SIMILAR PATTERNS OF AMINO ACIDS FOR 1MJO_B_SAMB200_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		4 HIS A1280
ALA A1279
PHE A1275
GLY A1281
 None
 1.42A 1mjoA-1eg7A:
undetectable		 1mjoA-1eg7A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 HIS A 180
ALA A 177
PHE A  38
GLY A 175
 GOL  A1538 (-3.9A)
None
None
None
 1.19A 1mjoA-1gz7A:
undetectable		 1mjoA-1gz7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hw2 FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Escherichia
coli) 		PF00392
(GntR)
PF07840
(FadR_C) 		4 HIS A 120
ALA A 155
PHE A 154
GLY A 157
 None
 1.15A 1mjoA-1hw2A:
undetectable		 1mjoA-1hw2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		4 HIS A 205
ALA A 206
PHE A 219
GLY A 221
 None
 1.31A 1mjoA-1ii2A:
undetectable		 1mjoA-1ii2A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 HIS A 464
ALA A 476
PHE A 479
GLY A 373
 None
 1.31A 1mjoA-1lnsA:
undetectable		 1mjoA-1lnsA:
9.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mjl METHIONINE REPRESSOR
PROTEIN METJ

(Escherichia
coli) 		PF01340
(MetJ) 		4 HIS A  63
ALA A  64
PHE A  65
GLY A  67
 SAM  A 200 ( 2.9A)
SAM  A 200 (-4.0A)
SAM  A 200 (-3.8A)
SAM  A 200 ( 4.1A)
 0.37A 1mjoA-1mjlA:
16.0		 1mjoA-1mjlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		4 HIS A 329
ALA A 328
PHE A 322
GLY A 330
 None
 1.38A 1mjoA-1phpA:
undetectable		 1mjoA-1phpA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		4 HIS A 225
ALA A 199
PHE A 198
GLY A 201
 None
 1.13A 1mjoA-1s2nA:
undetectable		 1mjoA-1s2nA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.35A 1mjoA-1suwA:
undetectable		 1mjoA-1suwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		4 HIS A 196
ALA A 122
PHE A 121
GLY A 125
 None
 1.18A 1mjoA-1sznA:
undetectable		 1mjoA-1sznA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wha KIAA0147 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 HIS A  76
ALA A  25
PHE A  41
GLY A  27
 HIS  A  76 ( 1.0A)
ALA  A  25 ( 0.0A)
PHE  A  41 ( 1.3A)
GLY  A  27 ( 0.0A)
 1.24A 1mjoA-1whaA:
undetectable		 1mjoA-1whaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 HIS A 249
ALA A 250
PHE A 201
GLY A 188
 GOL  A3020 ( 4.8A)
None
None
None
 1.42A 1mjoA-1yi7A:
undetectable		 1mjoA-1yi7A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.35A 1mjoA-1z0uA:
undetectable		 1mjoA-1z0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2av9 THIOESTERASE

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 HIS A  30
ALA A  77
PHE A  78
GLY A  29
 None
 1.10A 1mjoA-2av9A:
undetectable		 1mjoA-2av9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE

(Homo sapiens) 		PF01648
(ACPS) 		4 HIS A 121
ALA A  69
PHE A  31
GLY A  73
 COA  A1300 (-3.6A)
None
None
None
 1.14A 1mjoA-2cg5A:
undetectable		 1mjoA-2cg5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl1 SPARTIN

(Homo sapiens) 		PF04212
(MIT) 		4 HIS A  51
ALA A  22
PHE A  23
GLY A  48
 None
 1.42A 1mjoA-2dl1A:
undetectable		 1mjoA-2dl1A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyq AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 3

(Homo sapiens) 		no annotation 4 HIS A 395
ALA A 396
PHE A 374
GLY A 398
 None
 1.17A 1mjoA-2dyqA:
undetectable		 1mjoA-2dyqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 HIS A 471
ALA A 466
PHE A 531
GLY A 575
 None
 1.34A 1mjoA-2fafA:
undetectable		 1mjoA-2fafA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1n DISCS, LARGE HOMOLOG
3

(Homo sapiens) 		PF00595
(PDZ) 		4 HIS A 196
ALA A 146
PHE A 161
GLY A 148
 None
 1.29A 1mjoA-2i1nA:
undetectable		 1mjoA-2i1nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 304
ALA A 330
PHE A 331
GLY A 305
 None
 1.42A 1mjoA-2jiiA:
undetectable		 1mjoA-2jiiA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1

(Gallus gallus) 		PF01267
(F-actin_cap_A) 		4 HIS A  52
ALA A  51
PHE A  54
GLY A  49
 None
 1.31A 1mjoA-2kxpA:
undetectable		 1mjoA-2kxpA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 HIS A 194
ALA A 195
PHE A 192
GLY A 197
 None
 1.39A 1mjoA-2oi2A:
undetectable		 1mjoA-2oi2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF00481
(PP2C) 		4 HIS A 300
ALA A 299
PHE A 351
GLY A 301
 None
 1.34A 1mjoA-2popA:
undetectable		 1mjoA-2popA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		4 HIS A 224
ALA A 225
PHE A 226
GLY A 228
 None
None
MPD  A1317 (-4.0A)
None
 0.95A 1mjoA-2w48A:
undetectable		 1mjoA-2w48A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4f PROTEIN LAP4

(Homo sapiens) 		PF00595
(PDZ) 		4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 EDO  A1821 ( 4.4A)
None
None
None
 1.19A 1mjoA-2w4fA:
undetectable		 1mjoA-2w4fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl7 DISKS LARGE HOMOLOG
2

(Mus musculus) 		PF00595
(PDZ) 		4 HIS A 165
ALA A 115
PHE A 130
GLY A 117
 None
 1.34A 1mjoA-2wl7A:
undetectable		 1mjoA-2wl7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 HIS A 415
ALA A 414
PHE A 417
GLY A 412
 None
 1.26A 1mjoA-2xpiA:
undetectable		 1mjoA-2xpiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts CYTOCHROME

(Paracoccus
pantotrophus) 		PF13442
(Cytochrome_CBB3) 		4 HIS B  74
ALA B  78
PHE B  77
GLY B  80
 HEC  B 500 (-3.2A)
None
None
None
 1.26A 1mjoA-2xtsB:
undetectable		 1mjoA-2xtsB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypj ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
 None
 1.40A 1mjoA-2ypjA:
undetectable		 1mjoA-2ypjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3) 		4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
 None
None
None
GA4  A 345 (-3.1A)
 1.26A 1mjoA-2zsiA:
undetectable		 1mjoA-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 HIS B 216
ALA B 212
PHE B 144
GLY B 140
 None
 1.24A 1mjoA-3a0hB:
undetectable		 1mjoA-3a0hB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9i HOMOCITRATE SYNTHASE

(Thermus
thermophilus) 		PF00682
(HMGL-like) 		4 HIS A 195
ALA A 164
PHE A 140
GLY A 196
 LYS  A 378 ( 3.4A)
LYS  A 378 ( 3.9A)
None
None
 1.34A 1mjoA-3a9iA:
undetectable		 1mjoA-3a9iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 HIS A  20
ALA A  58
PHE A  57
GLY A  61
 None
 0.85A 1mjoA-3bjrA:
undetectable		 1mjoA-3bjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 HIS A 361
ALA A 326
PHE A 325
GLY A 363
 None
 1.42A 1mjoA-3cv2A:
undetectable		 1mjoA-3cv2A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es1 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Novosphingobium
aromaticivorans) 		PF07883
(Cupin_2) 		4 HIS A  20
ALA A  26
PHE A  28
GLY A  19
 None
 1.33A 1mjoA-3es1A:
undetectable		 1mjoA-3es1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7m ALKALINE SERINE
PROTEASE VER112

(Lecanicillium
psalliotae) 		PF00082
(Peptidase_S8) 		4 HIS A 333
ALA A 307
PHE A 306
GLY A 309
 None
 1.19A 1mjoA-3f7mA:
undetectable		 1mjoA-3f7mA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		4 HIS A 232
ALA A 206
PHE A 205
GLY A 208
 None
 1.17A 1mjoA-3f7oA:
undetectable		 1mjoA-3f7oA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 HIS A 391
ALA A 363
PHE A 362
GLY A 365
 None
 1.19A 1mjoA-3gcwA:
undetectable		 1mjoA-3gcwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		4 HIS A  66
ALA A 120
PHE A 149
GLY A  65
 GOL  A   5 (-4.7A)
None
None
None
 1.33A 1mjoA-3hbcA:
undetectable		 1mjoA-3hbcA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		4 HIS A 263
ALA A 344
PHE A 345
GLY A 347
 None
 1.01A 1mjoA-3hl0A:
undetectable		 1mjoA-3hl0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 HIS A 165
ALA A 403
PHE A 406
GLY A 166
 None
 1.25A 1mjoA-3ifeA:
undetectable		 1mjoA-3ifeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ii7 KELCH-LIKE PROTEIN 7

(Homo sapiens) 		PF01344
(Kelch_1) 		4 HIS A 474
ALA A 485
PHE A 484
GLY A 475
 None
 1.26A 1mjoA-3ii7A:
undetectable		 1mjoA-3ii7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		4 HIS A 305
ALA A 301
PHE A 300
GLY A 304
 None
 1.17A 1mjoA-3qh4A:
undetectable		 1mjoA-3qh4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubl GLUTATHIONE
TRANSFERASE

(Leptospira
interrogans) 		PF13417
(GST_N_3) 		4 HIS A 159
ALA A 158
PHE A 157
GLY A 156
 None
 1.22A 1mjoA-3ublA:
undetectable		 1mjoA-3ublA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		4 HIS A 754
ALA A 865
PHE A 866
GLY A 868
 None
 0.93A 1mjoA-3zdrA:
undetectable		 1mjoA-3zdrA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 HIS A 479
ALA A 478
PHE A 524
GLY A 522
 None
 1.25A 1mjoA-4acqA:
undetectable		 1mjoA-4acqA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A1687
ALA A1688
PHE A1704
GLY A1706
 None
FMT  A2824 ( 3.6A)
None
None
 1.33A 1mjoA-4c6oA:
undetectable		 1mjoA-4c6oA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus) 		PF00082
(Peptidase_S8) 		4 HIS A 227
ALA A 199
PHE A 198
GLY A 201
 None
 1.24A 1mjoA-4dztA:
undetectable		 1mjoA-4dztA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		4 HIS A 532
ALA A 255
PHE A 271
GLY A 530
 None
 1.19A 1mjoA-4f9dA:
undetectable		 1mjoA-4f9dA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		4 HIS A 326
ALA A 323
PHE A 321
GLY A 325
 None
 1.42A 1mjoA-4grxA:
undetectable		 1mjoA-4grxA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfw 6-26 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 HIS H  35
ALA H  97
PHE H 109
GLY H  99
 None
 1.21A 1mjoA-4hfwH:
undetectable		 1mjoA-4hfwH:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hx0 PUTATIVE
NUCLEOTIDYLTRANSFERA
SE TM1012

(Thermotoga
maritima) 		no annotation 4 HIS A  -4
ALA A  33
PHE A  32
GLY A  36
 NA  A 202 (-3.8A)
NA  A 202 (-3.9A)
None
NA  A 202 ( 3.9A)
 1.26A 1mjoA-4hx0A:
undetectable		 1mjoA-4hx0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmj RNA/RNP
COMPLEX-1-INTERACTIN
G PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc) 		4 HIS A 105
ALA A 106
PHE A 110
GLY A 109
 None
 1.34A 1mjoA-4jmjA:
undetectable		 1mjoA-4jmjA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 HIS A 330
ALA A 367
PHE A 365
GLY A 326
 None
 1.27A 1mjoA-4kwsA:
undetectable		 1mjoA-4kwsA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mda MARINER MOS1
TRANSPOSASE

(Drosophila
mauritiana) 		PF01359
(Transposase_1) 		4 HIS A 293
ALA A 289
PHE A 288
GLY A 292
 None
 1.22A 1mjoA-4mdaA:
undetectable		 1mjoA-4mdaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 HIS A 168
ALA A 169
PHE A 166
GLY A 171
 None
None
None
BGC  A 701 ( 3.8A)
 1.43A 1mjoA-4nfuA:
undetectable		 1mjoA-4nfuA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		4 HIS A  65
ALA A  59
PHE A  61
GLY A  64
 None
None
None
NA  A 401 ( 4.4A)
 1.37A 1mjoA-4o48A:
undetectable		 1mjoA-4o48A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4og1 ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		4 HIS A   7
ALA A  35
PHE A  37
GLY A  39
 None
 1.35A 1mjoA-4og1A:
undetectable		 1mjoA-4og1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.37A 1mjoA-4ouaB:
undetectable		 1mjoA-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.37A 1mjoA-4ouaA:
undetectable		 1mjoA-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 HIS B 391
ALA B 363
PHE B 362
GLY B 365
 None
 1.14A 1mjoA-4ov6B:
undetectable		 1mjoA-4ov6B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		4 HIS A 177
ALA A 172
PHE A 171
GLY A 175
 None
 1.39A 1mjoA-4ovjA:
undetectable		 1mjoA-4ovjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus) 		PF00822
(PMP22_Claudin) 		4 HIS A 124
ALA A 120
PHE A 180
GLY A 176
 None
 1.38A 1mjoA-4p79A:
undetectable		 1mjoA-4p79A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 HIS B 127
ALA B 100
PHE B  99
GLY B 128
 None
 1.19A 1mjoA-4pe5B:
undetectable		 1mjoA-4pe5B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 HIS A  98
ALA A  95
PHE A  94
GLY A  97
 NI  A1001 (-3.4A)
None
None
None
 0.77A 1mjoA-4q2cA:
undetectable		 1mjoA-4q2cA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 HIS A2807
ALA A2966
PHE A2961
GLY A2808
 None
 1.35A 1mjoA-4qyrA:
undetectable		 1mjoA-4qyrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 HIS B 389
ALA B 388
PHE B 387
GLY B 335
 CLA  B1226 (-4.0A)
CLA  B1226 ( 4.2A)
BCR  B6010 ( 3.2A)
BCR  B6010 ( 4.3A)
 1.09A 1mjoA-4rkuB:
undetectable		 1mjoA-4rkuB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzc FV M6P-1 HEAVY CHAIN

(Oryctolagus
cuniculus) 		no annotation 4 HIS L  89
ALA L  34
PHE L  71
GLY L  90
 None
 1.41A 1mjoA-4rzcL:
undetectable		 1mjoA-4rzcL:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01467
(CTP_transf_like) 		4 HIS A 157
ALA A 156
PHE A 155
GLY A 195
 None
 1.15A 1mjoA-4wsoA:
undetectable		 1mjoA-4wsoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 HIS A 823
ALA A 974
PHE A 969
GLY A 824
 None
 1.39A 1mjoA-4zdnA:
undetectable		 1mjoA-4zdnA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhy YFIR

(Pseudomonas
aeruginosa) 		PF13689
(DUF4154) 		4 HIS A 133
ALA A 131
PHE A 127
GLY A 107
 None
 1.30A 1mjoA-4zhyA:
undetectable		 1mjoA-4zhyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 HIS A 279
ALA A 278
PHE A 274
GLY A 280
 None
 1.41A 1mjoA-5a4jA:
undetectable		 1mjoA-5a4jA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 HIS A 278
ALA A 277
PHE A 273
GLY A 279
 None
 1.38A 1mjoA-5a5gA:
undetectable		 1mjoA-5a5gA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afe ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
 None
 1.42A 1mjoA-5afeA:
undetectable		 1mjoA-5afeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqr ELONGATOR COMPLEX
PROTEIN 1

(Homo sapiens) 		PF04762
(IKI3) 		4 HIS A1015
ALA A1010
PHE A1009
GLY A1013
 None
 1.40A 1mjoA-5cqrA:
undetectable		 1mjoA-5cqrA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		4 HIS A  94
ALA A 118
PHE A 117
GLY A 120
 None
 1.31A 1mjoA-5ddzA:
undetectable		 1mjoA-5ddzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de0 DEFERROCHELATASE

(Vibrio cholerae) 		PF04261
(Dyp_perox) 		4 HIS A 100
ALA A 101
PHE A  15
GLY A  13
 None
 0.90A 1mjoA-5de0A:
undetectable		 1mjoA-5de0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 HIS A 317
ALA A 312
PHE A 314
GLY A 316
 None
 1.29A 1mjoA-5et1A:
undetectable		 1mjoA-5et1A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		4 HIS A 340
ALA A 243
PHE A 242
GLY A 246
 None
 1.29A 1mjoA-5g5zA:
undetectable		 1mjoA-5g5zA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 HIS A 199
ALA A 170
PHE A 205
GLY A 198
 None
 1.40A 1mjoA-5h9dA:
undetectable		 1mjoA-5h9dA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 HIS A 435
ALA A 430
PHE A 496
GLY A 540
 None
 1.40A 1mjoA-5i67A:
undetectable		 1mjoA-5i67A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.24A 1mjoA-5iclA:
undetectable		 1mjoA-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA

(Bacillus
subtilis) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.42A 1mjoA-5iufA:
undetectable		 1mjoA-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jor FAB14.22 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 HIS B  82
ALA B  67
PHE B  63
GLY B  65
 None
 1.15A 1mjoA-5jorB:
undetectable		 1mjoA-5jorB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 HIS A 173
ALA A 169
PHE A 166
GLY A 172
 None
 1.34A 1mjoA-5ns8A:
undetectable		 1mjoA-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 HIS A 518
ALA A 490
PHE A 489
GLY A 519
 None
 0.93A 1mjoA-5opqA:
undetectable		 1mjoA-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ouo PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 HIS A1061
ALA A 993
PHE A1058
GLY A 991
 None
 1.13A 1mjoA-5ouoA:
undetectable		 1mjoA-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 4 HIS b 387
ALA b 386
PHE b 385
GLY b 333
 CLA  b1832 (-3.9A)
CLA  b1832 ( 3.9A)
BCR  b1848 ( 3.3A)
BCR  b1848 ( 4.4A)
 1.14A 1mjoA-5oy0b:
undetectable		 1mjoA-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A 139
ALA A  64
PHE A 142
GLY A 121
 None
 1.31A 1mjoA-5tnxA:
undetectable		 1mjoA-5tnxA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 HIS D 127
ALA D 100
PHE D  99
GLY D 128
 None
 1.36A 1mjoA-5tpzD:
undetectable		 1mjoA-5tpzD:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucm PROLINE--TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 HIS A 367
ALA A 358
PHE A 357
GLY A 360
 None
 1.29A 1mjoA-5ucmA:
undetectable		 1mjoA-5ucmA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzu UNCHARACTERISED
PROTEIN

(Staphylococcus
aureus) 		no annotation 4 HIS B  82
ALA B  77
PHE B  76
GLY B  80
 None
 1.06A 1mjoA-5uzuB:
undetectable		 1mjoA-5uzuB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 HIS A 391
ALA A 363
PHE A 362
GLY A 365
 None
 1.21A 1mjoA-5vlhA:
undetectable		 1mjoA-5vlhA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwk PROTEIN SCRIBBLE
HOMOLOG

(Homo sapiens) 		no annotation 4 HIS A 793
ALA A 743
PHE A 759
GLY A 745
 None
 1.19A 1mjoA-5vwkA:
undetectable		 1mjoA-5vwkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wou PROTEIN LAP4

(Drosophila
melanogaster) 		no annotation 4 HIS A  71
ALA A  21
PHE A  37
GLY A  23
 EDO  A 105 (-4.1A)
None
None
EDO  A 103 (-3.7A)
 1.22A 1mjoA-5wouA:
undetectable		 1mjoA-5wouA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 4 HIS A 229
ALA A 201
PHE A 200
GLY A 203
 None
 1.16A 1mjoA-5wslA:
undetectable		 1mjoA-5wslA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US12

(Toxoplasma
gondii) 		PF00164
(Ribosom_S12_S23) 		4 HIS X 110
ALA X 111
PHE X 105
GLY X 109
 U  21131 ( 4.3A)
U  21131 ( 4.7A)
None
None
 1.35A 1mjoA-5xxuX:
undetectable		 1mjoA-5xxuX:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp STAPHYLOCOCCAL
PEROXIDASE INHIBITOR

(Staphylococcus
aureus) 		no annotation 4 HIS B  82
ALA B  77
PHE B  76
GLY B  80
 None
 1.01A 1mjoA-6azpB:
undetectable		 1mjoA-6azpB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.02A 1mjoA-6c2hA:
undetectable		 1mjoA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE

(Candida
albicans) 		no annotation 4 HIS A 165
ALA A 122
PHE A 125
GLY A 128
 None
 1.39A 1mjoA-6c5cA:
undetectable		 1mjoA-6c5cA:
undetectable