SIMILAR PATTERNS OF AMINO ACIDS FOR 1MOG_A_RBFA200_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		3 PHE A  95
TRP A  66
GLU A 132
 None
 1.18A 1mogA-1cjaA:
undetectable		 1mogA-1cjaA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		3 PHE A  27
TRP A 254
GLU A 220
 None
 1.18A 1mogA-1egzA:
0.0		 1mogA-1egzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		3 PHE A 243
TRP A 240
GLU A 236
 None
 1.09A 1mogA-1egzA:
0.0		 1mogA-1egzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		3 PHE A 305
TRP A 310
GLU A 312
 None
 0.75A 1mogA-1h81A:
0.0		 1mogA-1h81A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		3 PHE A 309
TRP A 310
GLU A 312
 None
 1.15A 1mogA-1h81A:
0.0		 1mogA-1h81A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 PHE A 552
TRP A 471
GLU A 470
 None
MLZ  A 467 ( 3.4A)
MLZ  A 467 ( 3.8A)
 1.10A 1mogA-1iv8A:
0.0		 1mogA-1iv8A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j77 HEMO

(Neisseria
meningitidis) 		PF01126
(Heme_oxygenase) 		3 PHE A 183
TRP A 110
GLU A 102
 None
 0.99A 1mogA-1j77A:
undetectable		 1mogA-1j77A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 PHE A 195
TRP A 170
GLU A 191
 None
 1.19A 1mogA-1jioA:
undetectable		 1mogA-1jioA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		3 PHE A 518
TRP A 547
GLU A 545
 None
 1.10A 1mogA-1jnfA:
0.3		 1mogA-1jnfA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 PHE A 551
TRP A 590
GLU A 553
 None
 0.78A 1mogA-1m53A:
0.0		 1mogA-1m53A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		3 PHE A  16
TRP A  13
GLU A 789
 None
 1.17A 1mogA-1obhA:
0.0		 1mogA-1obhA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr0 4'-PHOSPHOPANTETHEIN
YL TRANSFERASE SFP

(Bacillus
subtilis) 		PF01648
(ACPS) 		3 PHE A 122
TRP A 147
GLU A 109
 None
None
MG  A 400 (-3.3A)
 1.14A 1mogA-1qr0A:
1.0		 1mogA-1qr0A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 PHE A 111
TRP A  73
GLU A 437
 None
 1.16A 1mogA-1rqbA:
undetectable		 1mogA-1rqbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens) 		PF06079
(Apyrase) 		3 PHE A 257
TRP A 192
GLU A 190
 None
 1.17A 1mogA-1s1dA:
undetectable		 1mogA-1s1dA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE

(Homo sapiens) 		PF00405
(Transferrin) 		3 PHE E 518
TRP E 547
GLU E 545
 None
 1.10A 1mogA-1suvE:
undetectable		 1mogA-1suvE:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REGULATORY PROTEIN
E2

(Alphapapillomavirus
7) 		PF00508
(PPV_E2_N) 		3 PHE B 114
TRP B  96
GLU B  94
 None
 1.04A 1mogA-1tueB:
undetectable		 1mogA-1tueB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		3 PHE A 245
TRP A 242
GLU A 238
 None
 1.17A 1mogA-1tvpA:
undetectable		 1mogA-1tvpA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii) 		PF00866
(Ring_hydroxyl_B) 		3 PHE B  46
TRP B  45
GLU B  33
 None
 1.11A 1mogA-1uliB:
0.9		 1mogA-1uliB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 PHE A 148
TRP A  99
GLU A 103
 None
 1.02A 1mogA-1xc6A:
undetectable		 1mogA-1xc6A:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		3 PHE A 379
TRP A  33
GLU A  32
 None
 1.17A 1mogA-1yifA:
undetectable		 1mogA-1yifA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 PHE I 176
TRP I 133
GLU I 170
 None
 0.99A 1mogA-1yveI:
undetectable		 1mogA-1yveI:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		3 PHE A 496
TRP A 755
GLU A 489
 None
 1.14A 1mogA-1z26A:
undetectable		 1mogA-1z26A:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdv PHAGE-RELATED
CONSERVED
HYPOTHETICAL
PROTEIN, BB2244

(Bordetella
bronchiseptica) 		PF02586
(SRAP) 		3 PHE A 200
TRP A 102
GLU A 104
 None
 0.54A 1mogA-2bdvA:
undetectable		 1mogA-2bdvA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2doi ANGIOSTATIN

(Homo sapiens) 		no annotation 3 PHE X 227
TRP X 225
GLU X 221
 None
 1.07A 1mogA-2doiX:
undetectable		 1mogA-2doiX:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 PHE A 452
TRP A 520
GLU A 518
 None
 0.89A 1mogA-2f57A:
undetectable		 1mogA-2f57A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 PHE A 590
TRP A 613
GLU A 593
 None
 0.98A 1mogA-2fjaA:
undetectable		 1mogA-2fjaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		3 PHE A 131
TRP A  34
GLU A  57
 None
None
MES  A 801 (-4.3A)
 1.18A 1mogA-2fk6A:
undetectable		 1mogA-2fk6A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96) 		PF00722
(Glyco_hydro_16) 		3 PHE A 147
TRP A 118
GLU A 123
 None
GOL  A 250 ( 4.0A)
GOL  A 250 ( 3.0A)
 1.10A 1mogA-2hykA:
undetectable		 1mogA-2hykA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		3 PHE A1688
TRP A1963
GLU A1961
 None
 1.19A 1mogA-2ix8A:
undetectable		 1mogA-2ix8A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ms7 MITOCHONDRIAL
ANTIVIRAL-SIGNALING
PROTEIN

(Homo sapiens) 		PF16739
(CARD_2) 		3 PHE A  59
TRP A  68
GLU A   5
 None
 1.08A 1mogA-2ms7A:
undetectable		 1mogA-2ms7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mui UPF0301 PROTEIN ALGH

(Pseudomonas
aeruginosa) 		PF02622
(DUF179) 		3 PHE A  25
TRP A 149
GLU A 143
 None
 1.05A 1mogA-2muiA:
undetectable		 1mogA-2muiA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		3 PHE A 291
TRP A 344
GLU A 293
 None
 1.14A 1mogA-2paaA:
undetectable		 1mogA-2paaA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdr UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF14499
(DUF4437) 		3 PHE A 280
TRP A 261
GLU A 239
 UNL  A 303 ( 4.7A)
UNL  A 303 (-3.1A)
UNL  A 303 ( 4.1A)
 1.03A 1mogA-2qdrA:
1.2		 1mogA-2qdrA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		3 PHE A 188
TRP A 202
GLU A 201
 None
 1.19A 1mogA-2vj5A:
undetectable		 1mogA-2vj5A:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vkg DODECIN

(Halobacterium
salinarum) 		PF07311
(Dodecin) 		3 PHE A   3
TRP A  36
GLU A  38
 CF4  A1064 ( 4.7A)
CF4  A1064 (-3.3A)
MG  A1061 ( 4.0A)
 0.09A 1mogA-2vkgA:
13.6		 1mogA-2vkgA:
95.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7w SUPEROXIDE DISMUTASE
[FE]

(Aliivibrio
salmonicida) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 PHE A  76
TRP A  72
GLU A  54
 None
 1.14A 1mogA-2w7wA:
undetectable		 1mogA-2w7wA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 PHE A 532
TRP A 553
GLU A 535
 None
 0.88A 1mogA-2wu5A:
undetectable		 1mogA-2wu5A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdv MYC-INDUCED NUCLEAR
ANTIGEN

(Homo sapiens) 		PF08007
(Cupin_4) 		3 PHE A 158
TRP A  59
GLU A  60
 None
 1.10A 1mogA-2xdvA:
0.5		 1mogA-2xdvA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 PHE A 299
TRP A 366
GLU A 368
 None
 1.15A 1mogA-2z2wA:
undetectable		 1mogA-2z2wA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		3 PHE A 220
TRP A 224
GLU A 151
 None
 1.16A 1mogA-2zblA:
undetectable		 1mogA-2zblA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 PHE A 251
TRP A 248
GLU A 244
 None
 0.99A 1mogA-3a3hA:
undetectable		 1mogA-3a3hA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		3 PHE A 251
TRP A  85
GLU A  83
 None
 1.04A 1mogA-3allA:
undetectable		 1mogA-3allA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 PHE B  30
TRP B  17
GLU B  82
 None
None
F4S  B 301 ( 4.8A)
 1.16A 1mogA-3ayxB:
undetectable		 1mogA-3ayxB:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 PHE A 662
TRP A 624
GLU A1005
 None
 1.06A 1mogA-3bg9A:
undetectable		 1mogA-3bg9A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		3 PHE A 156
TRP A 194
GLU A 193
 None
 0.97A 1mogA-3e8jA:
undetectable		 1mogA-3e8jA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 PHE A 977
TRP A 394
GLU A 859
 None
 1.03A 1mogA-3egwA:
undetectable		 1mogA-3egwA:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas
putida) 		PF00866
(Ring_hydroxyl_B) 		3 PHE B  46
TRP B  45
GLU B  33
 None
 1.06A 1mogA-3eqqB:
0.9		 1mogA-3eqqB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 PHE A 613
TRP A 636
GLU A 616
 None
 0.89A 1mogA-3gyxA:
undetectable		 1mogA-3gyxA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 PHE A 639
TRP A 425
GLU A 270
 None
 1.15A 1mogA-3gyxA:
undetectable		 1mogA-3gyxA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 PHE A 549
TRP A 469
GLU A 468
 None
 1.18A 1mogA-3hjeA:
undetectable		 1mogA-3hjeA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 EIF2 ALPHA

(Saccharomyces
cerevisiae) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		3 PHE j 145
TRP j 155
GLU j 152
 None
 1.11A 1mogA-3j81j:
undetectable		 1mogA-3j81j:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 PHE A 264
TRP A 258
GLU A 256
 None
 0.98A 1mogA-3k7nA:
undetectable		 1mogA-3k7nA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		3 PHE A1082
TRP A1077
GLU A1049
 None
 1.19A 1mogA-3l9xA:
undetectable		 1mogA-3l9xA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvg CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		3 PHE A1557
TRP A1556
GLU A1560
 None
 1.13A 1mogA-3lvgA:
undetectable		 1mogA-3lvgA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 3 PHE G  96
TRP G  93
GLU G  89
 None
 1.01A 1mogA-3mmpG:
undetectable		 1mogA-3mmpG:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 PHE A 148
TRP A  99
GLU A 103
 None
 1.04A 1mogA-3ogrA:
undetectable		 1mogA-3ogrA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 PHE A 251
TRP A 293
GLU A 228
 None
 1.18A 1mogA-3otrA:
undetectable		 1mogA-3otrA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm7 UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF02229
(PC4) 		3 PHE A   5
TRP A  44
GLU A  26
 None
 0.76A 1mogA-3pm7A:
undetectable		 1mogA-3pm7A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		3 PHE B 589
TRP B 654
GLU B 656
 None
 1.12A 1mogA-3qd2B:
undetectable		 1mogA-3qd2B:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx3 UNCHARACTERIZED
PROTEIN INVOLVED IN
CYSTEINE
BIOSYNTHESIS

(Idiomarina
loihiensis) 		PF07264
(EI24) 		3 PHE A 183
TRP A 236
GLU A 110
 None
 0.81A 1mogA-3tx3A:
undetectable		 1mogA-3tx3A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 PHE A 235
TRP A 220
GLU A 261
 None
 0.88A 1mogA-3ua4A:
undetectable		 1mogA-3ua4A:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukm POTASSIUM CHANNEL
SUBFAMILY K MEMBER 1

(Homo sapiens) 		PF07885
(Ion_trans_2) 		3 PHE A 110
TRP A 102
GLU A  49
 None
 1.07A 1mogA-3ukmA:
undetectable		 1mogA-3ukmA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		3 PHE A 126
TRP A  77
GLU A  81
 None
 1.15A 1mogA-3w5fA:
undetectable		 1mogA-3w5fA:
6.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b2h DODECIN

(Halobacterium
salinarum) 		PF07311
(Dodecin) 		3 PHE A   3
TRP A  36
GLU A  38
 C3F  A 103 (-4.6A)
C3F  A 103 (-3.3A)
NA  A 101 ( 4.0A)
 0.08A 1mogA-4b2hA:
13.5		 1mogA-4b2hA:
95.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 3 PHE A 241
TRP A  76
GLU A  74
 None
 1.18A 1mogA-4bpsA:
1.6		 1mogA-4bpsA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 PHE A 150
TRP A 334
GLU A 335
 None
 1.03A 1mogA-4btmA:
0.2		 1mogA-4btmA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 SMALL
SUBUNIT

(Salmonella
enterica) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 PHE B  24
TRP B  11
GLU B  76
 None
None
F4S  B1003 ( 4.8A)
 1.01A 1mogA-4c3oB:
undetectable		 1mogA-4c3oB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 PHE A 596
TRP A 556
GLU A 603
 None
 1.11A 1mogA-4fgvA:
undetectable		 1mogA-4fgvA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		3 PHE A 324
TRP A 392
GLU A 390
 None
 0.89A 1mogA-4fieA:
undetectable		 1mogA-4fieA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gah THIOESTERASE
SUPERFAMILY MEMBER 4

(Homo sapiens) 		PF03061
(4HBT) 		3 PHE A  61
TRP A  53
GLU A 122
 None
 1.07A 1mogA-4gahA:
1.6		 1mogA-4gahA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		3 PHE C 610
TRP C 570
GLU C 617
 None
 0.89A 1mogA-4hb4C:
undetectable		 1mogA-4hb4C:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjf GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF00563
(EAL) 		3 PHE A 308
TRP A 369
GLU A 537
 None
 1.06A 1mogA-4hjfA:
undetectable		 1mogA-4hjfA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 PHE A 285
TRP A 192
GLU A 150
 None
 0.95A 1mogA-4iqrA:
undetectable		 1mogA-4iqrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 PHE A 148
TRP A  99
GLU A 103
 None
 1.05A 1mogA-4iugA:
undetectable		 1mogA-4iugA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		3 PHE A 243
TRP A 240
GLU A 236
 None
 1.08A 1mogA-4m1rA:
undetectable		 1mogA-4m1rA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 PHE A 104
TRP A  55
GLU A  59
 None
 1.10A 1mogA-4madA:
undetectable		 1mogA-4madA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6c UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF08020
(DUF1706) 		3 PHE A 148
TRP A 133
GLU A  62
 None
 1.12A 1mogA-4n6cA:
undetectable		 1mogA-4n6cA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 PHE A 126
TRP A 310
GLU A 311
 None
 0.98A 1mogA-4nfnA:
undetectable		 1mogA-4nfnA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		3 PHE A 194
TRP A 122
GLU A 121
 None
 1.16A 1mogA-4nk6A:
undetectable		 1mogA-4nk6A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		3 PHE A 194
TRP A 122
GLU A 121
 None
 1.17A 1mogA-4ozyA:
undetectable		 1mogA-4ozyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		3 PHE A 299
TRP A 286
GLU A 289
 None
 1.01A 1mogA-4r12A:
undetectable		 1mogA-4r12A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 PHE A 135
TRP A  61
GLU A  65
 None
 0.94A 1mogA-4uozA:
undetectable		 1mogA-4uozA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		3 PHE A 324
TRP A 392
GLU A 390
 None
 0.85A 1mogA-4xbrA:
undetectable		 1mogA-4xbrA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 PHE A 410
TRP A 352
GLU A 316
 None
GOL  A2011 ( 3.7A)
XYL  A2015 ( 2.9A)
 1.09A 1mogA-4xwhA:
undetectable		 1mogA-4xwhA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66

(Homo sapiens) 		PF08007
(Cupin_4) 		3 PHE A 319
TRP A 223
GLU A 224
 None
 0.97A 1mogA-4y4rA:
undetectable		 1mogA-4y4rA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 PHE C  58
TRP A 110
GLU A 102
 None
 1.10A 1mogA-5aa5C:
undetectable		 1mogA-5aa5C:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyy S-RECEPTOR KINASE
SRK9

(Brassica rapa) 		PF00954
(S_locus_glycop)
PF01453
(B_lectin)
PF08276
(PAN_2) 		3 PHE A 239
TRP A 255
GLU A 198
 None
 0.71A 1mogA-5gyyA:
undetectable		 1mogA-5gyyA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		3 PHE A 272
TRP A 183
GLU A 268
 None
 1.10A 1mogA-5igpA:
undetectable		 1mogA-5igpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 PHE A 148
TRP A  99
GLU A 103
 None
 1.06A 1mogA-5ihrA:
undetectable		 1mogA-5ihrA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		3 PHE A 270
TRP A 267
GLU A 263
 None
 1.16A 1mogA-5ihsA:
undetectable		 1mogA-5ihsA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		3 PHE A 679
TRP A 623
GLU A 663
 None
 1.09A 1mogA-5j7tA:
undetectable		 1mogA-5j7tA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdj HOXK
UPTAKE HYDROGENASE
SMALL SUBUNIT

(Cupriavidus
necator) 		no annotation 3 PHE S  24
TRP S  11
GLU S  76
 None
None
F4S  S1003 (-4.1A)
 1.19A 1mogA-5mdjS:
undetectable		 1mogA-5mdjS:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noa FAMILY 88 GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		3 PHE A 307
TRP A 301
GLU A 370
 None
 1.17A 1mogA-5noaA:
undetectable		 1mogA-5noaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 PHE A  10
TRP A  38
GLU A  39
 None
 0.60A 1mogA-5nr1A:
undetectable		 1mogA-5nr1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 3 PHE A 107
TRP A 319
GLU A 318
 None
 0.86A 1mogA-5olkA:
undetectable		 1mogA-5olkA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 3 PHE A 324
TRP A 392
GLU A 390
 None
 0.90A 1mogA-5vefA:
undetectable		 1mogA-5vefA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 3 PHE A  23
TRP A 108
GLU A 110
 None
 1.12A 1mogA-5x1tA:
undetectable		 1mogA-5x1tA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 3 PHE A 299
TRP A 293
GLU A 291
 None
 1.11A 1mogA-5y31A:
undetectable		 1mogA-5y31A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yht HISTIDINOL-PHOSPHATA
SE

(Mycobacterium
tuberculosis) 		no annotation 3 PHE A 190
TRP A 124
GLU A 198
 None
 1.03A 1mogA-5yhtA:
undetectable		 1mogA-5yhtA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 3 PHE F 230
TRP F 225
GLU F 300
 None
 0.93A 1mogA-6f0kF:
undetectable		 1mogA-6f0kF:
24.36