SIMILAR PATTERNS OF AMINO ACIDS FOR 1MMT_A_H4BA1426

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		5 VAL A2002
LEU A2004
SER A2006
PHE A2009
LEU A2010
 None
 0.91A 1mmtA-1914A:
undetectable		 1mmtA-1914A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 VAL A  30
LEU A  92
SER A  94
LEU A  98
THR A  31
 None
 1.27A 1mmtA-1c3cA:
undetectable		 1mmtA-1c3cA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.98A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
 HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.92A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.87A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
 HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.87A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
HIS A 290
GLU A 330
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
FE  A 425 (-2.5A)
 0.99A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
HIS A 290
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
 0.92A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 VAL A 245
LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
GLU A 330
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
FE  A 425 (-2.5A)
 0.83A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 VAL A 245
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
 0.83A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 LEU A 335
PHE A  43
LEU A  45
GLU A 333
TYR A  74
 None
 1.09A 1mmtA-1eb3A:
undetectable		 1mmtA-1eb3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 311
LEU A 263
SER A  87
HIS A  79
TYR A  97
 None
 1.25A 1mmtA-1ivhA:
undetectable		 1mmtA-1ivhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 123
LEU A 288
LEU A 291
LEU A 271
TYR A 231
 None
 1.23A 1mmtA-1j6uA:
undetectable		 1mmtA-1j6uA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		6 VAL A  98
LEU A 101
PHE A 107
THR A 119
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
None
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.05A 1mmtA-1ltzA:
26.7		 1mmtA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		6 VAL A  98
LEU A 101
THR A 119
HIS A 143
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.72A 1mmtA-1ltzA:
26.7		 1mmtA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 VAL A1280
LEU A1273
THR A1279
HIS A  30
GLU A 367
 None
 1.32A 1mmtA-1ofeA:
undetectable		 1mmtA-1ofeA:
12.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		10 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 None
None
None
None
None
None
None
FE  A 501 ( 3.7A)
None
FE  A 501 ( 2.8A)
 0.86A 1mmtA-1phzA:
41.8		 1mmtA-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		10 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
 None
None
None
None
None
None
None
None
FE  A 501 ( 3.7A)
None
 0.80A 1mmtA-1phzA:
41.8		 1mmtA-1phzA:
95.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A) 		PF00073
(Rhv) 		5 SER 1 211
THR 2 147
HIS 2 217
TYR 1 194
GLU 2 129
 SUC  1 288 ( 4.5A)
None
None
None
None
 1.23A 1mmtA-1r1a1:
undetectable		 1mmtA-1r1a1:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 LEU A 133
SER A 131
LEU A  39
HIS A 139
GLU A  98
 None
 1.22A 1mmtA-1sfrA:
undetectable		 1mmtA-1sfrA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2q FAB NNA7 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 189
LEU H 165
SER H 164
THR H 193
GLU H 197
 None
 1.37A 1mmtA-1t2qH:
undetectable		 1mmtA-1t2qH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		5 VAL A 232
LEU A 195
SER A 193
LEU A 241
GLU A 160
 None
None
NDP  A 280 (-2.8A)
None
NDP  A 280 ( 2.7A)
 1.38A 1mmtA-1tcsA:
undetectable		 1mmtA-1tcsA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		5 VAL A 350
LEU A 359
LEU A 193
PHE A 192
THR A 351
 None
 1.31A 1mmtA-1w61A:
undetectable		 1mmtA-1w61A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 310
LEU A 338
GLU A 123
TYR A 317
GLU A 318
 LEU  A 310 ( 0.6A)
LEU  A 338 ( 0.6A)
GLU  A 123 ( 0.6A)
TYR  A 317 ( 1.3A)
GLU  A 318 ( 0.6A)
 1.20A 1mmtA-1wqaA:
undetectable		 1mmtA-1wqaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		5 VAL A 421
LEU A 368
SER A 366
LEU A 365
THR A 423
 None
 0.98A 1mmtA-1xr4A:
undetectable		 1mmtA-1xr4A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3d UBIQUITIN-CONJUGATIN
G ENZYME E2 1

(Caenorhabditis
elegans) 		PF00179
(UQ_con) 		5 VAL A  24
LEU A  16
LEU A   9
THR A 107
TYR A  63
 None
 1.38A 1mmtA-1z3dA:
undetectable		 1mmtA-1z3dA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		5 VAL A 132
LEU A 125
LEU A 165
SER A 169
LEU A 173
 None
 1.37A 1mmtA-2cwoA:
undetectable		 1mmtA-2cwoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		5 LEU A 316
LEU A 336
THR A 303
TYR A 260
GLU A 213
 None
 1.38A 1mmtA-2dwcA:
undetectable		 1mmtA-2dwcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 VAL X 110
LEU X 390
LEU X 387
SER X 385
PHE X 384
 None
 1.31A 1mmtA-2epkX:
undetectable		 1mmtA-2epkX:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 VAL A 428
LEU A 375
SER A 373
LEU A 372
THR A 430
 None
 0.97A 1mmtA-2hj0A:
undetectable		 1mmtA-2hj0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 VAL A 129
LEU A 110
LEU A  64
LEU A  59
GLU A 117
 None
 1.14A 1mmtA-2hyjA:
undetectable		 1mmtA-2hyjA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 VAL A 333
LEU A 367
SER A 421
THR A 329
GLU A 357
 None
 1.25A 1mmtA-2odlA:
undetectable		 1mmtA-2odlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		5 VAL A 302
LEU A 256
LEU A 354
LEU A 241
THR A 333
 None
 1.15A 1mmtA-2p0oA:
undetectable		 1mmtA-2p0oA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1w PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 VAL A 215
LEU A  20
LEU A  21
LEU A  48
THR A 211
 None
 1.32A 1mmtA-2q1wA:
undetectable		 1mmtA-2q1wA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcz OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		5 VAL A 258
LEU A 226
SER A 228
LEU A 231
THR A 243
 None
 1.17A 1mmtA-2qczA:
undetectable		 1mmtA-2qczA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 111
LEU H  83
LEU H 109
THR H  87
GLU H  46
 None
 1.36A 1mmtA-2r4sH:
undetectable		 1mmtA-2r4sH:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsp RSV PROTEASE

(Rous sarcoma
virus) 		PF00077
(RVP) 		5 VAL A  13
LEU A  35
LEU A  36
SER A  38
LEU A 121
 None
 1.13A 1mmtA-2rspA:
undetectable		 1mmtA-2rspA:
16.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		8 LEU A 294
LEU A 295
LEU A 301
THR A 312
GLU A 332
HIS A 336
TYR A 371
GLU A 376
 HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
HBI  A 500 ( 4.4A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
MTY  A 300 (-3.9A)
FE  A 501 (-2.1A)
 0.86A 1mmtA-2tohA:
43.0		 1mmtA-2tohA:
59.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		8 VAL A 291
LEU A 294
LEU A 295
LEU A 301
THR A 312
GLU A 332
HIS A 336
GLU A 376
 HBI  A 500 ( 4.6A)
HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
HBI  A 500 ( 4.4A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
FE  A 501 (-2.1A)
 0.84A 1mmtA-2tohA:
43.0		 1mmtA-2tohA:
59.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		5 VAL A  82
GLU A 123
HIS A 127
TYR A 162
GLU A 167
 None
 1.00A 1mmtA-2v28A:
26.8		 1mmtA-2v28A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vec PIRIN-LIKE PROTEIN
YHAK

(Escherichia
coli) 		PF02678
(Pirin) 		5 VAL A  42
LEU A  93
THR A  23
TYR A  75
GLU A 103
 None
 1.06A 1mmtA-2vecA:
undetectable		 1mmtA-2vecA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 LEU A 371
SER A 373
LEU A 353
THR A 140
HIS A 364
 None
None
None
TRS  A1478 ( 4.4A)
UDP  A1477 (-3.9A)
 1.35A 1mmtA-2vg8A:
undetectable		 1mmtA-2vg8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		5 VAL A 176
LEU A 100
LEU A 121
HIS A 103
GLU A 108
 None
None
None
MN  A1005 (-3.5A)
MN  A1005 (-2.5A)
 1.23A 1mmtA-2vqaA:
undetectable		 1mmtA-2vqaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 VAL A 796
LEU A 924
LEU A 921
LEU A 912
GLU A 906
 None
 1.36A 1mmtA-2x6kA:
undetectable		 1mmtA-2x6kA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5c RAS-LIKE PROTEIN 12

(Homo sapiens) 		PF00071
(Ras) 		5 VAL A 163
LEU A  95
LEU A  36
LEU A  41
HIS A 177
 None
 1.27A 1mmtA-3c5cA:
undetectable		 1mmtA-3c5cA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE

(Bacteroides
thetaiotaomicron) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  69
LEU A  70
PHE A 116
LEU A 113
THR A  67
 None
 1.22A 1mmtA-3ct9A:
undetectable		 1mmtA-3ct9A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2) 		5 VAL A 887
LEU A 848
LEU A 777
HIS A 854
GLU A 805
 None
 1.34A 1mmtA-3d3mA:
undetectable		 1mmtA-3d3mA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efc OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		5 VAL A 258
LEU A 226
SER A 228
LEU A 231
THR A 243
 None
 0.88A 1mmtA-3efcA:
undetectable		 1mmtA-3efcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8k PROTEIN
ACETYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF00583
(Acetyltransf_1) 		5 LEU A  71
SER A  78
PHE A  77
LEU A  79
THR A 109
 None
COA  A 301 (-3.4A)
None
COA  A 301 (-4.4A)
None
 1.32A 1mmtA-3f8kA:
undetectable		 1mmtA-3f8kA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxb TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		5 VAL A 284
PHE A 158
LEU A 138
HIS A 206
GLU A 183
 None
 1.29A 1mmtA-3fxbA:
undetectable		 1mmtA-3fxbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		6 VAL A 226
LEU A 261
SER A 259
PHE A 262
THR A 247
GLU A 300
 None
 1.47A 1mmtA-3g77A:
undetectable		 1mmtA-3g77A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		5 VAL A  90
LEU A  87
LEU A 145
LEU A 143
GLU A 151
 None
 1.31A 1mmtA-3gz8A:
undetectable		 1mmtA-3gz8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		5 VAL A  54
LEU A  81
LEU A 306
THR A  52
TYR A 369
 None
 1.15A 1mmtA-3h75A:
undetectable		 1mmtA-3h75A:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 LEU A 236
PHE A 241
LEU A 242
THR A 253
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 None
None
None
None
FE  A 400 ( 4.6A)
FE  A 400 (-3.2A)
None
FE  A 400 ( 1.9A)
 0.82A 1mmtA-3hf8A:
40.7		 1mmtA-3hf8A:
64.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		8 VAL A 232
LEU A 236
PHE A 241
LEU A 242
THR A 253
GLU A 273
HIS A 277
GLU A 317
 None
None
None
None
None
FE  A 400 ( 4.6A)
FE  A 400 (-3.2A)
FE  A 400 ( 1.9A)
 0.82A 1mmtA-3hf8A:
40.7		 1mmtA-3hf8A:
64.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		5 LEU A 254
LEU A 145
HIS A 354
TYR A 397
GLU A 393
 None
 0.82A 1mmtA-3ipoA:
undetectable		 1mmtA-3ipoA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		5 LEU A 508
LEU A 505
LEU A 478
THR A 518
HIS A 361
 None
 1.25A 1mmtA-3nmzA:
undetectable		 1mmtA-3nmzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6q STAGE II SPORULATION
PROTEIN SA

(Bacillus
subtilis) 		PF14171
(SpoIISA_toxin) 		5 VAL A 200
LEU A 156
LEU A 232
THR A 222
TYR A 120
 None
 1.32A 1mmtA-3o6qA:
undetectable		 1mmtA-3o6qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 VAL B 730
LEU B 794
SER B 793
THR B 842
TYR B 692
 None
 1.33A 1mmtA-3ohmB:
undetectable		 1mmtA-3ohmB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 LEU A 231
SER A 243
PHE A 246
LEU A 247
TYR A 287
 None
 1.34A 1mmtA-3opbA:
undetectable		 1mmtA-3opbA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opz HEAVY CHAIN OF THE
FAB FRAGMENT OF
IMMUNOGLOBULIN G

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 117
LEU H  83
LEU H 115
THR H  87
GLU H  46
 None
 1.22A 1mmtA-3opzH:
undetectable		 1mmtA-3opzH:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 VAL A 145
LEU A 336
LEU A 333
SER A 309
THR A 142
 None
 1.35A 1mmtA-3p5pA:
undetectable		 1mmtA-3p5pA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 987
LEU A 823
SER A 977
PHE A 976
THR A 948
 None
 1.31A 1mmtA-3pp0A:
undetectable		 1mmtA-3pp0A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Bacillus
anthracis) 		PF02525
(Flavodoxin_2) 		5 VAL A  96
SER A 208
LEU A  34
HIS A  26
GLU A 204
 None
 1.31A 1mmtA-3u7iA:
undetectable		 1mmtA-3u7iA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 VAL A 600
LEU A 623
PHE A 611
LEU A 614
THR A 599
 None
 1.27A 1mmtA-3ui7A:
undetectable		 1mmtA-3ui7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 VAL A 157
LEU A 188
SER A 184
PHE A 177
THR A 173
 None
 1.17A 1mmtA-3wa1A:
undetectable		 1mmtA-3wa1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3

(Homo sapiens) 		PF01299
(Lamp) 		5 LEU A 360
SER A 336
PHE A 337
THR A 355
GLU A 375
 None
 1.20A 1mmtA-4akmA:
undetectable		 1mmtA-4akmA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 LEU A 262
PHE A 278
LEU A 126
THR A 141
HIS A 297
 None
 1.31A 1mmtA-4aoaA:
undetectable		 1mmtA-4aoaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		5 VAL A  82
PHE A  91
GLU A 123
HIS A 127
GLU A 167
 None
PEG  A1260 (-3.8A)
None
None
PEG  A1261 (-3.1A)
 0.94A 1mmtA-4bptA:
26.6		 1mmtA-4bptA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 212
LEU A 104
LEU A 103
SER A  94
GLU A  60
 None
 1.32A 1mmtA-4d9rA:
undetectable		 1mmtA-4d9rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fh8 ACEPRX-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 VAL A  26
LEU A  71
THR A  15
HIS A  81
TYR A  41
 None
 1.21A 1mmtA-4fh8A:
undetectable		 1mmtA-4fh8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 VAL B 730
LEU B 794
SER B 793
THR B 842
TYR B 692
 None
 1.29A 1mmtA-4gnkB:
undetectable		 1mmtA-4gnkB:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw6 PEROXIREDOXIN-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA) 		5 VAL A  26
LEU A  71
THR A  15
HIS A  81
TYR A  41
 None
 1.21A 1mmtA-4kw6A:
undetectable		 1mmtA-4kw6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 VAL A 210
LEU A 205
LEU A 206
PHE A 237
LEU A 234
 None
 1.29A 1mmtA-4mtlA:
undetectable		 1mmtA-4mtlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nha ENDORIBONUCLEASE
DICER

(Homo sapiens) 		PF02170
(PAZ) 		5 LEU A 848
SER A 845
THR A 983
HIS A1031
TYR A 842
 None
 1.25A 1mmtA-4nhaA:
undetectable		 1mmtA-4nhaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 VAL A 399
LEU A 380
LEU A 561
HIS A 522
GLU A 315
 None
 1.32A 1mmtA-4q1vA:
undetectable		 1mmtA-4q1vA:
16.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		7 VAL A 278
LEU A 282
PHE A 287
LEU A 288
THR A 299
HIS A 323
TYR A 358
 None
None
IMD  A 600 ( 4.4A)
None
None
FE  A1491 ( 3.3A)
None
 0.93A 1mmtA-4v06A:
41.7		 1mmtA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		7 VAL A 278
LEU A 282
PHE A 287
THR A 299
HIS A 323
TYR A 358
GLU A 363
 None
None
IMD  A 600 ( 4.4A)
None
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 1.03A 1mmtA-4v06A:
41.7		 1mmtA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		7 VAL A 278
PHE A 287
LEU A 288
THR A 299
GLU A 319
HIS A 323
TYR A 358
 None
IMD  A 600 ( 4.4A)
None
None
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
None
 0.87A 1mmtA-4v06A:
41.7		 1mmtA-4v06A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		7 VAL A 278
PHE A 287
THR A 299
GLU A 319
HIS A 323
TYR A 358
GLU A 363
 None
IMD  A 600 ( 4.4A)
None
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
None
FE  A1491 ( 2.0A)
 0.91A 1mmtA-4v06A:
41.7		 1mmtA-4v06A:
61.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		5 VAL A 212
LEU A 258
SER A 295
LEU A 268
THR A 213
 None
 1.34A 1mmtA-4wgxA:
undetectable		 1mmtA-4wgxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xga OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF07244
(POTRA) 		5 VAL B 258
LEU B 226
SER B 228
LEU B 231
THR B 243
 None
 1.02A 1mmtA-4xgaB:
undetectable		 1mmtA-4xgaB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus) 		PF01707
(Peptidase_C9) 		5 LEU A 157
LEU A 174
GLU A 291
HIS A 217
TYR A 172
 GOL  A 401 ( 4.8A)
None
None
None
None
 1.36A 1mmtA-4ztbA:
undetectable		 1mmtA-4ztbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		5 LEU A  56
SER A  54
LEU A  51
THR A 289
GLU A 441
 None
 1.22A 1mmtA-5aexA:
undetectable		 1mmtA-5aexA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		5 VAL A 692
LEU A 757
SER A 681
PHE A 680
GLU A 651
 None
 1.30A 1mmtA-5by3A:
undetectable		 1mmtA-5by3A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1i CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Brucella
abortus) 		PF00027
(cNMP_binding) 		5 VAL A  76
LEU A  82
THR A  61
HIS A  64
GLU A  45
 None
 1.38A 1mmtA-5d1iA:
undetectable		 1mmtA-5d1iA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfv FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL C 409
LEU C 317
LEU C 407
THR C 321
GLU C 211
 None
 1.26A 1mmtA-5dfvC:
undetectable		 1mmtA-5dfvC:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd4 COMR

(Streptococcus
suis) 		PF13560
(HTH_31) 		5 VAL A  15
LEU A  41
SER A  37
TYR A 151
GLU A 120
 None
 1.37A 1mmtA-5fd4A:
undetectable		 1mmtA-5fd4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 VAL B 157
LEU B 188
SER B 184
PHE B 177
THR B 173
 None
 1.19A 1mmtA-5fozB:
undetectable		 1mmtA-5fozB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E

(Thalictrum
flavum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 VAL A 344
LEU A 177
SER A 175
LEU A 172
THR A 336
 None
 1.17A 1mmtA-5icgA:
undetectable		 1mmtA-5icgA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		6 LEU A 236
LEU A 237
LEU A 246
HIS A 278
TYR A 313
GLU A 318
 None
None
None
FE  A 502 (-3.2A)
None
FE  A 502 (-2.1A)
 1.49A 1mmtA-5jk6A:
41.4		 1mmtA-5jk6A:
47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		10 VAL A 233
LEU A 236
LEU A 237
PHE A 242
LEU A 243
THR A 254
GLU A 274
HIS A 278
TYR A 313
GLU A 318
 None
None
None
None
None
None
None
FE  A 502 (-3.2A)
None
FE  A 502 (-2.1A)
 0.79A 1mmtA-5jk6A:
41.4		 1mmtA-5jk6A:
47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kte DIVALENT METAL
CATION TRANSPORTER
MNTH

(Deinococcus
radiodurans) 		PF01566
(Nramp) 		5 VAL A 160
LEU A 325
SER A 323
LEU A 320
THR A 161
 None
 1.25A 1mmtA-5kteA:
undetectable		 1mmtA-5kteA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		9 VAL A 232
LEU A 236
PHE A 241
LEU A 242
THR A 253
GLU A 273
HIS A 277
TYR A 312
GLU A 317
 None
None
6Z4  A 502 ( 4.8A)
None
None
FE  A 501 ( 4.8A)
FE  A 501 (-3.3A)
6Z4  A 502 ( 4.6A)
FE  A 501 ( 1.8A)
 0.89A 1mmtA-5l01A:
41.2		 1mmtA-5l01A:
53.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		no annotation 5 VAL A 468
LEU A 497
SER A 489
LEU A 484
THR A 459
 None
 1.11A 1mmtA-5ndfA:
undetectable		 1mmtA-5ndfA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 VAL 7 456
LEU 7 434
LEU 7 432
LEU 7 426
GLU 7 715
 None
 1.29A 1mmtA-5v8f7:
undetectable		 1mmtA-5v8f7:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 5 LEU A 274
LEU A 105
LEU A  86
THR A 117
TYR A  90
 None
 1.29A 1mmtA-5vehA:
undetectable		 1mmtA-5vehA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 5 VAL A 344
LEU A 299
SER A 297
HIS A 386
GLU A 265
 None
 1.04A 1mmtA-5y50A:
undetectable		 1mmtA-5y50A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1q SOLUBLE CYTOCHROME
B562, C5A
ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU B 354
SER B 357
PHE B 361
LEU B 362
GLU B 285
 None
 1.17A 1mmtA-6c1qB:
undetectable		 1mmtA-6c1qB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejg SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 5 VAL C 287
LEU C 252
LEU C 285
THR C 256
GLU C 215
 None
 1.27A 1mmtA-6ejgC:
undetectable		 1mmtA-6ejgC:
12.46