SIMILAR PATTERNS OF AMINO ACIDS FOR 1MCL_P_DHIP1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1am2 | MXE GYRA INTEIN (Mycobacteriumxenopi) |
no annotation | 4 | TYR A 162GLU A 65PHE A 194TYR A 102 | None | 1.26A | 1mclA-1am2A:0.01mclB-1am2A:0.01mclP-1am2A:undetectable | 1mclA-1am2A:23.891mclB-1am2A:23.891mclP-1am2A:2.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufa | TT1467 PROTEIN (Thermusthermophilus) |
PF03065(Glyco_hydro_57)PF09210(DUF1957) | 4 | TYR A 426GLU A 429PHE A 486TYR A 421 | None | 1.35A | 1mclA-1ufaA:0.01mclB-1ufaA:0.01mclP-1ufaA:undetectable | 1mclA-1ufaA:16.121mclB-1ufaA:16.121mclP-1ufaA:0.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z01 | 2-OXO-1,2-DIHYDROQUINOLINE8-MONOOXYGENASE,OXYGENASE COMPONENT (Pseudomonasputida) |
PF00355(Rieske)PF11723(Aromatic_hydrox) | 4 | TYR A 437GLU A 327PHE A 206PRO A 435 | None | 1.46A | 1mclA-1z01A:0.01mclB-1z01A:0.01mclP-1z01A:undetectable | 1mclA-1z01A:15.741mclB-1z01A:15.741mclP-1z01A:1.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy9 | ALPHA-GALACTOSIDASE (Thermotogamaritima) |
PF02065(Melibiase) | 4 | TYR A 446PHE A 391TYR A 191PRO A 390 | None | 1.40A | 1mclA-1zy9A:0.01mclB-1zy9A:0.11mclP-1zy9A:undetectable | 1mclA-1zy9A:15.931mclB-1zy9A:15.931mclP-1zy9A:1.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayu | NUCLEOSOME ASSEMBLYPROTEIN (Saccharomycescerevisiae) |
PF00956(NAP) | 4 | TYR A 221GLU A 121TYR A 254PRO A 227 | None | 1.19A | 1mclA-2ayuA:0.01mclB-2ayuA:0.01mclP-2ayuA:undetectable | 1mclA-2ayuA:18.781mclB-2ayuA:18.781mclP-2ayuA:8.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f5u | VIRION PROTEIN UL25 (Humanalphaherpesvirus1) |
PF01499(Herpes_UL25) | 4 | TYR A 289GLU A 532TYR A 306PRO A 295 | None | 1.33A | 1mclA-2f5uA:0.01mclB-2f5uA:0.01mclP-2f5uA:undetectable | 1mclA-2f5uA:17.901mclB-2f5uA:17.901mclP-2f5uA:3.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gfq | UPF0204 PROTEINPH0006 (Pyrococcushorikoshii) |
PF04414(tRNA_deacylase) | 4 | TYR A 102PHE A 152TYR A 55PRO A 143 | None MG A2018 ( 4.6A)NoneNone | 1.40A | 1mclA-2gfqA:0.01mclB-2gfqA:0.01mclP-2gfqA:undetectable | 1mclA-2gfqA:21.901mclB-2gfqA:21.901mclP-2gfqA:0.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qts | ACID-SENSING IONCHANNEL (Gallus gallus) |
PF00858(ASC) | 4 | TYR A 335PHE A 153TYR A 341PRO A 338 | None | 1.33A | 1mclA-2qtsA:0.01mclB-2qtsA:0.91mclP-2qtsA:undetectable | 1mclA-2qtsA:17.831mclB-2qtsA:17.831mclP-2qtsA:0.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rg2 | CHOLOYLGLYCINEHYDROLASE (Clostridiumperfringens) |
PF02275(CBAH) | 4 | TYR A 52GLU A 73PHE A 32PRO A 34 | None | 1.16A | 1mclA-2rg2A:0.01mclB-2rg2A:0.01mclP-2rg2A:undetectable | 1mclA-2rg2A:20.421mclB-2rg2A:20.421mclP-2rg2A:6.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f7x | PUTATIVE POLYKETIDECYCLASE (Pseudomonasputida) |
PF12680(SnoaL_2) | 4 | TYR A 100GLU A 59TYR A 122PRO A 103 | UNL A 133 ( 4.9A)UNL A 133 ( 2.9A)UNL A 133 (-3.8A)EDO A 140 ( 4.6A) | 1.38A | 1mclA-3f7xA:undetectable1mclB-3f7xA:undetectable1mclP-3f7xA:undetectable | 1mclA-3f7xA:18.691mclB-3f7xA:18.691mclP-3f7xA:5.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8h | PUTATIVE POLYKETIDECYCLASE (Ruegeria sp.TM1040) |
PF12680(SnoaL_2) | 4 | TYR A 98GLU A 57TYR A 120PRO A 101 | MRD A 134 (-4.2A)MRD A 134 ( 2.7A)MRD A 134 (-3.9A)None | 1.40A | 1mclA-3f8hA:undetectable1mclB-3f8hA:undetectable1mclP-3f8hA:undetectable | 1mclA-3f8hA:19.721mclB-3f8hA:19.721mclP-3f8hA:2.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmw | BETA-LACTAMASEINHIBITORY PROTEINBLIP-I (Streptomycesexfoliatus) |
PF07467(BLIP) | 4 | TYR B 71GLU B 70PHE B 44TYR B 50 | None | 1.09A | 1mclA-3gmwB:undetectable1mclB-3gmwB:undetectable1mclP-3gmwB:undetectable | 1mclA-3gmwB:19.811mclB-3gmwB:19.811mclP-3gmwB:1.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i0y | PUTATIVE POLYKETIDECYCLASE (Xanthomonascampestris) |
PF12680(SnoaL_2) | 4 | TYR A 106GLU A 65TYR A 128PRO A 109 | NoneUNL A 143 (-2.1A)UNL A 143 ( 4.2A)None | 1.37A | 1mclA-3i0yA:undetectable1mclB-3i0yA:undetectable1mclP-3i0yA:undetectable | 1mclA-3i0yA:23.331mclB-3i0yA:23.331mclP-3i0yA:4.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7d | TOPOISOMERASE V (Methanopyruskandleri) |
PF13412(HTH_24) | 4 | TYR A 30GLU A 129PHE A 23PRO A 126 | None | 1.39A | 1mclA-3m7dA:undetectable1mclB-3m7dA:undetectable1mclP-3m7dA:undetectable | 1mclA-3m7dA:18.041mclB-3m7dA:18.041mclP-3m7dA:0.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7g | TOPOISOMERASE V (Methanopyruskandleri) |
PF13404(HTH_AsnC-type) | 4 | TYR A 30GLU A 129PHE A 23PRO A 126 | None | 1.45A | 1mclA-3m7gA:undetectable1mclB-3m7gA:undetectable1mclP-3m7gA:undetectable | 1mclA-3m7gA:21.551mclB-3m7gA:21.551mclP-3m7gA:1.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rm5 | HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20 (Saccharomycescerevisiae) |
PF03070(TENA_THI-4)PF08543(Phos_pyr_kin) | 4 | TYR A 445GLU A 540PHE A 372TYR A 383 | None | 1.46A | 1mclA-3rm5A:undetectable1mclB-3rm5A:undetectable1mclP-3rm5A:undetectable | 1mclA-3rm5A:18.181mclB-3rm5A:18.181mclP-3rm5A:0.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3roh | LEUCOTOXIN LUKEV (Staphylococcusaureus) |
PF07968(Leukocidin) | 4 | TYR A 269GLU A 281PHE A 273TYR A 96 | NoneNoneNonePGE A 312 (-4.2A) | 1.02A | 1mclA-3rohA:1.81mclB-3rohA:2.11mclP-3rohA:undetectable | 1mclA-3rohA:20.481mclB-3rohA:20.481mclP-3rohA:0.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w5n | PUTATIVERHAMNOSIDASE (Streptomycesavermitilis) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 4 | TYR A 375GLU A 330TYR A 439PRO A 563 | None | 1.47A | 1mclA-3w5nA:4.61mclB-3w5nA:undetectable1mclP-3w5nA:undetectable | 1mclA-3w5nA:13.081mclB-3w5nA:13.081mclP-3w5nA:8.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5du2 | ESPG2GLYCOSYLTRANSFERASE (Actinomaduraverrucosospora) |
PF00201(UDPGT) | 4 | TYR A 45GLU A 44TYR A 59PRO A 58 | None | 1.22A | 1mclA-5du2A:undetectable1mclB-5du2A:undetectable1mclP-5du2A:undetectable | 1mclA-5du2A:18.851mclB-5du2A:18.851mclP-5du2A:0.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4l | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Clostridium sp.) |
PF13561(adh_short_C2) | 4 | TYR A 261GLU A 224PHE A 235PRO A 198 | NoneNoneNoneNDP A1265 (-4.4A) | 1.31A | 1mclA-5g4lA:undetectable1mclB-5g4lA:undetectable1mclP-5g4lA:undetectable | 1mclA-5g4lA:19.161mclB-5g4lA:19.161mclP-5g4lA:0.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9g | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | TYR A 114PHE A 128TYR A 131PRO A 130 | None | 1.38A | 1mclA-5t9gA:5.21mclB-5t9gA:4.91mclP-5t9gA:undetectable | 1mclA-5t9gA:14.221mclB-5t9gA:14.221mclP-5t9gA:1.56 |