SIMILAR PATTERNS OF AMINO ACIDS FOR 1MEH_A_MOAA600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 ASP A  35
ILE A  54
GLY A  87
GLU A  16
GLY A  13
 None
None
None
None
FMN  A 177 (-3.8A)
 1.16A 1mehA-1ag9A:
undetectable		 1mehA-1ag9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		5 SER B 195
SER B 214
ILE B 212
GLY B 211
GLY B 226
 None
 1.29A 1mehA-1dlkB:
undetectable		 1mehA-1dlkB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 SER B  20
GLY B 311
GLU B  15
GLY B 100
GLU B 104
 None
PHY  B 355 (-3.3A)
None
None
PHY  B 355 ( 4.6A)
 0.85A 1mehA-1e4eB:
undetectable		 1mehA-1e4eB:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		5 ASP A 172
SER A 173
ASN A 201
ILE A 223
GLY A 224
 None
 0.78A 1mehA-1eepA:
43.8		 1mehA-1eepA:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 SER A 107
ASN A 111
ILE A 110
GLY A  32
GLU A  55
 FAD  A 600 (-3.4A)
FAD  A 600 (-3.9A)
None
FAD  A 600 ( 4.6A)
FAD  A 600 (-2.6A)
 1.20A 1mehA-1gpeA:
undetectable		 1mehA-1gpeA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h56 TYPE II RESTRICTION
ENZYME PVUII

(Proteus
vulgaris) 		PF09225
(Endonuc-PvuII) 		5 ASP A  58
ILE A  28
GLY A  27
GLY A  53
ARG A  54
 MG  A   1 (-3.3A)
None
None
None
None
 1.28A 1mehA-1h56A:
undetectable		 1mehA-1h56A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 SER E 195
SER E 214
ILE E 212
GLY E 211
GLY E 226
 None
 1.27A 1mehA-1h9hE:
undetectable		 1mehA-1h9hE:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		5 SER H 195
SER H 214
ILE H 212
GLY H 211
GLY H 226
 None
 1.27A 1mehA-1id5H:
undetectable		 1mehA-1id5H:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 274
SER A 275
SER A 276
ASN A 303
GLY A 326
 None
None
None
CPR  A 631 ( 4.5A)
None
 0.33A 1mehA-1jcnA:
40.6		 1mehA-1jcnA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP A 274
SER A 275
SER A 276
ASN A 303
GLY A 326
GLY A 415
 MOA  A1332 (-3.5A)
None
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 ( 3.1A)
 0.75A 1mehA-1jr1A:
47.1		 1mehA-1jr1A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo3 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		no annotation 5 SER Y  25
ASN Y  79
ILE Y  80
GLY Y 110
GLU Y   6
 None
 1.08A 1mehA-1lo3Y:
undetectable		 1mehA-1lo3Y:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 ASP A 261
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
None
None
IMP  A 801 (-3.2A)
 1.17A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		6 ASP A 261
ASN A 291
GLY A 316
GLU A 408
GLY A 409
ARG A 414
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.6A)
None
IMP  A 801 ( 3.2A)
None
 1.42A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 ASP A 261
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.3A)
None
IMP  A 801 (-3.2A)
 1.28A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		6 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 (-3.2A)
 1.32A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		7 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
ARG A 414
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 ( 3.2A)
None
 0.85A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 ( 3.2A)
 0.30A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 SER A 263
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
None
None
IMP  A 801 (-3.2A)
 1.26A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 SER A 263
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.3A)
None
IMP  A 801 (-3.2A)
 0.95A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 SER A 160
SER A 161
ILE A  46
GLY A  47
GLY A 183
 None
FAD  A 459 ( 4.0A)
None
FAD  A 459 (-3.3A)
None
 1.27A 1mehA-1lvlA:
undetectable		 1mehA-1lvlA:
24.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP A 261
ASN A 291
GLY A 314
GLU A 408
GLY A 409
ARG A 414
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.1A)
NAD  A 987 ( 4.9A)
XMP  A 602 ( 3.1A)
None
 0.75A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 261
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
None
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 1.16A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 261
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.8A)
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 1.29A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP A 261
ASN A 291
ILE A 313
GLU A 408
GLY A 409
GLU A 431
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 ( 4.9A)
XMP  A 602 ( 3.1A)
NAD  A 987 ( 3.5A)
 1.42A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 407
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 1.35A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
NAD  A 987 ( 4.9A)
XMP  A 602 ( 3.1A)
 0.32A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 263
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
None
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 1.21A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 263
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.8A)
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 0.88A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		5 ASP A 199
ASN A 136
ILE A 111
GLU A 239
GLY A  24
 None
 1.18A 1mehA-1o60A:
5.6		 1mehA-1o60A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASP A  49
SER A  48
ILE A 191
GLY A 165
GLY A  94
 None
ZN  A1502 (-3.2A)
None
None
None
 1.12A 1mehA-1q1nA:
undetectable		 1mehA-1q1nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		5 SER G 195
SER G 214
ILE G 212
GLY G 211
GLY G 226
 None
 1.29A 1mehA-1sgfG:
undetectable		 1mehA-1sgfG:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		5 ASP A 362
ASN A 430
GLY A 409
GLU A 360
GLY A 359
 None
 1.18A 1mehA-1t1eA:
undetectable		 1mehA-1t1eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		5 ASP A 265
ASN A 259
ILE A 258
GLY A 256
GLU A 279
 None
 1.00A 1mehA-1yf2A:
undetectable		 1mehA-1yf2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ASP A 619
ASN A 576
GLY A 494
GLY A 529
GLU A 530
 None
 1.04A 1mehA-1yr2A:
undetectable		 1mehA-1yr2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 SER A 112
SER A  89
ASN A 113
GLY A  21
GLY A  12
 None
None
NAP  A 900 (-3.3A)
None
None
 1.32A 1mehA-1ys4A:
undetectable		 1mehA-1ys4A:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 253
ASN A 282
ILE A 304
GLY A 305
GLY A 392
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-2.9A)
 1.04A 1mehA-1zfjA:
47.4		 1mehA-1zfjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 253
ASN A 282
ILE A 304
GLY A 305
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-3.0A)
 0.62A 1mehA-1zfjA:
47.4		 1mehA-1zfjA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		5 ASN C 147
ILE C 135
GLY C 134
GLU C 139
GLY C 141
 None
 1.15A 1mehA-2bl0C:
undetectable		 1mehA-2bl0C:
14.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 247
ASN A 275
ILE A 295
GLY A 296
GLU A 412
 None
XMP  A1001 ( 4.4A)
None
None
None
 1.13A 1mehA-2cu0A:
46.1		 1mehA-2cu0A:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 247
ASN A 275
ILE A 295
GLY A 296
GLY A 385
 None
XMP  A1001 ( 4.4A)
None
None
XMP  A1001 (-3.1A)
 0.42A 1mehA-2cu0A:
46.1		 1mehA-2cu0A:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0q THIOREDOXIN

(Sulfurisphaera
tokodaii) 		PF00085
(Thioredoxin) 		5 SER A  47
ASN A  44
ILE A  38
GLY A  87
GLY A 115
 None
 1.27A 1mehA-2e0qA:
undetectable		 1mehA-2e0qA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		5 SER A 195
SER A 214
ILE A 212
GLY A 211
GLY A 227
 None
 1.29A 1mehA-2f91A:
undetectable		 1mehA-2f91A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		5 SER A  49
ASN A 148
ILE A 149
GLY A 151
GLY A  54
 None
 1.13A 1mehA-2iy9A:
undetectable		 1mehA-2iy9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Aquifex
aeolicus) 		PF00793
(DAHP_synth_1) 		5 ASP A1182
ASN A1122
ILE A1097
GLU A1222
GLY A1009
 None
None
None
PEP  A1268 ( 4.4A)
None
 1.20A 1mehA-2nxgA:
11.0		 1mehA-2nxgA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		5 SER A 106
SER A 183
ILE A 182
GLU A  50
GLY A  51
 None
FAD  A 415 ( 4.3A)
None
None
None
 1.18A 1mehA-2ok8A:
undetectable		 1mehA-2ok8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Listeria
monocytogenes) 		PF06751
(EutB) 		5 ILE A 357
GLY A 352
GLU A 287
GLY A 289
GLU A 308
 None
 1.29A 1mehA-2qezA:
8.2		 1mehA-2qezA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 SER S 195
SER S 214
ILE S 212
GLY S 211
GLY S 226
 None
 1.30A 1mehA-2wpmS:
undetectable		 1mehA-2wpmS:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASN A 131
ILE A  85
GLY A 500
GLU A 458
GLY A 371
 None
None
BR  A1723 (-3.6A)
GOL  A1726 ( 4.7A)
None
 1.27A 1mehA-2x40A:
5.0		 1mehA-2x40A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 SER A 534
SER A 533
ASN A 596
GLY A 380
GLU A 487
 None
 1.30A 1mehA-3ahiA:
undetectable		 1mehA-3ahiA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ASP A 598
ASN A 555
GLY A 472
GLY A 508
GLU A 509
 None
 1.07A 1mehA-3dduA:
undetectable		 1mehA-3dduA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		5 SER A 110
GLY A  77
GLU A 204
GLY A 112
ARG A 205
 None
 1.30A 1mehA-3dh3A:
undetectable		 1mehA-3dh3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr8 YNCA

(Salmonella
enterica) 		PF13420
(Acetyltransf_4) 		5 SER A 122
ASN A 124
ILE A 120
GLY A 119
GLY A 146
 None
ACO  A1423 (-3.3A)
ACO  A1423 ( 4.3A)
ACT  A1428 (-3.4A)
None
 1.17A 1mehA-3dr8A:
undetectable		 1mehA-3dr8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 SER A 134
ASN A 133
ILE A 132
GLY A 145
GLU A  52
 None
 1.29A 1mehA-3e57A:
undetectable		 1mehA-3e57A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASP A 266
ILE A 269
GLY A 294
GLU A 298
GLY A 317
 None
 1.29A 1mehA-3fhhA:
undetectable		 1mehA-3fhhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		5 ASP A 232
SER A 341
ILE A  95
GLY A 192
GLU A 229
 None
 1.13A 1mehA-3foaA:
undetectable		 1mehA-3foaA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 SER A 106
SER A  83
ASN A 107
GLY A  16
GLY A   7
 None
 1.32A 1mehA-3hskA:
undetectable		 1mehA-3hskA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 ASP U 232
SER U 341
ILE U  95
GLY U 192
GLU U 229
 None
 1.12A 1mehA-3j2nU:
undetectable		 1mehA-3j2nU:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ASP A 582
ASN A 539
GLY A 457
GLY A 492
GLU A 493
 None
 1.03A 1mehA-3muoA:
undetectable		 1mehA-3muoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7k BOTULINUM NEUROTOXIN
TYPE C1

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 ASP A1212
SER A1234
ASN A1240
ILE A1241
GLY A1243
 None
 1.27A 1mehA-3n7kA:
undetectable		 1mehA-3n7kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		5 SER A 236
SER A 235
GLY A 244
GLU A 239
GLY A 231
 None
 1.27A 1mehA-3nzqA:
8.6		 1mehA-3nzqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		5 SER A 221
SER A 222
ASN A 223
GLY A 268
ARG A 267
 None
 1.32A 1mehA-3ojaA:
undetectable		 1mehA-3ojaA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ILE A  62
GLY A  63
GLU A  30
GLY A  29
GLU A  28
 None
 1.15A 1mehA-3rlfA:
undetectable		 1mehA-3rlfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 SER A 251
ASN A 252
ILE A 157
GLY A 158
GLY A 291
 TAU  A 501 (-2.6A)
None
None
TAU  A 501 ( 4.3A)
None
 1.18A 1mehA-3v39A:
undetectable		 1mehA-3v39A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 ASN A 496
ILE A 494
GLY A 271
GLU A 472
GLY A 244
 None
 1.14A 1mehA-3welA:
4.7		 1mehA-3welA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP B 288
SER B 289
SER B 290
ASN B 317
GLY B 340
GLY B 429
 MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 ( 3.3A)
 0.32A 1mehA-4af0B:
47.2		 1mehA-4af0B:
33.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		5 ILE A  37
GLY A  33
GLU A 106
GLY A  55
GLU A  51
 None
None
None
None
FAD  A1552 (-2.5A)
 1.01A 1mehA-4ap3A:
undetectable		 1mehA-4ap3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		5 SER A 302
ASN A 300
GLY A 195
ARG A 238
GLU A 211
 None
None
None
None
ZN  A 500 (-2.2A)
 1.31A 1mehA-4binA:
undetectable		 1mehA-4binA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		5 SER A 362
SER A 381
ILE A 379
GLY A 378
GLY A 393
 0GJ  A1411 (-1.4A)
None
None
None
0GJ  A1411 (-3.3A)
 1.24A 1mehA-4bxwA:
undetectable		 1mehA-4bxwA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		5 SER A 285
SER A 304
ILE A 324
GLY A 323
GLY A 416
 None
 1.21A 1mehA-4c60A:
3.8		 1mehA-4c60A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		5 ASP A 345
ILE A 368
GLY A 369
GLY A 360
GLU A 358
 K  A1007 (-4.2A)
BAT  A1000 ( 4.4A)
NA  A1003 ( 4.9A)
None
NA  A1003 ( 3.9A)
 1.31A 1mehA-4dd8A:
undetectable		 1mehA-4dd8A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 SER A 264
ASN A 267
GLY A 317
GLU A 296
GLY A 259
 None
 1.31A 1mehA-4fnvA:
undetectable		 1mehA-4fnvA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASP A 250
SER A 251
SER A 252
ILE A 301
GLY A 302
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
 0.82A 1mehA-4fxsA:
48.3		 1mehA-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.2A)
 0.47A 1mehA-4fxsA:
48.3		 1mehA-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 252
ASN A 279
ILE A 301
GLY A 302
GLY A 418
 MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.3A)
 1.29A 1mehA-4fxsA:
48.3		 1mehA-4fxsA:
36.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 SER A 185
ILE A 188
GLY A 241
GLY A 178
GLU A 244
 None
 1.07A 1mehA-4hdsA:
undetectable		 1mehA-4hdsA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		6 ASP A 250
SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
 None
None
None
IMP  A 501 ( 4.4A)
None
None
 0.80A 1mehA-4ix2A:
44.4		 1mehA-4ix2A:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		PF00793
(DAHP_synth_1) 		5 ASP A 203
ASN A 142
ILE A 117
GLU A 243
GLY A  30
 None
 1.25A 1mehA-4lu0A:
7.3		 1mehA-4lu0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		5 ASP A 442
GLY A 383
GLU A 456
GLY A 439
ARG A 457
 None
 1.21A 1mehA-4mh1A:
undetectable		 1mehA-4mh1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		5 ASP A 244
SER A 245
ILE A 295
GLY A 296
GLY A 385
 None
None
None
None
IMP  A 500 ( 3.3A)
 0.82A 1mehA-4mz1A:
48.4		 1mehA-4mz1A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		5 SER A 245
ASN A 273
ILE A 295
GLY A 296
GLY A 385
 None
IMP  A 500 ( 4.1A)
None
None
IMP  A 500 ( 3.3A)
 0.51A 1mehA-4mz1A:
48.4		 1mehA-4mz1A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ASN A 900
ILE A 909
GLY A 981
GLU A1003
GLY A1008
 None
 1.20A 1mehA-4rcnA:
undetectable		 1mehA-4rcnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF13407
(Peripla_BP_4) 		5 ASP A 115
ASN A 132
ILE A 167
GLY A 166
GLY A  93
 RIP  A 401 (-2.8A)
None
None
None
CL  A 402 (-3.5A)
 1.00A 1mehA-4ry0A:
undetectable		 1mehA-4ry0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 SER A 144
ASN A 142
GLY A 147
GLY A 187
GLU A 192
 None
 1.28A 1mehA-4xriA:
undetectable		 1mehA-4xriA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F

(Staphylococcus
aureus) 		PF01370
(Epimerase) 		5 ASN A 277
ILE A 278
GLY A 260
GLU A 340
GLY A 282
 3IT  A 402 ( 4.2A)
None
None
None
None
 1.21A 1mehA-4yrdA:
undetectable		 1mehA-4yrdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Helicobacter
pylori) 		PF00793
(DAHP_synth_1) 		5 ASP A 201
ASN A 128
ILE A 103
GLU A 241
GLY A  16
 None
 1.29A 1mehA-4z1aA:
11.0		 1mehA-4z1aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ASP A 103
ILE A 531
GLY A 534
GLU A 542
ARG A 219
 None
 1.25A 1mehA-5a8rA:
undetectable		 1mehA-5a8rA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		5 SER G 278
ASN G 281
GLY G 342
GLY G 254
GLU G 377
 PO4  G 501 (-2.0A)
None
PO4  G 501 ( 4.6A)
None
None
 1.31A 1mehA-5b04G:
undetectable		 1mehA-5b04G:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 SER A 110
SER A  87
ASN A 111
GLY A  19
GLY A  10
 None
 1.15A 1mehA-5cefA:
undetectable		 1mehA-5cefA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A  88
GLY A  35
GLU A  29
GLY A  30
ARG A  83
 None
 1.24A 1mehA-5cniA:
undetectable		 1mehA-5cniA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		5 SER A 164
ASN A 163
ILE A 162
GLY A 194
GLY A 200
 None
None
PLP  A 402 ( 4.8A)
PLP  A 402 (-3.5A)
None
 1.06A 1mehA-5cvcA:
undetectable		 1mehA-5cvcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i99 CONTACTIN-3

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		5 ASP A 623
SER A 626
ILE A 681
GLY A 682
GLU A 620
 None
 1.27A 1mehA-5i99A:
undetectable		 1mehA-5i99A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ILE A  88
GLY A  35
GLU A  29
GLY A  30
ARG A  83
 None
 1.11A 1mehA-5kznA:
undetectable		 1mehA-5kznA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		5 ASP B 118
SER B 117
ILE B 134
GLY B 123
GLY B 263
 None
None
None
EDO  B 715 (-3.4A)
None
 1.30A 1mehA-5lxzB:
undetectable		 1mehA-5lxzB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nen LIPASE C

(Serratia
marcescens) 		no annotation 5 ASP A 213
SER A 210
SER A 211
ASN A 209
ARG A 218
 None
 1.32A 1mehA-5nenA:
undetectable		 1mehA-5nenA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 ASP A 606
ASN A 563
GLY A 480
GLY A 516
GLU A 517
 None
 0.98A 1mehA-5o3wA:
undetectable		 1mehA-5o3wA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Aspergillus
fumigatus) 		PF01487
(DHquinase_I) 		5 ASP A1131
ILE A1095
GLY A1094
GLY A1127
ARG A1121
 None
 1.08A 1mehA-5swuA:
4.5		 1mehA-5swuA:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		6 ASP A 277
SER A 278
SER A 279
ASN A 306
GLY A 329
GLY A 418
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-3.1A)
 0.56A 1mehA-5tc3A:
45.0		 1mehA-5tc3A:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 5 SER B 195
SER B 214
ILE B 212
GLY B 211
GLY B 226
 SO4  B 304 ( 2.5A)
None
None
None
BEN  B 301 (-3.1A)
 1.29A 1mehA-6b74B:
undetectable		 1mehA-6b74B:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bng 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Acinetobacter
baumannii) 		no annotation 5 ASP A 201
ASN A 140
ILE A 115
GLU A 241
GLY A  28
 None
 1.21A 1mehA-6bngA:
5.6		 1mehA-6bngA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k CYTOCHROME C FAMILY
PROTEIN
FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 5 SER A 127
ASN A 131
ILE A 200
GLY A 199
GLU B 963
 HEC  A 302 (-2.5A)
HEC  A 302 (-2.7A)
HEC  A 302 (-3.4A)
None
None
 1.29A 1mehA-6f0kA:
undetectable		 1mehA-6f0kA:
9.57