SIMILAR PATTERNS OF AMINO ACIDS FOR 1M6E_X_SALX2000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8u EOSINOPHIL GRANULE
MAJOR BASIC PROTEIN
1

(Homo sapiens) 		PF00059
(Lectin_C) 		4 GLN A  84
TRP A 102
TRP A  75
VAL A  93
 None
 1.06A 1m6eX-1h8uA:
0.0		 1m6eX-1h8uA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 GLN X 146
TRP X 117
MET X 187
VAL X 179
 None
 0.98A 1m6eX-3n5nX:
undetectable		 1m6eX-3n5nX:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 LYS A 193
TRP A 167
TYR A 127
VAL A 279
 None
 1.33A 1m6eX-4qszA:
0.1		 1m6eX-4qszA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		4 GLN A 208
TYR A  58
MET A 213
VAL A 217
 UMP  A 401 (-4.2A)
None
None
None
 1.40A 1m6eX-5by6A:
0.0		 1m6eX-5by6A:
22.93