1vi7A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y88 HYPOTHETICAL PROTEIN
AF1548

(Archaeoglobus
fulgidus) 		PF04471
(Mrr_cat) 		4 ASP A 153
LEU A 148
GLY A 147
ARG A  13
 None
 0.84A 1mt1G-1y88A:
undetectable
1mt1J-1y88A:
undetectable		 1mt1G-1y88A:
15.58
1mt1J-1y88A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 ASP A 300
GLY A 243
ILE A 241
ARG A 216
 None
 0.83A 1mt1G-2bihA:
undetectable
1mt1J-2bihA:
undetectable		 1mt1G-2bihA:
8.31
1mt1J-2bihA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 ASP A 300
LEU A 301
GLY A 243
ILE A 241
ARG A 216
 None
 1.08A 1mt1G-2biiA:
undetectable
1mt1J-2biiA:
undetectable		 1mt1G-2biiA:
9.14
1mt1J-2biiA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 271
LEU A 245
GLY A 184
ILE A 186
 None
 0.91A 1mt1G-2cf5A:
undetectable
1mt1J-2cf5A:
undetectable		 1mt1G-2cf5A:
10.07
1mt1J-2cf5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ASP A 218
LEU A 217
GLY A 202
ARG A 191
 None
 0.85A 1mt1G-2djzA:
undetectable
1mt1J-2djzA:
undetectable		 1mt1G-2djzA:
12.34
1mt1J-2djzA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 441
ASP A 442
GLY A 353
ARG A 414
 NAD  A5555 (-4.5A)
None
None
None
 0.61A 1mt1G-2fknA:
undetectable
1mt1J-2fknA:
undetectable		 1mt1G-2fknA:
7.85
1mt1J-2fknA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g42 HYPOTHETICAL PROTEIN
TM_0693

(Thermotoga
maritima) 		no annotation 4 LEU A  52
ASP A  48
LEU A  45
ARG A  29
 None
 0.78A 1mt1G-2g42A:
undetectable
1mt1J-2g42A:
undetectable		 1mt1G-2g42A:
24.32
1mt1J-2g42A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfp MULTIDRUG RESISTANCE
PROTEIN D

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ASP A  33
LEU A 238
GLY A 239
ILE A  26
 None
 0.87A 1mt1G-2gfpA:
undetectable
1mt1J-2gfpA:
undetectable		 1mt1G-2gfpA:
10.13
1mt1J-2gfpA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.89A 1mt1G-2jgpA:
undetectable
1mt1J-2jgpA:
1.1		 1mt1G-2jgpA:
8.52
1mt1J-2jgpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 282
ASP A 283
LEU A 121
GLY A 120
ARG A 332
 None
 1.45A 1mt1G-2ongA:
undetectable
1mt1J-2ongA:
undetectable		 1mt1G-2ongA:
10.05
1mt1J-2ongA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.62A 1mt1G-2pbgA:
undetectable
1mt1J-2pbgA:
undetectable		 1mt1G-2pbgA:
8.62
1mt1J-2pbgA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR

(Geobacillus
stearothermophilus) 		PF01047
(MarR) 		4 LEU A  73
LEU A  82
GLY A 103
ILE A 107
 None
 0.82A 1mt1G-2rdpA:
undetectable
1mt1J-2rdpA:
undetectable		 1mt1G-2rdpA:
22.95
1mt1J-2rdpA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 445
ASP A 446
GLY A 357
ARG A 418
 NAD  A3001 (-4.1A)
None
None
None
 0.56A 1mt1G-2v7gA:
undetectable
1mt1J-2v7gA:
undetectable		 1mt1G-2v7gA:
7.71
1mt1J-2v7gA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		4 LEU A 385
LEU A 274
GLY A 275
ILE A 222
 None
 0.85A 1mt1G-2yg1A:
undetectable
1mt1J-2yg1A:
undetectable		 1mt1G-2yg1A:
12.19
1mt1J-2yg1A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 LEU A  40
ASP A  36
LEU A  33
ARG A 404
 None
 0.80A 1mt1G-2ynkA:
undetectable
1mt1J-2ynkA:
undetectable		 1mt1G-2ynkA:
7.69
1mt1J-2ynkA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ytw SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF00595
(PDZ) 		4 ASP A  70
LEU A  66
GLY A  65
ILE A 107
 None
 0.73A 1mt1G-2ytwA:
undetectable
1mt1J-2ytwA:
undetectable		 1mt1G-2ytwA:
21.51
1mt1J-2ytwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		4 ASP A 355
LEU A 351
GLY A 350
ILE A 393
 None
 0.79A 1mt1G-2zleA:
undetectable
1mt1J-2zleA:
undetectable		 1mt1G-2zleA:
9.53
1mt1J-2zleA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		5 LEU A 566
ASP A 433
LEU A 434
GLY A 411
ILE A 396
 None
 1.26A 1mt1G-3auoA:
undetectable
1mt1J-3auoA:
undetectable		 1mt1G-3auoA:
8.00
1mt1J-3auoA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		4 LEU A  43
ASP A  44
LEU A  53
GLY A  50
 None
 0.79A 1mt1G-3bxoA:
undetectable
1mt1J-3bxoA:
undetectable		 1mt1G-3bxoA:
14.10
1mt1J-3bxoA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		4 LEU A 287
ASP A 288
LEU A 297
GLY A 294
 None
 0.79A 1mt1G-3dliA:
undetectable
1mt1J-3dliA:
undetectable		 1mt1G-3dliA:
10.86
1mt1J-3dliA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		4 ASP A 139
LEU A 142
GLY A 143
ARG A 226
 None
 0.80A 1mt1G-3dpiA:
undetectable
1mt1J-3dpiA:
undetectable		 1mt1G-3dpiA:
10.56
1mt1J-3dpiA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		4 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.78A 1mt1G-3e8sA:
undetectable
1mt1J-3e8sA:
undetectable		 1mt1G-3e8sA:
12.15
1mt1J-3e8sA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gx1 LIN1832 PROTEIN

(Listeria
innocua) 		PF03610
(EIIA-man) 		4 LEU A 566
LEU A 646
GLY A 647
ILE A 653
 None
SO4  A 709 ( 4.2A)
None
None
 0.80A 1mt1G-3gx1A:
undetectable
1mt1J-3gx1A:
undetectable		 1mt1G-3gx1A:
21.54
1mt1J-3gx1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ASP A 141
GLY A 132
ILE A  82
ARG A  85
 None
 0.71A 1mt1G-3h55A:
undetectable
1mt1J-3h55A:
undetectable		 1mt1G-3h55A:
9.42
1mt1J-3h55A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 LEU B1061
LEU B 251
GLY B 250
ILE B 219
 None
 0.89A 1mt1G-3iz3B:
undetectable
1mt1J-3iz3B:
undetectable		 1mt1G-3iz3B:
3.39
1mt1J-3iz3B:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 LEU A 101
LEU A 129
GLY A 128
ILE A 181
 None
 0.90A 1mt1G-3kl4A:
undetectable
1mt1J-3kl4A:
undetectable		 1mt1G-3kl4A:
9.07
1mt1J-3kl4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m05 UNCHARACTERIZED
PROTEIN PEPE_1480

(Pediococcus
pentosaceus) 		PF06153
(CdAMP_rec) 		4 LEU A  18
ASP A  14
GLY A  96
ARG A  69
 None
 0.84A 1mt1G-3m05A:
undetectable
1mt1J-3m05A:
undetectable		 1mt1G-3m05A:
17.24
1mt1J-3m05A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)

(Rhodobacter
sphaeroides) 		PF00588
(SpoU_methylase) 		5 LEU A 129
ASP A 126
LEU A 122
GLY A 116
ARG A  11
 None
None
None
ACY  A 250 (-4.5A)
None
 1.35A 1mt1G-3onpA:
undetectable
1mt1J-3onpA:
undetectable		 1mt1G-3onpA:
12.18
1mt1J-3onpA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		4 LEU A 349
ASP A 177
GLY A 175
ARG A 233
 None
 0.87A 1mt1G-3pg5A:
undetectable
1mt1J-3pg5A:
undetectable		 1mt1G-3pg5A:
11.35
1mt1J-3pg5A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 LEU L 188
LEU L 181
GLY L 225
ILE L 266
 None
 0.90A 1mt1G-3rkoL:
undetectable
1mt1J-3rkoL:
undetectable		 1mt1G-3rkoL:
6.36
1mt1J-3rkoL:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 4 LEU A  62
LEU A 212
GLY A 209
ILE A 207
 None
 0.88A 1mt1G-3s4lA:
undetectable
1mt1J-3s4lA:
undetectable		 1mt1G-3s4lA:
11.62
1mt1J-3s4lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 ASP A 303
LEU A 273
GLY A 272
ARG A 265
 None
None
SO4  A 543 ( 3.8A)
None
 0.77A 1mt1G-3sqlA:
undetectable
1mt1J-3sqlA:
undetectable		 1mt1G-3sqlA:
7.61
1mt1J-3sqlA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A  23
ASP A 289
GLY A 256
ARG A 248
 None
 0.90A 1mt1G-3u4aA:
undetectable
1mt1J-3u4aA:
undetectable		 1mt1G-3u4aA:
5.93
1mt1J-3u4aA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1

(Actinomyces
oris) 		no annotation 4 LEU A 278
LEU A 323
GLY A 322
ILE A 208
 None
 0.85A 1mt1G-3uxfA:
undetectable
1mt1J-3uxfA:
undetectable		 1mt1G-3uxfA:
7.99
1mt1J-3uxfA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		4 LEU A 360
LEU A 299
GLY A 260
ILE A 262
 None
 0.86A 1mt1G-3wq8A:
undetectable
1mt1J-3wq8A:
undetectable		 1mt1G-3wq8A:
7.66
1mt1J-3wq8A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a29 ENGINEERED
RETRO-ALDOL ENZYME
RA95.0

(synthetic
construct) 		PF00218
(IGPS) 		4 LEU A  33
ASP A 128
GLY A 126
ARG A  28
 None
 0.60A 1mt1G-4a29A:
undetectable
1mt1J-4a29A:
undetectable		 1mt1G-4a29A:
15.02
1mt1J-4a29A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cd8 ENDO-BETA-1,4-MANNAN
ASE

(Alicyclobacillus
acidocaldarius) 		no annotation 4 ASP A 196
LEU A 176
GLY A 175
ARG A 170
 None
 0.75A 1mt1G-4cd8A:
undetectable
1mt1J-4cd8A:
undetectable		 1mt1G-4cd8A:
9.06
1mt1J-4cd8A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE

(Burkholderia
thailandensis) 		PF01208
(URO-D) 		4 LEU A  14
ASP A 271
GLY A 269
ARG A 242
 None
 0.89A 1mt1G-4exqA:
undetectable
1mt1J-4exqA:
undetectable		 1mt1G-4exqA:
10.71
1mt1J-4exqA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A1164
LEU A 291
GLY A1176
ILE A1174
 None
 0.89A 1mt1G-4f4cA:
undetectable
1mt1J-4f4cA:
undetectable		 1mt1G-4f4cA:
4.38
1mt1J-4f4cA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is7 CASKIN-2

(Homo sapiens) 		PF00536
(SAM_1) 		4 ASP A 125
LEU A 122
GLY A 121
ARG A 156
 None
 0.85A 1mt1G-4is7A:
undetectable
1mt1J-4is7A:
undetectable		 1mt1G-4is7A:
17.65
1mt1J-4is7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A  73
ASP A 234
GLY A  52
ILE A  38
 None
 0.88A 1mt1G-4jb6A:
0.0
1mt1J-4jb6A:
undetectable		 1mt1G-4jb6A:
9.62
1mt1J-4jb6A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaq R-SPECIFIC CARBONYL
REDUCTASE

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A  55
ASP A  51
LEU A  47
GLY A  46
 None
 0.77A 1mt1G-4oaqA:
undetectable
1mt1J-4oaqA:
undetectable		 1mt1G-4oaqA:
9.79
1mt1J-4oaqA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		4 LEU A 334
LEU A 373
GLY A 376
ILE A 189
 None
 0.83A 1mt1G-4pj1A:
undetectable
1mt1J-4pj1A:
undetectable		 1mt1G-4pj1A:
7.01
1mt1J-4pj1A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 LEU A 269
ASP A 272
LEU A 318
ARG A 328
 None
 0.90A 1mt1G-4umvA:
undetectable
1mt1J-4umvA:
undetectable		 1mt1G-4umvA:
4.92
1mt1J-4umvA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		4 ASP A 259
GLY A 289
ILE A 287
ARG A 288
 None
 0.92A 1mt1G-4uwqA:
undetectable
1mt1J-4uwqA:
undetectable		 1mt1G-4uwqA:
5.95
1mt1J-4uwqA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF03734
(YkuD) 		4 LEU A 184
ASP A 188
LEU A 191
GLY A 193
 None
 0.49A 1mt1G-4y4vA:
undetectable
1mt1J-4y4vA:
undetectable		 1mt1G-4y4vA:
9.14
1mt1J-4y4vA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycz FUSION PROTEIN OF
SEC13 AND NUP145C

(Thermothelomyces
thermophila) 		PF00400
(WD40)
PF12110
(Nup96) 		4 LEU A1731
ASP A1725
LEU A1724
GLY A1723
 None
 0.78A 1mt1G-4yczA:
undetectable
1mt1J-4yczA:
undetectable		 1mt1G-4yczA:
4.82
1mt1J-4yczA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP H  86
LEU H  82
GLY H  82
ARG H  66
 None
 0.91A 1mt1G-4ydiH:
undetectable
1mt1J-4ydiH:
undetectable		 1mt1G-4ydiH:
9.78
1mt1J-4ydiH:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		5 LEU A  70
ASP A 339
LEU A 308
GLY A 307
ARG A 296
 None
 0.93A 1mt1G-4yyfA:
undetectable
1mt1J-4yyfA:
undetectable		 1mt1G-4yyfA:
9.12
1mt1J-4yyfA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT A

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV) 		4 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.87A 1mt1G-4z2eA:
undetectable
1mt1J-4z2eA:
undetectable		 1mt1G-4z2eA:
8.01
1mt1J-4z2eA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		4 LEU A 422
LEU A 273
GLY A 274
ILE A 402
 LEU  A 422 ( 0.6A)
LEU  A 273 ( 0.6A)
GLY  A 274 ( 0.0A)
ILE  A 402 ( 0.7A)
 0.86A 1mt1G-4zkeA:
undetectable
1mt1J-4zkeA:
undetectable		 1mt1G-4zkeA:
12.77
1mt1J-4zkeA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 LEU A  16
ASP A 294
GLY A 263
ARG A 256
 None
 0.82A 1mt1G-4zm6A:
undetectable
1mt1J-4zm6A:
undetectable		 1mt1G-4zm6A:
5.34
1mt1J-4zm6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 LEU A 536
ASP A  88
LEU A  89
GLY A  86
 None
 0.85A 1mt1G-5a8rA:
undetectable
1mt1J-5a8rA:
undetectable		 1mt1G-5a8rA:
8.49
1mt1J-5a8rA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu9 BETA-N-ACETYLHEXOSAM
INIDASE

(Beutenbergia
cavernae) 		PF00933
(Glyco_hydro_3) 		4 LEU A  82
ASP A 362
GLY A 331
ARG A 324
 None
 0.80A 1mt1G-5bu9A:
undetectable
1mt1J-5bu9A:
undetectable		 1mt1G-5bu9A:
15.25
1mt1J-5bu9A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 ASP A  40
GLY A 741
ILE A 981
ARG A 978
 B12  A1101 (-3.5A)
None
None
None
 0.89A 1mt1G-5cjuA:
undetectable
1mt1J-5cjuA:
0.0		 1mt1G-5cjuA:
4.03
1mt1J-5cjuA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		4 LEU A 217
ASP A 196
GLY A 318
ARG A 172
 None
 0.88A 1mt1G-5d4kA:
undetectable
1mt1J-5d4kA:
undetectable		 1mt1G-5d4kA:
6.38
1mt1J-5d4kA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L1

(Deinococcus
radiodurans) 		PF00687
(Ribosomal_L1) 		4 LEU 0 192
LEU 0  60
GLY 0 155
ILE 0 157
 None
 0.92A 1mt1G-5dm60:
undetectable
1mt1J-5dm60:
undetectable		 1mt1G-5dm60:
16.84
1mt1J-5dm60:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		4 LEU A 115
ASP A 119
LEU A 122
GLY A 133
 None
 0.85A 1mt1G-5ftfA:
undetectable
1mt1J-5ftfA:
undetectable		 1mt1G-5ftfA:
7.62
1mt1J-5ftfA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.81A 1mt1G-5gl7A:
undetectable
1mt1J-5gl7A:
undetectable		 1mt1G-5gl7A:
8.70
1mt1J-5gl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2f CYTOCHROME B559
SUBUNIT ALPHA

(Thermosynechococcus
elongatus) 		PF00283
(Cytochrom_B559)
PF00284
(Cytochrom_B559a) 		4 ASP E  45
LEU E  42
GLY E  41
ARG E  51
 None
 0.66A 1mt1G-5h2fE:
undetectable
1mt1J-5h2fE:
undetectable		 1mt1G-5h2fE:
14.63
1mt1J-5h2fE:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 4 LEU E  93
ASP E  96
GLY E 133
ILE E 146
 None
 0.76A 1mt1G-5h36E:
undetectable
1mt1J-5h36E:
undetectable		 1mt1G-5h36E:
13.04
1mt1J-5h36E:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		4 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.75A 1mt1G-5h3oA:
undetectable
1mt1J-5h3oA:
undetectable		 1mt1G-5h3oA:
5.75
1mt1J-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		4 LEU A 256
LEU A 414
GLY A 415
ILE A 468
 None
 0.87A 1mt1G-5hy5A:
undetectable
1mt1J-5hy5A:
undetectable		 1mt1G-5hy5A:
8.67
1mt1J-5hy5A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES

(Corynebacterium
glutamicum) 		PF00933
(Glyco_hydro_3) 		4 LEU A  76
ASP A 346
GLY A 314
ARG A 302
 None
 0.77A 1mt1G-5iobA:
undetectable
1mt1J-5iobA:
undetectable		 1mt1G-5iobA:
10.45
1mt1J-5iobA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A 101
LEU A 129
GLY A 128
ILE A 181
 None
 0.88A 1mt1G-5l3sA:
undetectable
1mt1J-5l3sA:
undetectable		 1mt1G-5l3sA:
10.96
1mt1J-5l3sA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oac MAJOR CAPSID PROTEIN

(unidentified
phage) 		no annotation 4 LEU A 181
LEU A 184
GLY A 185
ILE A 256
 None
 0.91A 1mt1G-5oacA:
undetectable
1mt1J-5oacA:
undetectable		 1mt1G-5oacA:
12.77
1mt1J-5oacA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A  51
ASP A 320
GLY A 287
ARG A 280
 None
 0.77A 1mt1G-5tf0A:
undetectable
1mt1J-5tf0A:
undetectable		 1mt1G-5tf0A:
6.25
1mt1J-5tf0A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv1 BETA-ARRESTIN-2

(Bos taurus) 		no annotation 4 ASP A  70
LEU A  69
GLY A  65
ARG A  63
 None
 0.78A 1mt1G-5tv1A:
undetectable
1mt1J-5tv1A:
undetectable		 1mt1G-5tv1A:
10.59
1mt1J-5tv1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3

(Pseudomonas
aeruginosa) 		PF09615
(Cas_Csy3) 		4 LEU C 116
LEU C 119
GLY C 120
ILE C 350
 None
 0.83A 1mt1G-5uz9C:
undetectable
1mt1J-5uz9C:
undetectable		 1mt1G-5uz9C:
10.97
1mt1J-5uz9C:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.83A 1mt1G-5veuA:
undetectable
1mt1J-5veuA:
undetectable		 1mt1G-5veuA:
7.61
1mt1J-5veuA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 ASP A 314
GLY A 283
ILE A   5
ARG A 276
 None
 0.85A 1mt1G-5vqdA:
0.0
1mt1J-5vqdA:
undetectable		 1mt1G-5vqdA:
22.50
1mt1J-5vqdA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN

(Mus musculus) 		no annotation 4 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.88A 1mt1G-5vxrH:
undetectable
1mt1J-5vxrH:
undetectable		 1mt1G-5vxrH:
30.43
1mt1J-5vxrH:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO

(Homo sapiens) 		no annotation 4 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.72A 1mt1G-5w21A:
undetectable
1mt1J-5w21A:
undetectable		 1mt1G-5w21A:
18.75
1mt1J-5w21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 5 LEU A 118
ASP A 116
GLY A  78
ILE A  76
ARG A 151
 None
 1.45A 1mt1G-5wlyA:
undetectable
1mt1J-5wlyA:
undetectable		 1mt1G-5wlyA:
26.87
1mt1J-5wlyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl CYTOCHROME B559
SUBUNIT ALPHA

(Pisum sativum) 		PF00283
(Cytochrom_B559)
PF00284
(Cytochrom_B559a) 		4 ASP E  45
LEU E  42
GLY E  41
ARG E  51
 None
 0.79A 1mt1G-5xnlE:
undetectable
1mt1J-5xnlE:
undetectable		 1mt1G-5xnlE:
22.22
1mt1J-5xnlE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 LEU A  49
ASP A 314
GLY A 281
ARG A 274
 None
 0.87A 1mt1G-5xxoA:
undetectable
1mt1J-5xxoA:
undetectable		 1mt1G-5xxoA:
27.38
1mt1J-5xxoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 4 ASP B 188
LEU B 168
GLY B 167
ARG B 162
 None
 0.81A 1mt1G-5yllB:
0.0
1mt1J-5yllB:
undetectable		 1mt1G-5yllB:
23.38
1mt1J-5yllB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9x SMALL RNA DEGRADING
NUCLEASE 1

(Arabidopsis
thaliana) 		no annotation 4 LEU A 232
ASP A 228
LEU A 225
GLY A 222
 None
MG  A 502 (-3.5A)
None
None
 0.84A 1mt1G-5z9xA:
undetectable
1mt1J-5z9xA:
undetectable		 1mt1G-5z9xA:
19.51
1mt1J-5z9xA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A  50
ASP A  46
LEU A  42
GLY A  41
 None
 0.73A 1mt1G-6c49A:
undetectable
1mt1J-6c49A:
undetectable		 1mt1G-6c49A:
23.53
1mt1J-6c49A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1o -

(-) 		no annotation 5 LEU A 348
ASP A 347
GLY A 345
ILE A 240
ARG A 244
 None
 1.50A 1mt1G-6g1oA:
undetectable
1mt1J-6g1oA:
undetectable		 1mt1G-6g1oA:
undetectable
1mt1J-6g1oA:
undetectable