SIMILAR PATTERNS OF AMINO ACIDS FOR 1MJQ_H_SAMH200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 180
GLU A 174
LEU A 197
GLU A 200
LEU A 204
 None
 1.20A 1mjqG-1akmA:
undetectable
1mjqH-1akmA:
undetectable		 1mjqG-1akmA:
15.02
1mjqH-1akmA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.77A 1mjqG-1brwA:
undetectable
1mjqH-1brwA:
undetectable		 1mjqG-1brwA:
15.40
1mjqH-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		5 HIS A 460
GLU A 433
ARG A 437
LEU A 448
GLU A 453
 None
 1.44A 1mjqG-1e1kA:
undetectable
1mjqH-1e1kA:
undetectable		 1mjqG-1e1kA:
11.83
1mjqH-1e1kA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		5 HIS A 118
GLY A 138
LEU A  97
HIS A  44
PRO A  72
 CU  A 502 (-3.1A)
None
None
CU  A 502 (-3.3A)
None
 1.26A 1mjqG-1eqwA:
undetectable
1mjqH-1eqwA:
undetectable		 1mjqG-1eqwA:
20.41
1mjqH-1eqwA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE

(Grifola
frondosa) 		PF14521
(Aspzincin_M35) 		5 HIS A  59
GLY A 126
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.05A 1mjqG-1ge7A:
undetectable
1mjqH-1ge7A:
undetectable		 1mjqG-1ge7A:
20.00
1mjqH-1ge7A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mjl METHIONINE REPRESSOR
PROTEIN METJ

(Escherichia
coli) 		PF01340
(MetJ) 		7 GLU A  39
ARG A  43
LEU A  56
GLU A  59
HIS A  63
LEU A  70
PRO A  71
 None
None
None
None
SAM  A 200 ( 2.9A)
None
None
 0.29A 1mjqG-1mjlA:
14.1
1mjqH-1mjlA:
15.4		 1mjqG-1mjlA:
100.00
1mjqH-1mjlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		5 GLY A  77
ARG A 135
LEU A  70
GLU A  73
PRO A 137
 None
 1.39A 1mjqG-1r76A:
undetectable
1mjqH-1r76A:
undetectable		 1mjqG-1r76A:
12.25
1mjqH-1r76A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF05833
(FbpA)
PF09239
(Topo-VIb_trans) 		5 GLY A 318
ARG A 193
LEU A 371
HIS A 414
PRO A 378
 None
 1.30A 1mjqG-1z5aA:
undetectable
1mjqH-1z5aA:
undetectable		 1mjqG-1z5aA:
13.50
1mjqH-1z5aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		5 GLY A 237
GLU A 281
LEU A  37
HIS A 294
LEU A 283
 None
 1.24A 1mjqG-2ghsA:
undetectable
1mjqH-2ghsA:
undetectable		 1mjqG-2ghsA:
16.13
1mjqH-2ghsA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 GLY A 322
ARG A  29
LEU A 357
HIS A 344
LEU A 349
 FMN  A4401 (-3.4A)
None
None
None
FMN  A4401 ( 3.8A)
 1.04A 1mjqG-2gouA:
undetectable
1mjqH-2gouA:
undetectable		 1mjqG-2gouA:
14.25
1mjqH-2gouA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krk 26S PROTEASE
REGULATORY SUBUNIT 8

(Homo sapiens) 		no annotation 5 HIS A  10
GLY A  44
ARG A  36
LEU A  17
GLU A  14
 None
 1.47A 1mjqG-2krkA:
undetectable
1mjqH-2krkA:
undetectable		 1mjqG-2krkA:
20.91
1mjqH-2krkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peb PUTATIVE DIOXYGENASE

(Nostoc
punctiforme) 		PF08883
(DOPA_dioxygen) 		5 HIS A  51
GLY A  49
GLU A 110
HIS A  94
LEU A 112
 UNL  A 201 (-4.0A)
None
None
UNL  A 201 (-3.9A)
None
 1.38A 1mjqG-2pebA:
undetectable
1mjqH-2pebA:
undetectable		 1mjqG-2pebA:
17.19
1mjqH-2pebA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3n CARBONIC ANHYDRASE 2

(Cryptococcus
neoformans) 		PF00484
(Pro_CA) 		5 GLU A 141
GLU A 154
HIS A 161
LEU A 138
PRO A 139
 None
 1.45A 1mjqG-2w3nA:
undetectable
1mjqH-2w3nA:
undetectable		 1mjqG-2w3nA:
20.35
1mjqH-2w3nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 GLU M 502
ARG M 714
GLU M 499
HIS M 494
LEU M 498
 None
 1.49A 1mjqG-2w4gM:
undetectable
1mjqH-2w4gM:
undetectable		 1mjqG-2w4gM:
8.88
1mjqH-2w4gM:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 HIS A 514
PHE A 512
GLY A 510
LEU A 519
HIS A  79
 None
 1.45A 1mjqG-2x0qA:
undetectable
1mjqH-2x0qA:
undetectable		 1mjqG-2x0qA:
11.84
1mjqH-2x0qA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		5 GLY A 619
GLU A 599
GLU A 602
LEU A 603
PRO A 568
 None
 1.31A 1mjqG-2y3aA:
undetectable
1mjqH-2y3aA:
undetectable		 1mjqG-2y3aA:
7.52
1mjqH-2y3aA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
 None
 1.17A 1mjqG-2yp2A:
undetectable
1mjqH-2yp2A:
undetectable		 1mjqG-2yp2A:
11.02
1mjqH-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 HIS A 330
PHE A 225
GLU A 154
LEU A 158
LEU A 221
 None
 1.31A 1mjqG-3aeuA:
undetectable
1mjqH-3aeuA:
undetectable		 1mjqG-3aeuA:
14.11
1mjqH-3aeuA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 GLY B 363
ARG B  26
LEU B  28
GLU B  41
HIS B  42
 None
 1.41A 1mjqG-3bxwB:
undetectable
1mjqH-3bxwB:
undetectable		 1mjqG-3bxwB:
14.51
1mjqH-3bxwB:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		5 HIS A 123
PHE A 136
GLU A  56
HIS A  40
PRO A  13
 FE  A 310 (-3.3A)
None
None
ZN  A 301 (-3.5A)
None
 0.90A 1mjqG-3dcpA:
undetectable
1mjqH-3dcpA:
undetectable		 1mjqG-3dcpA:
16.86
1mjqH-3dcpA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 GLY A 182
LEU A 169
HIS A 222
LEU A 508
PRO A 505
 None
 1.46A 1mjqG-3dmyA:
undetectable
1mjqH-3dmyA:
undetectable		 1mjqG-3dmyA:
13.02
1mjqH-3dmyA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		5 GLU D 427
ARG D 423
GLU D 405
HIS D 380
LEU D 407
 None
 1.43A 1mjqG-3j9eD:
undetectable
1mjqH-3j9eD:
undetectable		 1mjqG-3j9eD:
13.66
1mjqH-3j9eD:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 HIS A 725
GLY A 784
LEU A 718
GLU A 721
LEU A 791
 None
 1.27A 1mjqG-3lj0A:
undetectable
1mjqH-3lj0A:
undetectable		 1mjqG-3lj0A:
13.23
1mjqH-3lj0A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE

(Thermotoga
maritima) 		no annotation 5 GLY A  64
GLU A  74
HIS A  69
LEU A  70
PRO A  71
 None
 1.43A 1mjqG-3n0uA:
undetectable
1mjqH-3n0uA:
undetectable		 1mjqG-3n0uA:
21.33
1mjqH-3n0uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		5 GLY A 489
ARG A 514
LEU A 518
GLU A 483
PRO A 484
 None
 1.47A 1mjqG-3pbkA:
undetectable
1mjqH-3pbkA:
undetectable		 1mjqG-3pbkA:
13.59
1mjqH-3pbkA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1) 		PF01663
(Phosphodiest) 		5 GLY A 310
ARG A 356
GLU A 353
LEU A 351
PRO A 352
 None
 1.48A 1mjqG-3q3qA:
undetectable
1mjqH-3q3qA:
undetectable		 1mjqG-3q3qA:
11.03
1mjqH-3q3qA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 PHE A 627
GLY A 643
ARG A 564
LEU A 485
LEU A 622
 None
 1.49A 1mjqG-3qdeA:
undetectable
1mjqH-3qdeA:
undetectable		 1mjqG-3qdeA:
9.46
1mjqH-3qdeA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		5 HIS A  36
PHE A  43
GLY A  37
LEU A 134
PRO A 137
 None
 1.39A 1mjqG-3twkA:
undetectable
1mjqH-3twkA:
undetectable		 1mjqG-3twkA:
18.73
1mjqH-3twkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLY A 347
ARG A 172
GLU A 237
LEU A 354
PRO A 360
 None
 1.49A 1mjqG-3uw2A:
undetectable
1mjqH-3uw2A:
undetectable		 1mjqG-3uw2A:
12.67
1mjqH-3uw2A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 GLY A 407
GLU A 393
GLU A 395
LEU A 563
PRO A 389
 None
 1.41A 1mjqG-3vexA:
undetectable
1mjqH-3vexA:
undetectable		 1mjqG-3vexA:
11.99
1mjqH-3vexA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		5 HIS A 186
LEU A  40
HIS A 180
LEU A 139
PRO A 140
 ZN  A 500 (-3.2A)
None
ZN  A 500 (-3.3A)
None
None
 1.47A 1mjqG-3vi1A:
undetectable
1mjqH-3vi1A:
undetectable		 1mjqG-3vi1A:
11.55
1mjqH-3vi1A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		5 GLY A 206
GLU A 214
LEU A 215
GLU A 152
LEU A 148
 None
 1.39A 1mjqG-3w53A:
undetectable
1mjqH-3w53A:
undetectable		 1mjqG-3w53A:
12.69
1mjqH-3w53A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
 None
 1.16A 1mjqG-3wheA:
undetectable
1mjqH-3wheA:
undetectable		 1mjqG-3wheA:
12.03
1mjqH-3wheA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		5 GLY A 615
ARG A 418
LEU A 414
GLU A 415
PRO A 357
 None
 1.37A 1mjqG-3wqyA:
undetectable
1mjqH-3wqyA:
undetectable		 1mjqG-3wqyA:
8.01
1mjqH-3wqyA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		5 GLY A  23
ARG A  34
LEU A  51
GLU A  53
LEU A  30
 None
 1.28A 1mjqG-4glfA:
undetectable
1mjqH-4glfA:
undetectable		 1mjqG-4glfA:
16.49
1mjqH-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1

(Bos taurus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		5 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.11A 1mjqG-4hh8A:
undetectable
1mjqH-4hh8A:
undetectable		 1mjqG-4hh8A:
18.26
1mjqH-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLY A 151
GLU A  31
LEU A  36
GLU A 676
PRO A 654
 None
 1.39A 1mjqG-4hvtA:
undetectable
1mjqH-4hvtA:
undetectable		 1mjqG-4hvtA:
8.93
1mjqH-4hvtA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 HIS A 415
GLY A 414
GLU A 505
LEU A 419
HIS A 464
 ZN  A 801 (-3.2A)
None
None
None
ZN  A 801 (-3.3A)
 1.44A 1mjqG-4ojzA:
undetectable
1mjqH-4ojzA:
undetectable		 1mjqG-4ojzA:
9.36
1mjqH-4ojzA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r81 NADH DEHYDROGENASE

(Methanothermobacter
marburgensis) 		PF02525
(Flavodoxin_2) 		5 GLY A 108
ARG A 103
GLU A  52
LEU A  65
PRO A  66
 None
 1.30A 1mjqG-4r81A:
undetectable
1mjqH-4r81A:
undetectable		 1mjqG-4r81A:
18.18
1mjqH-4r81A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		5 HIS A  59
GLY A  58
LEU A 102
LEU A 138
PRO A 139
 None
 1.28A 1mjqG-4wr2A:
undetectable
1mjqH-4wr2A:
undetectable		 1mjqG-4wr2A:
14.60
1mjqH-4wr2A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN

(Clostridioides
difficile) 		PF02661
(Fic) 		5 PHE A 165
ARG A 171
LEU A  95
GLU A  64
LEU A 101
 None
ATP  A 302 (-4.0A)
None
None
None
 1.42A 1mjqG-4x2dA:
undetectable
1mjqH-4x2dA:
undetectable		 1mjqG-4x2dA:
15.51
1mjqH-4x2dA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		5 GLY A 108
GLU A  32
GLU A 100
LEU A  15
PRO A  12
 None
FAD  A 503 (-2.5A)
FAD  A 503 ( 4.9A)
None
FAD  A 503 (-3.9A)
 1.33A 1mjqG-4x4jA:
undetectable
1mjqH-4x4jA:
undetectable		 1mjqG-4x4jA:
10.54
1mjqH-4x4jA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE-ASSOCIATE
D PROTEIN 19
TELOMERASE
ASSOCIATED PROTEIN
P45

(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		no annotation
no annotation 		5 PHE E  76
ARG A  38
LEU E  27
GLU E 112
HIS E 107
 None
 1.41A 1mjqG-5doiE:
undetectable
1mjqH-5doiE:
undetectable		 1mjqG-5doiE:
17.56
1mjqH-5doiE:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		5 HIS A 224
PHE A 335
GLY A 337
ARG A 326
LEU A 234
 None
 1.25A 1mjqG-5ej1A:
undetectable
1mjqH-5ej1A:
undetectable		 1mjqG-5ej1A:
9.13
1mjqH-5ej1A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE

(Escherichia
coli) 		PF01814
(Hemerythrin)
PF04405
(ScdA_N) 		5 HIS A 160
GLU A 165
LEU A 166
GLU A 125
HIS A 129
 ZN  A1221 (-3.3A)
None
None
None
ZN  A1221 ( 3.2A)
 1.42A 1mjqG-5fnpA:
undetectable
1mjqH-5fnpA:
undetectable		 1mjqG-5fnpA:
16.43
1mjqH-5fnpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 HIS A  22
PHE A  23
ARG A 103
LEU A  76
GLU A  72
 None
 1.22A 1mjqG-5fqdA:
undetectable
1mjqH-5fqdA:
undetectable		 1mjqG-5fqdA:
8.62
1mjqH-5fqdA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 HIS C 109
GLY C  55
GLU C 106
LEU C 311
GLU C 345
 None
 1.43A 1mjqG-5g5gC:
undetectable
1mjqH-5g5gC:
undetectable		 1mjqG-5g5gC:
9.15
1mjqH-5g5gC:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		5 GLY A  63
ARG A 187
GLU A  19
HIS A  17
LEU A  18
 None
 1.42A 1mjqG-5h5jA:
undetectable
1mjqH-5h5jA:
undetectable		 1mjqG-5h5jA:
16.99
1mjqH-5h5jA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		5 GLY A1283
GLU A1009
HIS A1002
LEU A1003
PRO A1004
 None
 1.44A 1mjqG-5hccA:
undetectable
1mjqH-5hccA:
undetectable		 1mjqG-5hccA:
7.62
1mjqH-5hccA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 HIS A  92
PHE A  91
GLY A  94
LEU A 208
PRO A 231
 None
 1.49A 1mjqG-5ip9A:
undetectable
1mjqH-5ip9A:
undetectable		 1mjqG-5ip9A:
5.74
1mjqH-5ip9A:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A  21
GLU A 301
ARG A 306
GLU A 249
PRO A  10
 None
 1.45A 1mjqG-5iq0A:
undetectable
1mjqH-5iq0A:
undetectable		 1mjqG-5iq0A:
19.17
1mjqH-5iq0A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 GLY A 782
GLU A 789
ARG A 966
LEU A 793
GLU A 485
 None
 1.48A 1mjqG-5iudA:
undetectable
1mjqH-5iudA:
undetectable		 1mjqG-5iudA:
8.50
1mjqH-5iudA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 5 GLY A 220
LEU A 229
GLU A 230
LEU A 199
PRO A 200
 None
 0.90A 1mjqG-5oieA:
undetectable
1mjqH-5oieA:
undetectable		 1mjqG-5oieA:
undetectable
1mjqH-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY B 299
GLU B 206
ARG B 210
LEU B 163
GLU B 166
 None
 1.15A 1mjqG-5op0B:
undetectable
1mjqH-5op0B:
undetectable		 1mjqG-5op0B:
17.30
1mjqH-5op0B:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 PHE A 518
GLY A 442
GLU A  59
LEU A  71
PRO A  49
 None
 1.49A 1mjqG-5u3cA:
undetectable
1mjqH-5u3cA:
undetectable		 1mjqG-5u3cA:
11.84
1mjqH-5u3cA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w25 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycobacterium
tuberculosis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 GLY A 507
GLU A 500
ARG A 496
LEU A 521
GLU A 514
 None
 1.45A 1mjqG-5w25A:
undetectable
1mjqH-5w25A:
undetectable		 1mjqG-5w25A:
10.52
1mjqH-5w25A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE
NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus;
Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S)
PF10588
(NADH-G_4Fe-4S_3)
PF13459
(Fer4_15)
PF13510
(Fer2_4) 		5 GLY A 328
LEU B 164
GLU B 169
LEU A  41
PRO A  42
 None
 1.13A 1mjqG-5xfaA:
undetectable
1mjqH-5xfaA:
undetectable		 1mjqG-5xfaA:
9.86
1mjqH-5xfaA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 HIS A 142
GLY A 140
GLU A 134
ARG A 130
PRO A 193
 None
 1.49A 1mjqG-5z9sA:
undetectable
1mjqH-5z9sA:
undetectable		 1mjqG-5z9sA:
undetectable
1mjqH-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A  13
GLU A  10
HIS A  45
LEU A   6
PRO A   7
 None
 1.44A 1mjqG-6c9mA:
undetectable
1mjqH-6c9mA:
undetectable		 1mjqG-6c9mA:
undetectable
1mjqH-6c9mA:
undetectable