SIMILAR PATTERNS OF AMINO ACIDS FOR 1MT1_C_AG2C7004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli) 		PF00043
(GST_C)
PF13409
(GST_N_2) 		4 ALA A  68
LEU A  62
GLU A  65
LEU A   3
 None
None
GTS  A 203 (-3.1A)
None
 1.00A 1mt1D-1a0fA:
0.0
1mt1E-1a0fA:
undetectable		 1mt1D-1a0fA:
19.21
1mt1E-1a0fA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnt CILIARY NEUROTROPHIC
FACTOR

(Homo sapiens) 		PF01110
(CNTF) 		4 LEU 1 130
GLU 1 125
LEU 1  16
LEU 1 176
 None
 0.73A 1mt1D-1cnt1:
undetectable
1mt1E-1cnt1:
undetectable		 1mt1D-1cnt1:
20.15
1mt1E-1cnt1:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		4 ALA A 581
LEU A 488
LEU A 454
LEU A 602
 None
 0.98A 1mt1D-1fkmA:
undetectable
1mt1E-1fkmA:
undetectable		 1mt1D-1fkmA:
13.28
1mt1E-1fkmA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 ALA A 167
LEU A 123
LEU A 154
LEU A 314
 None
HMO  A2000 (-3.8A)
None
None
 0.89A 1mt1D-1fp2A:
undetectable
1mt1E-1fp2A:
undetectable		 1mt1D-1fp2A:
13.07
1mt1E-1fp2A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 409
LEU A 402
LEU A 466
LEU A 267
 None
 0.90A 1mt1D-1gytA:
0.0
1mt1E-1gytA:
0.0		 1mt1D-1gytA:
12.03
1mt1E-1gytA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9a OLIGORIBONUCLEASE

(Haemophilus
influenzae) 		PF00929
(RNase_T) 		4 ALA A  44
GLU A  45
LEU A 164
LEU A  49
 None
 1.00A 1mt1D-1j9aA:
0.0
1mt1E-1j9aA:
undetectable		 1mt1D-1j9aA:
23.53
1mt1E-1j9aA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 LEU A  52
GLU A 121
LEU A 133
LEU A  43
 None
 0.84A 1mt1D-1lpeA:
undetectable
1mt1E-1lpeA:
undetectable		 1mt1D-1lpeA:
20.00
1mt1E-1lpeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lql OSMOTICAL INDUCIBLE
PROTEIN C LIKE
FAMILY

(Mycoplasma
pneumoniae) 		PF02566
(OsmC) 		4 ALA A 121
LEU A  46
GLU A  53
LEU A  95
 None
 0.77A 1mt1D-1lqlA:
0.0
1mt1E-1lqlA:
undetectable		 1mt1D-1lqlA:
20.25
1mt1E-1lqlA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 118
GLU A 277
LEU A  89
LEU A  96
 None
 0.99A 1mt1D-1n21A:
undetectable
1mt1E-1n21A:
undetectable		 1mt1D-1n21A:
11.66
1mt1E-1n21A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 ALA A  76
LEU A  54
LEU A 343
ASP A 339
 None
 0.91A 1mt1D-1t1eA:
0.0
1mt1E-1t1eA:
0.0		 1mt1D-1t1eA:
10.26
1mt1E-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 238
LEU A 354
GLU A 239
LEU A  26
 None
 0.93A 1mt1D-1tqyA:
0.3
1mt1E-1tqyA:
0.0		 1mt1D-1tqyA:
14.15
1mt1E-1tqyA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 4 ALA A 162
LEU A 180
ASP A 115
LEU A 106
 None
 0.90A 1mt1D-1u5uA:
0.0
1mt1E-1u5uA:
0.0		 1mt1D-1u5uA:
13.37
1mt1E-1u5uA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 ALA A 100
LEU A 108
LEU A  51
LEU A  44
 None
 1.00A 1mt1D-1upxA:
0.0
1mt1E-1upxA:
undetectable		 1mt1D-1upxA:
13.09
1mt1E-1upxA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi6 30S RIBOSOMAL
PROTEIN S2P

(Archaeoglobus
fulgidus) 		PF00318
(Ribosomal_S2) 		4 ALA A  59
GLU A 177
LEU A   9
LEU A  51
 None
 1.00A 1mt1D-1vi6A:
undetectable
1mt1E-1vi6A:
undetectable		 1mt1D-1vi6A:
19.31
1mt1E-1vi6A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ALA A 104
LEU A  78
LEU A 264
LEU A 272
 None
 0.89A 1mt1D-1wdtA:
undetectable
1mt1E-1wdtA:
undetectable		 1mt1D-1wdtA:
10.02
1mt1E-1wdtA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		4 ALA A  16
LEU A 275
LEU A 175
LEU A 150
 None
 0.89A 1mt1D-1ywfA:
undetectable
1mt1E-1ywfA:
undetectable		 1mt1D-1ywfA:
17.33
1mt1E-1ywfA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
LEU H  82
LEU H  20
LEU H  67
 None
 0.97A 1mt1D-1zanH:
undetectable
1mt1E-1zanH:
0.0		 1mt1D-1zanH:
17.76
1mt1E-1zanH:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agj YVO FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  93
LEU H  87
LEU H  20
LEU H  69
 None
 0.88A 1mt1D-2agjH:
undetectable
1mt1E-2agjH:
0.0		 1mt1D-2agjH:
18.14
1mt1E-2agjH:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eta TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF12796
(Ank_2) 		4 ALA A 167
LEU A 140
ASP A 143
LEU A 106
 None
 0.87A 1mt1D-2etaA:
undetectable
1mt1E-2etaA:
undetectable		 1mt1D-2etaA:
17.72
1mt1E-2etaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Homo sapiens) 		PF12796
(Ank_2) 		4 ALA A 166
LEU A 139
ASP A 142
LEU A 105
 None
 0.88A 1mt1D-2f37A:
undetectable
1mt1E-2f37A:
undetectable		 1mt1D-2f37A:
17.65
1mt1E-2f37A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		4 ALA A  26
LEU A 114
LEU A  92
LEU A  99
 None
 0.99A 1mt1D-2g0tA:
undetectable
1mt1E-2g0tA:
0.0		 1mt1D-2g0tA:
17.57
1mt1E-2g0tA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ALA A 122
LEU A  69
LEU A 126
LEU A 330
 None
 0.79A 1mt1D-2hjsA:
undetectable
1mt1E-2hjsA:
undetectable		 1mt1D-2hjsA:
16.12
1mt1E-2hjsA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsa TRIGGER FACTOR

(Thermotoga
maritima) 		PF05698
(Trigger_C) 		4 ALA A 391
LEU A 384
GLU A 359
LEU A 363
 SO4  A 415 (-3.8A)
None
SO4  A 415 (-3.0A)
None
 0.84A 1mt1D-2nsaA:
undetectable
1mt1E-2nsaA:
undetectable		 1mt1D-2nsaA:
22.22
1mt1E-2nsaA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nw0 PLYB

(unidentified
phage) 		PF01183
(Glyco_hydro_25) 		4 ALA A  69
LEU A 110
GLU A  72
LEU A 120
 None
 0.95A 1mt1D-2nw0A:
undetectable
1mt1E-2nw0A:
undetectable		 1mt1D-2nw0A:
19.89
1mt1E-2nw0A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		4 ALA A 126
LEU A  28
LEU A 119
ASP A  94
 None
 0.87A 1mt1D-2p35A:
undetectable
1mt1E-2p35A:
undetectable		 1mt1D-2p35A:
16.99
1mt1E-2p35A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 ALA A 185
LEU A 179
LEU A 386
LEU A 357
 None
 0.97A 1mt1D-2p8uA:
0.4
1mt1E-2p8uA:
undetectable		 1mt1D-2p8uA:
13.22
1mt1E-2p8uA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		4 LEU A  62
GLU A  54
LEU A  20
LEU A  13
 None
 0.85A 1mt1D-2q80A:
undetectable
1mt1E-2q80A:
undetectable		 1mt1D-2q80A:
16.27
1mt1E-2q80A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A 779
GLU A 772
LEU A 748
LEU A 784
 None
 0.83A 1mt1D-2wfhA:
undetectable
1mt1E-2wfhA:
undetectable		 1mt1D-2wfhA:
18.81
1mt1E-2wfhA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ALA A 394
LEU A 385
LEU A 328
LEU A 345
 None
 0.93A 1mt1D-2y0eA:
undetectable
1mt1E-2y0eA:
undetectable		 1mt1D-2y0eA:
12.76
1mt1E-2y0eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 ALA A 197
LEU A 260
LEU A 215
LEU A 222
 None
 1.00A 1mt1D-2ykfA:
undetectable
1mt1E-2ykfA:
undetectable		 1mt1D-2ykfA:
17.57
1mt1E-2ykfA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		4 ALA A 231
LEU A  28
GLU A 228
LEU A  63
 None
 0.77A 1mt1D-2zatA:
undetectable
1mt1E-2zatA:
undetectable		 1mt1D-2zatA:
16.41
1mt1E-2zatA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		4 ALA A 111
LEU A  29
ASP A 104
LEU A   8
 None
 0.98A 1mt1D-3bg2A:
undetectable
1mt1E-3bg2A:
undetectable		 1mt1D-3bg2A:
13.96
1mt1E-3bg2A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED

(Myxococcus
xanthus) 		PF00204
(DNA_gyraseB) 		4 ALA A 274
LEU A 342
LEU A 242
LEU A 352
 None
 0.91A 1mt1D-3cwvA:
undetectable
1mt1E-3cwvA:
undetectable		 1mt1D-3cwvA:
14.84
1mt1E-3cwvA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		4 ALA A 193
LEU A 187
LEU A  92
LEU A 148
 None
 0.75A 1mt1D-3da8A:
undetectable
1mt1E-3da8A:
undetectable		 1mt1D-3da8A:
20.09
1mt1E-3da8A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djb HYDROLASE, HD FAMILY

(Bacillus
thuringiensis) 		PF01966
(HD) 		4 GLU A 192
LEU A 124
ASP A 120
LEU A 117
 None
 0.89A 1mt1D-3djbA:
undetectable
1mt1E-3djbA:
undetectable		 1mt1D-3djbA:
19.63
1mt1E-3djbA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ALA A 162
LEU A 180
ASP A 115
LEU A 106
 None
 0.79A 1mt1D-3dy5A:
undetectable
1mt1E-3dy5A:
undetectable		 1mt1D-3dy5A:
8.60
1mt1E-3dy5A:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 4 ALA A1981
LEU A2033
ASP A2029
LEU A2026
 None
 0.63A 1mt1D-3dyjA:
undetectable
1mt1E-3dyjA:
undetectable		 1mt1D-3dyjA:
16.17
1mt1E-3dyjA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 4 ALA A 307
LEU A 314
GLU A 309
LEU A 302
 None
 0.98A 1mt1D-3e05A:
undetectable
1mt1E-3e05A:
undetectable		 1mt1D-3e05A:
20.11
1mt1E-3e05A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 ALA A  46
LEU A 106
LEU A 187
LEU A 157
 None
 0.83A 1mt1D-3ejnA:
undetectable
1mt1E-3ejnA:
undetectable		 1mt1D-3ejnA:
12.92
1mt1E-3ejnA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 4 ALA A1990
LEU A2042
ASP A2038
LEU A2035
 None
 0.67A 1mt1D-3fyqA:
undetectable
1mt1E-3fyqA:
undetectable		 1mt1D-3fyqA:
19.80
1mt1E-3fyqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu0 TRIGGER FACTOR

(Thermotoga
maritima) 		PF05697
(Trigger_N)
PF05698
(Trigger_C) 		4 ALA A 391
LEU A 384
GLU A 359
LEU A 363
 None
 0.74A 1mt1D-3gu0A:
undetectable
1mt1E-3gu0A:
undetectable		 1mt1D-3gu0A:
15.66
1mt1E-3gu0A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ALA A  47
LEU A  27
GLU A  49
LEU A   3
 None
 0.98A 1mt1D-3h7lA:
undetectable
1mt1E-3h7lA:
undetectable		 1mt1D-3h7lA:
11.13
1mt1E-3h7lA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25

(Bacillus
anthracis) 		PF01183
(Glyco_hydro_25) 		4 ALA A  72
LEU A 113
GLU A  75
LEU A 123
 None
 0.96A 1mt1D-3hmcA:
undetectable
1mt1E-3hmcA:
undetectable		 1mt1D-3hmcA:
19.13
1mt1E-3hmcA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 112
LEU A 105
GLU A 113
LEU A  51
 None
 1.00A 1mt1D-3ic1A:
undetectable
1mt1E-3ic1A:
undetectable		 1mt1D-3ic1A:
15.83
1mt1E-3ic1A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ico 6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacterium
tuberculosis) 		PF01182
(Glucosamine_iso) 		4 ALA A  25
LEU A 144
LEU A  53
LEU A  67
 None
 0.95A 1mt1D-3icoA:
undetectable
1mt1E-3icoA:
undetectable		 1mt1D-3icoA:
18.49
1mt1E-3icoA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 4 ALA B 401
LEU B 394
LEU B 458
LEU B 259
 None
 0.81A 1mt1D-3jruB:
undetectable
1mt1E-3jruB:
undetectable		 1mt1D-3jruB:
12.79
1mt1E-3jruB:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Toxoplasma
gondii) 		PF00490
(ALAD) 		4 ALA A 121
LEU A 114
LEU A  92
LEU A  70
 None
None
None
EDO  A 385 (-4.3A)
 1.00A 1mt1D-3obkA:
undetectable
1mt1E-3obkA:
undetectable		 1mt1D-3obkA:
17.05
1mt1E-3obkA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Toxoplasma
gondii) 		PF00490
(ALAD) 		4 ALA A 121
LEU A 115
LEU A 131
LEU A  50
 None
 0.76A 1mt1D-3obkA:
undetectable
1mt1E-3obkA:
undetectable		 1mt1D-3obkA:
17.05
1mt1E-3obkA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c PROBABLE PROTEIN
BRICK1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1

(Homo sapiens) 		PF02205
(WH2)
no annotation 		4 ALA E  66
GLU E  65
LEU D  76
LEU D  83
 None
 0.91A 1mt1D-3p8cE:
undetectable
1mt1E-3p8cE:
undetectable		 1mt1D-3p8cE:
24.55
1mt1E-3p8cE:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 389
LEU A 382
LEU A 447
LEU A 247
 EDO  A 510 (-4.0A)
EDO  A 502 (-4.1A)
None
None
 0.87A 1mt1D-3peiA:
undetectable
1mt1E-3peiA:
undetectable		 1mt1D-3peiA:
13.54
1mt1E-3peiA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 ALA A 192
GLU A 196
LEU A 361
LEU A 313
 None
 0.80A 1mt1D-3skvA:
undetectable
1mt1E-3skvA:
undetectable		 1mt1D-3skvA:
13.87
1mt1E-3skvA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		4 ALA B  91
GLU B  95
LEU B  57
LEU B 182
 None
 0.98A 1mt1D-3tniB:
undetectable
1mt1E-3tniB:
undetectable		 1mt1D-3tniB:
16.60
1mt1E-3tniB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7r NADPH-DEPENDENT FMN
REDUCTASE

(Paracoccus
denitrificans) 		PF03358
(FMN_red) 		4 ALA A 143
LEU A  72
LEU A  21
LEU A  28
 None
 0.83A 1mt1D-3u7rA:
undetectable
1mt1E-3u7rA:
undetectable		 1mt1D-3u7rA:
22.78
1mt1E-3u7rA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens) 		no annotation 4 ALA A 252
LEU A 204
GLU A 282
LEU A 307
 None
 0.90A 1mt1D-3x1oA:
undetectable
1mt1E-3x1oA:
undetectable		 1mt1D-3x1oA:
18.84
1mt1E-3x1oA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		4 ALA A 335
LEU A 342
LEU A 324
LEU A 368
 None
 0.98A 1mt1D-4cp6A:
undetectable
1mt1E-4cp6A:
undetectable		 1mt1D-4cp6A:
11.09
1mt1E-4cp6A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20) 		4 ALA A 112
LEU A 105
GLU A 113
LEU A  51
 None
 1.02A 1mt1D-4h2kA:
undetectable
1mt1E-4h2kA:
undetectable		 1mt1D-4h2kA:
20.45
1mt1E-4h2kA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hj3 LOV PROTEIN

(Rhodobacter
sphaeroides) 		PF13426
(PAS_9) 		4 ALA A 167
LEU A 161
LEU A  98
LEU A  81
 None
 0.71A 1mt1D-4hj3A:
undetectable
1mt1E-4hj3A:
undetectable		 1mt1D-4hj3A:
22.99
1mt1E-4hj3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ALA A 393
GLU A 394
LEU A 478
LEU A 484
 None
 0.92A 1mt1D-4hwvA:
undetectable
1mt1E-4hwvA:
undetectable		 1mt1D-4hwvA:
12.63
1mt1E-4hwvA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ALA A 460
LEU A 533
LEU A 501
LEU A 525
 None
 0.96A 1mt1D-4iglA:
undetectable
1mt1E-4iglA:
undetectable		 1mt1D-4iglA:
5.24
1mt1E-4iglA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdq SLR1964 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 4 ALA A  89
LEU A  95
GLU A  91
LEU A  20
 None
 0.86A 1mt1D-4jdqA:
undetectable
1mt1E-4jdqA:
undetectable		 1mt1D-4jdqA:
20.83
1mt1E-4jdqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 4 LEU A 147
GLU A 298
LEU A 242
LEU A  65
 None
 0.79A 1mt1D-4jw1A:
undetectable
1mt1E-4jw1A:
undetectable		 1mt1D-4jw1A:
11.67
1mt1E-4jw1A:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING

(Bacteroides
vulgatus) 		PF12771
(SusD-like_2) 		4 ALA A  50
LEU A 109
LEU A 190
LEU A 160
 None
 0.95A 1mt1D-4lerA:
undetectable
1mt1E-4lerA:
undetectable		 1mt1D-4lerA:
13.62
1mt1E-4lerA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		4 ALA A 231
LEU A 245
GLU A 200
LEU A 193
 None
 0.95A 1mt1D-4mnrA:
undetectable
1mt1E-4mnrA:
undetectable		 1mt1D-4mnrA:
14.10
1mt1E-4mnrA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 ALA A 144
LEU A 245
GLU A 145
LEU A  31
 None
 0.93A 1mt1D-4n8gA:
undetectable
1mt1E-4n8gA:
undetectable		 1mt1D-4n8gA:
15.25
1mt1E-4n8gA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 ALA A 267
LEU A 100
ASP A  96
LEU A  92
 None
 0.93A 1mt1D-4ofzA:
undetectable
1mt1E-4ofzA:
undetectable		 1mt1D-4ofzA:
12.65
1mt1E-4ofzA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qik ROQUIN-1

(Homo sapiens) 		no annotation 4 ALA A 252
LEU A 204
GLU A 282
LEU A 307
 None
 0.92A 1mt1D-4qikA:
undetectable
1mt1E-4qikA:
undetectable		 1mt1D-4qikA:
16.04
1mt1E-4qikA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		4 ALA A 252
LEU A 204
GLU A 282
LEU A 307
 None
 1.00A 1mt1D-4txaA:
undetectable
1mt1E-4txaA:
undetectable		 1mt1D-4txaA:
12.29
1mt1E-4txaA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		4 LEU A 474
GLU A 464
LEU A 401
LEU A 394
 None
 0.99A 1mt1D-4uqgA:
1.8
1mt1E-4uqgA:
undetectable		 1mt1D-4uqgA:
10.54
1mt1E-4uqgA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z31 ROQUIN-2

(Homo sapiens) 		no annotation 4 ALA A 249
LEU A 201
GLU A 279
LEU A 304
 None
 0.88A 1mt1D-4z31A:
undetectable
1mt1E-4z31A:
undetectable		 1mt1D-4z31A:
13.61
1mt1E-4z31A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 ALA A 168
LEU A  71
GLU A 167
LEU A  43
 None
 0.86A 1mt1D-4z8zA:
undetectable
1mt1E-4z8zA:
undetectable		 1mt1D-4z8zA:
15.48
1mt1E-4z8zA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlc ROQUIN-2

(Homo sapiens) 		no annotation 4 ALA A 249
LEU A 201
GLU A 279
LEU A 304
 None
 0.88A 1mt1D-4zlcA:
undetectable
1mt1E-4zlcA:
undetectable		 1mt1D-4zlcA:
21.12
1mt1E-4zlcA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE

(Thymus vulgaris) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 195
GLU A 223
LEU A 243
LEU A 236
 LEU  A 195 ( 0.6A)
GLU  A 223 ( 0.5A)
LEU  A 243 ( 0.5A)
LEU  A 236 ( 0.6A)
 1.00A 1mt1D-5c05A:
undetectable
1mt1E-5c05A:
undetectable		 1mt1D-5c05A:
11.27
1mt1E-5c05A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 408
GLU A 383
LEU A 432
LEU A 424
 None
 1.01A 1mt1D-5cx8A:
undetectable
1mt1E-5cx8A:
undetectable		 1mt1D-5cx8A:
11.85
1mt1E-5cx8A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		4 ALA A  25
GLU A  26
LEU A  36
LEU A  83
 None
 0.92A 1mt1D-5ddbA:
undetectable
1mt1E-5ddbA:
undetectable		 1mt1D-5ddbA:
12.81
1mt1E-5ddbA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		4 ALA A  25
LEU A  13
GLU A  26
LEU A  36
 None
 1.02A 1mt1D-5ddbA:
undetectable
1mt1E-5ddbA:
undetectable		 1mt1D-5ddbA:
12.81
1mt1E-5ddbA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5f ROQUIN-1

(Mus musculus) 		no annotation 4 ALA A 252
LEU A 204
GLU A 282
LEU A 307
 None
 0.98A 1mt1D-5f5fA:
undetectable
1mt1E-5f5fA:
undetectable		 1mt1D-5f5fA:
18.04
1mt1E-5f5fA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f96 HEAVY CHAIN OF
ANTIBODY CH235.12

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  88
LEU H  82
LEU H  20
LEU H  67
 None
 0.90A 1mt1D-5f96H:
undetectable
1mt1E-5f96H:
undetectable		 1mt1D-5f96H:
16.67
1mt1E-5f96H:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C

(Pseudomonas sp.) 		PF16670
(PI-PLC-C1) 		4 ALA A  96
GLU A  95
LEU A 139
LEU A 118
 None
 0.91A 1mt1D-5fyrA:
undetectable
1mt1E-5fyrA:
undetectable		 1mt1D-5fyrA:
16.61
1mt1E-5fyrA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		4 ALA A 207
LEU A 168
LEU A 232
LEU A 225
 None
 0.81A 1mt1D-5gooA:
undetectable
1mt1E-5gooA:
undetectable		 1mt1D-5gooA:
13.11
1mt1E-5gooA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 ALA q 527
LEU q 521
LEU q 139
LEU q 430
 None
 0.95A 1mt1D-5gw5q:
undetectable
1mt1E-5gw5q:
undetectable		 1mt1D-5gw5q:
13.88
1mt1E-5gw5q:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5v FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF02465
(FliD_N)
PF07195
(FliD_C) 		4 ALA A 156
LEU A 201
LEU A 178
LEU A 193
 None
 0.93A 1mt1D-5h5vA:
undetectable
1mt1E-5h5vA:
undetectable		 1mt1D-5h5vA:
11.41
1mt1E-5h5vA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		4 ALA A 156
LEU A 201
LEU A 178
LEU A 193
 None
 0.92A 1mt1D-5h5wA:
undetectable
1mt1E-5h5wA:
undetectable		 1mt1D-5h5wA:
15.92
1mt1E-5h5wA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifg ANTITOXIN HIGA
MRNA INTERFERASE
HIGB

(Escherichia
coli) 		PF01381
(HTH_3)
PF09907
(HigB_toxin) 		4 ALA A   8
LEU B  34
ASP B  38
LEU B  41
 None
 0.95A 1mt1D-5ifgA:
undetectable
1mt1E-5ifgA:
undetectable		 1mt1D-5ifgA:
24.19
1mt1E-5ifgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iki CYTOCHROME P450(MEG)

(Bacillus
megaterium) 		PF00067
(p450) 		4 LEU A 154
GLU A 116
LEU A 363
LEU A 146
 None
 0.92A 1mt1D-5ikiA:
undetectable
1mt1E-5ikiA:
undetectable		 1mt1D-5ikiA:
13.30
1mt1E-5ikiA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj7 ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
HOMOLOG

(Caenorhabditis
elegans) 		PF02661
(Fic) 		4 ALA A 414
LEU A 402
LEU A 444
LEU A 452
 None
 0.91A 1mt1D-5jj7A:
undetectable
1mt1E-5jj7A:
undetectable		 1mt1D-5jj7A:
15.19
1mt1E-5jj7A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius) 		PF00891
(Methyltransf_2) 		4 ALA A  35
LEU A  54
LEU A  78
LEU A  45
 None
 0.99A 1mt1D-5jr3A:
undetectable
1mt1E-5jr3A:
undetectable		 1mt1D-5jr3A:
15.52
1mt1E-5jr3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens) 		no annotation 4 ALA A  41
GLU A  42
LEU A 147
LEU A 116
 None
 0.92A 1mt1D-5lfdA:
undetectable
1mt1E-5lfdA:
undetectable		 1mt1D-5lfdA:
18.99
1mt1E-5lfdA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ALA A1411
LEU A1478
GLU A1412
LEU A1448
 None
 0.86A 1mt1D-5m59A:
undetectable
1mt1E-5m59A:
undetectable		 1mt1D-5m59A:
5.22
1mt1E-5m59A:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmh HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR

(Pseudomonas
aeruginosa) 		PF03466
(LysR_substrate) 		4 ALA A 100
LEU A 113
LEU A 285
LEU A  96
 None
 0.97A 1mt1D-5mmhA:
undetectable
1mt1E-5mmhA:
undetectable		 1mt1D-5mmhA:
15.60
1mt1E-5mmhA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 ALA A  81
LEU A 188
LEU A 164
LEU A 169
 None
 1.01A 1mt1D-5u2gA:
undetectable
1mt1E-5u2gA:
undetectable		 1mt1D-5u2gA:
8.73
1mt1E-5u2gA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 4 LEU A 463
LEU A 141
ASP A 137
LEU A 134
 None
 0.99A 1mt1D-5wi9A:
undetectable
1mt1E-5wi9A:
undetectable		 1mt1D-5wi9A:
undetectable
1mt1E-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 ALA A 411
LEU A 388
GLU A 381
LEU A 421
 None
 0.82A 1mt1D-5wwtA:
undetectable
1mt1E-5wwtA:
undetectable		 1mt1D-5wwtA:
13.92
1mt1E-5wwtA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 ALA A 270
LEU A 201
LEU A 255
LEU A 193
 None
 0.93A 1mt1D-5wy4A:
undetectable
1mt1E-5wy4A:
undetectable		 1mt1D-5wy4A:
18.97
1mt1E-5wy4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9s VV2_1132

(Vibrio
vulnificus) 		no annotation 4 LEU A  61
GLU A  73
LEU A  14
LEU A  43
 None
 0.92A 1mt1D-5y9sA:
undetectable
1mt1E-5y9sA:
undetectable		 1mt1D-5y9sA:
21.05
1mt1E-5y9sA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqw PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio harveyi) 		no annotation 4 LEU A 196
GLU A 181
LEU A 191
LEU A 520
 None
 0.89A 1mt1D-5yqwA:
undetectable
1mt1E-5yqwA:
undetectable		 1mt1D-5yqwA:
18.52
1mt1E-5yqwA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 4 ALA A 165
LEU A 138
ASP A 141
LEU A 104
 None
 0.86A 1mt1D-6bwmA:
undetectable
1mt1E-6bwmA:
undetectable		 1mt1D-6bwmA:
17.24
1mt1E-6bwmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		no annotation 4 ALA A 927
LEU A 910
GLU A 923
LEU A 957
 None
 1.00A 1mt1D-6by9A:
undetectable
1mt1E-6by9A:
undetectable		 1mt1D-6by9A:
28.16
1mt1E-6by9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 473
GLU B1066
LEU B1062
LEU B1079
 None
 0.59A 1mt1D-6f42A:
undetectable
1mt1E-6f42A:
undetectable		 1mt1D-6f42A:
20.72
1mt1E-6f42A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffv -

(-) 		no annotation 4 ALA A 172
LEU A   3
LEU A 116
LEU A 108
 BNG  A 307 ( 3.7A)
None
PG4  A 305 (-4.5A)
PG4  A 304 ( 4.6A)
 1.00A 1mt1D-6ffvA:
undetectable
1mt1E-6ffvA:
undetectable		 1mt1D-6ffvA:
undetectable
1mt1E-6ffvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 4 ALA A 232
LEU A 332
LEU A 248
LEU A 341
 None
 0.90A 1mt1D-6fydA:
undetectable
1mt1E-6fydA:
undetectable		 1mt1D-6fydA:
16.81
1mt1E-6fydA:
18.75