SIMILAR PATTERNS OF AMINO ACIDS FOR 1MAG_A_DVAA8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eng ENDOGLUCANASE V

(Humicola
insolens) 		PF02015
(Glyco_hydro_45) 		4 GLY A  71
VAL A 105
TRP A 169
TRP A 173
 None
 1.19A 1magA-2engA:
undetectable		 1magA-2engA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhs CBP21

(Serratia
marcescens) 		PF03067
(LPMO_10) 		4 GLY A   2
VAL A   4
TRP A 151
TRP A  92
 None
 1.42A 1magA-2lhsA:
undetectable		 1magA-2lhsA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alq CHITIN BINDING
PROTEIN

(Enterococcus
faecalis) 		PF03067
(LPMO_10) 		4 GLY A  30
VAL A  32
TRP A 176
TRP A 119
 None
 1.44A 1magA-4alqA:
undetectable		 1magA-4alqA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gly GLYCOSIDE HYDROLASE
FAMILY 45 PROTEIN

(Thielavia
terrestris) 		PF02015
(Glyco_hydro_45) 		4 GLY A  72
VAL A 106
TRP A 170
TRP A 174
 None
 1.11A 1magA-5glyA:
undetectable		 1magA-5glyA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg1 CHITINASE

(Jonesia
denitrificans) 		PF03067
(LPMO_10) 		4 GLY A  33
VAL A  35
TRP A 155
TRP A 114
 None
 1.48A 1magA-5vg1A:
undetectable		 1magA-5vg1A:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsz LPMO10A

(Bacillus
thuringiensis) 		PF03067
(LPMO_10) 		4 GLY A   2
VAL A   4
TRP A 149
TRP A  90
 None
 1.46A 1magA-5wszA:
undetectable		 1magA-5wszA:
6.51