SIMILAR PATTERNS OF AMINO ACIDS FOR 1M17_A_AQ4A999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
LYS A 430
THR A 474
MET A 477
GLY A 480
LEU A 528
ASP A 539
 None
 0.57A 1m17A-1k2pA:
30.0		 1m17A-1k2pA:
32.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 220
LYS A 222
GLU A 236
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.49A 1m17A-1k9aA:
31.9		 1m17A-1k9aA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
ALA A 288
LYS A 290
GLU A 305
THR A 334
MET A 337
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.70A 1m17A-1opkA:
31.9		 1m17A-1opkA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.45A 1m17A-1py5A:
22.9		 1m17A-1py5A:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.68A 1m17A-1t46A:
26.4		 1m17A-1t46A:
31.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
HYM  A 400 (-4.5A)
 0.70A 1m17A-1zltA:
23.4		 1m17A-1zltA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		8 ALA A  39
LYS A  41
GLU A  55
LEU A  83
LEU A  87
GLY A  89
LEU A 138
ASP A 154
 CKI  A 300 (-3.6A)
None
None
None
None
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 1.30A 1m17A-2csnA:
22.7		 1m17A-2csnA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
ALA X  37
LYS X  39
GLU X  54
THR X  82
MET X  85
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.1A)
None
STU  X 902 (-3.6A)
 0.77A 1m17A-2dq7X:
33.7		 1m17A-2dq7X:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
ALA X  37
LYS X  39
GLU X  54
THR X  82
MET X  85
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.59A 1m17A-2dq7X:
33.7		 1m17A-2dq7X:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A  19
ALA A  40
LYS A  42
GLU A  59
LEU A  95
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-4.3A)
 0.49A 1m17A-2f9gA:
23.1		 1m17A-2f9gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.50A 1m17A-2h8hA:
29.6		 1m17A-2h8hA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.70A 1m17A-2hckA:
28.3		 1m17A-2hckA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.44A 1m17A-2hk5A:
27.8		 1m17A-2hk5A:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
ALA A 269
LYS A 271
GLU A 286
THR A 315
MET A 318
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
 0.70A 1m17A-2hz0A:
30.9		 1m17A-2hz0A:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
LYS A 273
GLU A 288
THR A 316
MET A 319
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.76A 1m17A-2og8A:
24.2		 1m17A-2og8A:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		9 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 101
LEU A 105
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.71A 1m17A-2phkA:
24.9		 1m17A-2phkA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 LEU A  25
ALA A  46
LYS A  48
LEU A 105
MET A 106
GLY A 109
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.62A 1m17A-2phkA:
24.9		 1m17A-2phkA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 ALA B  67
GLU B  85
LEU B 112
MET B 117
GLY B 120
LEU B 171
THR B 181
 None
 0.70A 1m17A-2qkwB:
26.2		 1m17A-2qkwB:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 215
LYS A 217
GLU A 230
LEU A 263
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.68A 1m17A-2qluA:
26.4		 1m17A-2qluA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A 449
LYS A 451
GLU A 463
THR A 493
LEU A 495
MET A 496
ASP A 561
 None
 0.64A 1m17A-2qr7A:
21.3		 1m17A-2qr7A:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 724
ALA A 749
LYS A 751
LEU A 794
THR A 796
LEU A 798
MET A 799
GLY A 802
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.75A 1m17A-2r4bA:
32.2		 1m17A-2r4bA:
75.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 724
ALA A 749
LYS A 751
LEU A 794
THR A 796
LEU A 798
MET A 799
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.87A 1m17A-2r4bA:
32.2		 1m17A-2r4bA:
75.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
MG  A1304 ( 2.8A)
 0.77A 1m17A-2w4kA:
25.3		 1m17A-2w4kA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 445
LYS A 447
GLU A 459
LEU A 487
THR A 489
LEU A 491
MET A 492
 None
 0.62A 1m17A-2wntA:
21.0		 1m17A-2wntA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 226
ALA A 247
LYS A 249
LEU A 303
MET A 304
GLY A 307
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.85A 1m17A-2xk9A:
21.3		 1m17A-2xk9A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  51
LYS A  53
LEU A 105
LEU A 109
MET A 110
GLY A 113
LEU A 160
ASP A 171
 B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.49A 1m17A-2y7jA:
25.9		 1m17A-2y7jA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 LYS A  53
GLU A  77
LEU A 109
MET A 110
GLY A 113
LEU A 160
ASP A 171
 None
None
B49  A1294 ( 4.7A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.74A 1m17A-2y7jA:
25.9		 1m17A-2y7jA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.1A)
 0.81A 1m17A-2yabA:
21.5		 1m17A-2yabA:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1002
ALA A1028
LYS A1030
GLU A1047
LEU A1078
MET A1079
GLY A1082
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
S91  A   1 (-4.7A)
None
S91  A   1 (-3.3A)
None
 0.82A 1m17A-2z8cA:
31.9		 1m17A-2z8cA:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 253
ALA A 273
LYS A 275
GLU A 290
THR A 319
MET A 322
GLY A 325
LEU A 374
 None
 0.59A 1m17A-2zv7A:
32.7		 1m17A-2zv7A:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 220
LYS A 222
GLU A 236
THR A 266
MET A 269
GLY A 272
LEU A 321
 None
 0.49A 1m17A-3d7uA:
26.4		 1m17A-3d7uA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
ALA A 455
LYS A 457
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.89A 1m17A-3fzpA:
31.8		 1m17A-3fzpA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 ALA A 247
LEU A 303
MET A 304
GLY A 307
LEU A 354
THR A 367
ASP A 368
 None
 0.75A 1m17A-3i6uA:
17.1		 1m17A-3i6uA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 LEU A 226
ALA A 247
LEU A 303
MET A 304
LEU A 354
THR A 367
ASP A 368
 None
 0.71A 1m17A-3i6uA:
17.1		 1m17A-3i6uA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 696
LYS A 723
LEU A 766
THR A 768
GLY A 774
LEU A 822
ASP A 833
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
 0.84A 1m17A-3kexA:
32.0		 1m17A-3kexA:
54.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 199
LYS A 220
LEU A 267
THR A 269
MET A 272
GLY A 275
ASP A 339
 None
 0.88A 1m17A-3kmuA:
24.6		 1m17A-3kmuA:
24.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
LYS A 667
GLU A 684
THR A 713
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.67A 1m17A-3kulA:
30.5		 1m17A-3kulA:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
 0.93A 1m17A-3lm5A:
24.8		 1m17A-3lm5A:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 719
LEU A 764
THR A 766
LEU A 768
GLY A 772
LEU A 820
THR A 830
 ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
 1.00A 1m17A-3lzbA:
34.0		 1m17A-3lzbA:
86.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 719
THR A 766
LEU A 768
GLY A 772
LEU A 820
THR A 830
ASP A 831
 ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
 0.83A 1m17A-3lzbA:
34.0		 1m17A-3lzbA:
86.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 694
ALA A 719
THR A 766
LEU A 768
GLY A 772
THR A 830
ASP A 831
 ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
 0.96A 1m17A-3lzbA:
34.0		 1m17A-3lzbA:
86.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ALA A 229
LYS A 231
GLU A 244
LEU A 277
THR A 279
GLY A 285
LEU A 339
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.66A 1m17A-3mdyA:
26.6		 1m17A-3mdyA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
LYS A 229
GLU A 242
LEU A 275
THR A 277
GLY A 283
LEU A 337
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.81A 1m17A-3my0A:
26.4		 1m17A-3my0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.54A 1m17A-3nyoA:
24.5		 1m17A-3nyoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		7 ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
LEU A 109
MET A 110
 1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
None
 0.57A 1m17A-3ohtA:
3.8		 1m17A-3ohtA:
27.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 751
LEU A 796
THR A 798
LEU A 800
MET A 801
THR A 862
ASP A 863
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.83A 1m17A-3pp0A:
38.0		 1m17A-3pp0A:
78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 726
ALA A 751
LYS A 753
LEU A 796
THR A 798
LEU A 800
MET A 801
GLY A 804
LEU A 852
THR A 862
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.69A 1m17A-3pp0A:
38.0		 1m17A-3pp0A:
78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
THR A 625
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.76A 1m17A-3ppzA:
31.2		 1m17A-3ppzA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
MG  A 529 (-2.2A)
 0.84A 1m17A-3q5iA:
23.8		 1m17A-3q5iA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
ALA A 315
GLU A 334
LEU A 361
MET A 366
GLY A 369
LEU A 423
 None
 0.84A 1m17A-3ulzA:
24.4		 1m17A-3ulzA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
GLU A 334
LEU A 361
MET A 366
GLY A 369
LEU A 423
ASP A 434
 None
 0.91A 1m17A-3ulzA:
24.4		 1m17A-3ulzA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
ALA A  96
LYS A  98
MET A 147
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.88A 1m17A-3wigA:
22.2		 1m17A-3wigA:
26.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
ALA A1978
LYS A1980
LEU A2028
MET A2029
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.8A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.35A 1m17A-3zbfA:
27.6		 1m17A-3zbfA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
LYS A 651
GLU A 668
THR A 697
MET A 700
GLY A 703
LEU A 751
ASP A 762
 None
 0.72A 1m17A-3zfxA:
34.5		 1m17A-3zfxA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 121
LYS A 123
GLU A 140
THR A 169
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.74A 1m17A-4aw5A:
28.1		 1m17A-4aw5A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 233
GLU A 248
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
None
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.78A 1m17A-4c02A:
26.9		 1m17A-4c02A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 233
LYS A 235
LEU A 281
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.68A 1m17A-4c02A:
26.9		 1m17A-4c02A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
ALA A 267
LYS A 269
GLU A 288
GLY A 324
LEU A 371
THR A 381
ASP A 382
 None
 0.83A 1m17A-4c0tA:
23.8		 1m17A-4c0tA:
15.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 653
LYS A 655
GLU A 672
THR A 701
MET A 704
LEU A 773
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-4.5A)
 0.83A 1m17A-4ckrA:
29.5		 1m17A-4ckrA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
ALA A 400
LYS A 402
GLU A 420
LEU A 446
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.68A 1m17A-4f4pA:
34.8		 1m17A-4f4pA:
39.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.87A 1m17A-4fl3A:
29.4		 1m17A-4fl3A:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
ALA A1148
GLU A1167
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.44A 1m17A-4fodA:
31.5		 1m17A-4fodA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
ALA A1148
LYS A1150
GLU A1167
LEU A1198
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.83A 1m17A-4fodA:
31.5		 1m17A-4fodA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
ALA A 880
LYS A 882
GLU A 898
LEU A 927
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.80A 1m17A-4gl9A:
32.9		 1m17A-4gl9A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
ALA A 853
LYS A 855
GLU A 871
LEU A 900
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.88A 1m17A-4hviA:
28.2		 1m17A-4hviA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
ALA A 156
LYS A 158
THR A 205
LEU A 207
GLY A 211
LEU A 259
ASP A 270
 None
 0.72A 1m17A-4hzsA:
28.8		 1m17A-4hzsA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
ALA A 156
GLU A 177
THR A 205
LEU A 207
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.96A 1m17A-4id7A:
34.5		 1m17A-4id7A:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
ALA A 156
LYS A 158
THR A 205
LEU A 207
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.53A 1m17A-4id7A:
34.5		 1m17A-4id7A:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.77A 1m17A-4k11A:
29.2		 1m17A-4k11A:
25.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.44A 1m17A-4lggA:
29.2		 1m17A-4lggA:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
LEU A  93
THR A  95
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 0.67A 1m17A-4m69A:
14.7		 1m17A-4m69A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  46
ALA A  67
LYS A  69
GLU A  85
LEU A 121
THR A 123
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.63A 1m17A-4o38A:
20.8		 1m17A-4o38A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.99A 1m17A-4oliA:
31.6		 1m17A-4oliA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
MET A 266
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.71A 1m17A-4tnbA:
22.6		 1m17A-4tnbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
LYS A 215
GLU A 234
MET A 266
GLY A 269
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.98A 1m17A-4tnbA:
22.6		 1m17A-4tnbA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
ALA A  35
LYS A  37
GLU A  52
THR A  81
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.52A 1m17A-4ueuA:
32.4		 1m17A-4ueuA:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
ALA A 214
LYS A 216
GLU A 235
LEU A 262
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.64A 1m17A-4wboA:
25.9		 1m17A-4wboA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 LEU B 267
ALA B 288
LYS B 290
THR B 334
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.42A 1m17A-4xeyB:
28.0		 1m17A-4xeyB:
28.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.70A 1m17A-4xufA:
29.8		 1m17A-4xufA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.71A 1m17A-4y93A:
29.4		 1m17A-4y93A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
ALA A 428
LYS A 430
THR A 474
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.58A 1m17A-4y93A:
29.4		 1m17A-4y93A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
ALA A 214
LYS A 216
GLU A 235
LEU A 262
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
 0.62A 1m17A-4yhjA:
23.7		 1m17A-4yhjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.90A 1m17A-4ysjA:
25.2		 1m17A-4ysjA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 577
ALA A 597
LYS A 599
GLU A 612
LEU A 644
LEU A 695
ASP A 711
 None
 0.94A 1m17A-4z7gA:
19.9		 1m17A-4z7gA:
25.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.61A 1m17A-5a46A:
31.0		 1m17A-5a46A:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  44
LYS A  46
GLU A  63
LEU A  90
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.81A 1m17A-5ci7A:
26.0		 1m17A-5ci7A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
LYS A 277
GLU A 290
LEU A 323
THR A 325
GLY A 331
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.49A 1m17A-5e8yA:
26.6		 1m17A-5e8yA:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.81A 1m17A-5f1zA:
31.5		 1m17A-5f1zA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.63A 1m17A-5grnA:
24.3		 1m17A-5grnA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.76A 1m17A-5hu3A:
25.8		 1m17A-5hu3A:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 718
ALA A 743
LYS A 745
GLU A 762
LEU A 788
LEU A 792
MET A 793
GLY A 796
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.38A 1m17A-5j9zA:
40.8		 1m17A-5j9zA:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 417
LYS A 419
GLU A 436
LEU A 463
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.76A 1m17A-5jznA:
24.8		 1m17A-5jznA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ALA A 909
LYS A 911
GLU A 927
LEU A 954
MET A 959
GLY A 962
LEU A1016
 ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
 0.53A 1m17A-5lpyA:
26.0		 1m17A-5lpyA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ALA A 909
LYS A 911
GLU A 927
LEU A 954
MET A 959
GLY A 962
LEU A1016
 ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
None
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
 0.49A 1m17A-5lpzA:
25.8		 1m17A-5lpzA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 116
ALA A 137
GLU A 157
LEU A 185
THR A 187
LEU A 189
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
None
EDO  A 402 ( 2.9A)
 0.75A 1m17A-5vcxA:
24.5		 1m17A-5vcxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 116
ALA A 137
LYS A 139
GLU A 157
LEU A 185
THR A 187
LEU A 189
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
None
 0.89A 1m17A-5vcxA:
24.5		 1m17A-5vcxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.90A 1m17A-5wnoA:
30.5		 1m17A-5wnoA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 7 ALA A 237
LYS A 239
GLU A 259
LEU A 286
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.84A 1m17A-6bfnA:
24.6		 1m17A-6bfnA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.73A 1m17A-6c7yA:
32.9		 1m17A-6c7yA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
ALA A 217
LYS A 219
THR A 264
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.99A 1m17A-6cz4A:
28.4		 1m17A-6cz4A:
17.13