SIMILAR PATTERNS OF AMINO ACIDS FOR 1MT1_A_AG2A7005_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)

(Thermotoga
maritima) 		PF01584
(CheW)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		4 LEU A 517
ILE A 300
GLU A 398
ARG A 354
 None
 1.05A 1mt1A-1b3qA:
0.0
1mt1F-1b3qA:
0.0		 1mt1A-1b3qA:
12.16
1mt1F-1b3qA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 158
LEU A  19
ILE A  75
GLU A 100
 None
 0.93A 1mt1A-1b4pA:
undetectable
1mt1F-1b4pA:
undetectable		 1mt1A-1b4pA:
16.58
1mt1F-1b4pA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bey CAMPATH-1H ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP H  92
LEU H  18
ILE H  48
ARG H  69
 None
 1.06A 1mt1A-1beyH:
undetectable
1mt1F-1beyH:
0.0		 1mt1A-1beyH:
15.08
1mt1F-1beyH:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5r PROLINE OXIDASE

(Streptomyces
sp. TH1) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		4 LEU A  23
ASP A  19
LEU A  16
ILE A  81
 None
 1.07A 1mt1A-1e5rA:
0.0
1mt1F-1e5rA:
0.0		 1mt1A-1e5rA:
13.67
1mt1F-1e5rA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE

(Escherichia
coli) 		PF01817
(CM_2) 		4 LEU A  79
ASP A  83
LEU A  86
ARG A  29
 None
 0.92A 1mt1A-1ecmA:
undetectable
1mt1F-1ecmA:
undetectable		 1mt1A-1ecmA:
18.52
1mt1F-1ecmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqk ORYZACYSTATIN-I

(Oryza sativa) 		PF16845
(SQAPI) 		4 LEU A  26
ASP A  25
LEU A  21
GLU A  81
 None
 1.09A 1mt1A-1eqkA:
undetectable
1mt1F-1eqkA:
0.0		 1mt1A-1eqkA:
18.63
1mt1F-1eqkA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 LEU 1 343
ASP 1 252
LEU 1 188
ARG 1 248
 None
 0.74A 1mt1A-1gt91:
0.0
1mt1F-1gt91:
0.0		 1mt1A-1gt91:
9.86
1mt1F-1gt91:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 LEU A  78
LEU A 445
ILE A  86
GLU A  70
 None
 1.10A 1mt1A-1gz7A:
0.0
1mt1F-1gz7A:
0.0		 1mt1A-1gz7A:
9.58
1mt1F-1gz7A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 LEU P  40
ASP P 234
LEU P 232
ARG P  20
 None
 1.07A 1mt1A-1h71P:
0.0
1mt1F-1h71P:
0.0		 1mt1A-1h71P:
10.27
1mt1F-1h71P:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 LEU A  69
LEU A  10
ILE A  62
GLU A  68
 None
 1.09A 1mt1A-1j1wA:
0.0
1mt1F-1j1wA:
0.0		 1mt1A-1j1wA:
6.18
1mt1F-1j1wA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ors 33H1 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B  90
LEU B  18
ILE B  68
ARG B  67
 None
 1.03A 1mt1A-1orsB:
0.0
1mt1F-1orsB:
undetectable		 1mt1A-1orsB:
11.06
1mt1F-1orsB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF08992
(QH-AmDH_gamma)
no annotation 		4 LEU C  51
ASP C  39
LEU B 327
ARG B   9
 None
None
TRW  C  43 ( 4.2A)
None
 0.95A 1mt1A-1pbyC:
undetectable
1mt1F-1pbyC:
undetectable		 1mt1A-1pbyC:
22.67
1mt1F-1pbyC:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pff METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		4 ASP A 201
LEU A 180
GLU A  78
ARG A 174
 None
 0.94A 1mt1A-1pffA:
0.0
1mt1F-1pffA:
undetectable		 1mt1A-1pffA:
9.68
1mt1F-1pffA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		4 LEU A 135
ASP A 115
ILE A   8
GLU A 163
 None
 1.08A 1mt1A-1piiA:
undetectable
1mt1F-1piiA:
undetectable		 1mt1A-1piiA:
7.73
1mt1F-1piiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.83A 1mt1A-1t1eA:
undetectable
1mt1F-1t1eA:
undetectable		 1mt1A-1t1eA:
7.32
1mt1F-1t1eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 168
ASP A 172
LEU A 175
ARG A 126
 None
 0.96A 1mt1A-1tltA:
undetectable
1mt1F-1tltA:
undetectable		 1mt1A-1tltA:
10.06
1mt1F-1tltA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A  67
ASP A  71
LEU A  74
ILE A  82
 None
 0.81A 1mt1A-1u3dA:
undetectable
1mt1F-1u3dA:
undetectable		 1mt1A-1u3dA:
7.71
1mt1F-1u3dA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		4 LEU A  94
ASP A  96
LEU A  97
ARG A 271
 None
SAM  A3142 (-3.5A)
None
SAM  A3142 (-3.2A)
 0.99A 1mt1A-1wg8A:
undetectable
1mt1F-1wg8A:
undetectable		 1mt1A-1wg8A:
13.25
1mt1F-1wg8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN

(Yersinia pestis) 		PF07201
(HrpJ) 		4 ASP A 242
LEU A 239
ILE A 180
GLU A 172
 None
 1.03A 1mt1A-1xkpA:
undetectable
1mt1F-1xkpA:
undetectable		 1mt1A-1xkpA:
13.97
1mt1F-1xkpA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl3 SECRETION CONTROL
PROTEIN

(Yersinia pestis) 		PF07201
(HrpJ) 		4 ASP A 242
LEU A 239
ILE A 180
GLU A 172
 None
 0.98A 1mt1A-1xl3A:
undetectable
1mt1F-1xl3A:
undetectable		 1mt1A-1xl3A:
14.68
1mt1F-1xl3A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		4 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.04A 1mt1A-1yacA:
undetectable
1mt1F-1yacA:
undetectable		 1mt1A-1yacA:
17.33
1mt1F-1yacA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU I 323
LEU I 479
ILE I 490
GLU I 496
 HIO  I 603 ( 4.4A)
None
None
HIO  I 603 (-2.8A)
 1.04A 1mt1A-1yveI:
undetectable
1mt1F-1yveI:
undetectable		 1mt1A-1yveI:
7.07
1mt1F-1yveI:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be3 GTP
PYROPHOSPHOKINASE

(Streptococcus
pneumoniae) 		PF04607
(RelA_SpoT) 		4 LEU A 145
LEU A 183
GLU A  40
ARG A 117
 None
 1.04A 1mt1A-2be3A:
undetectable
1mt1F-2be3A:
undetectable		 1mt1A-2be3A:
12.95
1mt1F-2be3A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		4 ASP A  61
LEU A  58
ILE A  26
GLU A  34
 None
 0.92A 1mt1A-2chgA:
undetectable
1mt1F-2chgA:
undetectable		 1mt1A-2chgA:
13.99
1mt1F-2chgA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 ASP A  61
LEU A  58
ILE A  26
GLU A  34
 None
 0.98A 1mt1A-2chqA:
undetectable
1mt1F-2chqA:
undetectable		 1mt1A-2chqA:
10.19
1mt1F-2chqA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g42 HYPOTHETICAL PROTEIN
TM_0693

(Thermotoga
maritima) 		no annotation 4 LEU A  52
ASP A  48
LEU A  45
ARG A  29
 None
 0.74A 1mt1A-2g42A:
undetectable
1mt1F-2g42A:
undetectable		 1mt1A-2g42A:
24.32
1mt1F-2g42A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		4 LEU D 373
ASP D 369
LEU D 366
ILE D 343
 None
 0.94A 1mt1A-2gafD:
undetectable
1mt1F-2gafD:
undetectable		 1mt1A-2gafD:
9.11
1mt1F-2gafD:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		4 LEU A 314
ASP A 318
LEU A 321
GLU A 260
 None
 1.10A 1mt1A-2gryA:
undetectable
1mt1F-2gryA:
undetectable		 1mt1A-2gryA:
8.29
1mt1F-2gryA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.97A 1mt1A-2jgpA:
undetectable
1mt1F-2jgpA:
1.1		 1mt1A-2jgpA:
8.52
1mt1F-2jgpA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kma TALIN 1

(Mus musculus) 		PF09379
(FERM_N)
PF16511
(FERM_f0) 		4 LEU A 133
LEU A 174
ILE A  90
GLU A 186
 None
 1.08A 1mt1A-2kmaA:
undetectable
1mt1F-2kmaA:
undetectable		 1mt1A-2kmaA:
14.12
1mt1F-2kmaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE

(Shewanella
oneidensis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LEU A  53
LEU A  50
ILE A 111
GLU A 134
 None
 1.05A 1mt1A-2oasA:
undetectable
1mt1F-2oasA:
undetectable		 1mt1A-2oasA:
9.70
1mt1F-2oasA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.94A 1mt1A-2p3xA:
undetectable
1mt1F-2p3xA:
undetectable		 1mt1A-2p3xA:
10.62
1mt1F-2p3xA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.67A 1mt1A-2pbgA:
undetectable
1mt1F-2pbgA:
undetectable		 1mt1A-2pbgA:
8.62
1mt1F-2pbgA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 LEU A 189
ASP A 243
LEU A 244
ILE A  54
 None
 1.06A 1mt1A-2qmiA:
undetectable
1mt1F-2qmiA:
undetectable		 1mt1A-2qmiA:
9.17
1mt1F-2qmiA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A  56
ASP A  50
ILE A 441
GLU A 138
 None
 0.98A 1mt1A-2qyvA:
undetectable
1mt1F-2qyvA:
undetectable		 1mt1A-2qyvA:
7.22
1mt1F-2qyvA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 LEU B 440
LEU B 188
ILE B  30
GLU B 471
 None
 1.07A 1mt1A-2rhqB:
undetectable
1mt1F-2rhqB:
1.5		 1mt1A-2rhqB:
5.91
1mt1F-2rhqB:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv3 NEUROPLASTIN

(Rattus
norvegicus) 		PF13927
(Ig_3) 		4 LEU A 186
ASP A 165
GLU A 102
ARG A 143
 None
 1.06A 1mt1A-2wv3A:
undetectable
1mt1F-2wv3A:
undetectable		 1mt1A-2wv3A:
15.08
1mt1F-2wv3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 LEU A  40
ASP A  36
LEU A  33
ARG A 404
 None
 0.76A 1mt1A-2ynkA:
undetectable
1mt1F-2ynkA:
undetectable		 1mt1A-2ynkA:
7.69
1mt1F-2ynkA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 LEU A 330
ASP A 295
GLU A 349
ARG A 240
 None
 0.97A 1mt1A-2ynkA:
undetectable
1mt1F-2ynkA:
undetectable		 1mt1A-2ynkA:
7.69
1mt1F-2ynkA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 LEU A 547
LEU A 539
ILE A 561
GLU A 737
 None
 1.01A 1mt1A-3aibA:
undetectable
1mt1F-3aibA:
undetectable		 1mt1A-3aibA:
5.58
1mt1F-3aibA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 LEU A 128
LEU A 121
ILE A 155
GLU A 147
 None
 0.89A 1mt1A-3bdzA:
undetectable
1mt1F-3bdzA:
undetectable		 1mt1A-3bdzA:
8.59
1mt1F-3bdzA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 LEU X 269
LEU X 261
ILE X 241
GLU X 275
 None
 1.09A 1mt1A-3e13X:
undetectable
1mt1F-3e13X:
undetectable		 1mt1A-3e13X:
14.41
1mt1F-3e13X:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 323
LEU A 479
ILE A 490
GLU A 496
 None
None
None
MG  A   1 ( 3.0A)
 1.00A 1mt1A-3fr8A:
undetectable
1mt1F-3fr8A:
undetectable		 1mt1A-3fr8A:
7.47
1mt1F-3fr8A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 425
LEU A 472
ILE A 439
GLU A 431
 None
 0.97A 1mt1A-3hmjA:
undetectable
1mt1F-3hmjA:
undetectable		 1mt1A-3hmjA:
2.40
1mt1F-3hmjA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnp OXIDOREDUCTASE

(Bacillus cereus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 298
ASP A 300
GLU A 271
ARG A  25
 None
 1.06A 1mt1A-3hnpA:
undetectable
1mt1F-3hnpA:
undetectable		 1mt1A-3hnpA:
10.29
1mt1F-3hnpA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 322
LEU A 325
ILE A 152
GLU A 132
 None
 0.84A 1mt1A-3ik4A:
undetectable
1mt1F-3ik4A:
undetectable		 1mt1A-3ik4A:
8.86
1mt1F-3ik4A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 344
ASP A 401
ILE A  24
GLU A 323
 None
 0.87A 1mt1A-3k92A:
undetectable
1mt1F-3k92A:
undetectable		 1mt1A-3k92A:
8.70
1mt1F-3k92A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 344
ASP A 401
ILE A 331
GLU A 323
 None
 1.04A 1mt1A-3k92A:
undetectable
1mt1F-3k92A:
undetectable		 1mt1A-3k92A:
8.70
1mt1F-3k92A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)

(Sulfolobus
solfataricus) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		5 LEU A  84
ASP A  85
LEU A  66
ILE A 118
GLU A  82
 None
 1.49A 1mt1A-3kxiA:
undetectable
1mt1F-3kxiA:
undetectable		 1mt1A-3kxiA:
9.88
1mt1F-3kxiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 ASP B 182
LEU B 183
ILE B  60
ARG B  33
 SAM  B 301 (-3.1A)
SAM  B 301 (-4.0A)
SAM  B 301 (-4.2A)
SAM  B 301 ( 4.7A)
 1.06A 1mt1A-3lcvB:
undetectable
1mt1F-3lcvB:
undetectable		 1mt1A-3lcvB:
10.99
1mt1F-3lcvB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvg CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		4 LEU A1361
LEU A1336
ILE A1345
GLU A1353
 None
 0.98A 1mt1A-3lvgA:
undetectable
1mt1F-3lvgA:
undetectable		 1mt1A-3lvgA:
8.03
1mt1F-3lvgA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4e ALPHA-HEMOLYSIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		4 ASP A 272
ILE A 170
GLU A 250
ARG A 184
 None
 1.06A 1mt1A-3m4eA:
undetectable
1mt1F-3m4eA:
undetectable		 1mt1A-3m4eA:
10.75
1mt1F-3m4eA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ASP A  18
LEU A 130
GLU A  65
ARG A 133
 None
 0.96A 1mt1A-3nwrA:
undetectable
1mt1F-3nwrA:
undetectable		 1mt1A-3nwrA:
8.00
1mt1F-3nwrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		4 LEU A 520
ASP A 524
LEU A 549
ARG A 566
 None
 1.09A 1mt1A-3ozxA:
undetectable
1mt1F-3ozxA:
undetectable		 1mt1A-3ozxA:
7.82
1mt1F-3ozxA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 LEU B 325
ASP B 329
LEU B 332
ARG B 333
 None
 0.94A 1mt1A-3pdiB:
undetectable
1mt1F-3pdiB:
undetectable		 1mt1A-3pdiB:
8.78
1mt1F-3pdiB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 ASP A 462
LEU A 458
ILE A 467
ARG A   8
 None
 1.01A 1mt1A-3qp9A:
undetectable
1mt1F-3qp9A:
undetectable		 1mt1A-3qp9A:
5.92
1mt1F-3qp9A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzy BACULOVIRUS
SULFHYDRYL OXIDASE
AC92

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF05214
(Baculo_p33) 		4 LEU A 132
LEU A 139
ILE A 178
GLU A 183
 None
 1.02A 1mt1A-3qzyA:
undetectable
1mt1F-3qzyA:
undetectable		 1mt1A-3qzyA:
10.82
1mt1F-3qzyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00218
(IGPS) 		4 LEU A 140
ASP A 120
ILE A  10
GLU A 168
 None
None
None
IGP  A 300 (-3.0A)
 1.10A 1mt1A-3t44A:
undetectable
1mt1F-3t44A:
undetectable		 1mt1A-3t44A:
14.86
1mt1F-3t44A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B
ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 LEU B 680
ASP B 611
GLU A  72
ARG B 617
 None
 1.08A 1mt1A-3u44B:
undetectable
1mt1F-3u44B:
undetectable		 1mt1A-3u44B:
3.77
1mt1F-3u44B:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		4 ASP A 470
ILE A 389
GLU A 418
ARG A 394
 None
 0.97A 1mt1A-3vgfA:
undetectable
1mt1F-3vgfA:
undetectable		 1mt1A-3vgfA:
6.83
1mt1F-3vgfA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE

(Caldanaerobius
polysaccharolyticus) 		PF00150
(Cellulase) 		4 LEU A 280
ASP A 276
GLU A 283
ARG A 272
 None
 0.97A 1mt1A-3w0kA:
undetectable
1mt1F-3w0kA:
undetectable		 1mt1A-3w0kA:
12.54
1mt1F-3w0kA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		4 LEU A  84
LEU A 270
ILE A 156
GLU A 162
 None
 1.05A 1mt1A-3wrtA:
undetectable
1mt1F-3wrtA:
undetectable		 1mt1A-3wrtA:
10.91
1mt1F-3wrtA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		4 LEU A  79
LEU A 133
ILE A 116
GLU A  81
 None
 1.08A 1mt1A-3zdpA:
undetectable
1mt1F-3zdpA:
undetectable		 1mt1A-3zdpA:
9.58
1mt1F-3zdpA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		4 LEU A  92
ASP A  96
ILE A  39
GLU A 193
 None
K  A1497 (-4.0A)
None
None
 1.02A 1mt1A-4a0mA:
undetectable
1mt1F-4a0mA:
undetectable		 1mt1A-4a0mA:
7.19
1mt1F-4a0mA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 LEU C 343
ASP C 385
LEU C 384
ILE C  19
 None
 1.04A 1mt1A-4bujC:
undetectable
1mt1F-4bujC:
undetectable		 1mt1A-4bujC:
10.03
1mt1F-4bujC:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c45 PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
2

(Homo sapiens) 		PF01329
(Pterin_4a) 		4 ASP A  33
ILE A  35
GLU A  31
ARG A  14
 None
 1.08A 1mt1A-4c45A:
undetectable
1mt1F-4c45A:
undetectable		 1mt1A-4c45A:
17.65
1mt1F-4c45A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		PF05996
(Fe_bilin_red) 		4 LEU A 243
ASP A 245
GLU A  76
ARG A  71
 BLA  A1001 (-4.6A)
None
None
None
 1.10A 1mt1A-4eocA:
undetectable
1mt1F-4eocA:
undetectable		 1mt1A-4eocA:
17.31
1mt1F-4eocA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyj ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		4 ASP A 233
LEU A 236
ILE A 138
GLU A 133
 None
None
None
UNL  A 301 ( 2.7A)
 1.03A 1mt1A-4jyjA:
undetectable
1mt1F-4jyjA:
undetectable		 1mt1A-4jyjA:
9.27
1mt1F-4jyjA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		4 LEU A 530
ASP A 528
LEU A 527
ILE A 519
 None
 1.01A 1mt1A-4kvlA:
undetectable
1mt1F-4kvlA:
undetectable		 1mt1A-4kvlA:
6.38
1mt1F-4kvlA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		4 LEU A  21
ASP A  17
LEU A  14
GLU A 287
 None
 1.06A 1mt1A-4m88A:
undetectable
1mt1F-4m88A:
undetectable		 1mt1A-4m88A:
10.00
1mt1F-4m88A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF01884
(PcrB) 		4 LEU A 126
LEU A  21
ILE A  76
GLU A 124
 None
 0.94A 1mt1A-4mm1A:
undetectable
1mt1F-4mm1A:
undetectable		 1mt1A-4mm1A:
12.55
1mt1F-4mm1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		4 LEU A 108
LEU A 116
ILE A  75
GLU A  79
 None
 0.90A 1mt1A-4mmpA:
undetectable
1mt1F-4mmpA:
undetectable		 1mt1A-4mmpA:
16.04
1mt1F-4mmpA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 171
LEU A  21
ILE A  80
GLU A 105
 None
 0.87A 1mt1A-4q5nA:
undetectable
1mt1F-4q5nA:
undetectable		 1mt1A-4q5nA:
14.78
1mt1F-4q5nA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 774
LEU A 783
ILE A 805
GLU A 811
 None
 1.10A 1mt1A-4qmeA:
undetectable
1mt1F-4qmeA:
undetectable		 1mt1A-4qmeA:
8.61
1mt1F-4qmeA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7d ATP-DEPENDENT DNA
HELICASE Q1

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 LEU A  97
LEU A 121
ILE A  82
GLU A  71
 None
 0.97A 1mt1A-4u7dA:
undetectable
1mt1F-4u7dA:
undetectable		 1mt1A-4u7dA:
6.93
1mt1F-4u7dA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 LEU A 269
ASP A 272
LEU A 318
ARG A 328
 None
 0.86A 1mt1A-4umvA:
undetectable
1mt1F-4umvA:
undetectable		 1mt1A-4umvA:
4.92
1mt1F-4umvA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy4 SPINDLIN-4

(Homo sapiens) 		PF02513
(Spin-Ssty) 		4 LEU A  89
ASP A  92
ILE A 228
ARG A  94
 None
 1.10A 1mt1A-4uy4A:
undetectable
1mt1F-4uy4A:
undetectable		 1mt1A-4uy4A:
15.46
1mt1F-4uy4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		4 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.08A 1mt1A-4wh0A:
undetectable
1mt1F-4wh0A:
undetectable		 1mt1A-4wh0A:
11.94
1mt1F-4wh0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 LEU A 151
LEU A 246
ILE A 261
GLU A  90
 None
 1.09A 1mt1A-4xiiA:
undetectable
1mt1F-4xiiA:
undetectable		 1mt1A-4xiiA:
8.84
1mt1F-4xiiA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 LEU A 215
ASP A 248
ILE A  76
GLU A 208
 None
 1.04A 1mt1A-4ye5A:
undetectable
1mt1F-4ye5A:
undetectable		 1mt1A-4ye5A:
8.76
1mt1F-4ye5A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 LEU A 386
ILE A 439
GLU A 400
ARG A 432
 None
 1.05A 1mt1A-4ypjA:
undetectable
1mt1F-4ypjA:
undetectable		 1mt1A-4ypjA:
5.37
1mt1F-4ypjA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 LEU A  70
ASP A 339
LEU A 308
ARG A 296
 None
 0.88A 1mt1A-4yyfA:
undetectable
1mt1F-4yyfA:
undetectable		 1mt1A-4yyfA:
9.12
1mt1F-4yyfA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT A

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV) 		4 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.89A 1mt1A-4z2eA:
undetectable
1mt1F-4z2eA:
undetectable		 1mt1A-4z2eA:
8.01
1mt1F-4z2eA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo3 ACYLHOMOSERINE
LACTONASE

(Chryseobacterium
sp. StRB126) 		PF00753
(Lactamase_B) 		4 ASP A 263
LEU A 306
ILE A  91
ARG A  86
 None
 1.06A 1mt1A-4zo3A:
undetectable
1mt1F-4zo3A:
undetectable		 1mt1A-4zo3A:
9.97
1mt1F-4zo3A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B  86
LEU B  82
ILE B  67
ARG B  66
 None
 1.07A 1mt1A-5f9wB:
undetectable
1mt1F-5f9wB:
undetectable		 1mt1A-5f9wB:
10.67
1mt1F-5f9wB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.78A 1mt1A-5gl7A:
undetectable
1mt1F-5gl7A:
undetectable		 1mt1A-5gl7A:
8.70
1mt1F-5gl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		4 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.75A 1mt1A-5h3oA:
undetectable
1mt1F-5h3oA:
undetectable		 1mt1A-5h3oA:
5.75
1mt1F-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw4 NADH PYROPHOSPHATASE

(Escherichia
coli) 		PF00293
(NUDIX)
PF09297
(zf-NADH-PPase) 		4 LEU A 220
LEU A 143
ILE A 135
GLU A 178
 None
 1.09A 1mt1A-5iw4A:
undetectable
1mt1F-5iw4A:
undetectable		 1mt1A-5iw4A:
12.16
1mt1F-5iw4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		4 LEU A 210
ASP A 209
LEU A 163
ILE A 187
 None
 0.99A 1mt1A-5jufA:
undetectable
1mt1F-5jufA:
undetectable		 1mt1A-5jufA:
9.35
1mt1F-5jufA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 LEU A 645
ASP A 644
ILE A 513
ARG A 516
 None
 1.01A 1mt1A-5tusA:
undetectable
1mt1F-5tusA:
undetectable		 1mt1A-5tusA:
5.56
1mt1F-5tusA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.89A 1mt1A-5veuA:
undetectable
1mt1F-5veuA:
undetectable		 1mt1A-5veuA:
7.61
1mt1F-5veuA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae) 		PF04452
(Methyltrans_RNA) 		4 ASP A  90
LEU A  93
GLU A 194
ARG A 127
 None
 1.02A 1mt1A-5vm8A:
undetectable
1mt1F-5vm8A:
undetectable		 1mt1A-5vm8A:
13.60
1mt1F-5vm8A:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN

(Mus musculus) 		no annotation 4 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.91A 1mt1A-5vxrH:
undetectable
1mt1F-5vxrH:
undetectable		 1mt1A-5vxrH:
30.43
1mt1F-5vxrH:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO

(Homo sapiens) 		no annotation 4 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.64A 1mt1A-5w21A:
undetectable
1mt1F-5w21A:
undetectable		 1mt1A-5w21A:
18.75
1mt1F-5w21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
PF04939
(RRS1) 		4 LEU A 230
ASP A 231
ILE B  50
ARG B  46
 None
 1.05A 1mt1A-5wxlA:
undetectable
1mt1F-5wxlA:
undetectable		 1mt1A-5wxlA:
18.12
1mt1F-5wxlA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8j THYMIDYLATE KINASE

(Thermus
thermophilus) 		no annotation 4 ASP A  94
LEU A  97
GLU A  39
ARG A 172
 None
 1.02A 1mt1A-5x8jA:
undetectable
1mt1F-5x8jA:
undetectable		 1mt1A-5x8jA:
19.28
1mt1F-5x8jA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION

(Mycolicibacterium
smegmatis) 		PF00383
(dCMP_cyt_deam_1) 		4 LEU A   8
ASP A   7
GLU A 144
ARG A 100
 None
 0.75A 1mt1A-5xkoA:
undetectable
1mt1F-5xkoA:
undetectable		 1mt1A-5xkoA:
13.55
1mt1F-5xkoA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 LEU A2519
ASP A2144
GLU A2522
ARG A2040
 None
 1.05A 1mt1A-6bpzA:
undetectable
1mt1F-6bpzA:
undetectable		 1mt1A-6bpzA:
23.75
1mt1F-6bpzA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 LEU B  96
ASP B  92
LEU B  89
ARG B  24
 None
 1.07A 1mt1A-6fd2B:
undetectable
1mt1F-6fd2B:
undetectable		 1mt1A-6fd2B:
18.18
1mt1F-6fd2B:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3

(Rattus rattus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 158
LEU A  19
ILE A  75
GLU A 100
 None
 0.85A 1mt1A-6gswA:
undetectable
1mt1F-6gswA:
undetectable		 1mt1A-6gswA:
14.51
1mt1F-6gswA:
19.82