SIMILAR PATTERNS OF AMINO ACIDS FOR 1MAA_D_DMED999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 GLY A  76
GLU A 175
SER A 176
HIS A 448
 None
 0.86A 1maaD-1ac5A:
3.4		 1maaD-1ac5A:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 GLY A 107
GLU A 193
SER A 194
HIS A 435
 None
 0.67A 1maaD-1aqlA:
43.5		 1maaD-1aqlA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		7 GLY A 122
TYR A 124
GLU A 202
SER A 203
TRP A 286
TYR A 341
HIS A 447
 None
 1.24A 1maaD-1b41A:
62.6		 1maaD-1b41A:
88.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 TRP A  86
GLY A 120
SER A 203
HIS A 447
 None
 0.97A 1maaD-1b41A:
62.6		 1maaD-1b41A:
88.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		8 TRP A  86
GLY A 121
TYR A 124
GLU A 202
SER A 203
TRP A 286
TYR A 341
HIS A 447
 None
 0.55A 1maaD-1b41A:
62.6		 1maaD-1b41A:
88.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		7 GLY A 122
TYR A 124
GLU A 202
SER A 203
TRP A 286
TYR A 341
HIS A 447
 None
 1.09A 1maaD-1c2oA:
66.6		 1maaD-1c2oA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 TRP A  86
GLY A 120
SER A 203
HIS A 447
 None
 1.04A 1maaD-1c2oA:
66.6		 1maaD-1c2oA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		8 TRP A  86
GLY A 121
TYR A 124
GLU A 202
SER A 203
TRP A 286
TYR A 341
HIS A 447
 None
 0.12A 1maaD-1c2oA:
66.6		 1maaD-1c2oA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		4 GLY A 106
GLU A 188
SER A 189
HIS A 399
 None
 0.28A 1maaD-1c7jA:
43.3		 1maaD-1c7jA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		4 GLY A 123
GLU A 208
SER A 209
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.8A)
 0.42A 1maaD-1cleA:
37.0		 1maaD-1cleA:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		4 GLY A 124
GLU A 208
SER A 209
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.8A)
 0.85A 1maaD-1cleA:
37.0		 1maaD-1cleA:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 GLY A 123
GLU A 208
SER A 209
HIS A 449
 None
 0.34A 1maaD-1crlA:
37.0		 1maaD-1crlA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 GLY A 124
GLU A 208
SER A 209
HIS A 449
 None
 0.88A 1maaD-1crlA:
37.0		 1maaD-1crlA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 TRP A  85
GLY A  76
SER A 152
HIS A 263
 None
 1.02A 1maaD-1gplA:
9.5		 1maaD-1gplA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 TRP A  37
TYR A  33
TRP A 208
TYR A 338
 None
 1.03A 1maaD-1gpmA:
2.5		 1maaD-1gpmA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		7 GLY A 119
TYR A 121
GLU A 199
SER A 200
TRP A 279
TYR A 334
HIS A 440
 EMM  A1999 (-3.5A)
None
SAF  A1998 (-3.5A)
EMM  A1999 ( 1.4A)
None
None
EMM  A1999 ( 3.8A)
 1.30A 1maaD-1gqrA:
59.7		 1maaD-1gqrA:
58.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		8 TRP A  84
GLY A 118
TYR A 121
GLU A 199
SER A 200
TRP A 279
TYR A 334
HIS A 440
 SAF  A1998 (-3.8A)
SAF  A1998 ( 3.5A)
None
SAF  A1998 (-3.5A)
EMM  A1999 ( 1.4A)
None
None
EMM  A1999 ( 3.8A)
 0.73A 1maaD-1gqrA:
59.7		 1maaD-1gqrA:
58.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 GLY A 123
GLU A 208
SER A 209
HIS A 449
 None
 0.47A 1maaD-1gz7A:
37.7		 1maaD-1gz7A:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 GLY A 124
GLU A 208
SER A 209
HIS A 449
 None
 0.73A 1maaD-1gz7A:
37.7		 1maaD-1gz7A:
32.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 GLY A 377
TRP A 397
TYR A 339
HIS A 307
 None
 1.01A 1maaD-1hn0A:
undetectable		 1maaD-1hn0A:
18.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A 107
GLU A 193
SER A 194
HIS A 435
 None
 0.34A 1maaD-1jmyA:
42.9		 1maaD-1jmyA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		4 GLY A 142
GLU A 220
SER A 221
HIS A 467
 None
 0.94A 1maaD-1k4yA:
43.7		 1maaD-1k4yA:
33.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 TRP B  85
GLY B  76
SER B 152
HIS B 263
 None
MUP  B 901 (-3.0A)
MUP  B 901 ( 1.6A)
MUP  B 901 ( 4.1A)
 0.97A 1maaD-1lpbB:
8.7		 1maaD-1lpbB:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 151
GLU A 237
SER A 238
TRP A 321
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
SO4  A 593 (-4.1A)
 1.37A 1maaD-1qonA:
52.4		 1maaD-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		6 TRP A  83
GLY A 150
GLU A 237
SER A 238
TRP A 321
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
None
SO4  A 593 (-4.1A)
 0.69A 1maaD-1qonA:
52.4		 1maaD-1qonA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		6 TRP A  83
GLY A 150
GLU A 237
SER A 238
TYR A 374
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
SO4  A 593 (-1.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 0.53A 1maaD-1qonA:
52.4		 1maaD-1qonA:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		4 GLY A  23
SER A  91
TYR A 156
HIS A 240
 None
 1.04A 1maaD-1r3dA:
11.5		 1maaD-1r3dA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t62 CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF04266
(ASCH) 		4 GLY A1029
GLU A1119
TRP A1026
HIS A1120
 None
 1.08A 1maaD-1t62A:
undetectable		 1maaD-1t62A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN

(Mus musculus) 		no annotation 4 GLY H  94
TYR H  96
GLU H  42
SER H  40
 None
 1.09A 1maaD-1t66H:
undetectable		 1maaD-1t66H:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 GLY A1204
GLU A1148
TYR A1402
HIS A1207
 None
 1.10A 1maaD-1tllA:
undetectable		 1maaD-1tllA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 GLY A 191
GLU A 164
TYR A 323
HIS A 199
 None
 0.98A 1maaD-1wn1A:
undetectable		 1maaD-1wn1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 TRP A 221
GLY A 188
GLU A 133
SER A 165
 GOL  A 905 (-3.8A)
None
None
None
 0.93A 1maaD-2o3jA:
undetectable		 1maaD-2o3jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 GLY A  91
GLU A 201
SER A 169
HIS A 306
 4PA  A 369 ( 3.8A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.91A 1maaD-2o7rA:
18.4		 1maaD-2o7rA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 GLY A  92
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.5A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.72A 1maaD-2o7rA:
18.4		 1maaD-2o7rA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 GLY A  93
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.6A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.78A 1maaD-2o7rA:
18.4		 1maaD-2o7rA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 TRP A 152
TYR A  25
SER A 232
HIS A  83
 None
None
FE  A 501 ( 3.8A)
None
 1.05A 1maaD-2ohhA:
undetectable		 1maaD-2ohhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 TRP A 383
GLY A 244
TYR A 245
TRP A 272
 None
 1.05A 1maaD-2okxA:
undetectable		 1maaD-2okxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 161
TYR A 195
SER A 137
HIS A 154
 None
 1.05A 1maaD-2pceA:
undetectable		 1maaD-2pceA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 TRP A  85
GLY A  76
SER A 152
HIS A 263
 None
 1.07A 1maaD-2pvsA:
9.0		 1maaD-2pvsA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		4 GLY A  33
TYR A  38
SER A 102
HIS A 247
 PO4  A 273 ( 3.7A)
EDO  A 278 ( 4.6A)
PO4  A 273 (-2.3A)
PO4  A 273 (-4.0A)
 1.04A 1maaD-2qruA:
14.2		 1maaD-2qruA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		4 GLY A 438
SER A 352
TYR A 410
HIS A 354
 None
 0.93A 1maaD-2rkcA:
undetectable		 1maaD-2rkcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 GLY G1356
TYR G1357
SER G1408
HIS G1352
 None
 1.08A 1maaD-2uv8G:
undetectable		 1maaD-2uv8G:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 GLY A 366
GLU A 372
SER A 369
TYR A 315
 TRS  A1478 ( 3.5A)
UDP  A1477 (-2.6A)
UDP  A1477 (-2.6A)
EDO  A1480 (-4.8A)
 0.96A 1maaD-2vg8A:
undetectable		 1maaD-2vg8A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TRP A 355
GLY A 350
TYR A 496
SER A 348
 None
None
None
SO4  A1779 (-2.7A)
 1.10A 1maaD-2vwkA:
undetectable		 1maaD-2vwkA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE

(Paraburkholderia
xenovorans) 		PF12146
(Hydrolase_4) 		4 GLY A  36
TYR A 186
SER A  34
HIS A 244
 None
 1.11A 1maaD-2xuaA:
12.9		 1maaD-2xuaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		4 GLY A 166
SER A 163
TYR A 131
HIS A 129
 PE5  A 558 ( 3.7A)
None
None
None
 1.06A 1maaD-2yeqA:
undetectable		 1maaD-2yeqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4d ESTERASE D

(Agrobacterium
fabrum) 		PF00756
(Esterase) 		4 GLY A 145
SER A 168
TYR A  65
HIS A 272
 None
 0.97A 1maaD-3e4dA:
16.8		 1maaD-3e4dA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		4 GLY A 147
SER A 170
TYR A  67
HIS A 276
 None
 0.86A 1maaD-3fcxA:
16.5		 1maaD-3fcxA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnb ACYLAMINOACYL
PEPTIDASE SMU_737

(Streptococcus
mutans) 		PF12146
(Hydrolase_4) 		4 GLY A 165
TYR A 301
SER A 233
HIS A 377
 PGE  A 404 ( 4.1A)
PGE  A 404 ( 3.7A)
BME  A 403 ( 4.0A)
BME  A 403 (-4.4A)
 0.93A 1maaD-3fnbA:
13.9		 1maaD-3fnbA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 448
GLU A 475
SER A 474
TYR A 354
 None
 0.95A 1maaD-3gg4A:
undetectable		 1maaD-3gg4A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if1 IMMUNOGLOBULIN HEAVY
CHAIN (IGG2A)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  88
TYR B  90
GLU B  42
SER B  40
 None
 1.02A 1maaD-3if1B:
undetectable		 1maaD-3if1B:
16.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1142
GLU A1220
SER A1221
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 ( 4.2A)
WW2  A 193 (-1.4A)
None
 0.32A 1maaD-3k9bA:
45.2		 1maaD-3k9bA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1143
GLU A1220
SER A1221
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 ( 4.2A)
WW2  A 193 (-1.4A)
None
 0.97A 1maaD-3k9bA:
45.2		 1maaD-3k9bA:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		4 GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.74A 1maaD-3nwoA:
14.0		 1maaD-3nwoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzh 5F6 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  95
TYR H  97
GLU H  43
SER H  41
 None
 1.08A 1maaD-3nzhH:
undetectable		 1maaD-3nzhH:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE

(Rhodospirillum
rubrum) 		PF01261
(AP_endonuc_2) 		4 GLY A  72
GLU A 267
TRP A 141
HIS A 225
 None
FE  A 301 ( 2.6A)
None
FE  A 301 ( 3.3A)
 1.05A 1maaD-3qxbA:
2.6		 1maaD-3qxbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 GLY A 133
TYR A 107
GLU A 139
SER A 136
 None
 1.10A 1maaD-3t5bA:
2.1		 1maaD-3t5bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 188
GLU A 147
SER A 142
HIS A 351
 ACY  A 401 (-3.7A)
None
ACY  A 401 (-2.8A)
ACY  A 401 (-4.4A)
 1.08A 1maaD-3u37A:
2.6		 1maaD-3u37A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 GLY A 195
GLU A 235
TRP A 199
HIS A  79
 None
 1.09A 1maaD-3wdyA:
undetectable		 1maaD-3wdyA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmr PROLINE
IMINOPEPTIDASE

(Streptomyces
halstedii) 		PF00561
(Abhydrolase_1) 		4 GLY A  39
TYR A 211
SER A 110
HIS A 277
 None
 0.94A 1maaD-3wmrA:
13.3		 1maaD-3wmrA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 GLY A 134
GLU A 219
SER A 220
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
 0.39A 1maaD-4be9A:
37.0		 1maaD-4be9A:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 GLY A 135
GLU A 219
SER A 220
HIS A 465
 1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
 0.75A 1maaD-4be9A:
37.0		 1maaD-4be9A:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c89 ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 GLY A 107
TYR A 110
SER A 174
HIS A 313
 None
 0.60A 1maaD-4c89A:
14.3		 1maaD-4c89A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 GLY A 206
GLU A 179
TYR A 339
HIS A 214
 None
None
None
UNX  A 424 ( 3.2A)
 1.10A 1maaD-4egeA:
undetectable		 1maaD-4egeA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 GLY B 212
TYR B 214
GLU B 377
TYR B 454
 None
 1.06A 1maaD-4en8B:
undetectable		 1maaD-4en8B:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		4 GLY A 136
GLU A 217
SER A 218
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
 0.38A 1maaD-4fnmA:
38.2		 1maaD-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		4 GLY A 137
GLU A 217
SER A 218
HIS A 471
 DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
 0.80A 1maaD-4fnmA:
38.2		 1maaD-4fnmA:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd6 ENOYL-COA
HYDRATASE/ISOMERASE

(Paraburkholderia
graminis) 		PF00378
(ECH_1) 		4 GLY A  64
SER A  62
TRP A  81
TYR A  89
 None
 1.09A 1maaD-4kd6A:
undetectable		 1maaD-4kd6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		4 GLY A  57
GLU A 149
SER A 150
HIS A 429
 GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 0.79A 1maaD-4mwtA:
11.4		 1maaD-4mwtA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 GLY A 510
TYR A 509
SER A 512
HIS A 306
 None
 1.07A 1maaD-4mzdA:
undetectable		 1maaD-4mzdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		4 GLY X  76
TYR X 206
SER X 146
HIS X 278
 2HD  X 401 (-3.6A)
2HD  X 401 ( 3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.87A 1maaD-4n5iX:
19.5		 1maaD-4n5iX:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 GLY A 146
TYR A 233
SER A 212
HIS A  39
 None
 1.04A 1maaD-4nq8A:
undetectable		 1maaD-4nq8A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		7 GLY A 119
TYR A 121
GLU A 199
SER A 200
TRP A 279
TYR A 334
HIS A 440
 None
 1.17A 1maaD-4qwwA:
59.1		 1maaD-4qwwA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 TRP A  84
GLY A 117
SER A 200
HIS A 440
 None
 1.05A 1maaD-4qwwA:
59.1		 1maaD-4qwwA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		8 TRP A  84
GLY A 118
TYR A 121
GLU A 199
SER A 200
TRP A 279
TYR A 334
HIS A 440
 None
 0.57A 1maaD-4qwwA:
59.1		 1maaD-4qwwA:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		4 TRP A  58
GLY A 127
TYR A  85
SER A 125
 None
 1.02A 1maaD-4rgyA:
14.9		 1maaD-4rgyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgz XAA-PRO
AMINOPEPTIDASE

(Thermococcus
sibiricus) 		no annotation 4 GLY A 205
GLU A 176
TYR A 337
HIS A 213
 None
 0.94A 1maaD-4rgzA:
undetectable		 1maaD-4rgzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE

(Megavirus
chiliensis) 		PF02719
(Polysacc_synt_2) 		4 GLY A  13
SER A  35
TYR A  48
HIS A  41
 NDP  A 400 ( 4.4A)
NDP  A 400 (-3.7A)
None
None
 1.07A 1maaD-4tqgA:
undetectable		 1maaD-4tqgA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 TRP A  82
GLY A 115
SER A 198
HIS A 438
 40V  A1001 (-3.3A)
None
40V  A1001 (-3.1A)
40V  A1001 (-3.6A)
 1.04A 1maaD-4xiiA:
56.9		 1maaD-4xiiA:
52.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		6 TRP A  82
GLY A 116
GLU A 197
SER A 198
TYR A 332
HIS A 438
 40V  A1001 (-3.3A)
40V  A1001 (-3.2A)
40V  A1001 (-3.2A)
40V  A1001 (-3.1A)
40V  A1001 (-3.8A)
40V  A1001 (-3.6A)
 0.64A 1maaD-4xiiA:
56.9		 1maaD-4xiiA:
52.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		4 GLY A 244
TYR A 247
GLU A 267
TYR A 191
 None
None
HEM  A 504 (-4.5A)
None
 1.10A 1maaD-4xydA:
undetectable		 1maaD-4xydA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 GLY A 388
TYR A 378
GLU A 207
TYR A 344
 None
None
TRS  A7002 (-3.3A)
None
 1.04A 1maaD-5a2rA:
undetectable		 1maaD-5a2rA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 GLY A 125
GLU A 203
SER A 204
HIS A 449
 None
 0.32A 1maaD-5fv4A:
45.3		 1maaD-5fv4A:
35.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 GLY A 126
GLU A 203
SER A 204
HIS A 449
 None
 0.84A 1maaD-5fv4A:
45.3		 1maaD-5fv4A:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		4 GLY A 134
GLU A 167
TRP A  69
HIS A  90
 None
 1.04A 1maaD-5g56A:
undetectable		 1maaD-5g56A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00567
(TUDOR) 		4 GLY A 483
TRP A 431
TYR A 491
HIS A 488
 None
UNX  A 504 ( 4.3A)
None
None
 1.08A 1maaD-5j39A:
undetectable		 1maaD-5j39A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		4 GLY A 134
GLU A 167
TRP A  69
HIS A  90
 ARA  A 605 ( 4.0A)
None
None
None
 0.90A 1maaD-5la0A:
undetectable		 1maaD-5la0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc5 XAA-PRO DIPEPTIDASE

(Homo sapiens) 		no annotation 4 TRP A 326
GLY A 367
TYR A 382
HIS A 370
 None
None
GOL  A 506 ( 4.5A)
MN  A 499 ( 3.6A)
 1.08A 1maaD-5mc5A:
undetectable		 1maaD-5mc5A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtf RHOMBOID PROTEASE
GLPG

(Escherichia
coli) 		no annotation 4 GLY A 202
SER A 185
TRP A 158
HIS A 141
 None
 1.10A 1maaD-5mtfA:
undetectable		 1maaD-5mtfA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 4 GLY A 150
SER A 217
TYR A  30
HIS A 331
 None
 1.02A 1maaD-5no5A:
12.8		 1maaD-5no5A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 4 GLY A 149
TYR A   2
TYR A 145
HIS A 129
 None
 1.07A 1maaD-5nywA:
undetectable		 1maaD-5nywA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uem 354NC37 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 TRP H 103
GLY H 100
TYR H 100
HIS H  35
 None
 1.06A 1maaD-5uemH:
undetectable		 1maaD-5uemH:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		4 GLY A 319
GLU A 283
SER A 284
HIS A 438
 None
 1.02A 1maaD-5wveA:
undetectable		 1maaD-5wveA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrt -

(-) 		no annotation 4 GLY A 181
SER A 231
TYR A 195
HIS A 184
 None
 1.02A 1maaD-5xrtA:
undetectable		 1maaD-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 6 GLY A 280
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
 SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 1.20A 1maaD-5ydjA:
55.1		 1maaD-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 7 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 0.56A 1maaD-5ydjA:
55.1		 1maaD-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 TRP A 245
GLY A 278
SER A 360
HIS A 600
 None
 1.03A 1maaD-6arxA:
55.1		 1maaD-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 8 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
TRP A 441
TYR A 493
HIS A 600
 None
 0.60A 1maaD-6arxA:
55.1		 1maaD-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdt CALPAIN-3

(Homo sapiens) 		no annotation 4 GLY A 221
GLU A 226
TYR A  89
HIS A 213
 None
 0.95A 1maaD-6bdtA:
undetectable		 1maaD-6bdtA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 4 GLY A  91
TYR A 320
SER A 169
HIS A 421
 None
 0.95A 1maaD-6g21A:
10.0		 1maaD-6g21A:
10.20