SIMILAR PATTERNS OF AMINO ACIDS FOR 1MJO_B_SAMB200_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.76A 1mjoB-1brwA:
undetectable		 1mjoB-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		5 ARG A  58
ARG A  54
GLU A 279
ALA A 275
PRO A  92
 None
 1.21A 1mjoB-1dk5A:
undetectable		 1mjoB-1dk5A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		5 GLU A 685
ARG A 688
LEU A 636
ALA A 634
LEU A 563
 None
 1.32A 1mjoB-1kspA:
undetectable		 1mjoB-1kspA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		5 GLU A 195
ARG A 198
ARG A 199
GLU A 160
ALA A 164
 None
 1.38A 1mjoB-1m6yA:
undetectable		 1mjoB-1m6yA:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mjl METHIONINE REPRESSOR
PROTEIN METJ

(Escherichia
coli) 		PF01340
(MetJ) 		9 GLU A  39
ARG A  42
ARG A  43
LEU A  56
GLU A  59
ALA A  60
HIS A  63
LEU A  70
PRO A  71
 None
None
None
None
None
None
SAM  A 200 ( 2.9A)
None
None
 0.30A 1mjoB-1mjlA:
15.4		 1mjoB-1mjlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN

(Rattus
norvegicus) 		PF07686
(V-set) 		5 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.18A 1mjoB-1pkoA:
undetectable		 1mjoB-1pkoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 ARG A 239
LEU A 241
GLU A 245
ALA A 248
PRO A 256
 None
 1.47A 1mjoB-1sgvA:
undetectable		 1mjoB-1sgvA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0x NITROPHORIN 4

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		5 ARG A 139
LEU A  44
GLU A  55
ALA A  56
LEU A 182
 None
XE  A 187 ( 4.7A)
None
None
None
 1.40A 1mjoB-1u0xA:
undetectable		 1mjoB-1u0xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
delbrueckii) 		PF13419
(HAD_2) 		5 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  63
 None
 0.88A 1mjoB-2hi0A:
undetectable		 1mjoB-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt1 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Homo sapiens) 		no annotation 5 GLU A  24
ARG A  17
LEU A  26
ALA A  11
LEU A  31
 None
 1.50A 1mjoB-2kt1A:
undetectable		 1mjoB-2kt1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3n CARBONIC ANHYDRASE 2

(Cryptococcus
neoformans) 		PF00484
(Pro_CA) 		5 GLU A 141
GLU A 154
HIS A 161
LEU A 138
PRO A 139
 None
 1.50A 1mjoB-2w3nA:
undetectable		 1mjoB-2w3nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		5 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.21A 1mjoB-2x3nA:
undetectable		 1mjoB-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Pseudomonas
aeruginosa) 		PF01063
(Aminotran_4) 		5 GLU A  49
ARG A  52
ARG A  53
LEU A 139
ALA A 198
 PG4  A1272 (-3.6A)
None
PG4  A1272 ( 4.5A)
None
PG4  A1272 ( 4.1A)
 1.20A 1mjoB-2y4rA:
undetectable		 1mjoB-2y4rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU A 139
LEU A 286
GLU A 283
ALA A 282
HIS A 145
 None
 1.23A 1mjoB-2y7jA:
undetectable		 1mjoB-2y7jA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 GLU A 111
ARG A 114
ARG A 115
GLU A  83
ALA A  80
 None
 1.42A 1mjoB-2yysA:
undetectable		 1mjoB-2yysA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.93A 1mjoB-3bo5A:
undetectable		 1mjoB-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 GLU A  63
ARG A 254
ARG A 272
GLU A  74
ALA A  73
 None
 1.49A 1mjoB-3c8eA:
undetectable		 1mjoB-3c8eA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d36 SPORULATION KINASE B

(Geobacillus
stearothermophilus) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 GLU A 279
ARG A 282
ARG A 311
LEU A 274
GLU A 272
 None
 1.43A 1mjoB-3d36A:
undetectable		 1mjoB-3d36A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 ARG A 129
GLU A  75
ALA A  74
LEU A 122
PRO A 125
 None
 1.20A 1mjoB-3emkA:
undetectable		 1mjoB-3emkA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 ARG A 465
LEU A 197
GLU A 196
ALA A 200
PRO A 371
 None
 1.32A 1mjoB-3eo7A:
undetectable		 1mjoB-3eo7A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjy PROBABLE MUTT1
PROTEIN

(Bifidobacterium
adolescentis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		5 ARG A  76
GLU A  77
ALA A  12
HIS A  70
LEU A  64
 None
 1.45A 1mjoB-3fjyA:
undetectable		 1mjoB-3fjyA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR

(Sulfurisphaera
tokodaii) 		PF13463
(HTH_27) 		5 GLU A  25
ARG A  28
ARG A  29
LEU A 114
GLU A 117
 None
 1.02A 1mjoB-3gfmA:
undetectable		 1mjoB-3gfmA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 GLU A 279
LEU A 277
ALA A 354
LEU A 325
PRO A 326
 UPG  A 484 (-2.7A)
UPG  A 484 ( 4.9A)
None
None
None
 1.31A 1mjoB-3gueA:
undetectable		 1mjoB-3gueA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		5 GLU A 188
ARG A 208
LEU A 261
ALA A 254
LEU A 255
 None
 1.46A 1mjoB-3hdoA:
undetectable		 1mjoB-3hdoA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		5 GLU D 427
ARG D 423
GLU D 405
HIS D 380
LEU D 407
 None
 1.44A 1mjoB-3j9eD:
undetectable		 1mjoB-3j9eD:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npi TETR FAMILY
REGULATORY PROTEIN

(Corynebacterium
diphtheriae) 		PF00440
(TetR_N) 		5 GLU A  71
ARG A  74
ARG A  75
LEU A  27
ALA A  26
 None
SO4  A 257 (-2.8A)
None
None
None
 1.09A 1mjoB-3npiA:
1.1		 1mjoB-3npiA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		5 GLU A 210
ARG A 254
ALA A  46
LEU A  48
PRO A  49
 None
MG  A 339 ( 4.7A)
None
None
GDD  A 340 (-4.8A)
 1.07A 1mjoB-3o3pA:
undetectable		 1mjoB-3o3pA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		5 ARG A 514
LEU A 518
GLU A 483
ALA A 480
PRO A 484
 None
 1.31A 1mjoB-3pbkA:
undetectable		 1mjoB-3pbkA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6p BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00619
(CARD)
PF00653
(BIR)
PF13920
(zf-C3HC4_3) 		5 GLU A 560
ARG A 563
ARG A 564
LEU A 556
GLU A 551
 None
 0.96A 1mjoB-3t6pA:
undetectable		 1mjoB-3t6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLU A 308
ARG A 311
ALA A 181
HIS A 182
PRO A 128
 None
 1.37A 1mjoB-3zh2A:
undetectable		 1mjoB-3zh2A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acj WU:FB25H12 PROTEIN,

(Danio rerio) 		PF07534
(TLD) 		5 ARG A 657
GLU A 721
ALA A 706
LEU A 705
PRO A 655
 None
 1.47A 1mjoB-4acjA:
undetectable		 1mjoB-4acjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 5 GLU A  67
ARG A  63
ALA A  24
HIS A  23
PRO A  20
 None
 1.09A 1mjoB-4czxA:
undetectable		 1mjoB-4czxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1

(Bos taurus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		5 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.24A 1mjoB-4hh8A:
undetectable		 1mjoB-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 GLU A 128
ARG A 124
LEU A   7
GLU A   8
ALA A   9
 None
 1.34A 1mjoB-4knhA:
0.6		 1mjoB-4knhA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5f TYPE III
PANTOTHENATE KINASE

(Burkholderia
thailandensis) 		PF03309
(Pan_kinase) 		5 GLU A 131
LEU A 107
ALA A 110
HIS A 244
LEU A 247
 None
None
None
GOL  A 307 (-3.9A)
None
 1.31A 1mjoB-4o5fA:
undetectable		 1mjoB-4o5fA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		5 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.80A 1mjoB-4p7wA:
undetectable		 1mjoB-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 363
GLU A 362
ALA A 366
LEU A 148
PRO A 149
 None
HEM  A 503 ( 4.5A)
None
None
None
 1.45A 1mjoB-4wpzA:
undetectable		 1mjoB-4wpzA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ARG A 108
LEU A 118
ALA A 150
HIS A 151
LEU A  84
 None
 1.14A 1mjoB-4yhjA:
undetectable		 1mjoB-4yhjA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 GLU A 171
ARG A 174
ARG A 175
GLU A 102
ALA A 146
 None
 1.02A 1mjoB-5gmxA:
undetectable		 1mjoB-5gmxA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		5 GLU A 133
LEU A 137
GLU A  69
ALA A  66
LEU A 429
 None
 1.16A 1mjoB-5l44A:
undetectable		 1mjoB-5l44A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 5 GLU A 284
LEU A 282
ALA A 359
LEU A 330
PRO A 331
 UPG  A 601 (-2.7A)
UPG  A 601 ( 4.7A)
None
None
EDO  A 608 ( 4.2A)
 1.28A 1mjoB-5nzgA:
undetectable		 1mjoB-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		5 GLU A 408
ARG A 411
LEU A 265
GLU A 262
ALA A 263
 None
 1.48A 1mjoB-5uohA:
undetectable		 1mjoB-5uohA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A  13
GLU A  10
HIS A  45
LEU A   6
PRO A   7
 None
 1.48A 1mjoB-6c9mA:
undetectable		 1mjoB-6c9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis) 		no annotation 5 GLU B  14
ARG B  17
ARG B 224
ALA B   9
LEU B  37
 None
 1.42A 1mjoB-6conB:
undetectable		 1mjoB-6conB:
undetectable