SIMILAR PATTERNS OF AMINO ACIDS FOR 1ME7_A_MOAA600_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dot | DUCK OVOTRANSFERRIN (Anasplatyrhynchos) |
PF00405(Transferrin) | 4 | SER A 517SER A 516GLY A 491GLY A 504 | None | 0.73A | 1me7A-1dotA:undetectable | 1me7A-1dotA:20.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1eep | INOSINE5'-MONOPHOSPHATEDEHYDROGENASE (Borreliellaburgdorferi) |
PF00478(IMPDH) | 5 | ASP A 172SER A 173ASN A 201ILE A 223GLY A 224 | None | 0.81A | 1me7A-1eepA:44.3 | 1me7A-1eepA:33.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0x | D-LACTATEDEHYDROGENASE (Escherichiacoli) |
PF01565(FAD_binding_4)PF09330(Lact-deh-memb) | 4 | SER A 85ILE A 558GLY A 557GLY A 44 | FAD A 600 (-2.5A)NoneNoneNone | 0.72A | 1me7A-1f0xA:undetectable | 1me7A-1f0xA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzv | GLUCOSE-6-PHOSPHATEISOMERASE (Sus scrofa) |
PF00342(PGI) | 4 | ASN A 507ILE A 506GLY A 501GLY A 354 | None | 0.79A | 1me7A-1gzvA:undetectable | 1me7A-1gzvA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iq7 | OVOTRANSFERRIN (Gallus gallus) |
PF00405(Transferrin) | 4 | SER A 517SER A 516GLY A 491GLY A 504 | None | 0.77A | 1me7A-1iq7A:undetectable | 1me7A-1iq7A:20.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jcn | INOSINEMONOPHOSPHATEDEHYDROGENASE I (Homo sapiens) |
PF00478(IMPDH)PF00571(CBS) | 5 | ASP A 274SER A 275SER A 276ASN A 303GLY A 326 | NoneNoneNoneCPR A 631 ( 4.5A)None | 0.35A | 1me7A-1jcnA:40.6 | 1me7A-1jcnA:35.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jr1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (Cricetulusgriseus) |
PF00478(IMPDH)PF00571(CBS) | 6 | ASP A 274SER A 275ASN A 303GLY A 326CYH A 331GLY A 415 | MOA A1332 (-3.5A)NoneMOA A1332 (-3.7A)MOA A1332 ( 3.5A)IMP A1331 (-1.7A)IMP A1331 ( 3.1A) | 0.79A | 1me7A-1jr1A:48.8 | 1me7A-1jr1A:32.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jr1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (Cricetulusgriseus) |
PF00478(IMPDH)PF00571(CBS) | 6 | ASP A 274SER A 276ASN A 303GLY A 326CYH A 331GLY A 415 | MOA A1332 (-3.5A)MOA A1332 (-2.6A)MOA A1332 (-3.7A)MOA A1332 ( 3.5A)IMP A1331 (-1.7A)IMP A1331 ( 3.1A) | 0.48A | 1me7A-1jr1A:48.8 | 1me7A-1jr1A:32.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lgb | LACTOTRANSFERRIN (N2FRAGMENT) (Homo sapiens) |
PF00405(Transferrin) | 4 | SER C 185SER C 184GLY C 160GLY C 175 | None | 0.69A | 1me7A-1lgbC:undetectable | 1me7A-1lgbC:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lo3 | IG GAMMA 2A HEAVYCHAIN (Mus musculus) |
no annotation | 4 | SER Y 25ASN Y 79ILE Y 80GLY Y 110 | None | 0.67A | 1me7A-1lo3Y:undetectable | 1me7A-1lo3Y:19.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lrt | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonassuis) |
PF00478(IMPDH) | 7 | ASP A 261SER A 262SER A 263ASN A 291ILE A 313GLY A 314GLY A 409 | TAD A 901 (-2.3A)TAD A 901 ( 2.6A)TAD A 901 (-2.7A)IMP A 801 ( 4.6A)TAD A 901 (-4.1A)TAD A 901 (-3.9A)IMP A 801 ( 3.2A) | 0.33A | 1me7A-1lrtA:57.8 | 1me7A-1lrtA:74.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lrt | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonassuis) |
PF00478(IMPDH) | 6 | SER A 262SER A 263ILE A 313GLY A 314CYH A 319GLY A 409 | TAD A 901 ( 2.6A)TAD A 901 (-2.7A)TAD A 901 (-4.1A)TAD A 901 (-3.9A)IMP A 801 (-4.0A)IMP A 801 ( 3.2A) | 0.60A | 1me7A-1lrtA:57.8 | 1me7A-1lrtA:74.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m32 | 2-AMINOETHYLPHOSPHONATE-PYRUVATEAMINOTRANSFERASE (Salmonellaenterica) |
PF00266(Aminotran_5) | 4 | ASP A 167ILE A 175GLY A 174CYH A 194 | PLP A4401 (-2.9A)NoneNoneNone | 0.54A | 1me7A-1m32A:undetectable | 1me7A-1m32A:21.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mew | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonassuis) |
PF00478(IMPDH)PF00571(CBS) | 4 | ASP A 261ASN A 291GLY A 315GLY A 407 | NAD A 987 (-2.5A)XMP A 602 ( 4.4A)NoneXMP A 602 (-3.3A) | 0.66A | 1me7A-1mewA:61.3 | 1me7A-1mewA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mew | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonassuis) |
PF00478(IMPDH)PF00571(CBS) | 7 | ASP A 261SER A 262SER A 263ASN A 291ILE A 313GLY A 314GLY A 409 | NAD A 987 (-2.5A)NAD A 987 (-2.7A)NAD A 987 (-3.1A)XMP A 602 ( 4.4A)NAD A 987 (-4.5A)NAD A 987 (-4.1A)XMP A 602 ( 3.1A) | 0.18A | 1me7A-1mewA:61.3 | 1me7A-1mewA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1prt | PERTUSSIS TOXIN(SUBUNIT S1) (Bordetellapertussis) |
PF02917(Pertussis_S1) | 4 | SER A 40ILE A 187GLY A 189GLY A 199 | None | 0.61A | 1me7A-1prtA:undetectable | 1me7A-1prtA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlc | POSTSYNAPTIC DENSITYPROTEIN 95 (Rattusnorvegicus) |
PF00595(PDZ) | 4 | SER A 173ILE A 208GLY A 209GLY A 176 | None | 0.76A | 1me7A-1qlcA:undetectable | 1me7A-1qlcA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ska | 3-PHYTASE A (Aspergillusfumigatus) |
PF00328(His_Phos_2) | 4 | ASP A 311ASN A 184GLY A 190GLY A 293 | NoneNAG A 503 ( 1.8A)NoneNone | 0.78A | 1me7A-1skaA:undetectable | 1me7A-1skaA:21.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | ASN A 282ILE A 304GLY A 305CYH A 310GLY A 394 | IMP A 500 ( 4.5A)NoneNoneIMP A 500 ( 3.2A)IMP A 500 (-3.0A) | 0.43A | 1me7A-1zfjA:49.4 | 1me7A-1zfjA:33.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | ASP A 253ILE A 304GLY A 305CYH A 310GLY A 394 | IMP A 500 ( 4.7A)NoneNoneIMP A 500 ( 3.2A)IMP A 500 (-3.0A) | 0.62A | 1me7A-1zfjA:49.4 | 1me7A-1zfjA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bzn | GMP REDUCTASE 2 (Homo sapiens) |
PF00478(IMPDH) | 4 | ASN A 158ILE A 180GLY A 181CYH A 186 | IMP A1338 ( 4.3A)NoneNoneIMP A1338 (-2.5A) | 0.37A | 1me7A-2bznA:38.0 | 1me7A-2bznA:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bzn | GMP REDUCTASE 2 (Homo sapiens) |
PF00478(IMPDH) | 4 | ASP A 129ILE A 180GLY A 181CYH A 186 | NoneNoneNoneIMP A1338 (-2.5A) | 0.63A | 1me7A-2bznA:38.0 | 1me7A-2bznA:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1l | RESTRICTIONENDONUCLEASE (Bacillus firmus) |
PF13091(PLDc_2) | 4 | ASP A 209ILE A 202GLY A 343GLY A 339 | None | 0.68A | 1me7A-2c1lA:undetectable | 1me7A-2c1lA:20.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2cu0 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Pyrococcushorikoshii) |
PF00478(IMPDH)PF00571(CBS) | 6 | ASP A 247ASN A 275ILE A 295GLY A 296CYH A 301GLY A 385 | NoneXMP A1001 ( 4.4A)NoneNoneXMP A1001 (-2.6A)XMP A1001 (-3.1A) | 0.45A | 1me7A-2cu0A:48.0 | 1me7A-2cu0A:33.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxn | GLUCOSE-6-PHOSPHATEISOMERASE (Mus musculus) |
PF00342(PGI) | 4 | ASN A 508ILE A 507GLY A 502GLY A 355 | None | 0.75A | 1me7A-2cxnA:undetectable | 1me7A-2cxnA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dqi | LYSOZYME BINDING IGKAPPA CHAIN V23-J2REGION (Mus musculus) |
PF07686(V-set) | 4 | ASN L 32ILE L 29GLY L 68GLY L 64 | None | 0.73A | 1me7A-2dqiL:undetectable | 1me7A-2dqiL:11.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eiz | ANTI-LYSOZYMEANTIBODY FV REGION (Homo sapiens) |
PF07686(V-set) | 4 | ASN A 32ILE A 29GLY A 68GLY A 64 | None | 0.78A | 1me7A-2eizA:undetectable | 1me7A-2eizA:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ep5 | 350AA LONGHYPOTHETICALASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Sulfurisphaeratokodaii) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | SER A 106ASN A 148GLY A 332GLY A 17 | None | 0.63A | 1me7A-2ep5A:undetectable | 1me7A-2ep5A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fe5 | PRESYNAPTIC PROTEINSAP102 (Homo sapiens) |
PF00595(PDZ) | 4 | SER A 239ILE A 274GLY A 275GLY A 242 | None | 0.71A | 1me7A-2fe5A:undetectable | 1me7A-2fe5A:11.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iy9 | SUBA (Escherichiacoli) |
PF00082(Peptidase_S8) | 4 | SER A 49ILE A 149GLY A 151GLY A 54 | None | 0.70A | 1me7A-2iy9A:undetectable | 1me7A-2iy9A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4h | MEMBRANE-ASSOCIATEDGUANYLATE KINASE, WWAND PDZDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00595(PDZ) | 4 | SER A 18ILE A 48GLY A 49GLY A 21 | NoneHIS A 91 (-4.0A)NoneNone | 0.72A | 1me7A-2r4hA:undetectable | 1me7A-2r4hA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r87 | PURP PROTEIN PF1517 (Pyrococcusfuriosus) |
PF06849(DUF1246)PF06973(DUF1297) | 4 | SER A 12ILE A 16GLY A 313GLY A 291 | None | 0.78A | 1me7A-2r87A:undetectable | 1me7A-2r87A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjt | BETA-KETOACYL-ACPSYNTHASE II (Streptococcuspneumoniae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | SER A 194ILE A 112GLY A 111GLY A 234 | None | 0.72A | 1me7A-2rjtA:undetectable | 1me7A-2rjtA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w45 | ALKALINE EXONUCLEASE (Humangammaherpesvirus4) |
PF01771(Herpes_alk_exo) | 4 | SER A 129SER A 128ILE A 126GLY A 125 | None | 0.77A | 1me7A-2w45A:undetectable | 1me7A-2w45A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddr | HASR PROTEIN (Serratiamarcescens) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | SER A 311ILE A 298GLY A 294GLY A 288 | None | 0.73A | 1me7A-3ddrA:undetectable | 1me7A-3ddrA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed4 | ARYLSULFATASE (Escherichiacoli) |
PF00884(Sulfatase) | 4 | SER A 111ILE A 423GLY A 422GLY A 108 | None | 0.68A | 1me7A-3ed4A:undetectable | 1me7A-3ed4A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3faw | RETICULOCYTE BINDINGPROTEIN (Streptococcusagalactiae) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | ASP A1079ASN A1099ILE A1148GLY A1073 | None | 0.71A | 1me7A-3fawA:4.9 | 1me7A-3fawA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1q | ETHANOLAMINEUTILIZATION PROTEINEUTJ (Carboxydothermushydrogenoformans) |
PF14450(FtsA) | 4 | ASP A 36ILE A 265GLY A 264GLY A 231 | ATP A 301 (-2.5A)NoneNoneATP A 301 (-3.5A) | 0.58A | 1me7A-3h1qA:undetectable | 1me7A-3h1qA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5c | PROTEIN Z-DEPENDENTPROTEASE INHIBITOR (Homo sapiens) |
PF00079(Serpin) | 4 | SER A 382ILE A 380GLY A 379GLY A 252 | None | 0.69A | 1me7A-3h5cA:undetectable | 1me7A-3h5cA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khj | INOSINE-5-MONOPHOSPHATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00478(IMPDH) | 4 | SER A 164ASN A 191ILE A 213GLY A 214 | NoneIMP A 801 ( 4.2A)NoneNone | 0.54A | 1me7A-3khjA:42.4 | 1me7A-3khjA:28.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myo | TAGATOSE1,6-DIPHOSPHATEALDOLASE 1 (Streptococcuspyogenes) |
PF01791(DeoC) | 4 | SER A 21ILE A 19GLY A 18GLY A 85 | None | 0.78A | 1me7A-3myoA:4.9 | 1me7A-3myoA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxp | PRETHROMBIN-1 (Homo sapiens) |
PF00051(Kringle)PF00089(Trypsin)PF09396(Thrombin_light) | 4 | SER A 595ILE A 612GLY A 611GLY A 626 | None | 0.78A | 1me7A-3nxpA:undetectable | 1me7A-3nxpA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv4 | DEGQ (Legionellafallonii) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 4 | SER A 193ILE A 207GLY A 206GLY A 222 | None | 0.76A | 1me7A-3pv4A:undetectable | 1me7A-3pv4A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sl1 | ARGINASE (Plasmodiumfalciparum) |
PF00491(Arginase) | 4 | ASP A 325SER A 326ILE A 291GLY A 219 | MN A 412 ( 2.0A)NoneNoneNone | 0.76A | 1me7A-3sl1A:undetectable | 1me7A-3sl1A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssz | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Rhodobacteraceaebacterium KLH11) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | SER A 28ILE A 107GLY A 108GLY A 80 | None | 0.74A | 1me7A-3sszA:2.9 | 1me7A-3sszA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3suc | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 4 | SER A 491ASN A 519ILE A 518GLY A 468 | None | 0.72A | 1me7A-3sucA:undetectable | 1me7A-3sucA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t02 | PHOSPHONOACETATEHYDROLASE (Sinorhizobiummeliloti) |
PF01663(Phosphodiest) | 4 | ASP A 131ILE A 166GLY A 165GLY A 138 | None | 0.68A | 1me7A-3t02A:undetectable | 1me7A-3t02A:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqf | HPR(SER) KINASE (Coxiellaburnetii) |
PF07475(Hpr_kinase_C) | 4 | ASP A 57ILE A 86GLY A 85GLY A 39 | NoneNoneNonePO4 A 201 (-3.4A) | 0.63A | 1me7A-3tqfA:undetectable | 1me7A-3tqfA:15.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 4 | ASN A 280GLY A 303CYH A 308GLY A 390 | XMP A 500 ( 4.4A)NoneXMP A 500 (-3.3A)XMP A 500 (-3.2A) | 0.75A | 1me7A-3tsdA:45.4 | 1me7A-3tsdA:34.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 4 | ASN A 280ILE A 302GLY A 303CYH A 308 | XMP A 500 ( 4.4A)NoneNoneXMP A 500 (-3.3A) | 0.43A | 1me7A-3tsdA:45.4 | 1me7A-3tsdA:34.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | ASN B 397ILE B 396GLY B 62GLY B 422 | NoneNoneNoneSO4 B1195 (-3.3A) | 0.77A | 1me7A-3v0aB:undetectable | 1me7A-3v0aB:18.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4af0 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Cryptococcusneoformans) |
PF00478(IMPDH)PF00571(CBS) | 7 | ASP B 288SER B 289SER B 290ASN B 317GLY B 340CYH B 345GLY B 429 | MOA B1526 (-3.3A)MOA B1526 (-3.9A)MOA B1526 (-2.6A)MOA B1526 ( 3.6A)MOA B1526 (-4.0A)IMP B1527 (-3.3A)IMP B1527 ( 3.3A) | 0.46A | 1me7A-4af0B:47.8 | 1me7A-4af0B:33.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dwq | TRNA-SPLICING LIGASERTCB (Pyrococcushorikoshii) |
PF01139(RtcB) | 4 | SER A 88SER A 270ILE A 256GLY A 85 | None | 0.56A | 1me7A-4dwqA:undetectable | 1me7A-4dwqA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezg | PUTATIVEUNCHARACTERIZEDPROTEIN (Listeriamonocytogenes) |
no annotation | 4 | ASP A 146ILE A 177GLY A 175GLY A 125 | None | 0.79A | 1me7A-4ezgA:undetectable | 1me7A-4ezgA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0x | MALONYL-COADECARBOXYLASE,MITOCHONDRIAL (Homo sapiens) |
PF05292(MCD)PF17408(MCD_N) | 4 | SER A 381SER A 382ILE A 444GLY A 443 | None | 0.77A | 1me7A-4f0xA:undetectable | 1me7A-4f0xA:21.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fxs | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH)PF00571(CBS) | 4 | ASN A 279ILE A 301GLY A 302GLY A 389 | MOA A 702 (-3.5A)MOA A 702 (-4.1A)MOA A 702 ( 3.9A)IMP A 701 (-3.1A) | 0.78A | 1me7A-4fxsA:50.2 | 1me7A-4fxsA:36.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fxs | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH)PF00571(CBS) | 4 | ASP A 250SER A 251SER A 252CYH A 307 | MOA A 702 (-3.2A)MOA A 702 (-3.7A)MOA A 702 (-2.8A)IMP A 701 (-3.0A) | 0.67A | 1me7A-4fxsA:50.2 | 1me7A-4fxsA:36.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fxs | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH)PF00571(CBS) | 7 | SER A 251SER A 252ASN A 279ILE A 301GLY A 302CYH A 307GLY A 391 | MOA A 702 (-3.7A)MOA A 702 (-2.8A)MOA A 702 (-3.5A)MOA A 702 (-4.1A)MOA A 702 ( 3.9A)IMP A 701 (-3.0A)IMP A 701 (-3.2A) | 0.52A | 1me7A-4fxsA:50.2 | 1me7A-4fxsA:36.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnn | DIHYDRODIPICOLINATESYNTHASE (Vitis vinifera) |
PF00701(DHDPS) | 4 | ASP A 59ILE A 302GLY A 303GLY A 309 | None | 0.74A | 1me7A-4hnnA:4.2 | 1me7A-4hnnA:21.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ix2 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH) | 6 | ASP A 250SER A 251SER A 252ILE A 301GLY A 302CYH A 307 | NoneNoneNoneNoneNoneIMP A 501 (-4.9A) | 0.85A | 1me7A-4ix2A:45.7 | 1me7A-4ix2A:31.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ix2 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00478(IMPDH) | 6 | SER A 251SER A 252ASN A 279ILE A 301GLY A 302CYH A 307 | NoneNoneIMP A 501 ( 4.4A)NoneNoneIMP A 501 (-4.9A) | 0.61A | 1me7A-4ix2A:45.7 | 1me7A-4ix2A:31.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jbd | PROLINE RACEMASE (Pseudomonasputida) |
PF05544(Pro_racemase) | 4 | ASP A 293SER A 294ILE A 4GLY A 22 | None | 0.71A | 1me7A-4jbdA:undetectable | 1me7A-4jbdA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mbg | CAAXFARNESYLTRANSFERASEALPHA SUBUNIT RAM2CAAXFARNESYLTRANSFERASEBETA SUBUNIT RAM1 (Aspergillusfumigatus) |
PF00432(Prenyltrans)PF01239(PPTA) | 4 | SER B 346ILE A 327GLY B 354GLY B 373 | None | 0.70A | 1me7A-4mbgB:undetectable | 1me7A-4mbgB:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Campylobacterjejuni) |
PF00478(IMPDH) | 5 | ASP A 244SER A 245ILE A 295CYH A 301GLY A 385 | NoneNoneNoneIMP A 500 ( 3.1A)IMP A 500 ( 3.3A) | 0.82A | 1me7A-4mz1A:50.2 | 1me7A-4mz1A:29.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Campylobacterjejuni) |
PF00478(IMPDH) | 6 | SER A 245ASN A 273ILE A 295GLY A 296CYH A 301GLY A 385 | NoneIMP A 500 ( 4.1A)NoneNoneIMP A 500 ( 3.1A)IMP A 500 ( 3.3A) | 0.49A | 1me7A-4mz1A:50.2 | 1me7A-4mz1A:29.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ozy | POLY(BETA-D-MANNURONATE) C5 EPIMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF13229(Beta_helix) | 4 | ASP A 331SER A 357ILE A 381GLY A 334 | MLY A 356 ( 3.5A)MLY A 356 ( 4.6A)NoneNone | 0.78A | 1me7A-4ozyA:undetectable | 1me7A-4ozyA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6y | AMINOPEPTIDASE (Thermotogamaritima) |
PF05343(Peptidase_M42) | 4 | ASP A 220ILE A 64GLY A 83GLY A 280 | None | 0.74A | 1me7A-4p6yA:undetectable | 1me7A-4p6yA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4per | RIBONUCLEASEINHIBITOR (Gallus gallus) |
PF13516(LRR_6) | 4 | ASP A 65GLY A 116CYH A 147GLY A 124 | None | 0.74A | 1me7A-4perA:undetectable | 1me7A-4perA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4per | RIBONUCLEASEINHIBITOR (Gallus gallus) |
PF13516(LRR_6) | 4 | ASP A 179GLY A 230CYH A 261GLY A 238 | None | 0.71A | 1me7A-4perA:undetectable | 1me7A-4perA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmh | PECTINESTERASE (Sitophilusoryzae) |
PF01095(Pectinesterase) | 4 | ASP A 250SER A 249GLY A 223GLY A 174 | None | 0.68A | 1me7A-4pmhA:undetectable | 1me7A-4pmhA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qex | ANTIBODY HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | ASN H 52ILE H 51GLY H 50GLY H 95 | None | 0.78A | 1me7A-4qexH:undetectable | 1me7A-4qexH:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qyj | ALDEHYDEDEHYDROGENASE (Pseudomonasputida) |
PF00171(Aldedh) | 4 | ILE A 328GLY A 325CYH A 368GLY A 370 | None | 0.74A | 1me7A-4qyjA:undetectable | 1me7A-4qyjA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt6 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 4 | SER A 410ASN A 438GLY A 442GLY A 388 | None | 0.73A | 1me7A-4rt6A:undetectable | 1me7A-4rt6A:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqg | PUTATIVEDTDP-D-GLUCOSE 46-DEHYDRATASE (Megaviruschiliensis) |
PF02719(Polysacc_synt_2) | 4 | SER A 302SER A 303ILE A 307GLY A 169 | NoneNoneNoneNDP A 400 (-4.8A) | 0.68A | 1me7A-4tqgA:undetectable | 1me7A-4tqgA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wa0 | POSSIBLE ADHESIN (Caldicellulosiruptorkronotskyensis) |
no annotation | 4 | ASP A 473SER A 477ILE A 508GLY A 497 | MG A 601 (-3.3A)NoneNoneNone | 0.68A | 1me7A-4wa0A:undetectable | 1me7A-4wa0A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wmj | GLUCOSE-6-PHOSPHATEISOMERASE (Coliaseurytheme) |
PF00342(PGI) | 4 | ASN A 511ILE A 510GLY A 505GLY A 358 | None | 0.75A | 1me7A-4wmjA:undetectable | 1me7A-4wmjA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wss | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | ASP A 109SER A 77ILE A 301GLY A 302 | None | 0.72A | 1me7A-4wssA:undetectable | 1me7A-4wssA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcq | TUBZ (Clostridiumphage c-st) |
PF00091(Tubulin) | 4 | ASP A 39ILE A 104GLY A 103GLY A 59 | None | 0.74A | 1me7A-4xcqA:undetectable | 1me7A-4xcqA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwu | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Eremotheciumgossypii) |
PF00478(IMPDH) | 4 | ASP A 277SER A 278SER A 279ASN A 306 | None | 0.29A | 1me7A-4xwuA:38.6 | 1me7A-4xwuA:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yvd | PLEIOTROPICREGULATOR 1 (Homo sapiens) |
PF00400(WD40) | 5 | SER A 263ILE A 228GLY A 222CYH A 209GLY A 293 | NoneNoneNoneNone NA A 601 (-3.6A) | 1.31A | 1me7A-4yvdA:undetectable | 1me7A-4yvdA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zow | MULTIDRUGTRANSPORTER MDFA (Escherichiacoli) |
PF07690(MFS_1) | 4 | SER A 118ILE A 117GLY A 64GLY A 32 | None | 0.78A | 1me7A-4zowA:undetectable | 1me7A-4zowA:21.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ahm | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Pseudomonasaeruginosa) |
PF00478(IMPDH) | 5 | ASN A 276ILE A 298GLY A 299CYH A 304GLY A 388 | IMP A 501 ( 4.3A)NoneNoneIMP A 501 (-3.0A)IMP A 501 (-3.1A) | 0.43A | 1me7A-5ahmA:49.9 | 1me7A-5ahmA:30.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ap9 | LIPASE (Thermomyceslanuginosus) |
PF01764(Lipase_3)PF03893(Lipase3_N) | 4 | SER A 17ILE A 265GLY A 266GLY A 65 | None | 0.68A | 1me7A-5ap9A:undetectable | 1me7A-5ap9A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5edl | PUTATIVEHMP/THIAMINEPERMEASE PROTEINYKOE (Bacillussubtilis) |
PF09819(ABC_cobalt) | 4 | SER A 127ILE A 91GLY A 92GLY A 120 | NoneVIB A 201 ( 4.2A)VIB A 201 ( 4.6A)None | 0.73A | 1me7A-5edlA:undetectable | 1me7A-5edlA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8o | HMM5 ANTIBODY LIGHTCHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | ASN L 99ILE L 98GLY L 96GLY L 31 | None | 0.71A | 1me7A-5i8oL:undetectable | 1me7A-5i8oL:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iai | SUGAR ABCTRANSPORTER (Agrobacteriumtumefaciens) |
PF01547(SBP_bac_1) | 4 | ASP A 209ILE A 255GLY A 253GLY A 260 | None | 0.73A | 1me7A-5iaiA:undetectable | 1me7A-5iaiA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j8j | HISTONE DEACETYLASEHDA1 (Saccharomycescerevisiae) |
PF09757(Arb2) | 4 | ASP A 511SER A 510ASN A 533GLY A 594 | None | 0.79A | 1me7A-5j8jA:undetectable | 1me7A-5j8jA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mgy | FAD:PROTEIN FMNTRANSFERASE (Pseudomonasstutzeri) |
no annotation | 4 | ASP H 121SER H 120ILE H 320GLY H 319 | None | 0.66A | 1me7A-5mgyH:undetectable | 1me7A-5mgyH:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msz | THERMOBIA DOMESTICADOMESTICA AA15 (Thermobiadomestica) |
no annotation | 4 | ASN A 164ILE A 92GLY A 93GLY A 2 | None | 0.79A | 1me7A-5mszA:undetectable | 1me7A-5mszA:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngk | GLUCOSYLCERAMIDASE (Bacteroidesthetaiotaomicron) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 4 | ASN A 413ILE A 342GLY A 343GLY A 386 | None | 0.73A | 1me7A-5ngkA:7.5 | 1me7A-5ngkA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ou3 | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Mycolicibacteriumthermoresistibile) |
no annotation | 4 | ASN A 173GLY A 196CYH A 201GLY A 285 | AUN A 401 ( 3.1A)NoneIMP A 400 (-3.2A)AUN A 401 ( 3.2A) | 0.34A | 1me7A-5ou3A:47.0 | 1me7A-5ou3A:10.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tc3 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Eremotheciumgossypii) |
PF00478(IMPDH)PF00571(CBS) | 6 | ASP A 277SER A 278SER A 279ASN A 306GLY A 329GLY A 418 | NoneNoneNone5GP A 600 (-3.2A)5GP A 600 ( 3.2A)5GP A 600 (-3.1A) | 0.59A | 1me7A-5tc3A:46.8 | 1me7A-5tc3A:34.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upy | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Listeriamonocytogenes) |
PF00478(IMPDH) | 5 | ASN A 280ILE A 302GLY A 303CYH A 308GLY A 392 | IMP A 500 ( 4.3A)NoneNoneIMP A 500 (-3.2A)IMP A 500 ( 3.3A) | 0.41A | 1me7A-5upyA:46.8 | 1me7A-5upyA:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upy | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Listeriamonocytogenes) |
PF00478(IMPDH) | 4 | ASN A 280ILE A 302GLY A 303GLY A 390 | IMP A 500 ( 4.3A)NoneNoneIMP A 500 (-3.2A) | 0.78A | 1me7A-5upyA:46.8 | 1me7A-5upyA:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upy | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Listeriamonocytogenes) |
PF00478(IMPDH) | 4 | ASP A 251ILE A 302GLY A 303CYH A 308 | NoneNoneNoneIMP A 500 (-3.2A) | 0.74A | 1me7A-5upyA:46.8 | 1me7A-5upyA:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuw | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH) | 5 | ASN A 280ILE A 302GLY A 303CYH A 308GLY A 392 | IMP A 501 (-4.1A)None K A 507 (-4.8A)IMP A 501 ( 3.2A)IMP A 501 ( 3.2A) | 0.38A | 1me7A-5uuwA:47.3 | 1me7A-5uuwA:29.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uze | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Clostridiumperfringens) |
PF00478(IMPDH) | 5 | ASN A 275ILE A 297GLY A 298CYH A 303GLY A 387 | IMP A 500 (-4.0A)NoneNoneIMP A 500 (-3.1A)IMP A 500 ( 3.1A) | 0.45A | 1me7A-5uzeA:48.2 | 1me7A-5uzeA:30.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z5c | CYSTEINE SYNTHASE (Fusobacteriumnucleatum) |
no annotation | 4 | ASP A 232ILE A 271GLY A 270GLY A 75 | None | 0.77A | 1me7A-5z5cA:undetectable | 1me7A-5z5cA:10.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c6l | V-TYPE PROTON ATPASESUBUNIT C'V-TYPE PROTON ATPASESUBUNIT C'' (Saccharomycescerevisiae) |
no annotation | 4 | ASP D 121SER D 41GLY C 167GLY D 47 | None | 0.77A | 1me7A-6c6lD:undetectable | 1me7A-6c6lD:10.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6frv | GLUCOAMYLASE (Aspergillusniger) |
no annotation | 4 | ASP A 238SER A 235GLY A 231GLY A 223 | None | 0.75A | 1me7A-6frvA:undetectable | 1me7A-6frvA:11.33 |