SIMILAR PATTERNS OF AMINO ACIDS FOR 1MRL_A_DOLA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		5 ILE A 201
LEU A 302
PRO A 235
VAL A 264
ASP A 304
 None
 1.38A 1mrlA-1inpA:
0.0
1mrlB-1inpA:
undetectable		 1mrlA-1inpA:
18.70
1mrlB-1inpA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 TYR A 540
LEU A 576
PRO A 559
LEU A 164
ASP A 140
 None
 1.32A 1mrlA-1kqfA:
0.0
1mrlB-1kqfA:
0.1		 1mrlA-1kqfA:
11.76
1mrlB-1kqfA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 ILE A 507
LEU A 369
LEU A 530
ASN A 274
VAL A 204
 None
 1.38A 1mrlA-1lnsA:
0.3
1mrlB-1lnsA:
0.1		 1mrlA-1lnsA:
14.42
1mrlB-1lnsA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyd TYROSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		5 ILE E  66
HIS E  48
LEU E 105
ASN E 198
ASP E 194
 None
 1.42A 1mrlA-1tydE:
0.0
1mrlB-1tydE:
0.0		 1mrlA-1tydE:
18.90
1mrlB-1tydE:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ILE A 186
PRO A 191
LEU A 194
ASN A 155
VAL A 128
 None
 1.30A 1mrlA-1xecA:
1.4
1mrlB-1xecA:
1.5		 1mrlA-1xecA:
19.51
1mrlB-1xecA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		5 ILE A 171
LEU A  84
PRO A 137
LEU A  77
ASN A  87
 None
 1.39A 1mrlA-1ygaA:
undetectable
1mrlB-1ygaA:
0.0		 1mrlA-1ygaA:
20.82
1mrlB-1ygaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 ILE A 532
LEU A 448
PRO A 498
LEU A 441
ASN A 451
 None
 1.43A 1mrlA-1z45A:
0.0
1mrlB-1z45A:
0.0		 1mrlA-1z45A:
15.50
1mrlB-1z45A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 218
PRO A 152
LEU A 135
VAL A 283
ASP A 290
 None
 1.38A 1mrlA-2g17A:
0.0
1mrlB-2g17A:
0.0		 1mrlA-2g17A:
20.41
1mrlB-2g17A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 TYR A 213
ILE A 202
LEU A 187
VAL A 180
ASP A 395
 None
 1.49A 1mrlA-2hv2A:
undetectable
1mrlB-2hv2A:
undetectable		 1mrlA-2hv2A:
19.35
1mrlB-2hv2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A 105
LEU A 289
MET A 310
LEU A  94
ASN A 228
 None
G1L  A 400 (-4.0A)
G1L  A 400 (-4.0A)
G1L  A 400 (-4.3A)
None
 1.33A 1mrlA-2i80A:
undetectable
1mrlB-2i80A:
undetectable		 1mrlA-2i80A:
21.43
1mrlB-2i80A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ILE A 207
LEU A 247
PRO A 240
LEU A 255
ASN A 225
 None
None
None
None
NAG  A 488 (-1.8A)
 1.17A 1mrlA-2id5A:
undetectable
1mrlB-2id5A:
undetectable		 1mrlA-2id5A:
15.72
1mrlB-2id5A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 5 ILE A 331
HIS A 279
LEU A 274
ASN A 263
VAL A 237
 None
 1.24A 1mrlA-2invA:
undetectable
1mrlB-2invA:
undetectable		 1mrlA-2invA:
18.93
1mrlB-2invA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		5 ILE A 574
PRO A 389
LEU A 358
TYR A 642
ASP A 605
 None
 1.19A 1mrlA-2y3aA:
undetectable
1mrlB-2y3aA:
undetectable		 1mrlA-2y3aA:
10.35
1mrlB-2y3aA:
10.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dho STREPTOGRAMIN A
ACETYLTRANSFERASE

(Enterococcus
faecium) 		PF00132
(Hexapep) 		5 TYR A  54
HIS A  82
MET A 102
PRO A 103
LEU A 108
 None
 0.88A 1mrlA-3dhoA:
31.0
1mrlB-3dhoA:
30.9		 1mrlA-3dhoA:
100.00
1mrlB-3dhoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dho STREPTOGRAMIN A
ACETYLTRANSFERASE

(Enterococcus
faecium) 		PF00132
(Hexapep) 		5 TYR A  54
ILE A  56
HIS A  82
PRO A 103
LEU A 108
 None
 0.59A 1mrlA-3dhoA:
31.0
1mrlB-3dhoA:
30.9		 1mrlA-3dhoA:
100.00
1mrlB-3dhoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 ILE A 110
LEU A 200
LEU A  47
ASN A 105
ASP A 178
 None
 1.30A 1mrlA-3dlaA:
undetectable
1mrlB-3dlaA:
undetectable		 1mrlA-3dlaA:
14.26
1mrlB-3dlaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		5 LEU A 477
LEU A 461
ASN A 415
VAL A 411
TYR A 384
 None
 1.44A 1mrlA-3fnrA:
undetectable
1mrlB-3fnrA:
undetectable		 1mrlA-3fnrA:
18.98
1mrlB-3fnrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  53
LEU A  39
PRO A  61
LEU A   6
VAL A 315
 None
 1.29A 1mrlA-3nx4A:
undetectable
1mrlB-3nx4A:
undetectable		 1mrlA-3nx4A:
20.53
1mrlB-3nx4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		5 TYR A1205
ILE A1312
PRO A1260
ASN A1321
VAL A1323
 None
 1.29A 1mrlA-3opuA:
undetectable
1mrlB-3opuA:
undetectable		 1mrlA-3opuA:
22.53
1mrlB-3opuA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ILE A 426
LEU A 480
PRO A 447
LEU A 448
VAL A 469
 None
 1.38A 1mrlA-3pigA:
undetectable
1mrlB-3pigA:
undetectable		 1mrlA-3pigA:
17.11
1mrlB-3pigA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 331
PRO A 519
ASN A 554
VAL A 348
ASP A 344
 None
 1.49A 1mrlA-3um6A:
undetectable
1mrlB-3um6A:
undetectable		 1mrlA-3um6A:
16.47
1mrlB-3um6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 TYR A1209
PRO A1130
LEU A1123
ASN A 965
VAL A 967
 None
 1.28A 1mrlA-3va7A:
undetectable
1mrlB-3va7A:
undetectable		 1mrlA-3va7A:
11.14
1mrlB-3va7A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 ILE A 574
PRO A 389
LEU A 358
TYR A 642
ASP A 605
 None
 1.24A 1mrlA-4bfrA:
undetectable
1mrlB-4bfrA:
undetectable		 1mrlA-4bfrA:
12.55
1mrlB-4bfrA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		5 TYR A 144
ILE A 143
MET A 195
LEU A 154
VAL A 258
 None
 1.35A 1mrlA-4fguA:
undetectable
1mrlB-4fguA:
undetectable		 1mrlA-4fguA:
15.94
1mrlB-4fguA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		5 ILE A  76
HIS A 349
LEU A  70
PRO A 417
TYR A 378
 None
LLP  A 247 ( 4.5A)
None
None
None
 1.23A 1mrlA-4k2bA:
undetectable
1mrlB-4k2bA:
undetectable		 1mrlA-4k2bA:
19.82
1mrlB-4k2bA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00132
(Hexapep) 		6 TYR A  59
HIS A  87
LEU A  98
MET A 107
PRO A 108
LEU A 113
 None
 0.54A 1mrlA-4myoA:
29.0
1mrlB-4myoA:
29.0		 1mrlA-4myoA:
59.52
1mrlB-4myoA:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		5 ILE A 328
LEU A 377
MET A 387
LEU A 394
ASN A  36
 None
 1.39A 1mrlA-4o6zA:
undetectable
1mrlB-4o6zA:
undetectable		 1mrlA-4o6zA:
18.54
1mrlB-4o6zA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 ILE A 369
LEU A 319
PRO A 345
LEU A 327
ASN A 356
 None
 1.50A 1mrlA-4pufA:
undetectable
1mrlB-4pufA:
undetectable		 1mrlA-4pufA:
15.34
1mrlB-4pufA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1u CINNAMOYL COA
REDUCTASE

(Medicago
truncatula) 		PF01370
(Epimerase) 		5 PRO A 265
LEU A 264
ASN A 192
VAL A 181
TYR A 216
 None
 1.34A 1mrlA-4r1uA:
undetectable
1mrlB-4r1uA:
undetectable		 1mrlA-4r1uA:
19.89
1mrlB-4r1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 ILE A  30
LEU A 241
MET A 296
LEU A  60
ASP A 236
 None
 1.48A 1mrlA-4rtbA:
undetectable
1mrlB-4rtbA:
undetectable		 1mrlA-4rtbA:
20.04
1mrlB-4rtbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		5 TYR B1209
ILE B1316
PRO B1264
ASN B1325
VAL B1327
 None
None
None
None
MG  B1503 (-4.4A)
 1.25A 1mrlA-4tshB:
undetectable
1mrlB-4tshB:
undetectable		 1mrlA-4tshB:
19.76
1mrlB-4tshB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		5 PRO A 453
LEU A 452
VAL A 134
TYR A 363
ASP A 354
 None
 1.28A 1mrlA-4txgA:
undetectable
1mrlB-4txgA:
undetectable		 1mrlA-4txgA:
13.51
1mrlB-4txgA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		5 ILE A  88
LEU A  64
PRO A 103
VAL A  32
TYR A  68
 None
 1.39A 1mrlA-4udnA:
undetectable
1mrlB-4udnA:
undetectable		 1mrlA-4udnA:
20.57
1mrlB-4udnA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 ILE A 384
HIS A 357
LEU A 353
TYR A 197
ASP A 201
 None
 1.36A 1mrlA-4wctA:
undetectable
1mrlB-4wctA:
undetectable		 1mrlA-4wctA:
17.07
1mrlB-4wctA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
ALPHA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		5 MET A   7
PRO A   8
LEU A  10
ASN A 265
VAL A 269
 None
 1.50A 1mrlA-4wvmA:
undetectable
1mrlB-4wvmA:
undetectable		 1mrlA-4wvmA:
14.56
1mrlB-4wvmA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqe HOMOSPERMIDINE
SYNTHASE

(Blastochloris
viridis) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 HIS A 322
MET A 253
PRO A 254
LEU A 270
TYR A 368
 None
 1.37A 1mrlA-4xqeA:
undetectable
1mrlB-4xqeA:
undetectable		 1mrlA-4xqeA:
17.05
1mrlB-4xqeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156

(uncultured
organism) 		no annotation 5 TYR A 408
ILE A 405
LEU A 365
PRO A 369
LEU A 138
 None
 1.47A 1mrlA-5d8mA:
undetectable
1mrlB-5d8mA:
undetectable		 1mrlA-5d8mA:
16.43
1mrlB-5d8mA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651

(Bacteroides
ovatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 TYR A 309
ILE A 357
LEU A 289
VAL A  92
ASP A  96
 None
None
None
CL  A 615 (-4.0A)
None
 1.50A 1mrlA-5e76A:
undetectable
1mrlB-5e76A:
undetectable		 1mrlA-5e76A:
17.61
1mrlB-5e76A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwt 4-HYDROXYISOLECUINE
DEHYDROGENASE

(Bacillus
thuringiensis) 		no annotation 5 ILE A  56
LEU A  81
LEU A  71
ASN A 134
VAL A 175
 None
 1.43A 1mrlA-5gwtA:
undetectable
1mrlB-5gwtA:
undetectable		 1mrlA-5gwtA:
20.96
1mrlB-5gwtA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 ILE A 877
HIS A 926
LEU A 933
LEU A 854
ASP A 944
 None
 1.02A 1mrlA-5h42A:
undetectable
1mrlB-5h42A:
undetectable		 1mrlA-5h42A:
10.96
1mrlB-5h42A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		5 TYR A 151
ILE A  45
MET A 296
LEU A 145
ASP A 138
 None
 1.35A 1mrlA-5i4kA:
undetectable
1mrlB-5i4kA:
undetectable		 1mrlA-5i4kA:
20.32
1mrlB-5i4kA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A1213
PRO A1130
LEU A1123
ASN A 965
VAL A 967
 None
 1.29A 1mrlA-5i8iA:
undetectable
1mrlB-5i8iA:
undetectable		 1mrlA-5i8iA:
7.39
1mrlB-5i8iA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 TYR A1209
PRO A1130
LEU A1123
ASN A 965
VAL A 967
 None
 1.26A 1mrlA-5i8iA:
undetectable
1mrlB-5i8iA:
undetectable		 1mrlA-5i8iA:
7.39
1mrlB-5i8iA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 TYR A 502
ILE A 511
HIS A 340
LEU A  11
LEU A 357
 None
 1.34A 1mrlA-5tqrA:
undetectable
1mrlB-5tqrA:
undetectable		 1mrlA-5tqrA:
15.66
1mrlB-5tqrA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 5 ILE A 210
HIS A 305
PRO A 438
VAL A 407
ASP A 408
 None
OAA  A 501 (-4.4A)
None
None
None
 1.32A 1mrlA-5uqrA:
undetectable
1mrlB-5uqrA:
undetectable		 1mrlA-5uqrA:
15.71
1mrlB-5uqrA:
15.71