SIMILAR PATTERNS OF AMINO ACIDS FOR 1MRQ_A_STRA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 TYR A 106
LEU A 143
HIS A 168
LEU A 156
LEU A 150
 None
 1.22A 1mrqA-1axdA:
undetectable		 1mrqA-1axdA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		5 LEU A 139
VAL A 192
ILE A 225
LEU A 215
LEU A 216
 None
 1.35A 1mrqA-1b8gA:
undetectable		 1mrqA-1b8gA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT

(Escherichia
virus RB69) 		PF02916
(DNA_PPF)
PF09116
(gp45-slide_C) 		5 LEU A  64
GLU A  72
ILE A  73
LEU A  57
LEU A  54
 None
 1.34A 1mrqA-1b8hA:
undetectable		 1mrqA-1b8hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 GLU A 250
ILE A 251
GLU A 516
LEU A 429
LEU A 315
 None
 1.18A 1mrqA-1dcqA:
undetectable		 1mrqA-1dcqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epv ALANINE RACEMASE

(Geobacillus
stearothermophilus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLU A 153
VAL A 149
ILE A 152
HIS A 200
LEU A  83
 None
 1.35A 1mrqA-1epvA:
5.3		 1mrqA-1epvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		5 LEU B 486
TYR B 453
VAL B 531
LEU B 400
LEU B 461
 None
 1.28A 1mrqA-1gh6B:
undetectable		 1mrqA-1gh6B:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 LEU A 290
VAL A 313
HIS A 298
GLU A 297
LEU A 127
 None
 1.25A 1mrqA-1idmA:
undetectable		 1mrqA-1idmA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j26 IMMATURE COLON
CARCINOMA TRANSCRIPT
1

(Mus musculus) 		PF00472
(RF-1) 		5 GLU A  57
VAL A  60
ILE A  56
LEU A  80
LEU A  78
 None
 1.19A 1mrqA-1j26A:
undetectable		 1mrqA-1j26A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		5 LEU A 264
VAL A 256
ILE A 258
LEU A 307
LEU A 298
 None
 1.21A 1mrqA-1k7hA:
undetectable		 1mrqA-1k7hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 ILE A 261
HIS A 221
GLU A 218
LEU A 270
LEU A 272
 None
 1.29A 1mrqA-1lnzA:
2.5		 1mrqA-1lnzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 321
GLU A 317
VAL A 318
GLU A 216
TRP A 255
 None
GDR  A 801 (-2.9A)
None
NDP  A 701 ( 4.8A)
None
 1.22A 1mrqA-1n7gA:
2.1		 1mrqA-1n7gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1x RIBOSE-5-PHOSPHATE
ISOMERASE RPIB

(Thermotoga
maritima) 		PF02502
(LacAB_rpiB) 		5 LEU A  22
TYR A  21
VAL A  29
ILE A   5
LEU A 106
 None
 1.31A 1mrqA-1o1xA:
undetectable		 1mrqA-1o1xA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7r PREDICTED
AMIDOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF01174
(SNO) 		5 GLU A  20
VAL A  16
ILE A  19
LEU A  35
LEU A  41
 None
 1.36A 1mrqA-1q7rA:
undetectable		 1mrqA-1q7rA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 286
GLU A 282
VAL A 283
GLU A 181
TRP A 220
 None
GDP  A1601 (-2.6A)
None
NDP  A1501 ( 4.7A)
None
 1.17A 1mrqA-1rpnA:
undetectable		 1mrqA-1rpnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 TYR A 499
GLU A 606
ILE A 604
HIS A 488
LEU A 594
 None
 1.20A 1mrqA-1u1hA:
6.9		 1mrqA-1u1hA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 TYR A 130
ILE A 396
GLU A 443
LEU A 518
LEU A 430
 None
 1.05A 1mrqA-2bxyA:
9.2		 1mrqA-2bxyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 VAL A 248
ILE A 221
GLU A 174
LEU A 199
LEU A 440
 None
 1.17A 1mrqA-2dkdA:
undetectable		 1mrqA-2dkdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 LEU A 299
TYR A 296
GLU A 307
VAL A 303
LEU A 327
 None
 1.17A 1mrqA-2dq3A:
undetectable		 1mrqA-2dq3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		5 LEU A 159
VAL A 168
ILE A 171
LEU A 107
LEU A 141
 None
 1.34A 1mrqA-2grmA:
undetectable		 1mrqA-2grmA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 TYR A  55
ILE A 129
HIS A 222
GLU A 224
LEU A 306
LEU A 308
 FFA  A 325 ( 4.3A)
None
NAP  A   1 ( 4.8A)
None
FFA  A 325 (-4.8A)
FFA  A 325 (-4.5A)
 0.80A 1mrqA-2ipjA:
55.2		 1mrqA-2ipjA:
97.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 TYR A  55
VAL A 128
ILE A 129
HIS A 222
LEU A 306
LEU A 308
 FFA  A 325 ( 4.3A)
None
None
NAP  A   1 ( 4.8A)
FFA  A 325 (-4.8A)
FFA  A 325 (-4.5A)
 0.65A 1mrqA-2ipjA:
55.2		 1mrqA-2ipjA:
97.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 TYR A  55
VAL A 128
ILE A 129
HIS A 222
TRP A 227
 FFA  A 325 ( 4.3A)
None
None
NAP  A   1 ( 4.8A)
FFA  A 325 (-3.8A)
 0.95A 1mrqA-2ipjA:
55.2		 1mrqA-2ipjA:
97.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 LEU A 229
TYR A 228
ILE A 133
TRP A 122
LEU A 123
 None
 1.20A 1mrqA-2okcA:
undetectable		 1mrqA-2okcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd2 HYPOTHETICAL PROTEIN
ST0148

(Sulfurisphaera
tokodaii) 		PF02635
(DrsE) 		5 LEU A  36
VAL A  34
ILE A  64
LEU A  45
LEU A  81
 None
 1.34A 1mrqA-2pd2A:
2.5		 1mrqA-2pd2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rk5 PUTATIVE HEMOLYSIN

(Streptococcus
mutans) 		PF03471
(CorC_HlyC) 		5 LEU A  83
TYR A  43
VAL A  14
ILE A  13
HIS A  58
 None
 1.28A 1mrqA-2rk5A:
undetectable		 1mrqA-2rk5A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xes PROTEIN PAT1 HOMOLOG
1

(Homo sapiens) 		PF09770
(PAT1) 		5 LEU A 759
VAL A 751
GLU A 724
LEU A 689
LEU A 693
 None
 1.33A 1mrqA-2xesA:
undetectable		 1mrqA-2xesA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 367
VAL A 343
ILE A 341
LEU A 412
LEU A 389
 None
 1.19A 1mrqA-2z7xA:
undetectable		 1mrqA-2z7xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 367
VAL A 343
ILE A 341
LEU A 412
LEU A 389
 None
PCJ  A   1 (-4.8A)
PCJ  A   1 ( 4.6A)
None
None
 1.21A 1mrqA-2z81A:
undetectable		 1mrqA-2z81A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		5 LEU A 460
VAL A 430
ILE A 433
GLU A 411
LEU A 419
 None
 1.09A 1mrqA-2zj8A:
undetectable		 1mrqA-2zj8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		5 LEU A 471
VAL A 278
HIS A 432
LEU A 455
LEU A 459
 None
 1.31A 1mrqA-3ayxA:
undetectable		 1mrqA-3ayxA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byi RHO GTPASE
ACTIVATING PROTEIN
15

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A 463
VAL A 417
ILE A 416
LEU A 438
LEU A 409
 None
 1.34A 1mrqA-3byiA:
undetectable		 1mrqA-3byiA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 TYR A 200
LEU A 300
GLU A 386
LEU A 274
LEU A 277
 None
 1.34A 1mrqA-3caiA:
undetectable		 1mrqA-3caiA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 TYR A3293
LEU A3283
GLU A3325
LEU A3309
LEU A3274
 None
 1.30A 1mrqA-3cmvA:
undetectable		 1mrqA-3cmvA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 152
VAL A  89
ILE A  92
LEU A 175
LEU A 209
 None
 1.22A 1mrqA-3eb7A:
undetectable		 1mrqA-3eb7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A  61
TYR A  55
VAL A  70
ILE A  71
LEU A  45
 None
 1.34A 1mrqA-3ec7A:
undetectable		 1mrqA-3ec7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		5 LEU A  25
TYR A  24
VAL A  32
ILE A  10
LEU A 108
 None
 1.33A 1mrqA-3eq2A:
undetectable		 1mrqA-3eq2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9s PUTATIVE POLYKETIDE
CYCLASE

(Acidithiobacillus
ferrooxidans) 		PF07366
(SnoaL) 		5 TYR A  35
GLU A  25
ILE A  24
HIS A 125
LEU A  62
 None
None
None
GOL  A 146 (-4.1A)
None
 1.19A 1mrqA-3f9sA:
undetectable		 1mrqA-3f9sA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b ANTI-ERBB2 ANTIBODY
CHA21

(Mus musculus) 		PF07686
(V-set) 		5 LEU C 110
GLU C  17
VAL C  13
LEU C  53
LEU C  79
 None
 1.35A 1mrqA-3h3bC:
undetectable		 1mrqA-3h3bC:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 LEU A  71
TYR A  72
GLU A 293
ILE A 294
GLU A 134
 GOL  A 311 (-4.7A)
GOL  A 311 (-3.9A)
None
None
GOL  A 311 (-3.5A)
 1.24A 1mrqA-3hc1A:
undetectable		 1mrqA-3hc1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		5 LEU A 341
VAL A 218
GLU A 227
LEU A 258
LEU A 233
 None
 1.33A 1mrqA-3i32A:
undetectable		 1mrqA-3i32A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A  46
TYR A  50
ILE A 120
LEU A 199
LEU A 137
 None
EDO  A 559 ( 4.3A)
None
None
None
 1.24A 1mrqA-3ihvA:
undetectable		 1mrqA-3ihvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isa PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Bordetella
parapertussis) 		PF00378
(ECH_1) 		5 LEU A 117
GLU A  89
ILE A  88
LEU A  10
LEU A  36
 None
 1.32A 1mrqA-3isaA:
undetectable		 1mrqA-3isaA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0l RIBOSOMAL PROTEIN S5

(Oryctolagus
cuniculus) 		PF00177
(Ribosomal_S7) 		5 LEU T  67
GLU T 171
ILE T 172
LEU T  13
LEU T 104
 None
 1.28A 1mrqA-3j0lT:
undetectable		 1mrqA-3j0lT:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja7 PORTAL PROTEIN GP20

(Escherichia
virus T4) 		PF07230
(Peptidase_S80) 		5 LEU A 254
TYR A  79
VAL A  92
ILE A  95
LEU A 242
 None
 1.23A 1mrqA-3ja7A:
undetectable		 1mrqA-3ja7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ja7 PORTAL PROTEIN GP20

(Escherichia
virus T4) 		PF07230
(Peptidase_S80) 		5 LEU A 254
TYR A  79
VAL A  92
ILE A  95
TRP A 150
 None
 1.17A 1mrqA-3ja7A:
undetectable		 1mrqA-3ja7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		5 LEU A 904
GLU A 833
ILE A 829
LEU A 962
LEU A 958
 None
 1.30A 1mrqA-3jbyA:
undetectable		 1mrqA-3jbyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
avermitilis) 		PF00440
(TetR_N) 		5 LEU A  85
GLU A  92
ILE A 175
LEU A 149
LEU A 153
 None
 1.28A 1mrqA-3jsjA:
undetectable		 1mrqA-3jsjA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le1 PHOSPHOTRANSFERASE
SYSTEM, HPR-RELATED
PROTEINS

(Caldanaerobacter
subterraneus) 		PF00381
(PTS-HPr) 		5 LEU A  63
GLU A  82
VAL A  78
ILE A  81
LEU A  53
 None
 0.92A 1mrqA-3le1A:
undetectable		 1mrqA-3le1A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		5 GLU A 205
VAL A 201
ILE A 204
LEU A 101
LEU A 236
 None
 1.34A 1mrqA-3p3lA:
undetectable		 1mrqA-3p3lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6y CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 6

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU C 140
VAL C 131
ILE C 109
LEU C 149
LEU C  97
 None
 1.28A 1mrqA-3p6yC:
undetectable		 1mrqA-3p6yC:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkd MONOCLONAL ANTIBODY,
LIGHT CHAIN

(Mus musculus) 		no annotation 5 LEU L 104
GLU L  17
VAL L  13
LEU L  47
LEU L  73
 None
 1.34A 1mrqA-3rkdL:
undetectable		 1mrqA-3rkdL:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 272
ILE A 278
GLU A 302
LEU A 317
LEU A 308
 None
 1.19A 1mrqA-3toyA:
5.5		 1mrqA-3toyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wn6 ALPHA-AMYLASE

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A 388
GLU A 406
VAL A 405
ILE A 409
HIS A 339
 None
 1.36A 1mrqA-3wn6A:
4.9		 1mrqA-3wn6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wn6 ALPHA-AMYLASE

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A 388
TYR A 387
GLU A 406
VAL A 405
ILE A 409
 None
 1.30A 1mrqA-3wn6A:
4.9		 1mrqA-3wn6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7p UDP-GLUCOSE
DEHYDROGENASE

(Sphingomonas
elodea) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 413
GLU A 230
VAL A 432
LEU A 384
LEU A 410
 None
 1.36A 1mrqA-4a7pA:
undetectable		 1mrqA-4a7pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE

(Trypanosoma
cruzi) 		PF00102
(Y_phosphatase) 		5 TYR A  75
VAL A 223
GLU A 110
LEU A 151
LEU A 176
 None
 1.13A 1mrqA-4az1A:
undetectable		 1mrqA-4az1A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo sapiens) 		PF00027
(cNMP_binding)
PF02197
(RIIa) 		5 LEU B 269
VAL B 346
ILE B 292
GLU B 245
LEU B 254
 None
 1.35A 1mrqA-4dinB:
undetectable		 1mrqA-4dinB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		5 LEU A 486
TYR A 453
VAL A 531
LEU A 400
LEU A 461
 None
 1.27A 1mrqA-4eljA:
undetectable		 1mrqA-4eljA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Borreliella
burgdorferi) 		PF00300
(His_Phos_1) 		5 LEU A  70
VAL A  84
ILE A  82
LEU A  48
LEU A  77
 None
 1.18A 1mrqA-4embA:
undetectable		 1mrqA-4embA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epi PESTICIN, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Yersinia pestis) 		PF00959
(Phage_lysozyme) 		5 GLU A  78
VAL A 147
ILE A 148
LEU A 124
LEU A 160
 None
 1.35A 1mrqA-4epiA:
undetectable		 1mrqA-4epiA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 GLU A 343
VAL A 339
ILE A 342
LEU A 328
LEU A 359
 None
 1.15A 1mrqA-4f9oA:
undetectable		 1mrqA-4f9oA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 LEU A 252
VAL A 169
ILE A 186
LEU A 233
LEU A 243
 None
 1.23A 1mrqA-4fn5A:
undetectable		 1mrqA-4fn5A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  85
VAL A 107
ILE A  37
LEU A  92
LEU A  71
 None
 1.22A 1mrqA-4h2hA:
4.2		 1mrqA-4h2hA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krp CETUXIMAB LIGHT
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU C 104
GLU C  17
VAL C  13
LEU C  47
LEU C  73
 None
 1.35A 1mrqA-4krpC:
undetectable		 1mrqA-4krpC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 TYR A 339
GLU A 348
ILE A 347
LEU A  28
LEU A   8
 None
 1.28A 1mrqA-4l1kA:
undetectable		 1mrqA-4l1kA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l62 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		5 TYR A  62
LEU A 125
GLU A 113
VAL A 114
LEU A 166
 None
 1.25A 1mrqA-4l62A:
undetectable		 1mrqA-4l62A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU B 707
GLU B 613
ILE B 614
LEU B 596
LEU B 663
 None
 1.35A 1mrqA-4oavB:
undetectable		 1mrqA-4oavB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1

(Homo sapiens) 		PF05641
(Agenet) 		5 TYR A 161
LEU A 168
ILE A 185
GLU A 135
LEU A 192
 None
 1.31A 1mrqA-4ovaA:
undetectable		 1mrqA-4ovaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1n ATG1 TMIT

(Kluyveromyces
marxianus) 		PF12063
(DUF3543) 		5 LEU A 669
TYR A 670
GLU A 746
VAL A 745
ILE A 749
 None
 1.17A 1mrqA-4p1nA:
undetectable		 1mrqA-4p1nA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		5 TYR A 161
LEU A 209
ILE A 231
LEU A 181
LEU A 205
 None
 1.09A 1mrqA-4p8sA:
undetectable		 1mrqA-4p8sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pg6 HOMOSERINE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 LEU A   8
GLU A  23
VAL A  19
ILE A  22
LEU A  73
 None
 1.36A 1mrqA-4pg6A:
undetectable		 1mrqA-4pg6A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		5 TYR A 204
VAL A 278
ILE A 328
LEU A 148
LEU A 307
 None
 1.14A 1mrqA-4r39A:
undetectable		 1mrqA-4r39A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		5 LEU A 142
VAL A 114
ILE A 112
LEU A 172
LEU A 149
 None
 1.14A 1mrqA-4rg1A:
undetectable		 1mrqA-4rg1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		5 TYR A 322
VAL A 353
GLU A 345
LEU A 284
LEU A 280
 None
 1.34A 1mrqA-4u0tA:
undetectable		 1mrqA-4u0tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF00155
(Aminotran_1_2) 		5 LEU A 320
GLU A 333
ILE A 332
LEU A 352
LEU A 344
 None
 1.11A 1mrqA-4w5kA:
undetectable		 1mrqA-4w5kA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		5 TYR B 928
VAL B 815
GLU B 803
LEU B 882
LEU B 879
 None
 1.21A 1mrqA-4wwxB:
undetectable		 1mrqA-4wwxB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny LIGHT CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU L 104
GLU L  17
VAL L  13
LEU L  47
LEU L  73
 None
 1.33A 1mrqA-4xnyL:
undetectable		 1mrqA-4xnyL:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 LEU A 121
GLU A 173
ILE A 174
LEU A 100
LEU A 163
 None
 1.22A 1mrqA-5affA:
undetectable		 1mrqA-5affA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 LEU A 216
VAL A 253
ILE A 252
HIS A  34
LEU A 309
 None
GOL  A 401 ( 4.8A)
None
None
None
 1.27A 1mrqA-5c54A:
11.7		 1mrqA-5c54A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0n PYRUVATE, PHOSPHATE
DIKINASE REGULATORY
PROTEIN,
CHLOROPLASTIC

(Zea mays) 		PF03618
(Kinase-PPPase) 		5 GLU A 375
VAL A 319
ILE A 318
LEU A 284
LEU A 328
 None
 1.22A 1mrqA-5d0nA:
undetectable		 1mrqA-5d0nA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d68 KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF00373
(FERM_M)
PF13857
(Ank_5) 		5 LEU A 514
TYR A 460
ILE A 664
GLU A 534
LEU A 626
 None
 1.24A 1mrqA-5d68A:
undetectable		 1mrqA-5d68A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejb FUSION GLYCOPROTEIN
F0

(Hendra
henipavirus) 		no annotation 5 LEU B  87
VAL B 269
ILE B 276
LEU B 207
LEU B 210
 None
 1.17A 1mrqA-5ejbB:
undetectable		 1mrqA-5ejbB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evm FUSION GLYCOPROTEIN
F0

(Nipah
henipavirus) 		PF00523
(Fusion_gly) 		5 LEU A  87
VAL A 269
ILE A 276
LEU A 207
LEU A 210
 None
 1.32A 1mrqA-5evmA:
undetectable		 1mrqA-5evmA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3j ANTIBODY 2D10 SINGLE
CHAIN VARIABLE
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 LEU C 148
GLU C  56
VAL C  52
LEU C  91
LEU C 117
 None
 1.36A 1mrqA-5f3jC:
undetectable		 1mrqA-5f3jC:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 168
ILE A 195
GLU A 141
LEU A 155
LEU A 179
 None
 1.15A 1mrqA-5gmhA:
undetectable		 1mrqA-5gmhA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		5 LEU A 589
VAL A 603
ILE A 577
LEU A 617
LEU A 614
 None
 1.35A 1mrqA-5ijlA:
undetectable		 1mrqA-5ijlA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		5 LEU A  79
ILE A  82
GLU A 133
LEU A  94
LEU A  93
 None
 1.31A 1mrqA-5jygA:
undetectable		 1mrqA-5jygA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 LEU A 299
TYR A 297
ILE A 543
LEU A 383
LEU A 386
 None
 1.34A 1mrqA-5k3hA:
undetectable		 1mrqA-5k3hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv1 PTXB

(Prochlorococcus
marinus) 		no annotation 5 LEU A 267
GLU A  60
VAL A 271
ILE A  59
LEU A  75
 None
 1.14A 1mrqA-5lv1A:
undetectable		 1mrqA-5lv1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 5 LEU A 260
VAL A 243
ILE A 125
LEU A 234
LEU A 113
 None
None
None
EDO  A 410 ( 4.9A)
EDO  A 410 ( 4.3A)
 1.07A 1mrqA-5nfqA:
undetectable		 1mrqA-5nfqA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4x RETINAL ROD
RHODOPSIN-SENSITIVE
CGMP 3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT DELTA

(Mus musculus) 		no annotation 5 LEU A  22
VAL A  59
ILE A 109
LEU A  17
LEU A  63
 None
 1.32A 1mrqA-5t4xA:
undetectable		 1mrqA-5t4xA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 LEU A 271
GLU A 305
VAL A 306
LEU A 255
LEU A 288
 None
 1.25A 1mrqA-5u0lA:
undetectable		 1mrqA-5u0lA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 LEU E 152
VAL E 148
GLU E 239
LEU E 237
LEU E 131
 None
 1.35A 1mrqA-5u8sE:
undetectable		 1mrqA-5u8sE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A1414
VAL A1240
ILE A1398
LEU A1227
LEU A1253
 None
 1.34A 1mrqA-5uakA:
undetectable		 1mrqA-5uakA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		5 TYR A 496
LEU A 544
TYR A 541
VAL A 617
LEU A 599
 None
 1.30A 1mrqA-5wzrA:
5.4		 1mrqA-5wzrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnl NKT VALPHA14 (MOUSE)
- 2C12 TCR - HYBRID
MOUSE VARIABLE AND
HUMAN CONSTANT
DOMAINS

(Homo sapiens) 		no annotation 5 LEU C 112
GLU C  16
VAL C  12
LEU C  46
LEU C  75
 None
 1.35A 1mrqA-6bnlC:
undetectable		 1mrqA-6bnlC:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 5 LEU C 245
TYR C 266
VAL C 278
ILE C 279
LEU C 307
 None
 1.33A 1mrqA-6c4mC:
undetectable		 1mrqA-6c4mC:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 5 TYR A 928
VAL A 815
GLU A 803
LEU A 882
LEU A 879
 None
 1.24A 1mrqA-6cg0A:
undetectable		 1mrqA-6cg0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsf GTPASE-ACTIVATING
PROTEIN BEM3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 596
VAL A 556
ILE A 553
GLU A 724
LEU A 580
 None
 1.02A 1mrqA-6fsfA:
undetectable		 1mrqA-6fsfA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 5 LEU B 332
GLU B 328
VAL B 329
GLU B 210
TRP B 249
 None
F7E  B 402 (-2.9A)
None
NAP  B 403 ( 4.9A)
None
 1.23A 1mrqA-6gplB:
2.0		 1mrqA-6gplB:
undetectable