SIMILAR PATTERNS OF AMINO ACIDS FOR 1MRG_A_ADNA300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1abr ABRIN-A

(Abrus
precatorius)
PF00161
(RIP)
6 GLY A 111
TYR A 113
ILE A 159
ALA A 163
GLU A 164
ARG A 167
None
0.49A 1mrgA-1abrA:
33.6
1mrgA-1abrA:
33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia)
PF00161
(RIP)
8 ILE A  71
PHE A  83
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
ADE  A 339 (-3.9A)
ADE  A 339 ( 4.8A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
0.30A 1mrgA-1ahaA:
43.5
1mrgA-1ahaA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia)
PF00161
(RIP)
5 TYR A  70
ILE A  71
TYR A 111
ILE A 155
ALA A 159
ADE  A 339 ( 3.8A)
ADE  A 339 (-3.9A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
1.06A 1mrgA-1ahaA:
43.5
1mrgA-1ahaA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apa POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
americana)
PF00161
(RIP)
5 PHE A  94
TYR A 128
ILE A 175
GLU A 180
ARG A 183
None
0.51A 1mrgA-1apaA:
30.6
1mrgA-1apaA:
29.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bry BRYODIN I

(Bryonia dioica)
PF00161
(RIP)
8 ILE Y  71
PHE Y  83
GLY Y 109
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
ARG Y 163
None
0.33A 1mrgA-1bryY:
41.0
1mrgA-1bryY:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bry BRYODIN I

(Bryonia dioica)
PF00161
(RIP)
5 TYR Y  70
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
None
1.11A 1mrgA-1bryY:
41.0
1mrgA-1bryY:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cf5 PROTEIN
(BETA-MOMORCHARIN)


(Momordica
charantia)
PF00161
(RIP)
7 PHE A  83
GLY A 107
TYR A 109
ILE A 153
ALA A 157
GLU A 158
ARG A 161
None
0.49A 1mrgA-1cf5A:
38.1
1mrgA-1cf5A:
51.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT


(Shigella
dysenteriae)
PF00161
(RIP)
5 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
None
0.57A 1mrgA-1dm0A:
22.4
1mrgA-1dm0A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT


(Shigella
dysenteriae)
PF00161
(RIP)
5 TYR A  77
PHE A  95
ALA A 166
GLU A 167
ARG A 170
None
1.28A 1mrgA-1dm0A:
22.4
1mrgA-1dm0A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus)
PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing)
5 ILE A  93
PHE A 101
TYR A 442
ILE A   2
ALA A   6
None
1.27A 1mrgA-1dq3A:
undetectable
1mrgA-1dq3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE


(Lactobacillus
pentosus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A  94
PHE A 133
TYR A  83
ILE A 120
ALA A  96
None
None
None
NAD  A1352 ( 4.9A)
NAD  A1352 (-3.5A)
1.15A 1mrgA-1ez4A:
undetectable
1mrgA-1ez4A:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hwn EBULIN

(Sambucus ebulus)
PF00161
(RIP)
6 PHE A  90
GLY A 114
TYR A 116
ILE A 158
GLU A 163
ARG A 166
None
0.80A 1mrgA-1hwnA:
32.5
1mrgA-1hwnA:
36.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 TYR A 270
GLY A 238
TYR A 240
ILE A 403
ALA A 402
None
1.29A 1mrgA-1ig8A:
undetectable
1mrgA-1ig8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi)
PF00921
(Lipoprotein_2)
5 ILE A 284
PHE A 202
GLY A 199
ILE A 280
ALA A 222
None
1.24A 1mrgA-1l8wA:
undetectable
1mrgA-1l8wA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus)
PF00161
(RIP)
6 PHE A  91
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
None
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
0.53A 1mrgA-1lpcA:
27.9
1mrgA-1lpcA:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nio B-LUFFIN

(Luffa
aegyptiaca)
PF00161
(RIP)
8 ILE A  72
PHE A  84
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
None
0.23A 1mrgA-1nioA:
40.6
1mrgA-1nioA:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qcj POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
americana)
PF00161
(RIP)
5 PHE A  90
TYR A 123
ILE A 171
GLU A 176
ARG A 179
APT  A 901 ( 4.7A)
APT  A 901 (-4.7A)
APT  A 901 (-3.7A)
APT  A 901 ( 3.6A)
APT  A 901 (-3.0A)
0.46A 1mrgA-1qcjA:
30.6
1mrgA-1qcjA:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)


(Saponaria
officinalis)
PF00161
(RIP)
5 PHE A  90
TYR A 120
ILE A 171
GLU A 176
ARG A 179
None
0.72A 1mrgA-1qi7A:
27.9
1mrgA-1qi7A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)


(Saponaria
officinalis)
PF00161
(RIP)
5 TYR A  72
TYR A 120
ALA A 175
GLU A 176
ARG A 179
None
1.14A 1mrgA-1qi7A:
27.9
1mrgA-1qi7A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)


(Saponaria
officinalis)
PF00161
(RIP)
5 TYR A 120
ILE A 171
ALA A 175
GLU A 176
ARG A 179
None
0.34A 1mrgA-1qi7A:
27.9
1mrgA-1qi7A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT


(Escherichia
coli)
PF00161
(RIP)
5 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
FMT  A3015 ( 4.9A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
0.41A 1mrgA-1r4pA:
23.2
1mrgA-1r4pA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii)
PF00161
(RIP)
7 ILE A  71
PHE A  83
GLY A 109
TYR A 111
ILE A 155
GLU A 160
ARG A 163
NDP  A 280 (-4.5A)
NDP  A 280 ( 4.8A)
NDP  A 280 (-3.9A)
NDP  A 280 ( 3.7A)
NDP  A 280 (-3.9A)
NDP  A 280 ( 2.7A)
NDP  A 280 ( 2.6A)
0.30A 1mrgA-1tcsA:
40.5
1mrgA-1tcsA:
63.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE


(Arthrobacter
sp. KM)
PF00480
(ROK)
5 ILE A  15
GLY A  26
ILE A  28
ALA A  71
GLU A  70
None
1.11A 1mrgA-1woqA:
undetectable
1mrgA-1woqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6z HEAT SHOCK PROTEIN,
PUTATIVE


(Plasmodium
falciparum)
PF00183
(HSP90)
5 TYR A 155
ILE A 158
PHE A  64
ILE A 236
GLU A 234
None
1.31A 1mrgA-1y6zA:
undetectable
1mrgA-1y6zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN


(Silene
chalcedonica)
PF00161
(RIP)
7 TYR A  69
PHE A  88
TYR A 119
ILE A 165
ALA A 169
GLU A 170
ARG A 173
None
0.70A 1mrgA-2g5xA:
25.6
1mrgA-2g5xA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
5 ILE C 222
GLY C 224
ALA C 133
GLU C 130
ARG C 160
None
1.32A 1mrgA-2inpC:
undetectable
1mrgA-2inpC:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL


(Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
5 ILE C 222
GLY C 224
TYR C 227
ALA C 133
GLU C 130
None
1.27A 1mrgA-2inpC:
undetectable
1mrgA-2inpC:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida)
PF11477
(PM0188)
5 ILE A 184
TYR A 217
ILE A 161
ALA A 164
GLU A 165
None
1.31A 1mrgA-2iy8A:
undetectable
1mrgA-2iy8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1


(Homo sapiens)
PF00171
(Aldedh)
5 TYR A 129
ILE A 126
GLY A 482
ILE A 180
ALA A 179
None
1.27A 1mrgA-2j6lA:
undetectable
1mrgA-2j6lA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwi HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus)
PF01947
(DUF98)
5 ILE A  96
TYR A 139
ILE A 151
ALA A  72
GLU A 153
None
1.38A 1mrgA-2nwiA:
undetectable
1mrgA-2nwiA:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oqa LUFFACULIN 1

(Luffa
acutangula)
PF00161
(RIP)
8 ILE A  71
PHE A  83
GLY A 108
TYR A 110
ILE A 154
ALA A 158
GLU A 159
ARG A 162
None
0.32A 1mrgA-2oqaA:
39.8
1mrgA-2oqaA:
69.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oqa LUFFACULIN 1

(Luffa
acutangula)
PF00161
(RIP)
5 TYR A  70
TYR A 110
ILE A 154
ALA A 158
GLU A 159
None
0.95A 1mrgA-2oqaA:
39.8
1mrgA-2oqaA:
69.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN


(Staphylococcus
epidermidis)
PF01933
(UPF0052)
5 ILE A 200
ILE A 171
ALA A 203
GLU A 175
ARG A 206
None
1.34A 1mrgA-2ppvA:
undetectable
1mrgA-2ppvA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3


(Zea mays)
PF00161
(RIP)
6 TYR A  94
PHE A 108
GLY A 128
TYR A 130
GLU A 207
ARG A 210
None
0.50A 1mrgA-2pqiA:
24.2
1mrgA-2pqiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE


(Renilla
reniformis)
PF00561
(Abhydrolase_1)
5 ILE A  15
GLY A  17
TYR A 202
GLU A 289
ARG A 192
None
1.25A 1mrgA-2psfA:
undetectable
1mrgA-2psfA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q8w POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
acinosa)
PF00161
(RIP)
6 PHE A  89
GLY A 120
TYR A 122
ILE A 170
GLU A 175
ARG A 178
None
0.35A 1mrgA-2q8wA:
30.7
1mrgA-2q8wA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4


(Phytolacca
dioica)
PF00161
(RIP)
5 PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
ADE  A 501 ( 4.9A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 ( 4.7A)
ADE  A 501 (-2.9A)
0.28A 1mrgA-2qesA:
30.8
1mrgA-2qesA:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL


(Trichormus
variabilis)
PF01261
(AP_endonuc_2)
5 GLY A 127
TYR A 133
ILE A 184
GLU A 188
ARG A 252
XLS  A 401 ( 4.7A)
XLS  A 401 ( 3.8A)
XLS  A 401 ( 4.3A)
XLS  A 401 (-3.2A)
XLS  A 401 ( 4.0A)
1.01A 1mrgA-2qw5A:
undetectable
1mrgA-2qw5A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
5 ILE A  33
PHE A  67
GLY A  56
TYR A 317
GLU A 307
None
1.31A 1mrgA-2rg2A:
undetectable
1mrgA-2rg2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III


(Cinnamomum
camphora)
PF00161
(RIP)
PF00652
(Ricin_B_lectin)
6 GLY A 113
TYR A 115
ILE A 162
ALA A 166
GLU A 167
ARG A 170
None
0.26A 1mrgA-2vlcA:
30.6
1mrgA-2vlcA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III


(Cinnamomum
camphora)
PF00161
(RIP)
PF00652
(Ricin_B_lectin)
6 TYR A  75
TYR A 115
ILE A 162
ALA A 166
GLU A 167
ARG A 170
None
0.84A 1mrgA-2vlcA:
30.6
1mrgA-2vlcA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE


(Leishmania
major)
PF03738
(GSP_synth)
PF05257
(CHAP)
5 ILE A 598
PHE A 272
ILE A 612
ALA A 596
GLU A 614
None
1.33A 1mrgA-2vobA:
undetectable
1mrgA-2vobA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG


(Methanothermobacter
thermautotrophicus)
PF01172
(SBDS)
PF09377
(SBDS_C)
5 TYR A 180
ILE A 183
ILE A 189
ALA A 202
GLU A 192
None
None
None
None
GOL  A1235 (-3.5A)
1.21A 1mrgA-2wbmA:
undetectable
1mrgA-2wbmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj9 INTERGENIC-REGION
PROTEIN


(Escherichia
coli)
PF03230
(Antirestrict)
5 ILE A 152
TYR A 142
ILE A 113
ALA A 110
GLU A 109
None
1.27A 1mrgA-2wj9A:
undetectable
1mrgA-2wj9A:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zr1 AGGLUTININ-1 CHAIN A

(Abrus
precatorius)
PF00161
(RIP)
7 PHE A  86
GLY A 110
TYR A 112
ILE A 158
ALA A 162
GLU A 163
ARG A 166
None
0.44A 1mrgA-2zr1A:
33.4
1mrgA-2zr1A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa)
PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C)
5 ILE A  14
GLY A  16
ALA A  12
GLU A 556
ARG A 132
None
1.29A 1mrgA-2zwsA:
undetectable
1mrgA-2zwsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE


(Mesorhizobium
japonicum)
PF01494
(FAD_binding_3)
5 ILE A 332
TYR A 375
ILE A 335
GLU A 364
ARG A 338
None
1.36A 1mrgA-3allA:
undetectable
1mrgA-3allA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwh CUCURMOSIN

(Cucurbita
moschata)
PF00161
(RIP)
7 ILE A  71
PHE A  83
GLY A 107
TYR A 109
ILE A 153
GLU A 158
ARG A 161
None
None
EDO  A 253 (-4.5A)
EDO  A 253 ( 4.1A)
EDO  A 253 ( 4.1A)
EDO  A 253 ( 4.6A)
EDO  A 253 (-2.9A)
0.37A 1mrgA-3bwhA:
39.0
1mrgA-3bwhA:
57.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis)
PF00161
(RIP)
5 GLY A 112
TYR A 114
ILE A 160
GLU A 165
ARG A 168
None
0.24A 1mrgA-3ctkA:
33.0
1mrgA-3ctkA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF12741
(SusD-like)
5 ILE A 104
GLY A  24
ILE A 119
ALA A 108
GLU A 116
None
0.98A 1mrgA-3ehmA:
undetectable
1mrgA-3ehmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
5 TYR A 221
ILE A 206
GLY A 204
ILE A 229
GLU A 196
None
1.34A 1mrgA-3eluA:
undetectable
1mrgA-3eluA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE


(Rhodopseudomonas
palustris)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
5 ILE P  32
ILE P  75
ALA P  30
GLU P  73
ARG P  28
FAD  P 449 ( 4.5A)
None
None
None
None
1.00A 1mrgA-3fg2P:
undetectable
1mrgA-3fg2P:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1


(Staphylococcus
aureus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A  80
PHE A 119
TYR A  69
ILE A 106
ALA A  82
None
None
None
NAD  A 500 ( 4.9A)
NAD  A 500 (-3.5A)
1.28A 1mrgA-3h3jA:
undetectable
1mrgA-3h3jA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2


(Phytolacca
dioica)
PF00161
(RIP)
5 PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
None
EDO  A 264 (-3.5A)
EDO  A 264 (-4.0A)
None
None
0.32A 1mrgA-3h5kA:
30.9
1mrgA-3h5kA:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2


(Streptococcus
mutans)
PF01791
(DeoC)
5 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
EDO  A 336 (-4.1A)
None
None
None
None
1.30A 1mrgA-3iv3A:
undetectable
1mrgA-3iv3A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2


(Streptococcus
pyogenes)
PF01791
(DeoC)
5 TYR A 141
ILE A 142
TYR A  87
ILE A 145
GLU A 148
None
1.35A 1mrgA-3jrkA:
undetectable
1mrgA-3jrkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Staphylococcus
aureus)
PF01791
(DeoC)
5 TYR A 145
ILE A 146
TYR A  91
ILE A 149
GLU A 152
None
1.36A 1mrgA-3kaoA:
undetectable
1mrgA-3kaoA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kes NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae)
PF04096
(Nucleoporin2)
5 ILE A 494
PHE A 520
GLY A 492
ILE A 548
ALA A 546
None
None
EDO  A   4 ( 4.8A)
None
None
1.30A 1mrgA-3kesA:
undetectable
1mrgA-3kesA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN


(Suregada
multiflora)
PF00161
(RIP)
7 TYR A  74
PHE A  87
GLY A 111
TYR A 113
ILE A 161
GLU A 166
ARG A 169
ADE  A 800 (-3.5A)
ADE  A 800 (-4.6A)
ADE  A 800 (-4.1A)
ADE  A 800 (-3.5A)
ADE  A 800 (-4.0A)
ADE  A 800 ( 4.5A)
ADE  A 800 (-2.7A)
0.32A 1mrgA-3ku0A:
33.9
1mrgA-3ku0A:
33.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvg RIBOSOME
INACTIVATING TYPE 1
PROTEIN


(Iris x
hollandica)
PF00161
(RIP)
5 GLY A 106
TYR A 108
ILE A 156
GLU A 161
ARG A 164
GOL  A 284 ( 4.9A)
GOL  A 281 (-4.4A)
None
None
GOL  A 284 (-3.1A)
0.55A 1mrgA-3mvgA:
32.6
1mrgA-3mvgA:
33.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1


(Streptococcus
pyogenes)
PF01791
(DeoC)
5 TYR A 144
ILE A 145
TYR A  90
ILE A 148
GLU A 151
None
1.33A 1mrgA-3myoA:
undetectable
1mrgA-3myoA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf5 NUCLEOPORIN NUP116

([Candida]
glabrata)
PF04096
(Nucleoporin2)
5 ILE A 927
PHE A 950
GLY A 925
ILE A 977
ALA A 975
None
1.27A 1mrgA-3nf5A:
undetectable
1mrgA-3nf5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT


(Pyrococcus
horikoshii)
PF03833
(PolC_DP2)
5 TYR X 101
ILE X  88
GLY X  90
ILE X  87
ALA X 105
None
1.19A 1mrgA-3o59X:
undetectable
1mrgA-3o59X:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 TYR A 269
GLY A 237
TYR A 239
ILE A 402
ALA A 401
None
1.26A 1mrgA-3o80A:
undetectable
1mrgA-3o80A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis)
PF12741
(SusD-like)
5 ILE A 230
GLY A 393
TYR A 390
ILE A 395
ALA A 233
None
1.01A 1mrgA-3p1uA:
undetectable
1mrgA-3p1uA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbp NUCLEOPORIN
NUP116/NSP116


(Saccharomyces
cerevisiae)
PF04096
(Nucleoporin2)
5 ILE B1003
PHE B1026
GLY B1001
ILE B1053
ALA B1051
None
1.31A 1mrgA-3pbpB:
undetectable
1mrgA-3pbpB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy9 DIHYDRODIPICOLINATE
REDUCTASE


(Staphylococcus
aureus)
PF01113
(DapB_N)
PF05173
(DapB_C)
5 ILE A   3
GLY A  28
TYR A  40
ALA A  19
GLU A  20
None
1.24A 1mrgA-3qy9A:
undetectable
1mrgA-3qy9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Sinorhizobium
meliloti)
PF00106
(adh_short)
5 ILE A  41
GLY A  14
ILE A  44
ALA A  43
GLU A  47
None
1.03A 1mrgA-3tfoA:
undetectable
1mrgA-3tfoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9


(Veillonella
parvula)
PF01075
(Glyco_transf_9)
5 ILE A 185
GLY A 211
TYR A 209
ALA A 338
GLU A 339
None
1.33A 1mrgA-3tovA:
undetectable
1mrgA-3tovA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN


(Nostoc sp. PCC
7120)
PF01590
(GAF)
5 ILE A  36
PHE A  40
ILE A 180
ALA A 183
GLU A 184
None
1.34A 1mrgA-3w2zA:
undetectable
1mrgA-3w2zA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE


(Plasmodium
berghei)
PF01680
(SOR_SNZ)
5 ILE A  25
PHE A 213
GLY A 234
ILE A  43
ALA A  42
None
1.17A 1mrgA-4adsA:
undetectable
1mrgA-4adsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis)
PF00161
(RIP)
5 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
None
0.64A 1mrgA-4imvA:
18.5
1mrgA-4imvA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae)
PF00266
(Aminotran_5)
5 ILE A 180
GLY A  56
TYR A  64
ILE A 182
ALA A 190
None
1.29A 1mrgA-4ixoA:
undetectable
1mrgA-4ixoA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea)
PF00232
(Glyco_hydro_1)
5 TYR A 424
PHE A 403
TYR A 308
ALA A  12
GLU A 377
None
None
GOL  A 507 (-4.1A)
None
GOL  A 507 (-3.8A)
1.28A 1mrgA-4mdpA:
undetectable
1mrgA-4mdpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli)
PF00905
(Transpeptidase)
5 ILE A 179
PHE A 232
GLY A 231
ILE A  71
ALA A  72
None
1.26A 1mrgA-4mllA:
undetectable
1mrgA-4mllA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkm MCCA

(Wolinella
succinogenes)
no annotation 5 ILE A 679
GLY A 622
TYR A 624
ILE A 644
ALA A 647
None
0.98A 1mrgA-4rkmA:
undetectable
1mrgA-4rkmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umf 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE KDSC


(Moraxella
catarrhalis)
PF00702
(Hydrolase)
5 ILE A 108
GLY A 124
TYR A 140
ALA A 150
GLU A 153
None
1.20A 1mrgA-4umfA:
undetectable
1mrgA-4umfA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB


(Drosophila
melanogaster)
PF10613
(Lig_chan-Glu_bd)
5 PHE A 109
GLY A 227
TYR A 226
ALA A 149
GLU A 200
None
None
GLU  A 301 ( 4.6A)
GLU  A 301 (-3.0A)
GLU  A 301 (-2.1A)
1.34A 1mrgA-4wxjA:
undetectable
1mrgA-4wxjA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
5 TYR A  81
ILE A 100
GLY A  36
ILE A  39
ALA A  77
None
1.13A 1mrgA-5a3yA:
undetectable
1mrgA-5a3yA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d55 HDAB,HDAA (ADHESIN),
HUS-ASSOCIATED
DIFFUSE ADHERENCE


(Escherichia
coli)
PF05775
(AfaD)
5 ILE A  26
PHE A  94
GLY A  24
ILE A   3
ALA A   1
None
1.30A 1mrgA-5d55A:
undetectable
1mrgA-5d55A:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ddz RICIN

(Ricinus
communis)
PF00161
(RIP)
6 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
ARG A 180
None
0.47A 1mrgA-5ddzA:
33.9
1mrgA-5ddzA:
32.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum)
PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C)
5 ILE A2260
GLY A2264
TYR A2186
ILE A2177
GLU A2180
None
1.30A 1mrgA-5ejsA:
undetectable
1mrgA-5ejsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
5 TYR A  81
ILE A 100
GLY A  36
ILE A  39
ALA A  77
None
1.11A 1mrgA-5fxnA:
undetectable
1mrgA-5fxnA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Streptococcus
porcinus)
PF01791
(DeoC)
5 TYR A 144
ILE A 145
TYR A  90
ILE A 148
GLU A 151
None
1.35A 1mrgA-5hjlA:
undetectable
1mrgA-5hjlA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ido 3' TERMINAL URIDYLYL
TRANSFERASE


(Trypanosoma
brucei)
PF03828
(PAP_assoc)
5 ILE A 311
GLY A 307
ILE A 470
ALA A 276
GLU A 466
None
1.37A 1mrgA-5idoA:
undetectable
1mrgA-5idoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT


(Pyrococcus
abyssi)
PF03833
(PolC_DP2)
5 TYR A  98
ILE A  85
GLY A  87
ILE A  84
ALA A 102
None
1.18A 1mrgA-5ijlA:
undetectable
1mrgA-5ijlA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum)
PF00232
(Glyco_hydro_1)
5 TYR A 431
PHE A 410
TYR A 316
ALA A  17
GLU A 384
None
1.18A 1mrgA-5jboA:
undetectable
1mrgA-5jboA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7


(Saccharomyces
cerevisiae)
PF00160
(Pro_isomerase)
PF00515
(TPR_1)
5 ILE A 243
GLY A 214
ILE A 242
ALA A 239
GLU A 238
None
1.34A 1mrgA-5jheA:
undetectable
1mrgA-5jheA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE


(Pseudomonas)
PF00202
(Aminotran_3)
5 TYR A 294
GLY A  64
ILE A 342
ALA A 338
GLU A  69
None
1.26A 1mrgA-5kqwA:
undetectable
1mrgA-5kqwA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE


(Pseudomonas)
PF00202
(Aminotran_3)
5 TYR A 294
GLY A  64
ILE A 342
ALA A 338
GLU A  69
None
1.26A 1mrgA-5kr6A:
undetectable
1mrgA-5kr6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L27,
CHLOROPLASTIC


(Spinacia
oleracea)
PF01016
(Ribosomal_L27)
5 ILE X  93
PHE X 125
GLY X  83
ILE X  81
ALA X  91
None
G  A 867 ( 4.0A)
G  A 866 ( 3.1A)
None
A  A2371 ( 4.0A)
1.23A 1mrgA-5mlcX:
undetectable
1mrgA-5mlcX:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Mycolicibacterium
smegmatis)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
5 GLY A  46
ILE A  48
ALA A  40
GLU A  77
ARG A  18
None
1.25A 1mrgA-5mp7A:
undetectable
1mrgA-5mp7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 ILE A 181
GLY A 198
ILE A  68
ALA A  77
ARG A 169
None
1.26A 1mrgA-5troA:
undetectable
1mrgA-5troA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE


(Homo sapiens)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1)
5 TYR A1028
GLY A1281
TYR A1512
ILE A1229
ALA A1231
None
1.22A 1mrgA-5vadA:
undetectable
1mrgA-5vadA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE


(Leishmania
major)
no annotation 5 TYR A 267
GLY A 519
TYR A 756
ILE A 467
ALA A 469
ACT  A1003 (-4.1A)
None
ACT  A1003 (-4.5A)
None
None
1.23A 1mrgA-5xilA:
undetectable
1mrgA-5xilA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL


(Homo sapiens)
no annotation 5 ILE d  96
TYR d  10
ILE d  99
ALA e 122
GLU e 123
None
1.38A 1mrgA-5xtcd:
undetectable
1mrgA-5xtcd:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxf PROTECTION OF
TELOMERES PROTEIN
POZ1


(Schizosaccharomyces
pombe)
no annotation 5 ILE A  54
PHE A 235
TYR A 219
ILE A 106
GLU A 107
None
1.30A 1mrgA-5xxfA:
undetectable
1mrgA-5xxfA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydg MULTIPLE ORGANELLAR
RNA EDITING FACTOR
2, CHLOROPLASTIC


(Arabidopsis
thaliana)
no annotation 5 ILE A 126
PHE A 176
GLY A 179
ILE A 109
GLU A 119
None
1.32A 1mrgA-5ydgA:
undetectable
1mrgA-5ydgA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydg MULTIPLE ORGANELLAR
RNA EDITING FACTOR
2, CHLOROPLASTIC


(Arabidopsis
thaliana)
no annotation 5 PHE A 176
GLY A 179
ILE A 109
ALA A 113
GLU A 119
None
1.26A 1mrgA-5ydgA:
undetectable
1mrgA-5ydgA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Pseudomonas
putida)
no annotation 5 ILE A 398
GLY A 401
ILE A 405
GLU A 406
ARG A 418
None
1.12A 1mrgA-6cn1A:
undetectable
1mrgA-6cn1A:
20.18