SIMILAR PATTERNS OF AMINO ACIDS FOR 1ME7_A_MOAA600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dot DUCK OVOTRANSFERRIN

(Anas
platyrhynchos)
PF00405
(Transferrin)
4 SER A 517
SER A 516
GLY A 491
GLY A 504
None
0.73A 1me7A-1dotA:
undetectable
1me7A-1dotA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE


(Borreliella
burgdorferi)
PF00478
(IMPDH)
5 ASP A 172
SER A 173
ASN A 201
ILE A 223
GLY A 224
None
0.81A 1me7A-1eepA:
44.3
1me7A-1eepA:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE


(Escherichia
coli)
PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb)
4 SER A  85
ILE A 558
GLY A 557
GLY A  44
FAD  A 600 (-2.5A)
None
None
None
0.72A 1me7A-1f0xA:
undetectable
1me7A-1f0xA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE


(Sus scrofa)
PF00342
(PGI)
4 ASN A 507
ILE A 506
GLY A 501
GLY A 354
None
0.79A 1me7A-1gzvA:
undetectable
1me7A-1gzvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq7 OVOTRANSFERRIN

(Gallus gallus)
PF00405
(Transferrin)
4 SER A 517
SER A 516
GLY A 491
GLY A 504
None
0.77A 1me7A-1iq7A:
undetectable
1me7A-1iq7A:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I


(Homo sapiens)
PF00478
(IMPDH)
PF00571
(CBS)
5 ASP A 274
SER A 275
SER A 276
ASN A 303
GLY A 326
None
None
None
CPR  A 631 ( 4.5A)
None
0.35A 1me7A-1jcnA:
40.6
1me7A-1jcnA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2


(Cricetulus
griseus)
PF00478
(IMPDH)
PF00571
(CBS)
6 ASP A 274
SER A 275
ASN A 303
GLY A 326
CYH A 331
GLY A 415
MOA  A1332 (-3.5A)
None
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
IMP  A1331 ( 3.1A)
0.79A 1me7A-1jr1A:
48.8
1me7A-1jr1A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2


(Cricetulus
griseus)
PF00478
(IMPDH)
PF00571
(CBS)
6 ASP A 274
SER A 276
ASN A 303
GLY A 326
CYH A 331
GLY A 415
MOA  A1332 (-3.5A)
MOA  A1332 (-2.6A)
MOA  A1332 (-3.7A)
MOA  A1332 ( 3.5A)
IMP  A1331 (-1.7A)
IMP  A1331 ( 3.1A)
0.48A 1me7A-1jr1A:
48.8
1me7A-1jr1A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgb LACTOTRANSFERRIN (N2
FRAGMENT)


(Homo sapiens)
PF00405
(Transferrin)
4 SER C 185
SER C 184
GLY C 160
GLY C 175
None
0.69A 1me7A-1lgbC:
undetectable
1me7A-1lgbC:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo3 IG GAMMA 2A HEAVY
CHAIN


(Mus musculus)
no annotation 4 SER Y  25
ASN Y  79
ILE Y  80
GLY Y 110
None
0.67A 1me7A-1lo3Y:
undetectable
1me7A-1lo3Y:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
7 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLY A 409
TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
0.33A 1me7A-1lrtA:
57.8
1me7A-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
6 SER A 262
SER A 263
ILE A 313
GLY A 314
CYH A 319
GLY A 409
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
0.60A 1me7A-1lrtA:
57.8
1me7A-1lrtA:
74.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00266
(Aminotran_5)
4 ASP A 167
ILE A 175
GLY A 174
CYH A 194
PLP  A4401 (-2.9A)
None
None
None
0.54A 1me7A-1m32A:
undetectable
1me7A-1m32A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
PF00571
(CBS)
4 ASP A 261
ASN A 291
GLY A 315
GLY A 407
NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
None
XMP  A 602 (-3.3A)
0.66A 1me7A-1mewA:
61.3
1me7A-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
PF00571
(CBS)
7 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLY A 409
NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
XMP  A 602 ( 3.1A)
0.18A 1me7A-1mewA:
61.3
1me7A-1mewA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prt PERTUSSIS TOXIN
(SUBUNIT S1)


(Bordetella
pertussis)
PF02917
(Pertussis_S1)
4 SER A  40
ILE A 187
GLY A 189
GLY A 199
None
0.61A 1me7A-1prtA:
undetectable
1me7A-1prtA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlc POSTSYNAPTIC DENSITY
PROTEIN 95


(Rattus
norvegicus)
PF00595
(PDZ)
4 SER A 173
ILE A 208
GLY A 209
GLY A 176
None
0.76A 1me7A-1qlcA:
undetectable
1me7A-1qlcA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus)
PF00328
(His_Phos_2)
4 ASP A 311
ASN A 184
GLY A 190
GLY A 293
None
NAG  A 503 ( 1.8A)
None
None
0.78A 1me7A-1skaA:
undetectable
1me7A-1skaA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
5 ASN A 282
ILE A 304
GLY A 305
CYH A 310
GLY A 394
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 ( 3.2A)
IMP  A 500 (-3.0A)
0.43A 1me7A-1zfjA:
49.4
1me7A-1zfjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
5 ASP A 253
ILE A 304
GLY A 305
CYH A 310
GLY A 394
IMP  A 500 ( 4.7A)
None
None
IMP  A 500 ( 3.2A)
IMP  A 500 (-3.0A)
0.62A 1me7A-1zfjA:
49.4
1me7A-1zfjA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens)
PF00478
(IMPDH)
4 ASN A 158
ILE A 180
GLY A 181
CYH A 186
IMP  A1338 ( 4.3A)
None
None
IMP  A1338 (-2.5A)
0.37A 1me7A-2bznA:
38.0
1me7A-2bznA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens)
PF00478
(IMPDH)
4 ASP A 129
ILE A 180
GLY A 181
CYH A 186
None
None
None
IMP  A1338 (-2.5A)
0.63A 1me7A-2bznA:
38.0
1me7A-2bznA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE


(Bacillus firmus)
PF13091
(PLDc_2)
4 ASP A 209
ILE A 202
GLY A 343
GLY A 339
None
0.68A 1me7A-2c1lA:
undetectable
1me7A-2c1lA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Pyrococcus
horikoshii)
PF00478
(IMPDH)
PF00571
(CBS)
6 ASP A 247
ASN A 275
ILE A 295
GLY A 296
CYH A 301
GLY A 385
None
XMP  A1001 ( 4.4A)
None
None
XMP  A1001 (-2.6A)
XMP  A1001 (-3.1A)
0.45A 1me7A-2cu0A:
48.0
1me7A-2cu0A:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE


(Mus musculus)
PF00342
(PGI)
4 ASN A 508
ILE A 507
GLY A 502
GLY A 355
None
0.75A 1me7A-2cxnA:
undetectable
1me7A-2cxnA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqi LYSOZYME BINDING IG
KAPPA CHAIN V23-J2
REGION


(Mus musculus)
PF07686
(V-set)
4 ASN L  32
ILE L  29
GLY L  68
GLY L  64
None
0.73A 1me7A-2dqiL:
undetectable
1me7A-2dqiL:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eiz ANTI-LYSOZYME
ANTIBODY FV REGION


(Homo sapiens)
PF07686
(V-set)
4 ASN A  32
ILE A  29
GLY A  68
GLY A  64
None
0.78A 1me7A-2eizA:
undetectable
1me7A-2eizA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 SER A 106
ASN A 148
GLY A 332
GLY A  17
None
0.63A 1me7A-2ep5A:
undetectable
1me7A-2ep5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe5 PRESYNAPTIC PROTEIN
SAP102


(Homo sapiens)
PF00595
(PDZ)
4 SER A 239
ILE A 274
GLY A 275
GLY A 242
None
0.71A 1me7A-2fe5A:
undetectable
1me7A-2fe5A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli)
PF00082
(Peptidase_S8)
4 SER A  49
ILE A 149
GLY A 151
GLY A  54
None
0.70A 1me7A-2iy9A:
undetectable
1me7A-2iy9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4h MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00595
(PDZ)
4 SER A  18
ILE A  48
GLY A  49
GLY A  21
None
HIS  A  91 (-4.0A)
None
None
0.72A 1me7A-2r4hA:
undetectable
1me7A-2r4hA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus)
PF06849
(DUF1246)
PF06973
(DUF1297)
4 SER A  12
ILE A  16
GLY A 313
GLY A 291
None
0.78A 1me7A-2r87A:
undetectable
1me7A-2r87A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II


(Streptococcus
pneumoniae)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 SER A 194
ILE A 112
GLY A 111
GLY A 234
None
0.72A 1me7A-2rjtA:
undetectable
1me7A-2rjtA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4)
PF01771
(Herpes_alk_exo)
4 SER A 129
SER A 128
ILE A 126
GLY A 125
None
0.77A 1me7A-2w45A:
undetectable
1me7A-2w45A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 SER A 311
ILE A 298
GLY A 294
GLY A 288
None
0.73A 1me7A-3ddrA:
undetectable
1me7A-3ddrA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli)
PF00884
(Sulfatase)
4 SER A 111
ILE A 423
GLY A 422
GLY A 108
None
0.68A 1me7A-3ed4A:
undetectable
1me7A-3ed4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN


(Streptococcus
agalactiae)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 ASP A1079
ASN A1099
ILE A1148
GLY A1073
None
0.71A 1me7A-3fawA:
4.9
1me7A-3fawA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
4 ASP A  36
ILE A 265
GLY A 264
GLY A 231
ATP  A 301 (-2.5A)
None
None
ATP  A 301 (-3.5A)
0.58A 1me7A-3h1qA:
undetectable
1me7A-3h1qA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR


(Homo sapiens)
PF00079
(Serpin)
4 SER A 382
ILE A 380
GLY A 379
GLY A 252
None
0.69A 1me7A-3h5cA:
undetectable
1me7A-3h5cA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE


(Cryptosporidium
parvum)
PF00478
(IMPDH)
4 SER A 164
ASN A 191
ILE A 213
GLY A 214
None
IMP  A 801 ( 4.2A)
None
None
0.54A 1me7A-3khjA:
42.4
1me7A-3khjA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1


(Streptococcus
pyogenes)
PF01791
(DeoC)
4 SER A  21
ILE A  19
GLY A  18
GLY A  85
None
0.78A 1me7A-3myoA:
4.9
1me7A-3myoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens)
PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light)
4 SER A 595
ILE A 612
GLY A 611
GLY A 626
None
0.78A 1me7A-3nxpA:
undetectable
1me7A-3nxpA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
4 SER A 193
ILE A 207
GLY A 206
GLY A 222
None
0.76A 1me7A-3pv4A:
undetectable
1me7A-3pv4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum)
PF00491
(Arginase)
4 ASP A 325
SER A 326
ILE A 291
GLY A 219
MN  A 412 ( 2.0A)
None
None
None
0.76A 1me7A-3sl1A:
undetectable
1me7A-3sl1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN


(Rhodobacteraceae
bacterium KLH11)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 SER A  28
ILE A 107
GLY A 108
GLY A  80
None
0.74A 1me7A-3sszA:
2.9
1me7A-3sszA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN


(Bacillus virus
phi29)
PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3)
4 SER A 491
ASN A 519
ILE A 518
GLY A 468
None
0.72A 1me7A-3sucA:
undetectable
1me7A-3sucA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE


(Sinorhizobium
meliloti)
PF01663
(Phosphodiest)
4 ASP A 131
ILE A 166
GLY A 165
GLY A 138
None
0.68A 1me7A-3t02A:
undetectable
1me7A-3t02A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqf HPR(SER) KINASE

(Coxiella
burnetii)
PF07475
(Hpr_kinase_C)
4 ASP A  57
ILE A  86
GLY A  85
GLY A  39
None
None
None
PO4  A 201 (-3.4A)
0.63A 1me7A-3tqfA:
undetectable
1me7A-3tqfA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
4 ASN A 280
GLY A 303
CYH A 308
GLY A 390
XMP  A 500 ( 4.4A)
None
XMP  A 500 (-3.3A)
XMP  A 500 (-3.2A)
0.75A 1me7A-3tsdA:
45.4
1me7A-3tsdA:
34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
4 ASN A 280
ILE A 302
GLY A 303
CYH A 308
XMP  A 500 ( 4.4A)
None
None
XMP  A 500 (-3.3A)
0.43A 1me7A-3tsdA:
45.4
1me7A-3tsdA:
34.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
4 ASN B 397
ILE B 396
GLY B  62
GLY B 422
None
None
None
SO4  B1195 (-3.3A)
0.77A 1me7A-3v0aB:
undetectable
1me7A-3v0aB:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Cryptococcus
neoformans)
PF00478
(IMPDH)
PF00571
(CBS)
7 ASP B 288
SER B 289
SER B 290
ASN B 317
GLY B 340
CYH B 345
GLY B 429
MOA  B1526 (-3.3A)
MOA  B1526 (-3.9A)
MOA  B1526 (-2.6A)
MOA  B1526 ( 3.6A)
MOA  B1526 (-4.0A)
IMP  B1527 (-3.3A)
IMP  B1527 ( 3.3A)
0.46A 1me7A-4af0B:
47.8
1me7A-4af0B:
33.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB


(Pyrococcus
horikoshii)
PF01139
(RtcB)
4 SER A  88
SER A 270
ILE A 256
GLY A  85
None
0.56A 1me7A-4dwqA:
undetectable
1me7A-4dwqA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezg PUTATIVE
UNCHARACTERIZED
PROTEIN


(Listeria
monocytogenes)
no annotation 4 ASP A 146
ILE A 177
GLY A 175
GLY A 125
None
0.79A 1me7A-4ezgA:
undetectable
1me7A-4ezgA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL


(Homo sapiens)
PF05292
(MCD)
PF17408
(MCD_N)
4 SER A 381
SER A 382
ILE A 444
GLY A 443
None
0.77A 1me7A-4f0xA:
undetectable
1me7A-4f0xA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
PF00571
(CBS)
4 ASN A 279
ILE A 301
GLY A 302
GLY A 389
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.1A)
0.78A 1me7A-4fxsA:
50.2
1me7A-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
PF00571
(CBS)
4 ASP A 250
SER A 251
SER A 252
CYH A 307
MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
IMP  A 701 (-3.0A)
0.67A 1me7A-4fxsA:
50.2
1me7A-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
PF00571
(CBS)
7 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
CYH A 307
GLY A 391
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
IMP  A 701 (-3.2A)
0.52A 1me7A-4fxsA:
50.2
1me7A-4fxsA:
36.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE


(Vitis vinifera)
PF00701
(DHDPS)
4 ASP A  59
ILE A 302
GLY A 303
GLY A 309
None
0.74A 1me7A-4hnnA:
4.2
1me7A-4hnnA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
6 ASP A 250
SER A 251
SER A 252
ILE A 301
GLY A 302
CYH A 307
None
None
None
None
None
IMP  A 501 (-4.9A)
0.85A 1me7A-4ix2A:
45.7
1me7A-4ix2A:
31.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Vibrio cholerae)
PF00478
(IMPDH)
6 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
CYH A 307
None
None
IMP  A 501 ( 4.4A)
None
None
IMP  A 501 (-4.9A)
0.61A 1me7A-4ix2A:
45.7
1me7A-4ix2A:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida)
PF05544
(Pro_racemase)
4 ASP A 293
SER A 294
ILE A   4
GLY A  22
None
0.71A 1me7A-4jbdA:
undetectable
1me7A-4jbdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1


(Aspergillus
fumigatus)
PF00432
(Prenyltrans)
PF01239
(PPTA)
4 SER B 346
ILE A 327
GLY B 354
GLY B 373
None
0.70A 1me7A-4mbgB:
undetectable
1me7A-4mbgB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Campylobacter
jejuni)
PF00478
(IMPDH)
5 ASP A 244
SER A 245
ILE A 295
CYH A 301
GLY A 385
None
None
None
IMP  A 500 ( 3.1A)
IMP  A 500 ( 3.3A)
0.82A 1me7A-4mz1A:
50.2
1me7A-4mz1A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Campylobacter
jejuni)
PF00478
(IMPDH)
6 SER A 245
ASN A 273
ILE A 295
GLY A 296
CYH A 301
GLY A 385
None
IMP  A 500 ( 4.1A)
None
None
IMP  A 500 ( 3.1A)
IMP  A 500 ( 3.3A)
0.49A 1me7A-4mz1A:
50.2
1me7A-4mz1A:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF13229
(Beta_helix)
4 ASP A 331
SER A 357
ILE A 381
GLY A 334
MLY  A 356 ( 3.5A)
MLY  A 356 ( 4.6A)
None
None
0.78A 1me7A-4ozyA:
undetectable
1me7A-4ozyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima)
PF05343
(Peptidase_M42)
4 ASP A 220
ILE A  64
GLY A  83
GLY A 280
None
0.74A 1me7A-4p6yA:
undetectable
1me7A-4p6yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR


(Gallus gallus)
PF13516
(LRR_6)
4 ASP A  65
GLY A 116
CYH A 147
GLY A 124
None
0.74A 1me7A-4perA:
undetectable
1me7A-4perA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR


(Gallus gallus)
PF13516
(LRR_6)
4 ASP A 179
GLY A 230
CYH A 261
GLY A 238
None
0.71A 1me7A-4perA:
undetectable
1me7A-4perA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae)
PF01095
(Pectinesterase)
4 ASP A 250
SER A 249
GLY A 223
GLY A 174
None
0.68A 1me7A-4pmhA:
undetectable
1me7A-4pmhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 ASN H  52
ILE H  51
GLY H  50
GLY H  95
None
0.78A 1me7A-4qexH:
undetectable
1me7A-4qexH:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE


(Pseudomonas
putida)
PF00171
(Aldedh)
4 ILE A 328
GLY A 325
CYH A 368
GLY A 370
None
0.74A 1me7A-4qyjA:
undetectable
1me7A-4qyjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN


(Haemophilus
influenzae)
PF05860
(Haemagg_act)
4 SER A 410
ASN A 438
GLY A 442
GLY A 388
None
0.73A 1me7A-4rt6A:
undetectable
1me7A-4rt6A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE


(Megavirus
chiliensis)
PF02719
(Polysacc_synt_2)
4 SER A 302
SER A 303
ILE A 307
GLY A 169
None
None
None
NDP  A 400 (-4.8A)
0.68A 1me7A-4tqgA:
undetectable
1me7A-4tqgA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa0 POSSIBLE ADHESIN

(Caldicellulosiruptor
kronotskyensis)
no annotation 4 ASP A 473
SER A 477
ILE A 508
GLY A 497
MG  A 601 (-3.3A)
None
None
None
0.68A 1me7A-4wa0A:
undetectable
1me7A-4wa0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE


(Colias
eurytheme)
PF00342
(PGI)
4 ASN A 511
ILE A 510
GLY A 505
GLY A 358
None
0.75A 1me7A-4wmjA:
undetectable
1me7A-4wmjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wss HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 ASP A 109
SER A  77
ILE A 301
GLY A 302
None
0.72A 1me7A-4wssA:
undetectable
1me7A-4wssA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st)
PF00091
(Tubulin)
4 ASP A  39
ILE A 104
GLY A 103
GLY A  59
None
0.74A 1me7A-4xcqA:
undetectable
1me7A-4xcqA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE


(Eremothecium
gossypii)
PF00478
(IMPDH)
4 ASP A 277
SER A 278
SER A 279
ASN A 306
None
0.29A 1me7A-4xwuA:
38.6
1me7A-4xwuA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvd PLEIOTROPIC
REGULATOR 1


(Homo sapiens)
PF00400
(WD40)
5 SER A 263
ILE A 228
GLY A 222
CYH A 209
GLY A 293
None
None
None
None
NA  A 601 (-3.6A)
1.31A 1me7A-4yvdA:
undetectable
1me7A-4yvdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA


(Escherichia
coli)
PF07690
(MFS_1)
4 SER A 118
ILE A 117
GLY A  64
GLY A  32
None
0.78A 1me7A-4zowA:
undetectable
1me7A-4zowA:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00478
(IMPDH)
5 ASN A 276
ILE A 298
GLY A 299
CYH A 304
GLY A 388
IMP  A 501 ( 4.3A)
None
None
IMP  A 501 (-3.0A)
IMP  A 501 (-3.1A)
0.43A 1me7A-5ahmA:
49.9
1me7A-5ahmA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus)
PF01764
(Lipase_3)
PF03893
(Lipase3_N)
4 SER A  17
ILE A 265
GLY A 266
GLY A  65
None
0.68A 1me7A-5ap9A:
undetectable
1me7A-5ap9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE


(Bacillus
subtilis)
PF09819
(ABC_cobalt)
4 SER A 127
ILE A  91
GLY A  92
GLY A 120
None
VIB  A 201 ( 4.2A)
VIB  A 201 ( 4.6A)
None
0.73A 1me7A-5edlA:
undetectable
1me7A-5edlA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8o HMM5 ANTIBODY LIGHT
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 ASN L  99
ILE L  98
GLY L  96
GLY L  31
None
0.71A 1me7A-5i8oL:
undetectable
1me7A-5i8oL:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iai SUGAR ABC
TRANSPORTER


(Agrobacterium
tumefaciens)
PF01547
(SBP_bac_1)
4 ASP A 209
ILE A 255
GLY A 253
GLY A 260
None
0.73A 1me7A-5iaiA:
undetectable
1me7A-5iaiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8j HISTONE DEACETYLASE
HDA1


(Saccharomyces
cerevisiae)
PF09757
(Arb2)
4 ASP A 511
SER A 510
ASN A 533
GLY A 594
None
0.79A 1me7A-5j8jA:
undetectable
1me7A-5j8jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgy FAD:PROTEIN FMN
TRANSFERASE


(Pseudomonas
stutzeri)
no annotation 4 ASP H 121
SER H 120
ILE H 320
GLY H 319
None
0.66A 1me7A-5mgyH:
undetectable
1me7A-5mgyH:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15


(Thermobia
domestica)
no annotation 4 ASN A 164
ILE A  92
GLY A  93
GLY A   2
None
0.79A 1me7A-5mszA:
undetectable
1me7A-5mszA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
4 ASN A 413
ILE A 342
GLY A 343
GLY A 386
None
0.73A 1me7A-5ngkA:
7.5
1me7A-5ngkA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE


(Mycolicibacterium
thermoresistibile)
no annotation 4 ASN A 173
GLY A 196
CYH A 201
GLY A 285
AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
AUN  A 401 ( 3.2A)
0.34A 1me7A-5ou3A:
47.0
1me7A-5ou3A:
10.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Eremothecium
gossypii)
PF00478
(IMPDH)
PF00571
(CBS)
6 ASP A 277
SER A 278
SER A 279
ASN A 306
GLY A 329
GLY A 418
None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-3.1A)
0.59A 1me7A-5tc3A:
46.8
1me7A-5tc3A:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Listeria
monocytogenes)
PF00478
(IMPDH)
5 ASN A 280
ILE A 302
GLY A 303
CYH A 308
GLY A 392
IMP  A 500 ( 4.3A)
None
None
IMP  A 500 (-3.2A)
IMP  A 500 ( 3.3A)
0.41A 1me7A-5upyA:
46.8
1me7A-5upyA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Listeria
monocytogenes)
PF00478
(IMPDH)
4 ASN A 280
ILE A 302
GLY A 303
GLY A 390
IMP  A 500 ( 4.3A)
None
None
IMP  A 500 (-3.2A)
0.78A 1me7A-5upyA:
46.8
1me7A-5upyA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Listeria
monocytogenes)
PF00478
(IMPDH)
4 ASP A 251
ILE A 302
GLY A 303
CYH A 308
None
None
None
IMP  A 500 (-3.2A)
0.74A 1me7A-5upyA:
46.8
1me7A-5upyA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
5 ASN A 280
ILE A 302
GLY A 303
CYH A 308
GLY A 392
IMP  A 501 (-4.1A)
None
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
IMP  A 501 ( 3.2A)
0.38A 1me7A-5uuwA:
47.3
1me7A-5uuwA:
29.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE


(Clostridium
perfringens)
PF00478
(IMPDH)
5 ASN A 275
ILE A 297
GLY A 298
CYH A 303
GLY A 387
IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
IMP  A 500 ( 3.1A)
0.45A 1me7A-5uzeA:
48.2
1me7A-5uzeA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum)
no annotation 4 ASP A 232
ILE A 271
GLY A 270
GLY A  75
None
0.77A 1me7A-5z5cA:
undetectable
1me7A-5z5cA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'
V-TYPE PROTON ATPASE
SUBUNIT C''


(Saccharomyces
cerevisiae)
no annotation 4 ASP D 121
SER D  41
GLY C 167
GLY D  47
None
0.77A 1me7A-6c6lD:
undetectable
1me7A-6c6lD:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger)
no annotation 4 ASP A 238
SER A 235
GLY A 231
GLY A 223
None
0.75A 1me7A-6frvA:
undetectable
1me7A-6frvA:
11.33