SIMILAR PATTERNS OF AMINO ACIDS FOR 1MJL_B_SAMB400

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.81A 1mjlA-1brwA:
undetectable
1mjlB-1brwA:
undetectable		 1mjlA-1brwA:
15.40
1mjlB-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 ARG A 454
LEU A 409
GLU A 405
HIS A 401
GLY A 416
 SO4  A2001 (-3.8A)
None
None
None
None
 1.20A 1mjlA-1c7tA:
undetectable
1mjlB-1c7tA:
undetectable		 1mjlA-1c7tA:
8.93
1mjlB-1c7tA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		5 GLU A 433
ARG A 437
LEU A 448
GLU A 453
HIS A 460
 None
 1.46A 1mjlA-1e1kA:
undetectable
1mjlB-1e1kA:
undetectable		 1mjlA-1e1kA:
11.83
1mjlB-1e1kA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 GLU A 242
GLU A 249
HIS A 224
HIS A 226
PHE A 228
 None
 1.47A 1mjlA-1e4oA:
undetectable
1mjlB-1e4oA:
undetectable		 1mjlA-1e4oA:
11.11
1mjlB-1e4oA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE

(Grifola
frondosa) 		PF14521
(Aspzincin_M35) 		5 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 126
 ZN  A 200 ( 4.2A)
None
None
None
None
 0.98A 1mjlA-1ge7A:
undetectable
1mjlB-1ge7A:
undetectable		 1mjlA-1ge7A:
20.00
1mjlB-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE

(Grifola
frondosa) 		PF14521
(Aspzincin_M35) 		5 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 127
 ZN  A 200 ( 4.2A)
None
None
None
None
 1.09A 1mjlA-1ge7A:
undetectable
1mjlB-1ge7A:
undetectable		 1mjlA-1ge7A:
20.00
1mjlB-1ge7A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mjl METHIONINE REPRESSOR
PROTEIN METJ

(Escherichia
coli) 		PF01340
(MetJ) 		6 GLU A  39
ARG A  43
LEU A  56
GLU A  59
HIS A  63
LEU A  70
 None
None
None
None
SAM  A 200 ( 2.9A)
None
 0.02A 1mjlA-1mjlA:
21.9
1mjlB-1mjlA:
14.6		 1mjlA-1mjlA:
100.00
1mjlB-1mjlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pci PROCARICAIN

(Carica papaya) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 GLU A  47
ARG A  17
GLU A  50
HIS A  81
GLY A 102
 None
 1.37A 1mjlA-1pciA:
undetectable
1mjlB-1pciA:
0.2		 1mjlA-1pciA:
15.65
1mjlB-1pciA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica;
Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLU C 112
ARG C 116
LEU C  52
GLU C  74
GLY A  26
 None
 1.09A 1mjlA-1sb3C:
undetectable
1mjlB-1sb3C:
undetectable		 1mjlA-1sb3C:
23.78
1mjlB-1sb3C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		5 GLU A  40
LEU A  38
GLU A 281
HIS A 294
GLY A 258
 EDO  A 317 (-3.9A)
None
None
None
None
 1.19A 1mjlA-2ghsA:
undetectable
1mjlB-2ghsA:
undetectable		 1mjlA-2ghsA:
16.13
1mjlB-2ghsA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		5 GLU A 281
LEU A  37
HIS A 294
LEU A 283
GLY A 237
 None
 1.34A 1mjlA-2ghsA:
undetectable
1mjlB-2ghsA:
undetectable		 1mjlA-2ghsA:
16.13
1mjlB-2ghsA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 ARG A  29
LEU A 357
HIS A 344
LEU A 349
GLY A 322
 None
None
None
FMN  A4401 ( 3.8A)
FMN  A4401 (-3.4A)
 0.94A 1mjlA-2gouA:
undetectable
1mjlB-2gouA:
undetectable		 1mjlA-2gouA:
14.25
1mjlB-2gouA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 5 HIS A 355
LEU A 316
HIS A 123
PHE A  26
GLY A  25
 None
 1.48A 1mjlA-2hihA:
undetectable
1mjlB-2hihA:
undetectable		 1mjlA-2hihA:
12.91
1mjlB-2hihA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k54 PROTEIN ATU0742

(Agrobacterium
fabrum) 		PF12680
(SnoaL_2) 		5 GLU A  92
GLU A  65
HIS A  79
LEU A  67
GLY A 114
 None
 1.38A 1mjlA-2k54A:
undetectable
1mjlB-2k54A:
undetectable		 1mjlA-2k54A:
20.00
1mjlB-2k54A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		5 GLU A 171
LEU A 186
HIS A 220
HIS A 191
GLY A 218
 None
 1.42A 1mjlA-2vdjA:
undetectable
1mjlB-2vdjA:
undetectable		 1mjlA-2vdjA:
17.39
1mjlB-2vdjA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 GLU M 502
ARG M 714
GLU M 499
HIS M 494
LEU M 498
 None
 1.49A 1mjlA-2w4gM:
undetectable
1mjlB-2w4gM:
undetectable		 1mjlA-2w4gM:
8.88
1mjlB-2w4gM:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		5 LEU A 286
HIS A 281
LEU A 292
HIS A 169
GLY A 319
 None
None
None
None
FAD  A 500 ( 4.7A)
 1.35A 1mjlA-2xlrA:
undetectable
1mjlB-2xlrA:
undetectable		 1mjlA-2xlrA:
13.11
1mjlB-2xlrA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 GLU A  89
ARG A 269
GLU A 396
PHE A  87
GLY A 116
 None
 1.20A 1mjlA-2yp2A:
undetectable
1mjlB-2yp2A:
undetectable		 1mjlA-2yp2A:
11.02
1mjlB-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 GLU A 154
LEU A 158
LEU A 221
HIS A 330
PHE A 225
 None
 1.34A 1mjlA-3aeuA:
undetectable
1mjlB-3aeuA:
undetectable		 1mjlA-3aeuA:
14.11
1mjlB-3aeuA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn6 LACTADHERIN

(Bos taurus) 		PF00754
(F5_F8_type_C) 		5 LEU A 155
GLU A 154
HIS A 124
LEU A  40
GLY A  77
 None
 1.47A 1mjlA-3bn6A:
undetectable
1mjlB-3bn6A:
undetectable		 1mjlA-3bn6A:
21.25
1mjlB-3bn6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bru REGULATORY PROTEIN,
TETR FAMILY

(Rhodobacter
sphaeroides) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		5 LEU A 159
HIS A 173
LEU A 169
HIS A 212
GLY A 210
 None
 1.30A 1mjlA-3bruA:
undetectable
1mjlB-3bruA:
1.3		 1mjlA-3bruA:
25.42
1mjlB-3bruA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 ARG B  26
LEU B  28
GLU B  41
HIS B  42
GLY B 363
 None
 1.34A 1mjlA-3bxwB:
undetectable
1mjlB-3bxwB:
undetectable		 1mjlA-3bxwB:
14.51
1mjlB-3bxwB:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		5 GLU A 122
ARG A 119
LEU A 118
GLU A 130
HIS A 132
 None
 1.39A 1mjlA-3e1tA:
undetectable
1mjlB-3e1tA:
undetectable		 1mjlA-3e1tA:
11.07
1mjlB-3e1tA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9

(Thermus
thermophilus) 		PF12838
(Fer4_7) 		5 ARG 9 167
GLU 9 105
HIS 9  41
LEU 9 115
PHE 9 173
 None
None
SF4  9 183 (-4.5A)
None
None
 1.48A 1mjlA-3i9v9:
undetectable
1mjlB-3i9v9:
undetectable		 1mjlA-3i9v9:
20.32
1mjlB-3i9v9:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 GLU A 558
LEU A 624
HIS A 520
PHE A 627
GLY A 554
 None
 1.21A 1mjlA-3l4kA:
undetectable
1mjlB-3l4kA:
undetectable		 1mjlA-3l4kA:
9.20
1mjlB-3l4kA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 LEU A 718
GLU A 721
LEU A 791
HIS A 725
GLY A 784
 None
 1.12A 1mjlA-3lj0A:
undetectable
1mjlB-3lj0A:
undetectable		 1mjlA-3lj0A:
13.23
1mjlB-3lj0A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 GLU A  89
ARG A 269
GLU A 396
PHE A  87
GLY A 116
 None
 1.17A 1mjlA-3wheA:
undetectable
1mjlB-3wheA:
undetectable		 1mjlA-3wheA:
12.03
1mjlB-3wheA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 340
GLU A 343
HIS A 465
LEU A 362
HIS A 466
 None
 1.49A 1mjlA-4fdhA:
undetectable
1mjlB-4fdhA:
0.1		 1mjlA-4fdhA:
12.24
1mjlB-4fdhA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 GLU A 558
LEU A 624
HIS A 520
PHE A 627
GLY A 554
 None
 1.16A 1mjlA-4gfhA:
undetectable
1mjlB-4gfhA:
undetectable		 1mjlA-4gfhA:
6.52
1mjlB-4gfhA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		5 ARG A  34
LEU A  51
GLU A  53
LEU A  30
GLY A  23
 None
 1.37A 1mjlA-4glfA:
undetectable
1mjlB-4glfA:
undetectable		 1mjlA-4glfA:
16.49
1mjlB-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1

(Bos taurus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		5 GLU A  36
ARG A  52
LEU A  50
GLU A  60
PHE A  99
 None
 1.10A 1mjlA-4hh8A:
undetectable
1mjlB-4hh8A:
undetectable		 1mjlA-4hh8A:
18.26
1mjlB-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7w HD DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF13023
(HD_3) 		5 GLU A 146
ARG A  52
LEU A 149
GLU A 153
GLY A  34
 None
 1.16A 1mjlA-4l7wA:
undetectable
1mjlB-4l7wA:
undetectable		 1mjlA-4l7wA:
16.99
1mjlB-4l7wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		5 GLU A  72
ARG A  75
LEU A  76
PHE A  64
GLY A  92
 None
 1.41A 1mjlA-4mcaA:
undetectable
1mjlB-4mcaA:
undetectable		 1mjlA-4mcaA:
14.01
1mjlB-4mcaA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 GLU A 505
LEU A 419
HIS A 464
HIS A 415
GLY A 414
 None
None
ZN  A 801 (-3.3A)
ZN  A 801 (-3.2A)
None
 1.41A 1mjlA-4ojzA:
undetectable
1mjlB-4ojzA:
undetectable		 1mjlA-4ojzA:
9.36
1mjlB-4ojzA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m) 		5 LEU A 183
GLU A 187
LEU A 227
HIS A 236
GLY A  51
 None
 1.42A 1mjlA-4q6pA:
undetectable
1mjlB-4q6pA:
undetectable		 1mjlA-4q6pA:
13.75
1mjlB-4q6pA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 5 ARG C 217
LEU C 295
GLU C 299
PHE C 259
GLY C 261
 None
 1.00A 1mjlA-4wzsC:
undetectable
1mjlB-4wzsC:
undetectable		 1mjlA-4wzsC:
8.59
1mjlB-4wzsC:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 LEU A 615
GLU A 618
LEU A 682
HIS A 622
GLY A 675
 None
 1.10A 1mjlA-4z7gA:
undetectable
1mjlB-4z7gA:
undetectable		 1mjlA-4z7gA:
12.11
1mjlB-4z7gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 ARG A 103
LEU A  76
GLU A  72
HIS A  22
PHE A  23
 None
 1.33A 1mjlA-5fqdA:
undetectable
1mjlB-5fqdA:
undetectable		 1mjlA-5fqdA:
8.62
1mjlB-5fqdA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		5 LEU A 281
HIS A 276
LEU A 287
HIS A 164
GLY A 314
 None
None
None
None
FAD  A 502 ( 4.3A)
 1.40A 1mjlA-5ipyA:
undetectable
1mjlB-5ipyA:
undetectable		 1mjlA-5ipyA:
14.42
1mjlB-5ipyA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 GLU A 789
ARG A 966
LEU A 793
GLU A 485
GLY A 782
 None
 1.45A 1mjlA-5iudA:
undetectable
1mjlB-5iudA:
undetectable		 1mjlA-5iudA:
8.50
1mjlB-5iudA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lda JAMM1

(Pyrococcus
furiosus) 		PF14464
(Prok-JAB) 		5 GLU A  63
LEU A  56
GLU A  61
HIS A  88
GLY A  37
 None
None
None
ZN  A 201 (-3.4A)
None
 1.39A 1mjlA-5ldaA:
undetectable
1mjlB-5ldaA:
undetectable		 1mjlA-5ldaA:
22.22
1mjlB-5ldaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLU B 206
ARG B 210
LEU B 163
GLU B 166
GLY B 299
 None
 1.14A 1mjlA-5op0B:
undetectable
1mjlB-5op0B:
undetectable		 1mjlA-5op0B:
17.30
1mjlB-5op0B:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		5 ARG C1229
LEU C1225
GLU C1226
PHE C1243
GLY C1274
 None
 1.40A 1mjlA-5swvC:
undetectable
1mjlB-5swvC:
undetectable		 1mjlA-5swvC:
12.26
1mjlB-5swvC:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w25 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycobacterium
tuberculosis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 GLU A 500
ARG A 496
LEU A 521
GLU A 514
GLY A 507
 None
 1.45A 1mjlA-5w25A:
undetectable
1mjlB-5w25A:
undetectable		 1mjlA-5w25A:
10.52
1mjlB-5w25A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 5 HIS F 308
LEU F 307
HIS F  54
PHE F  49
GLY F  50
 None
 1.21A 1mjlA-5xagF:
undetectable
1mjlB-5xagF:
undetectable		 1mjlA-5xagF:
undetectable
1mjlB-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 GLU A  72
ARG A  75
LEU A  76
PHE A  64
GLY A  92
 None
 1.43A 1mjlA-5xn8A:
undetectable
1mjlB-5xn8A:
undetectable		 1mjlA-5xn8A:
12.91
1mjlB-5xn8A:
12.91