SIMILAR PATTERNS OF AMINO ACIDS FOR 1MIC_B_DVAB8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 384
TRP A 457
VAL A 428
TRP A 413
 None
 1.38A 1micA-2a9cA:
undetectable
1micB-2a9cA:
undetectable		 1micA-2a9cA:
4.58
1micB-2a9cA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 VAL A 285
TRP A 225
VAL A 287
TRP A 172
 None
 1.39A 1micA-2vouA:
undetectable
1micB-2vouA:
undetectable		 1micA-2vouA:
3.56
1micB-2vouA:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN

(Methylococcus
capsulatus) 		no annotation 4 VAL A 206
TRP A 130
TRP A 136
VAL A 204
 None
 1.24A 1micA-2vowA:
undetectable
1micB-2vowA:
undetectable		 1micA-2vowA:
3.65
1micB-2vowA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 384
TRP A 457
VAL A 428
TRP A 413
 None
 1.38A 1micA-3r18A:
undetectable
1micB-3r18A:
undetectable		 1micA-3r18A:
3.47
1micB-3r18A:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF07470
(Glyco_hydro_88) 		4 VAL A 116
TRP A 153
TRP A 228
VAL A 162
 None
 1.40A 1micA-4q88A:
undetectable
1micB-4q88A:
undetectable		 1micA-4q88A:
4.68
1micB-4q88A:
4.68