SIMILAR PATTERNS OF AMINO ACIDS FOR 1MIC_A_DVAA8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 VAL A 287
TRP A 172
VAL A 285
TRP A 225
 None
 1.15A 1micA-2vouA:
undetectable
1micB-2vouA:
undetectable		 1micA-2vouA:
3.56
1micB-2vouA:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		4 VAL A  70
TRP A  20
VAL A  68
TRP A 278
 None
 1.24A 1micA-3ow8A:
undetectable
1micB-3ow8A:
undetectable		 1micA-3ow8A:
11.11
1micB-3ow8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anp BA41

(Bizionia
argentinensis) 		PF04536
(TPM_phosphatase) 		4 VAL A  47
TRP A  97
VAL A  80
TRP A 101
 None
 1.37A 1micA-5anpA:
undetectable
1micB-5anpA:
undetectable		 1micA-5anpA:
10.89
1micB-5anpA:
10.89