SIMILAR PATTERNS OF AMINO ACIDS FOR 1MT1_B_AG2B7001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A  75
GLU A 100
LEU A 158
LEU A  19
 None
 0.93A 1mt1B-1b4pA:
0.0
1mt1C-1b4pA:
undetectable		 1mt1B-1b4pA:
19.82
1mt1C-1b4pA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5r PROLINE OXIDASE

(Streptomyces
sp. TH1) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		4 ILE A  81
LEU A  23
ASP A  19
LEU A  16
 None
 1.04A 1mt1B-1e5rA:
0.0
1mt1C-1e5rA:
0.0		 1mt1B-1e5rA:
17.89
1mt1C-1e5rA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE

(Escherichia
coli) 		PF01817
(CM_2) 		4 ARG A  29
LEU A  79
ASP A  83
LEU A  86
 None
 0.92A 1mt1B-1ecmA:
undetectable
1mt1C-1ecmA:
undetectable		 1mt1B-1ecmA:
19.51
1mt1C-1ecmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqk ORYZACYSTATIN-I

(Oryza sativa) 		PF16845
(SQAPI) 		4 GLU A  81
LEU A  26
ASP A  25
LEU A  21
 None
 1.03A 1mt1B-1eqkA:
undetectable
1mt1C-1eqkA:
undetectable		 1mt1B-1eqkA:
24.79
1mt1C-1eqkA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A 249
GLU A 230
LEU A 217
LEU A 267
 None
 1.02A 1mt1B-1ftsA:
0.0
1mt1C-1ftsA:
0.0		 1mt1B-1ftsA:
15.93
1mt1C-1ftsA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 ARG 1 248
LEU 1 343
ASP 1 252
LEU 1 188
 None
 0.77A 1mt1B-1gt91:
0.0
1mt1C-1gt91:
0.0		 1mt1B-1gt91:
13.55
1mt1C-1gt91:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 ILE A 307
GLU A 380
ARG A 267
ASP A 312
 None
 1.00A 1mt1B-1jxkA:
0.0
1mt1C-1jxkA:
undetectable		 1mt1B-1jxkA:
11.41
1mt1C-1jxkA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ors 33H1 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE B  68
ARG B  67
ASP B  90
LEU B  18
 None
 1.01A 1mt1B-1orsB:
0.0
1mt1C-1orsB:
0.0		 1mt1B-1orsB:
19.05
1mt1C-1orsB:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF08992
(QH-AmDH_gamma)
no annotation 		4 ARG B   9
LEU C  51
ASP C  39
LEU B 327
 None
None
None
TRW  C  43 ( 4.2A)
 0.99A 1mt1B-1pbyB:
0.0
1mt1C-1pbyB:
0.0		 1mt1B-1pbyB:
19.05
1mt1C-1pbyB:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9c SON OF SEVENLESS
PROTEIN

(Homo sapiens) 		PF00125
(Histone) 		4 ILE A 141
GLU A 135
LEU A 105
LEU A  45
 None
 1.05A 1mt1B-1q9cA:
undetectable
1mt1C-1q9cA:
undetectable		 1mt1B-1q9cA:
21.47
1mt1C-1q9cA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		4 GLU A  22
ARG A  40
LEU A   2
ASP A   4
 None
 1.03A 1mt1B-1sr8A:
0.0
1mt1C-1sr8A:
0.0		 1mt1B-1sr8A:
18.56
1mt1C-1sr8A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.85A 1mt1B-1t1eA:
undetectable
1mt1C-1t1eA:
0.0		 1mt1B-1t1eA:
10.26
1mt1C-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlj HYPOTHETICAL UPF0130
PROTEIN SSO0622

(Sulfolobus
solfataricus) 		PF02676
(TYW3) 		4 ILE A 117
GLU A 112
ARG A  41
ASP A  43
 None
 1.04A 1mt1B-1tljA:
undetectable
1mt1C-1tljA:
undetectable		 1mt1B-1tljA:
18.60
1mt1C-1tljA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		4 ARG A 126
LEU A 168
ASP A 172
LEU A 175
 None
 0.93A 1mt1B-1tltA:
undetectable
1mt1C-1tltA:
0.0		 1mt1B-1tltA:
16.51
1mt1C-1tltA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ILE A  82
LEU A  67
ASP A  71
LEU A  74
 None
 0.81A 1mt1B-1u3dA:
undetectable
1mt1C-1u3dA:
undetectable		 1mt1B-1u3dA:
12.57
1mt1C-1u3dA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		4 ARG A 271
LEU A  94
ASP A  96
LEU A  97
 SAM  A3142 (-3.2A)
None
SAM  A3142 (-3.5A)
None
 0.96A 1mt1B-1wg8A:
undetectable
1mt1C-1wg8A:
undetectable		 1mt1B-1wg8A:
19.43
1mt1C-1wg8A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN

(Yersinia pestis) 		PF07201
(HrpJ) 		4 ILE A 180
GLU A 172
ASP A 242
LEU A 239
 None
 0.95A 1mt1B-1xkpA:
undetectable
1mt1C-1xkpA:
undetectable		 1mt1B-1xkpA:
17.67
1mt1C-1xkpA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 SECRETION CONTROL
PROTEIN

(Yersinia pestis) 		PF07201
(HrpJ) 		4 ILE A 180
GLU A 172
ASP A 242
LEU A 239
 None
 0.91A 1mt1B-1xl3A:
undetectable
1mt1C-1xl3A:
undetectable		 1mt1B-1xl3A:
17.06
1mt1C-1xl3A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		4 ILE A  88
ARG A  84
LEU A  24
ASP A  19
 None
 1.01A 1mt1B-1yacA:
undetectable
1mt1C-1yacA:
undetectable		 1mt1B-1yacA:
18.18
1mt1C-1yacA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ILE I 490
GLU I 496
LEU I 323
LEU I 479
 None
HIO  I 603 (-2.8A)
HIO  I 603 ( 4.4A)
None
 0.89A 1mt1B-1yveI:
undetectable
1mt1C-1yveI:
undetectable		 1mt1B-1yveI:
12.60
1mt1C-1yveI:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be3 GTP
PYROPHOSPHOKINASE

(Streptococcus
pneumoniae) 		PF04607
(RelA_SpoT) 		4 GLU A  40
ARG A 117
LEU A 145
LEU A 183
 None
 0.98A 1mt1B-2be3A:
undetectable
1mt1C-2be3A:
undetectable		 1mt1B-2be3A:
16.81
1mt1C-2be3A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		4 ILE A  26
GLU A  34
ASP A  61
LEU A  58
 None
 0.96A 1mt1B-2chgA:
undetectable
1mt1C-2chgA:
undetectable		 1mt1B-2chgA:
20.27
1mt1C-2chgA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 ILE A  26
GLU A  34
ASP A  61
LEU A  58
 None
 0.92A 1mt1B-2chqA:
undetectable
1mt1C-2chqA:
undetectable		 1mt1B-2chqA:
16.88
1mt1C-2chqA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g42 HYPOTHETICAL PROTEIN
TM_0693

(Thermotoga
maritima) 		no annotation 4 ARG A  29
LEU A  52
ASP A  48
LEU A  45
 None
 0.73A 1mt1B-2g42A:
undetectable
1mt1C-2g42A:
undetectable		 1mt1B-2g42A:
23.89
1mt1C-2g42A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		4 ILE D 343
LEU D 373
ASP D 369
LEU D 366
 None
 0.94A 1mt1B-2gafD:
undetectable
1mt1C-2gafD:
undetectable		 1mt1B-2gafD:
12.62
1mt1C-2gafD:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218

(Pseudomonas
aeruginosa) 		PF02129
(Peptidase_S15) 		4 ILE A 173
GLU A 167
LEU A  87
LEU A 128
 None
 1.03A 1mt1B-2hdwA:
undetectable
1mt1C-2hdwA:
undetectable		 1mt1B-2hdwA:
15.47
1mt1C-2hdwA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 ARG A 297
LEU A 467
ASP A 466
LEU A 289
 None
 0.96A 1mt1B-2jgpA:
1.1
1mt1C-2jgpA:
undetectable		 1mt1B-2jgpA:
11.37
1mt1C-2jgpA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jx3 PROTEIN DEK

(Homo sapiens) 		PF02037
(SAP) 		4 ILE A  17
GLU A  28
LEU A  32
LEU A 106
 None
 0.97A 1mt1B-2jx3A:
undetectable
1mt1C-2jx3A:
undetectable		 1mt1B-2jx3A:
21.60
1mt1C-2jx3A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 ILE A 333
ARG A 277
LEU A 199
ASP A 145
 None
 0.95A 1mt1B-2p3xA:
undetectable
1mt1C-2p3xA:
undetectable		 1mt1B-2p3xA:
14.16
1mt1C-2p3xA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 ARG A 132
LEU A 284
ASP A 280
LEU A 276
 None
 0.61A 1mt1B-2pbgA:
undetectable
1mt1C-2pbgA:
undetectable		 1mt1B-2pbgA:
13.23
1mt1C-2pbgA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 GLU A 135
ARG A 105
ASP A 132
LEU A 131
 None
 1.03A 1mt1B-2w61A:
undetectable
1mt1C-2w61A:
undetectable		 1mt1B-2w61A:
11.89
1mt1C-2w61A:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		4 GLU A 456
ARG A 446
LEU A 390
ASP A 386
 None
 1.00A 1mt1B-2x1mA:
undetectable
1mt1C-2x1mA:
undetectable		 1mt1B-2x1mA:
11.46
1mt1C-2x1mA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 ARG A 404
LEU A  40
ASP A  36
LEU A  33
 None
 0.76A 1mt1B-2ynkA:
undetectable
1mt1C-2ynkA:
undetectable		 1mt1B-2ynkA:
13.36
1mt1C-2ynkA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 ILE A 155
GLU A 147
LEU A 128
LEU A 121
 None
 0.94A 1mt1B-3bdzA:
undetectable
1mt1C-3bdzA:
undetectable		 1mt1B-3bdzA:
15.86
1mt1C-3bdzA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		4 ILE A 173
GLU A 122
LEU A 125
LEU A 161
 None
 1.04A 1mt1B-3beoA:
undetectable
1mt1C-3beoA:
undetectable		 1mt1B-3beoA:
16.27
1mt1C-3beoA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 ILE B 357
GLU B 374
LEU B 375
LEU B 296
 None
 0.94A 1mt1B-3bg0B:
undetectable
1mt1C-3bg0B:
undetectable		 1mt1B-3bg0B:
13.54
1mt1C-3bg0B:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 ILE A  41
GLU A  38
LEU A 377
LEU A 330
 None
 1.04A 1mt1B-3cinA:
undetectable
1mt1C-3cinA:
undetectable		 1mt1B-3cinA:
14.03
1mt1C-3cinA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		4 ILE A 289
GLU A 285
ARG A 226
ASP A 287
 None
 0.94A 1mt1B-3cm5A:
undetectable
1mt1C-3cm5A:
undetectable		 1mt1B-3cm5A:
15.21
1mt1C-3cm5A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 GLU A  62
ARG A  27
LEU A 448
LEU A 389
 None
 0.97A 1mt1B-3cp2A:
undetectable
1mt1C-3cp2A:
undetectable		 1mt1B-3cp2A:
10.31
1mt1C-3cp2A:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djb HYDROLASE, HD FAMILY

(Bacillus
thuringiensis) 		PF01966
(HD) 		4 GLU A 192
LEU A 124
ASP A 120
LEU A 117
 None
 0.84A 1mt1B-3djbA:
undetectable
1mt1C-3djbA:
undetectable		 1mt1B-3djbA:
19.63
1mt1C-3djbA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ILE A 490
GLU A 496
LEU A 323
LEU A 479
 None
MG  A   1 ( 3.0A)
None
None
 0.93A 1mt1B-3fr8A:
undetectable
1mt1C-3fr8A:
undetectable		 1mt1B-3fr8A:
11.83
1mt1C-3fr8A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE B  79
GLU B 104
LEU B 162
LEU B  23
 None
 0.96A 1mt1B-3gtuB:
undetectable
1mt1C-3gtuB:
undetectable		 1mt1B-3gtuB:
20.36
1mt1C-3gtuB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLU A 271
ARG A  25
LEU A 298
ASP A 300
 None
 0.95A 1mt1B-3hnpA:
undetectable
1mt1C-3hnpA:
undetectable		 1mt1B-3hnpA:
16.23
1mt1C-3hnpA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icy SENSOR PROTEIN

(Chlorobaculum
tepidum) 		PF08447
(PAS_3) 		4 ILE A 107
GLU A   1
ASP A  92
LEU A  76
 None
None
None
GOL  A 116 ( 4.6A)
 1.02A 1mt1B-3icyA:
undetectable
1mt1C-3icyA:
undetectable		 1mt1B-3icyA:
23.26
1mt1C-3icyA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 152
GLU A 132
ASP A 322
LEU A 325
 None
 0.88A 1mt1B-3ik4A:
undetectable
1mt1C-3ik4A:
undetectable		 1mt1B-3ik4A:
15.62
1mt1C-3ik4A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		4 ILE A  49
GLU A  18
LEU A  32
LEU A  65
 None
 1.00A 1mt1B-3imhA:
undetectable
1mt1C-3imhA:
undetectable		 1mt1B-3imhA:
12.81
1mt1C-3imhA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 ILE A1358
GLU A1375
LEU A1376
LEU A1297
 None
 0.88A 1mt1B-3jroA:
undetectable
1mt1C-3jroA:
undetectable		 1mt1B-3jroA:
9.63
1mt1C-3jroA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4e ALPHA-HEMOLYSIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 ILE A 170
GLU A 250
ARG A 184
ASP A 272
 None
 0.99A 1mt1B-3m4eA:
undetectable
1mt1C-3m4eA:
undetectable		 1mt1B-3m4eA:
14.13
1mt1C-3m4eA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA

(Histophilus
somni) 		PF02661
(Fic) 		4 ILE A3614
GLU A3619
ARG A3725
ASP A3655
 None
 0.94A 1mt1B-3n3uA:
undetectable
1mt1C-3n3uA:
undetectable		 1mt1B-3n3uA:
19.39
1mt1C-3n3uA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 ARG B 333
LEU B 325
ASP B 329
LEU B 332
 None
 0.89A 1mt1B-3pdiB:
undetectable
1mt1C-3pdiB:
undetectable		 1mt1B-3pdiB:
12.66
1mt1C-3pdiB:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 ILE A  93
GLU A 258
LEU A 390
ASP A 388
 None
 0.95A 1mt1B-3q9oA:
undetectable
1mt1C-3q9oA:
undetectable		 1mt1B-3q9oA:
10.24
1mt1C-3q9oA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 ILE A 467
ARG A   8
ASP A 462
LEU A 458
 None
 0.98A 1mt1B-3qp9A:
undetectable
1mt1C-3qp9A:
undetectable		 1mt1B-3qp9A:
11.72
1mt1C-3qp9A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzy BACULOVIRUS
SULFHYDRYL OXIDASE
AC92

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		4 ILE A 178
GLU A 183
LEU A 132
LEU A 139
 None
 0.90A 1mt1B-3qzyA:
undetectable
1mt1C-3qzyA:
undetectable		 1mt1B-3qzyA:
18.15
1mt1C-3qzyA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		4 ILE A 389
GLU A 418
ARG A 394
ASP A 470
 None
 0.92A 1mt1B-3vgfA:
undetectable
1mt1C-3vgfA:
undetectable		 1mt1B-3vgfA:
10.91
1mt1C-3vgfA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zph CHALCONE ISOMERASE

(Eubacterium
ramulus) 		no annotation 4 GLU A 145
ARG A 198
ASP A 147
LEU A 148
 None
 1.00A 1mt1B-3zphA:
undetectable
1mt1C-3zphA:
undetectable		 1mt1B-3zphA:
18.84
1mt1C-3zphA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE C  19
LEU C 343
ASP C 385
LEU C 384
 None
 1.01A 1mt1B-4bujC:
undetectable
1mt1C-4bujC:
undetectable		 1mt1B-4bujC:
14.04
1mt1C-4bujC:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 ILE A 123
GLU A 115
LEU A 111
LEU A 204
 None
 1.04A 1mt1B-4cfhA:
undetectable
1mt1C-4cfhA:
undetectable		 1mt1B-4cfhA:
11.26
1mt1C-4cfhA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo sapiens) 		PF00027
(cNMP_binding)
PF02197
(RIIa) 		4 ILE B 253
GLU B 362
ARG B 370
LEU B 257
 None
 1.03A 1mt1B-4dinB:
undetectable
1mt1C-4dinB:
undetectable		 1mt1B-4dinB:
17.24
1mt1C-4dinB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		4 ILE A 287
GLU A 355
ARG A 258
LEU A 234
 None
 1.02A 1mt1B-4eppA:
undetectable
1mt1C-4eppA:
undetectable		 1mt1B-4eppA:
13.79
1mt1C-4eppA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 GLU A 360
ARG A 724
LEU A 352
ASP A 349
 None
 1.03A 1mt1B-4ex4A:
undetectable
1mt1C-4ex4A:
undetectable		 1mt1B-4ex4A:
9.71
1mt1C-4ex4A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		4 ILE C 299
GLU C 339
LEU C  31
LEU C 302
 None
 1.01A 1mt1B-4ifdC:
undetectable
1mt1C-4ifdC:
undetectable		 1mt1B-4ifdC:
16.25
1mt1C-4ifdC:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isd GLUTATHIONE
S-TRANSFERASE

(Burkholderia
glumae) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		4 GLU A  28
ARG A 110
ASP A 170
LEU A 173
 None
GSH  A 301 (-4.7A)
None
None
 1.00A 1mt1B-4isdA:
undetectable
1mt1C-4isdA:
undetectable		 1mt1B-4isdA:
18.02
1mt1C-4isdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 220
GLU A 308
ARG A 196
ASP A 131
 None
 1.04A 1mt1B-4jhvA:
undetectable
1mt1C-4jhvA:
undetectable		 1mt1B-4jhvA:
11.74
1mt1C-4jhvA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		4 ILE A 519
LEU A 530
ASP A 528
LEU A 527
 None
 1.03A 1mt1B-4kvlA:
undetectable
1mt1C-4kvlA:
undetectable		 1mt1B-4kvlA:
11.00
1mt1C-4kvlA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9w ARA H 8 ALLERGEN

(Arachis
hypogaea) 		PF00407
(Bet_v_1) 		4 ILE A 146
GLU A 140
LEU A 115
LEU A 103
 None
 1.05A 1mt1B-4m9wA:
undetectable
1mt1C-4m9wA:
undetectable		 1mt1B-4m9wA:
25.62
1mt1C-4m9wA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		4 GLU A  43
ARG A   8
LEU A  15
ASP A  14
 None
 1.00A 1mt1B-4mi4A:
undetectable
1mt1C-4mi4A:
undetectable		 1mt1B-4mi4A:
18.32
1mt1C-4mi4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF01884
(PcrB) 		4 ILE A  76
GLU A 124
LEU A 126
LEU A  21
 None
 0.96A 1mt1B-4mm1A:
undetectable
1mt1C-4mm1A:
undetectable		 1mt1B-4mm1A:
19.83
1mt1C-4mm1A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		4 ILE A  75
GLU A  79
LEU A 108
LEU A 116
 None
 0.80A 1mt1B-4mmpA:
undetectable
1mt1C-4mmpA:
undetectable		 1mt1B-4mmpA:
13.64
1mt1C-4mmpA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  80
GLU A 105
LEU A 171
LEU A  21
 None
 0.78A 1mt1B-4q5nA:
undetectable
1mt1C-4q5nA:
undetectable		 1mt1B-4q5nA:
17.99
1mt1C-4q5nA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ILE A 231
GLU A 234
ARG A 267
ASP A 419
 None
 0.98A 1mt1B-4rl6A:
undetectable
1mt1C-4rl6A:
undetectable		 1mt1B-4rl6A:
14.02
1mt1C-4rl6A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7d ATP-DEPENDENT DNA
HELICASE Q1

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 ILE A  82
GLU A  71
LEU A  97
LEU A 121
 None
 1.01A 1mt1B-4u7dA:
undetectable
1mt1C-4u7dA:
undetectable		 1mt1B-4u7dA:
12.05
1mt1C-4u7dA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 ARG A 328
LEU A 269
ASP A 272
LEU A 318
 None
 0.91A 1mt1B-4umvA:
undetectable
1mt1C-4umvA:
undetectable		 1mt1B-4umvA:
8.95
1mt1C-4umvA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		4 ILE A  88
ARG A  84
LEU A  24
ASP A  19
 None
 1.05A 1mt1B-4wh0A:
undetectable
1mt1C-4wh0A:
undetectable		 1mt1B-4wh0A:
19.51
1mt1C-4wh0A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 439
GLU A 400
ARG A 432
LEU A 386
 None
 0.84A 1mt1B-4ypjA:
undetectable
1mt1C-4ypjA:
undetectable		 1mt1B-4ypjA:
8.50
1mt1C-4ypjA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 ARG A 296
LEU A  70
ASP A 339
LEU A 308
 None
 0.91A 1mt1B-4yyfA:
undetectable
1mt1C-4yyfA:
undetectable		 1mt1B-4yyfA:
13.61
1mt1C-4yyfA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT A

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV) 		4 ILE A 464
ARG A 460
LEU A 447
ASP A 450
 None
 0.88A 1mt1B-4z2eA:
undetectable
1mt1C-4z2eA:
undetectable		 1mt1B-4z2eA:
14.88
1mt1C-4z2eA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ILE A 733
ARG A 762
ASP A 488
LEU A 487
 None
 1.04A 1mt1B-4ztxA:
undetectable
1mt1C-4ztxA:
undetectable		 1mt1B-4ztxA:
9.55
1mt1C-4ztxA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 ILE A 137
GLU A 141
LEU A 171
LEU A 178
 None
 1.02A 1mt1B-5bp7A:
undetectable
1mt1C-5bp7A:
undetectable		 1mt1B-5bp7A:
14.49
1mt1C-5bp7A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c08 1E6 TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU E  11
ARG E  64
LEU E 113
ASP E  86
 None
 0.97A 1mt1B-5c08E:
undetectable
1mt1C-5c08E:
undetectable		 1mt1B-5c08E:
17.96
1mt1C-5c08E:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ILE A 672
GLU A 666
LEU A 588
ASP A 589
 None
 0.91A 1mt1B-5chcA:
undetectable
1mt1C-5chcA:
undetectable		 1mt1B-5chcA:
10.70
1mt1C-5chcA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 ILE A1335
GLU A1329
ARG A1338
ASP A1325
 None
 1.00A 1mt1B-5d0fA:
undetectable
1mt1C-5d0fA:
undetectable		 1mt1B-5d0fA:
5.04
1mt1C-5d0fA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE B  67
ARG B  66
ASP B  86
LEU B  82
 None
 1.05A 1mt1B-5f9wB:
undetectable
1mt1C-5f9wB:
undetectable		 1mt1B-5f9wB:
17.59
1mt1C-5f9wB:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 ARG A 737
LEU A 681
ASP A 678
LEU A 674
 None
 0.79A 1mt1B-5gl7A:
undetectable
1mt1C-5gl7A:
undetectable		 1mt1B-5gl7A:
11.48
1mt1C-5gl7A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		4 ARG A 280
LEU A 216
ASP A 212
LEU A 209
 None
 0.78A 1mt1B-5h3oA:
undetectable
1mt1C-5h3oA:
undetectable		 1mt1B-5h3oA:
8.77
1mt1C-5h3oA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j68 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		4 ILE A1051
GLU A1069
ASP A1076
LEU A1077
 None
 0.89A 1mt1B-5j68A:
undetectable
1mt1C-5j68A:
undetectable		 1mt1B-5j68A:
11.11
1mt1C-5j68A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		4 ILE A 187
LEU A 210
ASP A 209
LEU A 163
 None
 1.01A 1mt1B-5jufA:
undetectable
1mt1C-5jufA:
undetectable		 1mt1B-5jufA:
13.87
1mt1C-5jufA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ILE A 513
ARG A 516
LEU A 645
ASP A 644
 None
 1.01A 1mt1B-5tusA:
undetectable
1mt1C-5tusA:
undetectable		 1mt1B-5tusA:
9.47
1mt1C-5tusA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ILE A 276
ARG A 260
ASP A 270
LEU A 269
 None
 0.83A 1mt1B-5veuA:
undetectable
1mt1C-5veuA:
undetectable		 1mt1B-5veuA:
12.24
1mt1C-5veuA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg9 PROTEIN-S-ISOPRENYLC
YSTEINE
O-METHYLTRANSFERASE

(Tribolium
castaneum) 		no annotation 4 ILE A 225
GLU A 145
LEU A 152
LEU A 158
 None
 1.01A 1mt1B-5vg9A:
undetectable
1mt1C-5vg9A:
undetectable		 1mt1B-5vg9A:
18.64
1mt1C-5vg9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN

(Mus musculus) 		no annotation 4 ILE H  67
ARG H  66
ASP H  89
LEU H  18
 None
 0.89A 1mt1B-5vxrH:
undetectable
1mt1C-5vxrH:
undetectable		 1mt1B-5vxrH:
20.72
1mt1C-5vxrH:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO

(Homo sapiens) 		no annotation 4 ILE A 812
ARG B 198
ASP A 756
LEU A 753
 None
 0.70A 1mt1B-5w21A:
undetectable
1mt1C-5w21A:
undetectable		 1mt1B-5w21A:
20.54
1mt1C-5w21A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 ILE A 664
GLU A 683
LEU A 642
LEU A 649
 None
 1.00A 1mt1B-5weaA:
undetectable
1mt1C-5weaA:
undetectable		 1mt1B-5weaA:
26.17
1mt1C-5weaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		4 GLU D 356
ARG D 113
LEU D 253
ASP D 254
 None
 0.89A 1mt1B-5xfaD:
undetectable
1mt1C-5xfaD:
undetectable		 1mt1B-5xfaD:
13.46
1mt1C-5xfaD:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION

(Mycolicibacterium
smegmatis) 		PF00383
(dCMP_cyt_deam_1) 		4 GLU A 144
ARG A 100
LEU A   8
ASP A   7
 None
 0.91A 1mt1B-5xkoA:
undetectable
1mt1C-5xkoA:
undetectable		 1mt1B-5xkoA:
16.88
1mt1C-5xkoA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		4 ILE A 178
GLU A 183
LEU A 132
LEU A 139
 None
 0.89A 1mt1B-5xtoA:
undetectable
1mt1C-5xtoA:
undetectable		 1mt1B-5xtoA:
16.04
1mt1C-5xtoA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 4 GLU A 128
LEU A  41
ASP A 131
LEU A 135
 None
 0.97A 1mt1B-5yo8A:
undetectable
1mt1C-5yo8A:
undetectable		 1mt1B-5yo8A:
22.58
1mt1C-5yo8A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 ILE 2 349
GLU 2 255
LEU 2 241
LEU 2 263
 None
 1.03A 1mt1B-5zvs2:
undetectable
1mt1C-5zvs2:
undetectable		 1mt1B-5zvs2:
20.72
1mt1C-5zvs2:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 ILE K 227
GLU E 181
LEU E 171
ASP E 173
 None
 1.02A 1mt1B-6d6qK:
undetectable
1mt1C-6d6qK:
undetectable		 1mt1B-6d6qK:
16.95
1mt1C-6d6qK:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 ARG B  24
LEU B  96
ASP B  92
LEU B  89
 None
 1.04A 1mt1B-6fd2B:
undetectable
1mt1C-6fd2B:
undetectable		 1mt1B-6fd2B:
21.55
1mt1C-6fd2B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3

(Rattus rattus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A  75
GLU A 100
LEU A 158
LEU A  19
 None
 0.86A 1mt1B-6gswA:
undetectable
1mt1C-6gswA:
undetectable		 1mt1B-6gswA:
19.82
1mt1C-6gswA:
14.51