SIMILAR PATTERNS OF AMINO ACIDS FOR 1MSK_A_ACTA1302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1k7y	METHIONINE SYNTHASE (Escherichia coli)	PF02310 (B12-binding) PF02607 (B12-binding_2) PF02965 (Met_synt_B12)	4	GLN A 932 VAL A 934 ARG A1106 TYR A1111	SO4 A 267 (-3.0A) None SO4 A 267 (-3.6A) SO4 A 267 (-4.8A)	1.18A	1mskA-1k7yA: 49.2	1mskA-1k7yA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1m7j	D-AMINOACYLASE (Alcaligenes faecalis)	PF07969 (Amidohydro_3)	4	GLN A 353 VAL A 352 ARG A 384 TYR A 389	None	1.09A	1mskA-1m7jA: 0.0	1mskA-1m7jA: 21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1msk	COBALAMIN-DEPENDENT METHIONINE SYNTHASE (Escherichia coli)	PF02965 (Met_synt_B12)	4	GLN A 932 VAL A 934 ARG A1106 TYR A1111	ACT A1302 ( 4.3A) ACT A1302 (-3.9A) ACT A1302 (-4.0A) ACT A1302 (-4.7A)	0.02A	1mskA-1mskA: 53.9	1mskA-1mskA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pnc	COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus)	PF01179 (Cu_amine_oxid) PF02727 (Cu_amine_oxidN2) PF02728 (Cu_amine_oxidN3)	4	GLN A 279 VAL A 285 ARG A 268 TYR A 270	None	1.44A	1mskA-2pncA: 0.0	1mskA-2pncA: 17.11

[["1MSK_A_ACTA1302_0","1k7y","Escherichia coli","METHIONINE SYNTHASE","PF02310(B12-binding);PF02607(B12-binding_2);PF02965(Met_synt_B12)",4,"GLN A 932;VAL A 934;ARG A1106;TYR A1111","SO4 A 267 (-3.0A);None;SO4 A 267 (-3.6A);SO4 A 267 (-4.8A)","1.18A","1mskA-1k7yA:49.2","1mskA-1k7yA:100.00"],["1MSK_A_ACTA1302_0","1m7j","Alcaligenes faecalis","D-AMINOACYLASE","PF07969(Amidohydro_3)",4,"GLN A 353;VAL A 352;ARG A 384;TYR A 389","None","1.09A","1mskA-1m7jA:0.0","1mskA-1m7jA:21.78"],["1MSK_A_ACTA1302_0","1msk","Escherichia coli","COBALAMIN-DEPENDENT METHIONINE SYNTHASE","PF02965(Met_synt_B12)",4,"GLN A 932;VAL A 934;ARG A1106;TYR A1111","ACT A1302 ( 4.3A);ACT A1302 (-3.9A);ACT A1302 (-4.0A);ACT A1302 (-4.7A)","0.02A","1mskA-1mskA:53.9","1mskA-1mskA:100.00"],["1MSK_A_ACTA1302_0","2pnc","Bos taurus","COPPER AMINE OXIDASE, LIVER ISOZYME","PF01179(Cu_amine_oxid);PF02727(Cu_amine_oxidN2);PF02728(Cu_amine_oxidN3)",4,"GLN A 279;VAL A 285;ARG A 268;TYR A 270","None","1.44A","1mskA-2pncA:0.0","1mskA-2pncA:17.11"]]