SIMILAR PATTERNS OF AMINO ACIDS FOR 1MIC_A_DVAA6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ALA B 210
VAL B 208
TRP A 155
 None
 0.89A 1micA-1bplB:
undetectable
1micB-1bplB:
undetectable		 1micA-1bplB:
5.35
1micB-1bplB:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ALA A 470
VAL A 182
TRP A 186
 None
 0.87A 1micA-1dgfA:
undetectable
1micB-1dgfA:
undetectable		 1micA-1dgfA:
4.41
1micB-1dgfA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ALA A 210
VAL A 208
TRP A 153
 None
 0.79A 1micA-1e43A:
undetectable
1micB-1e43A:
undetectable		 1micA-1e43A:
4.90
1micB-1e43A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcf NEUROTROPHIN-4

(Homo sapiens) 		PF00243
(NGF) 		3 ALA A  46
VAL A  44
TRP A 110
 None
 0.89A 1micA-1hcfA:
undetectable
1micB-1hcfA:
undetectable		 1micA-1hcfA:
10.71
1micB-1hcfA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		3 ALA A 151
VAL A 195
TRP A 191
 None
 0.75A 1micA-1hjuA:
undetectable
1micB-1hjuA:
undetectable		 1micA-1hjuA:
3.45
1micB-1hjuA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		3 ALA A 158
VAL A 160
TRP A 247
 None
 0.90A 1micA-1mg5A:
undetectable
1micB-1mg5A:
undetectable		 1micA-1mg5A:
5.83
1micB-1mg5A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum) 		PF01536
(SAM_decarbox) 		3 ALA A 292
VAL A 330
TRP A 318
 None
 0.87A 1micA-1mhmA:
undetectable
1micB-1mhmA:
undetectable		 1micA-1mhmA:
4.53
1micB-1mhmA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ALA A  35
VAL A   7
TRP A  96
 None
 0.89A 1micA-1r0lA:
undetectable
1micB-1r0lA:
undetectable		 1micA-1r0lA:
3.37
1micB-1r0lA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		3 ALA A  62
VAL A  57
TRP A  46
 None
None
HEM  A 144 (-4.2A)
 0.89A 1micA-1spgA:
undetectable
1micB-1spgA:
undetectable		 1micA-1spgA:
7.63
1micB-1spgA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ALA A 460
VAL A 462
TRP A 466
 None
 0.81A 1micA-1vbgA:
undetectable
1micB-1vbgA:
undetectable		 1micA-1vbgA:
2.66
1micB-1vbgA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ALA A 210
VAL A 208
TRP A 155
 None
 0.92A 1micA-1vjsA:
undetectable
1micB-1vjsA:
undetectable		 1micA-1vjsA:
8.22
1micB-1vjsA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weu INHIBITOR OF GROWTH
FAMILY, MEMBER 4

(Mus musculus) 		PF00628
(PHD) 		3 ALA A  65
VAL A  67
TRP A  77
 None
 0.89A 1micA-1weuA:
undetectable
1micB-1weuA:
undetectable		 1micA-1weuA:
7.69
1micB-1weuA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ALA A 554
VAL A 551
TRP A 549
 None
 0.63A 1micA-1xc6A:
undetectable
1micB-1xc6A:
undetectable		 1micA-1xc6A:
1.97
1micB-1xc6A:
1.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE SMALL
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00866
(Ring_hydroxyl_B) 		3 ALA B 659
VAL B 545
TRP B 541
 None
 0.58A 1micA-2b24B:
undetectable
1micB-2b24B:
undetectable		 1micA-2b24B:
6.63
1micB-2b24B:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2e SUFC PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		3 ALA A 183
VAL A 181
TRP A 131
 None
 0.86A 1micA-2d2eA:
undetectable
1micB-2d2eA:
undetectable		 1micA-2d2eA:
9.23
1micB-2d2eA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE

(Pyrococcus
horikoshii) 		PF00390
(malic)
PF03949
(Malic_M) 		3 ALA A 382
VAL A 407
TRP A 406
 None
 0.88A 1micA-2dvmA:
undetectable
1micB-2dvmA:
undetectable		 1micA-2dvmA:
3.63
1micB-2dvmA:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 ALA A 286
VAL A 310
TRP A 303
 None
 0.85A 1micA-2e4uA:
undetectable
1micB-2e4uA:
undetectable		 1micA-2e4uA:
3.85
1micB-2e4uA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		3 ALA A 407
VAL A 405
TRP A 352
 None
 0.79A 1micA-2g29A:
undetectable
1micB-2g29A:
undetectable		 1micA-2g29A:
5.65
1micB-2g29A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i32 ANTI-SILENCING
FACTOR 1 PARALOG A

(Homo sapiens) 		PF04729
(ASF1_hist_chap) 		3 ALA A  67
VAL A   4
TRP A 153
 None
 0.90A 1micA-2i32A:
undetectable
1micB-2i32A:
undetectable		 1micA-2i32A:
8.18
1micB-2i32A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imj HYPOTHETICAL PROTEIN
DUF1348

(Pseudomonas
protegens) 		PF07080
(DUF1348) 		3 ALA A  83
VAL A  91
TRP A 113
 None
 0.63A 1micA-2imjA:
undetectable
1micB-2imjA:
undetectable		 1micA-2imjA:
10.84
1micB-2imjA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxy MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin) 		3 ALA A 382
VAL A 396
TRP A 401
 CA  A 471 ( 4.3A)
None
None
 0.77A 1micA-2jxyA:
undetectable
1micB-2jxyA:
undetectable		 1micA-2jxyA:
5.15
1micB-2jxyA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ms7 MITOCHONDRIAL
ANTIVIRAL-SIGNALING
PROTEIN

(Homo sapiens) 		PF16739
(CARD_2) 		3 ALA A  74
VAL A  69
TRP A  68
 None
 0.91A 1micA-2ms7A:
undetectable
1micB-2ms7A:
undetectable		 1micA-2ms7A:
11.27
1micB-2ms7A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ALA A 173
VAL A 175
TRP A 217
 None
 0.85A 1micA-2pm9A:
undetectable
1micB-2pm9A:
undetectable		 1micA-2pm9A:
4.56
1micB-2pm9A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		3 ALA A  44
VAL A  92
TRP A  89
 None
 0.85A 1micA-2q3oA:
undetectable
1micB-2q3oA:
undetectable		 1micA-2q3oA:
5.17
1micB-2q3oA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00121
(TIM) 		3 ALA A 200
VAL A 194
TRP A 193
 None
 0.90A 1micA-2x2gA:
undetectable
1micB-2x2gA:
undetectable		 1micA-2x2gA:
8.55
1micB-2x2gA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yka RNA AND EXPORT
FACTOR-BINDING
PROTEIN 2
52 KDA
IMMEDIATE-EARLY
PHOSPHOPROTEIN

(Mus musculus;
Saimiriine
gammaherpesvirus
2) 		PF00076
(RRM_1)
no annotation 		3 ALA A  89
VAL A  86
TRP B 108
 None
 0.80A 1micA-2ykaA:
undetectable
1micB-2ykaA:
undetectable		 1micA-2ykaA:
12.50
1micB-2ykaA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		3 ALA B 318
VAL B 364
TRP B 429
 None
 0.81A 1micA-2ziuB:
undetectable
1micB-2ziuB:
undetectable		 1micA-2ziuB:
3.47
1micB-2ziuB:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 ALA A 478
VAL A 476
TRP A 956
 None
 0.81A 1micA-3aibA:
undetectable
1micB-3aibA:
undetectable		 1micA-3aibA:
2.46
1micB-3aibA:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		3 ALA A 139
VAL A 137
TRP A 146
 None
 0.88A 1micA-3cc8A:
undetectable
1micB-3cc8A:
undetectable		 1micA-3cc8A:
9.38
1micB-3cc8A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjx PROTEIN OF UNKNOWN
FUNCTION WITH A
CUPIN-LIKE FOLD

(Cupriavidus
pinatubonensis) 		no annotation 3 ALA A 138
VAL A 140
TRP A 144
 None
 0.91A 1micA-3cjxA:
undetectable
1micB-3cjxA:
undetectable		 1micA-3cjxA:
12.00
1micB-3cjxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE

(Methanoculleus
marisnigri) 		PF06314
(ADC) 		3 ALA A  84
VAL A 103
TRP A 105
 None
 0.90A 1micA-3cmbA:
undetectable
1micB-3cmbA:
undetectable		 1micA-3cmbA:
4.56
1micB-3cmbA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		3 ALA A  33
VAL A  79
TRP A 230
 FAD  A 298 (-3.5A)
FAD  A 298 (-4.0A)
None
 0.88A 1micA-3fbsA:
undetectable
1micB-3fbsA:
undetectable		 1micA-3fbsA:
6.72
1micB-3fbsA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		3 ALA A  45
VAL A  92
TRP A  89
 None
 0.80A 1micA-3gkaA:
undetectable
1micB-3gkaA:
undetectable		 1micA-3gkaA:
4.90
1micB-3gkaA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		3 ALA A 327
VAL A 325
TRP A 272
 None
 0.68A 1micA-3gq2A:
undetectable
1micB-3gq2A:
undetectable		 1micA-3gq2A:
2.68
1micB-3gq2A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		3 ALA A 250
VAL A 245
TRP A 536
 None
None
ACT  A  13 (-4.6A)
 0.84A 1micA-3gzsA:
undetectable
1micB-3gzsA:
undetectable		 1micA-3gzsA:
2.71
1micB-3gzsA:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		3 ALA A 234
VAL A 257
TRP A 179
 None
 0.91A 1micA-3h4xA:
undetectable
1micB-3h4xA:
undetectable		 1micA-3h4xA:
5.68
1micB-3h4xA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		3 ALA A 197
VAL A 191
TRP A 194
 None
 0.90A 1micA-3i4iA:
undetectable
1micB-3i4iA:
undetectable		 1micA-3i4iA:
6.19
1micB-3i4iA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 3 ALA X 545
VAL X 583
TRP X 603
 None
 0.91A 1micA-3kvnX:
undetectable
1micB-3kvnX:
undetectable		 1micA-3kvnX:
2.39
1micB-3kvnX:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpz GET4 (YOR164C
HOMOLOG)

(Chaetomium
thermophilum) 		PF04190
(DUF410) 		3 ALA A  88
VAL A  85
TRP A 117
 None
 0.90A 1micA-3lpzA:
undetectable
1micB-3lpzA:
undetectable		 1micA-3lpzA:
4.26
1micB-3lpzA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p42 PREDICTED PROTEIN

(Escherichia
coli) 		PF06251
(Caps_synth_GfcC) 		3 ALA A 224
VAL A 226
TRP A  88
 None
 0.80A 1micA-3p42A:
undetectable
1micB-3p42A:
undetectable		 1micA-3p42A:
13.27
1micB-3p42A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13416
(SBP_bac_8) 		3 ALA A 184
VAL A 181
TRP A 240
 ALA  A 184 ( 0.0A)
VAL  A 181 ( 0.6A)
TRP  A 240 ( 0.5A)
 0.90A 1micA-3pu5A:
undetectable
1micB-3pu5A:
undetectable		 1micA-3pu5A:
3.86
1micB-3pu5A:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4h PE FAMILY PROTEIN
LOW MOLECULAR WEIGHT
PROTEIN ANTIGEN 7

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		no annotation
PF06013
(WXG100) 		3 ALA A  67
VAL A  65
TRP B  58
 None
 0.91A 1micA-3q4hA:
undetectable
1micB-3q4hA:
undetectable		 1micA-3q4hA:
8.16
1micB-3q4hA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE

(Scaptodrosophila
lebanonensis) 		PF00106
(adh_short) 		3 ALA A 157
VAL A 159
TRP A 246
 None
 0.88A 1micA-3rj9A:
undetectable
1micB-3rj9A:
undetectable		 1micA-3rj9A:
5.49
1micB-3rj9A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rti RICIN

(Ricinus
communis) 		PF00652
(Ricin_B_lectin) 		3 ALA B  33
VAL B  23
TRP B  49
 None
 0.88A 1micA-3rtiB:
undetectable
1micB-3rtiB:
undetectable		 1micA-3rtiB:
9.32
1micB-3rtiB:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		3 ALA A  11
VAL A 217
TRP A  87
 None
 0.90A 1micA-3t8iA:
undetectable
1micB-3t8iA:
undetectable		 1micA-3t8iA:
3.96
1micB-3t8iA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ALA A 527
VAL A 532
TRP A 356
 None
 0.88A 1micA-3uk1A:
undetectable
1micB-3uk1A:
undetectable		 1micA-3uk1A:
3.67
1micB-3uk1A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		3 ALA A  73
VAL A  75
TRP A  83
 None
 0.84A 1micA-3vglA:
undetectable
1micB-3vglA:
undetectable		 1micA-3vglA:
4.63
1micB-3vglA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		3 ALA A 374
VAL A 232
TRP A 233
 EDO  A1003 ( 4.0A)
ACT  A1002 ( 3.3A)
FAD  A1001 (-4.7A)
 0.84A 1micA-3vqrA:
undetectable
1micB-3vqrA:
undetectable		 1micA-3vqrA:
3.81
1micB-3vqrA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab4 XENOBIOTIC REDUCTASE
B

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		3 ALA A  37
VAL A  84
TRP A  81
 None
 0.85A 1micA-4ab4A:
undetectable
1micB-4ab4A:
undetectable		 1micA-4ab4A:
3.45
1micB-4ab4A:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 ALA A1025
VAL A1023
TRP A1510
 None
 0.88A 1micA-4amcA:
undetectable
1micB-4amcA:
undetectable		 1micA-4amcA:
5.19
1micB-4amcA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 ALA A1026
VAL A1024
TRP A1505
 GOL  A2791 (-3.6A)
None
None
 0.87A 1micA-4aygA:
undetectable
1micB-4aygA:
undetectable		 1micA-4aygA:
3.52
1micB-4aygA:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		3 ALA A 173
VAL A 175
TRP A 217
 None
 0.85A 1micA-4bzkA:
undetectable
1micB-4bzkA:
undetectable		 1micA-4bzkA:
1.52
1micB-4bzkA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		3 ALA A 237
VAL A 240
TRP A 475
 None
 0.89A 1micA-4ccaA:
undetectable
1micB-4ccaA:
undetectable		 1micA-4ccaA:
2.66
1micB-4ccaA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 ALA B 171
VAL B 166
TRP B 185
 None
 0.76A 1micA-4ccyB:
undetectable
1micB-4ccyB:
undetectable		 1micA-4ccyB:
3.50
1micB-4ccyB:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 ALA A 393
VAL A 391
TRP A 384
 None
 0.88A 1micA-4f0xA:
undetectable
1micB-4f0xA:
undetectable		 1micA-4f0xA:
3.27
1micB-4f0xA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4m PAPAIN PEPTIDOGLYCAN
AMIDASE EFFECTOR
TSE1

(Pseudomonas
aeruginosa) 		no annotation 3 ALA A  39
VAL A  43
TRP A  61
 None
 0.90A 1micA-4f4mA:
undetectable
1micB-4f4mA:
undetectable		 1micA-4f4mA:
8.33
1micB-4f4mA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		3 ALA A  10
VAL A   8
TRP A 279
 None
 0.82A 1micA-4gxwA:
undetectable
1micB-4gxwA:
undetectable		 1micA-4gxwA:
5.22
1micB-4gxwA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		3 ALA A  98
VAL A  93
TRP A  92
 None
 0.86A 1micA-4jndA:
undetectable
1micB-4jndA:
undetectable		 1micA-4jndA:
2.68
1micB-4jndA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdw ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 ALA A  12
VAL A  10
TRP A  64
 None
 0.62A 1micA-4kdwA:
undetectable
1micB-4kdwA:
undetectable		 1micA-4kdwA:
7.34
1micB-4kdwA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		3 ALA A 305
VAL A 310
TRP A 151
 None
 0.86A 1micA-4kvlA:
undetectable
1micB-4kvlA:
undetectable		 1micA-4kvlA:
2.96
1micB-4kvlA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg3 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF16175
(DUF4875) 		3 ALA A 102
VAL A 133
TRP A 139
 None
 0.76A 1micA-4lg3A:
undetectable
1micB-4lg3A:
undetectable		 1micA-4lg3A:
6.59
1micB-4lg3A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN

(Vibrio cholerae) 		PF03480
(DctP) 		3 ALA A  65
VAL A 214
TRP A 120
 None
 0.89A 1micA-4magA:
undetectable
1micB-4magA:
undetectable		 1micA-4magA:
5.69
1micB-4magA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis) 		no annotation 3 ALA A 398
VAL A 393
TRP A 392
 None
 0.89A 1micA-4o7pA:
undetectable
1micB-4o7pA:
undetectable		 1micA-4o7pA:
3.17
1micB-4o7pA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ALA A 789
VAL A 774
TRP A 757
 None
None
GLC  A1011 ( 4.2A)
 0.91A 1micA-4okdA:
undetectable
1micB-4okdA:
undetectable		 1micA-4okdA:
1.43
1micB-4okdA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 3 ALA A  12
VAL A  10
TRP A  64
 None
 0.61A 1micA-4p99A:
undetectable
1micB-4p99A:
undetectable		 1micA-4p99A:
3.53
1micB-4p99A:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 3 ALA A 116
VAL A 114
TRP A 168
 None
 0.62A 1micA-4p99A:
undetectable
1micB-4p99A:
undetectable		 1micA-4p99A:
3.53
1micB-4p99A:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 3 ALA A 220
VAL A 218
TRP A 272
 EDO  A 527 ( 4.7A)
None
None
 0.62A 1micA-4p99A:
undetectable
1micB-4p99A:
undetectable		 1micA-4p99A:
3.53
1micB-4p99A:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 3 ALA A 324
VAL A 322
TRP A 376
 EDO  A 528 (-3.9A)
None
None
 0.61A 1micA-4p99A:
undetectable
1micB-4p99A:
undetectable		 1micA-4p99A:
3.53
1micB-4p99A:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2

(Mus musculus) 		PF00773
(RNB)
PF17216
(Rrp44_CSD1) 		3 ALA A 393
VAL A 406
TRP A 466
 None
 0.90A 1micA-4pmwA:
undetectable
1micB-4pmwA:
undetectable		 1micA-4pmwA:
2.64
1micB-4pmwA:
2.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		3 ALA A  75
VAL A  73
TRP A  43
 None
 0.83A 1micA-4twfA:
undetectable
1micB-4twfA:
undetectable		 1micA-4twfA:
4.08
1micB-4twfA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		3 ALA A 385
VAL A 380
TRP A 379
 None
 0.90A 1micA-4u98A:
undetectable
1micB-4u98A:
undetectable		 1micA-4u98A:
2.31
1micB-4u98A:
2.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		3 ALA A  52
VAL A  49
TRP A 145
 None
 0.90A 1micA-4wrwA:
undetectable
1micB-4wrwA:
undetectable		 1micA-4wrwA:
6.13
1micB-4wrwA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		3 ALA A 451
VAL A 448
TRP A 386
 None
 0.90A 1micA-4x4jA:
undetectable
1micB-4x4jA:
undetectable		 1micA-4x4jA:
3.07
1micB-4x4jA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 ALA A 241
VAL A 306
TRP A 308
 None
 0.87A 1micA-4xhbA:
undetectable
1micB-4xhbA:
undetectable		 1micA-4xhbA:
1.92
1micB-4xhbA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		3 ALA A 404
VAL A 402
TRP A 675
 None
 0.90A 1micA-4yu5A:
undetectable
1micB-4yu5A:
undetectable		 1micA-4yu5A:
1.95
1micB-4yu5A:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		3 ALA A 210
VAL A 208
TRP A 206
 None
 0.51A 1micA-4z1pA:
undetectable
1micB-4z1pA:
undetectable		 1micA-4z1pA:
4.98
1micB-4z1pA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		3 ALA A 210
VAL A 208
TRP A 206
 None
 0.56A 1micA-4z23A:
undetectable
1micB-4z23A:
undetectable		 1micA-4z23A:
5.19
1micB-4z23A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		3 ALA A 476
VAL A 470
TRP A 466
 None
 0.84A 1micA-4zfmA:
undetectable
1micB-4zfmA:
undetectable		 1micA-4zfmA:
2.93
1micB-4zfmA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 ALA A 894
VAL A 940
TRP A 952
 None
 0.88A 1micA-4zmhA:
undetectable
1micB-4zmhA:
undetectable		 1micA-4zmhA:
2.77
1micB-4zmhA:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2t COAT PROTEIN

(Bamboo mosaic
virus) 		PF00286
(Flexi_CP) 		3 ALA A 138
VAL A 133
TRP A  68
 None
 0.79A 1micA-5a2tA:
undetectable
1micB-5a2tA:
undetectable		 1micA-5a2tA:
11.43
1micB-5a2tA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ALA A 682
VAL A 677
TRP A 716
 None
 0.80A 1micA-5bp1A:
undetectable
1micB-5bp1A:
undetectable		 1micA-5bp1A:
2.07
1micB-5bp1A:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ALA A 300
VAL A 260
TRP A 263
 None
 0.80A 1micA-5bwdA:
undetectable
1micB-5bwdA:
undetectable		 1micA-5bwdA:
1.76
1micB-5bwdA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans) 		PF00899
(ThiF) 		3 ALA A  48
VAL A  43
TRP A  42
 None
 0.75A 1micA-5ff5A:
undetectable
1micB-5ff5A:
undetectable		 1micA-5ff5A:
5.26
1micB-5ff5A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		3 ALA A 242
VAL A  42
TRP A  69
 None
 0.89A 1micA-5ff9A:
undetectable
1micB-5ff9A:
undetectable		 1micA-5ff9A:
6.67
1micB-5ff9A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		3 ALA A 233
VAL A 248
TRP A 250
 None
 0.83A 1micA-5hx9A:
undetectable
1micB-5hx9A:
undetectable		 1micA-5hx9A:
4.07
1micB-5hx9A:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis) 		no annotation 3 ALA A 402
VAL A 400
TRP A 454
 None
 0.61A 1micA-5irbA:
undetectable
1micB-5irbA:
undetectable		 1micA-5irbA:
7.87
1micB-5irbA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		3 ALA B1067
VAL B1123
TRP B1077
 None
 0.86A 1micA-5jtwB:
undetectable
1micB-5jtwB:
undetectable		 1micA-5jtwB:
3.06
1micB-5jtwB:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 ALA A  12
VAL A  10
TRP A  64
 None
 0.67A 1micA-5k8gA:
undetectable
1micB-5k8gA:
undetectable		 1micA-5k8gA:
3.04
1micB-5k8gA:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		3 ALA A 313
VAL A 357
TRP A 349
 None
 0.88A 1micA-5k9tA:
undetectable
1micB-5k9tA:
undetectable		 1micA-5k9tA:
2.29
1micB-5k9tA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ALA A 458
VAL A 460
TRP A 464
 None
 0.90A 1micA-5lu4A:
undetectable
1micB-5lu4A:
undetectable		 1micA-5lu4A:
2.66
1micB-5lu4A:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 3 ALA D 392
VAL D 390
TRP D 295
 None
 0.86A 1micA-5t4yD:
undetectable
1micB-5t4yD:
undetectable		 1micA-5t4yD:
2.14
1micB-5t4yD:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Bacillus
subtilis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		3 ALA A 173
VAL A 163
TRP A  40
 None
7C5  A 302 (-4.6A)
None
 0.91A 1micA-5th5A:
undetectable
1micB-5th5A:
undetectable		 1micA-5th5A:
4.26
1micB-5th5A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ALA A  82
VAL A  88
TRP A 300
 None
 0.91A 1micA-5v72A:
undetectable
1micB-5v72A:
undetectable		 1micA-5v72A:
4.76
1micB-5v72A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 141
VAL A 136
TRP A 135
 None
 0.89A 1micA-5vm1A:
undetectable
1micB-5vm1A:
undetectable		 1micA-5vm1A:
8.59
1micB-5vm1A:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwn TRIOSEPHOSPHATE
ISOMERASE

(Trichomonas
vaginalis) 		no annotation 3 ALA A 193
VAL A 191
TRP A 152
 None
 0.90A 1micA-5vwnA:
undetectable
1micB-5vwnA:
undetectable		 1micA-5vwnA:
undetectable
1micB-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 3 ALA U 262
VAL U 161
TRP U 210
 None
 0.90A 1micA-5zvtU:
undetectable
1micB-5zvtU:
undetectable		 1micA-5zvtU:
undetectable
1micB-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 3 ALA A 415
VAL A 417
TRP A 420
 None
 0.83A 1micA-6bo6A:
undetectable
1micB-6bo6A:
undetectable		 1micA-6bo6A:
undetectable
1micB-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 3 ALA A 130
VAL A 128
TRP A 102
 None
 0.90A 1micA-6ci7A:
undetectable
1micB-6ci7A:
undetectable		 1micA-6ci7A:
undetectable
1micB-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 3 ALA A 431
VAL A 433
TRP A 436
 None
 0.78A 1micA-6etzA:
undetectable
1micB-6etzA:
undetectable		 1micA-6etzA:
undetectable
1micB-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A  23
VAL A  20
TRP A 237
 None
 0.89A 1micA-6f0qA:
undetectable
1micB-6f0qA:
undetectable		 1micA-6f0qA:
undetectable
1micB-6f0qA:
undetectable