SIMILAR PATTERNS OF AMINO ACIDS FOR 1LWE_A_NVPA999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		4 LEU A 153
VAL A 211
TYR A 156
GLY A 212
 None
 1.02A 1lweA-1f2pA:
0.0		 1lweA-1f2pA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		4 VAL A  30
TYR A 107
TYR A 110
GLY A  29
 None
 0.99A 1lweA-1gmzA:
undetectable		 1lweA-1gmzA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 VAL A 331
TYR A 165
GLY A 330
TYR A 298
 None
None
None
FAD  A 579 (-4.4A)
 1.00A 1lweA-1h81A:
0.0		 1lweA-1h81A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 LEU A1024
TYR A1100
GLY A1080
TYR A1025
 None
 1.00A 1lweA-1ha5A:
2.1		 1lweA-1ha5A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 VAL A 106
TYR A 181
TYR A 188
GLY A 190
 None
 0.50A 1lweA-1harA:
23.1		 1lweA-1harA:
42.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		4 LEU A  94
TYR A 156
GLY A 105
TYR A  93
 None
 1.02A 1lweA-1k7hA:
0.0		 1lweA-1k7hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		5 LEU A 193
TYR A 178
GLY A 149
TRP A 189
TYR A  25
 None
 1.36A 1lweA-1mn6A:
undetectable		 1lweA-1mn6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 182
VAL A 166
TYR A 136
GLY A 138
 None
 1.00A 1lweA-1qfjA:
undetectable		 1lweA-1qfjA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LEU A 233
VAL A 148
TYR A 152
GLY A 178
 None
None
None
PLP  A 413 (-3.9A)
 1.03A 1lweA-1ve1A:
0.0		 1lweA-1ve1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmo VITELLINE MEMBRANE
OUTER LAYER PROTEIN
I

(Gallus gallus) 		PF03762
(VOMI) 		4 LEU A  58
VAL A  78
TYR A  83
GLY A  33
 None
 0.98A 1lweA-1vmoA:
undetectable		 1lweA-1vmoA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.85A 1lweA-1wzaA:
undetectable		 1lweA-1wzaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 VAL A 207
TYR A 244
TYR A 215
GLY A 217
 None
 0.80A 1lweA-1xfdA:
undetectable		 1lweA-1xfdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxg ENTEROTOXIN

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 LEU A  28
TYR A 110
GLY A  84
TYR A  29
 None
 0.99A 1lweA-1xxgA:
undetectable		 1lweA-1xxgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amy PHOSPHOMANNOMUTASE 2

(Homo sapiens) 		PF03332
(PMM) 		4 VAL A 231
TYR A 205
TYR A 229
GLY A 208
 None
 1.02A 1lweA-2amyA:
2.8		 1lweA-2amyA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 LEU A  31
VAL A  15
GLY A  17
TYR A  42
 None
 0.95A 1lweA-2b5mA:
undetectable		 1lweA-2b5mA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.37A 1lweA-2c6rA:
undetectable		 1lweA-2c6rA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A  10
TYR A  11
GLY A 161
TYR A 264
 None
 1.01A 1lweA-2ebdA:
undetectable		 1lweA-2ebdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493

(Streptococcus
pyogenes) 		PF02645
(DegV) 		4 LEU A 213
VAL A 189
TYR A 158
GLY A 160
 None
 0.85A 1lweA-2g7zA:
2.7		 1lweA-2g7zA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LEU A 100
VAL A 106
TYR A 181
TYR A 188
GLY A 190
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.3A)
 0.33A 1lweA-2hnzA:
34.2		 1lweA-2hnzA:
98.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 324
TYR A 279
GLY A 296
TYR A 300
 None
 1.00A 1lweA-2iopA:
undetectable		 1lweA-2iopA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 LEU A 149
VAL A 123
GLY A 122
TYR A 144
 None
 0.92A 1lweA-2ipcA:
undetectable		 1lweA-2ipcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbg NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A  20
VAL A  37
TYR A  71
TYR A  39
 None
 0.99A 1lweA-2kbgA:
undetectable		 1lweA-2kbgA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kcw UNCHARACTERIZED
ACETYLTRANSFERASE
YJAB

(Escherichia
coli) 		PF13673
(Acetyltransf_10) 		4 LEU A 102
VAL A 120
TYR A 117
GLY A 121
 None
 0.90A 1lweA-2kcwA:
undetectable		 1lweA-2kcwA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxf UNCHARACTERIZED
PROTEIN

(Giardia
intestinalis) 		PF00708
(Acylphosphatase) 		4 LEU A  92
VAL A  66
GLY A  76
TYR A  91
 None
 1.00A 1lweA-2lxfA:
3.2		 1lweA-2lxfA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0p TYPE 2A
PHOSPHATASE-ASSOCIAT
ED PROTEIN 42

(Saccharomyces
cerevisiae) 		PF04177
(TAP42) 		4 LEU A 146
VAL A 128
GLY A 129
TYR A 147
 None
 0.98A 1lweA-2v0pA:
undetectable		 1lweA-2v0pA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 VAL A 103
TYR A  64
GLY A  25
TYR A  81
 None
GOL  A1366 (-3.7A)
None
None
 1.02A 1lweA-2we8A:
undetectable		 1lweA-2we8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 LEU A 669
TYR A 531
TYR A 678
GLY A 674
 None
 1.00A 1lweA-2xaxA:
undetectable		 1lweA-2xaxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 LEU A  77
TYR A 286
GLY A  46
TRP A 288
TYR A  68
 None
 1.28A 1lweA-2y24A:
2.2		 1lweA-2y24A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 VAL A 381
TYR A 264
GLY A 379
TYR A 343
 None
 0.93A 1lweA-2y3sA:
3.1		 1lweA-2y3sA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy7 L-THREONINE
DEHYDROGENASE

(Flavobacterium
frigidimaris) 		PF01370
(Epimerase) 		4 VAL A 165
TYR A 156
TYR A 157
TRP A 153
 None
None
None
PE8  A2002 (-4.8A)
 0.91A 1lweA-2yy7A:
undetectable		 1lweA-2yy7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00622
(SPRY) 		4 VAL A  58
TYR A  80
GLY A  59
TYR A  42
 None
 0.92A 1lweA-2yyoA:
undetectable		 1lweA-2yyoA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta) 		4 LEU B 189
VAL B 131
GLY B 148
TYR B 145
 None
 0.98A 1lweA-2zpbB:
undetectable		 1lweA-2zpbB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a55 PROTEIN-GLUTAMINASE

(Chryseobacterium
proteolyticum) 		no annotation 4 VAL A  30
TYR A  50
GLY A  31
TYR A 196
 None
 1.01A 1lweA-3a55A:
undetectable		 1lweA-3a55A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		4 LEU A 205
VAL A 234
TYR A 214
TYR A 275
 None
 0.75A 1lweA-3alxA:
undetectable		 1lweA-3alxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 LEU A  75
VAL A 274
GLY A 275
TYR A 107
 None
 0.88A 1lweA-3c9fA:
undetectable		 1lweA-3c9fA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 LEU A 320
GLY A 277
TRP A  46
TYR A  36
 None
 0.96A 1lweA-3cc1A:
undetectable		 1lweA-3cc1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 18 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04099
(Sybindin) 		4 LEU C  86
VAL C 115
TYR C 123
TYR C 107
 None
 0.93A 1lweA-3cueC:
undetectable		 1lweA-3cueC:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzm HYPOTHETICAL
CONSERVED PROTEIN

(Thermus
thermophilus) 		no annotation 4 VAL A  62
TYR A  51
GLY A  60
TYR A 109
 None
 0.94A 1lweA-3dzmA:
undetectable		 1lweA-3dzmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5o UNCHARACTERIZED
PROTEIN RV2866

(Mycobacterium
tuberculosis) 		PF05016
(ParE_toxin) 		4 LEU B  77
VAL B  56
GLY B  57
TYR B  75
 None
 1.01A 1lweA-3g5oB:
undetectable		 1lweA-3g5oB:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 201
VAL A 213
GLY A 212
TYR A  11
 None
 1.03A 1lweA-3gdnA:
undetectable		 1lweA-3gdnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfa PUTATIVE
NITROREDUCTASE

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		4 LEU A  75
TYR A 153
TYR A 156
GLY A  64
 None
 1.02A 1lweA-3gfaA:
undetectable		 1lweA-3gfaA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it8 2L PROTEIN

(Tanapox virus) 		no annotation 4 LEU D  93
TYR D 120
GLY D  96
TYR D   7
 None
 1.01A 1lweA-3it8D:
undetectable		 1lweA-3it8D:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 LEU A 145
VAL A 119
GLY A 118
TYR A 140
 None
 1.00A 1lweA-3juxA:
undetectable		 1lweA-3juxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		4 LEU A 367
VAL A 205
TYR A 403
GLY A 393
 None
 1.01A 1lweA-3jzjA:
undetectable		 1lweA-3jzjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		4 VAL A  97
TYR A 361
GLY A  74
TYR A 109
 None
 1.01A 1lweA-3kk7A:
undetectable		 1lweA-3kk7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		4 LEU A 298
VAL A 293
TYR A 284
GLY A 289
 None
 1.03A 1lweA-3m4uA:
undetectable		 1lweA-3m4uA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 LEU A 806
VAL A 827
TYR A 816
GLY A 818
 None
 0.94A 1lweA-3pieA:
undetectable		 1lweA-3pieA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 LEU A 167
VAL A 155
TYR A 126
GLY A 128
 None
 0.94A 1lweA-3rhyA:
undetectable		 1lweA-3rhyA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy6 FIMBRIAL PROTEIN
BF1861

(Bacteroides
fragilis) 		PF13149
(Mfa_like_1) 		4 LEU A 116
TYR A 131
GLY A  55
TYR A 107
 None
 0.90A 1lweA-3sy6A:
undetectable		 1lweA-3sy6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		4 LEU A  22
TYR A  37
TYR A  57
GLY A  55
 None
 0.90A 1lweA-3tl6A:
undetectable		 1lweA-3tl6A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A2431
VAL A2512
TYR A2505
TYR A2430
 None
 0.89A 1lweA-3vkgA:
undetectable		 1lweA-3vkgA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		4 VAL A 242
TYR A   7
TYR A   6
GLY A   4
 None
None
FUD  A 301 (-4.6A)
None
 1.01A 1lweA-3vnkA:
undetectable		 1lweA-3vnkA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A 989
VAL A1007
TYR A 926
GLY A1006
 None
 0.88A 1lweA-3w9hA:
undetectable		 1lweA-3w9hA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		4 VAL A  54
TYR A 174
TYR A 171
GLY A 168
 None
 0.92A 1lweA-4bmrA:
undetectable		 1lweA-4bmrA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 LEU A 234
VAL A  81
TYR A  67
GLY A  69
 None
 0.86A 1lweA-4c1oA:
undetectable		 1lweA-4c1oA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus
subtilis) 		PF01048
(PNP_UDP_1) 		4 LEU A  17
TYR A  32
TYR A  52
GLY A  50
 None
 0.94A 1lweA-4daoA:
undetectable		 1lweA-4daoA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrobaculum
neutrophilum) 		PF00215
(OMPdecase) 		4 LEU A  11
VAL A  29
TYR A  53
GLY A  31
 None
 0.99A 1lweA-4df1A:
undetectable		 1lweA-4df1A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		4 LEU A 298
VAL A 218
TYR A 174
GLY A 176
 None
None
SO4  A 401 (-4.6A)
None
 0.87A 1lweA-4ee8A:
undetectable		 1lweA-4ee8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		4 LEU A 168
TYR A 151
GLY A 163
TYR A 171
 None
 1.01A 1lweA-4effA:
2.3		 1lweA-4effA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6b ALLENE OXIDE CYCLASE

(Physcomitrella
patens) 		PF06351
(Allene_ox_cyc) 		4 LEU A 133
TYR A  87
GLY A 105
TYR A 144
 None
10Y  A 202 ( 3.8A)
None
None
 0.94A 1lweA-4h6bA:
undetectable		 1lweA-4h6bA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifa EXTRACELLULAR
PROTEIN CONTAINING A
SCP DOMAIN

(Bacillus
anthracis) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 VAL A 116
TYR A  89
GLY A 113
TYR A 187
 CL  A 404 ( 3.9A)
None
None
None
 1.03A 1lweA-4ifaA:
undetectable		 1lweA-4ifaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		4 LEU A  69
VAL A 138
TYR A 135
GLY A 139
 GOL  A 301 ( 4.5A)
None
None
None
 0.94A 1lweA-4jfcA:
undetectable		 1lweA-4jfcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1

(Mycobacterium
tuberculosis) 		PF05108
(T7SS_ESX1_EccB) 		4 LEU A 445
VAL A 395
TYR A 418
TYR A 410
 None
 0.99A 1lweA-4kk7A:
undetectable		 1lweA-4kk7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krt AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25)
PF08239
(SH3_3) 		4 LEU A 221
VAL A 258
TYR A 256
GLY A 265
 None
None
ACT  A 404 ( 4.6A)
None
 0.93A 1lweA-4krtA:
undetectable		 1lweA-4krtA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 4 VAL A 311
TYR A 296
TYR A 308
GLY A 280
 HEC  A 801 ( 4.0A)
None
HEC  A 801 ( 4.6A)
None
 0.95A 1lweA-4lmhA:
undetectable		 1lweA-4lmhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi) 		no annotation 4 LEU A 292
TYR A 165
GLY A 163
TYR A 294
 None
 1.02A 1lweA-4lt5A:
undetectable		 1lweA-4lt5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 LEU A 192
VAL A 168
GLY A 167
TYR A 194
 None
 0.90A 1lweA-4maeA:
undetectable		 1lweA-4maeA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN

(Paraburkholderia
graminis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 VAL A 203
TYR A 197
GLY A 200
TRP A 189
 None
BEZ  A 303 (-4.2A)
None
GSH  A 302 (-4.4A)
 1.00A 1lweA-4mf6A:
undetectable		 1lweA-4mf6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF08003
(Methyltransf_9) 		4 LEU A  51
VAL A  96
GLY A  95
TYR A 163
 None
 0.95A 1lweA-4p7cA:
undetectable		 1lweA-4p7cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		4 LEU A 263
TYR A 138
GLY A 135
TYR A 267
 None
 1.00A 1lweA-4p98A:
undetectable		 1lweA-4p98A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 VAL A 340
TYR A 355
GLY A 357
TRP A 379
 None
 1.01A 1lweA-4qanA:
undetectable		 1lweA-4qanA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		4 LEU A 153
TYR A  58
GLY A  52
TYR A 154
 None
 0.70A 1lweA-5a2oA:
undetectable		 1lweA-5a2oA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1

(Homo sapiens) 		no annotation 4 LEU A  50
VAL A  32
GLY A  29
TYR A  47
 None
 0.90A 1lweA-5aj1A:
undetectable		 1lweA-5aj1A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwj SENSORY TRANSDUCTION
HISTIDINE KINASE,
PUTATIVE

(Borreliella
burgdorferi) 		PF00497
(SBP_bac_3) 		4 LEU A  97
VAL A  35
TYR A  88
GLY A  90
 None
 1.03A 1lweA-5bwjA:
undetectable		 1lweA-5bwjA:
16.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 VAL B 106
TYR B 181
TYR B 188
GLY B 190
 None
 0.47A 1lweA-5c24B:
18.9		 1lweA-5c24B:
96.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		4 LEU A 127
VAL A 103
TYR A 101
TYR A 124
 None
 0.74A 1lweA-5c77A:
undetectable		 1lweA-5c77A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cc2 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A  37
VAL A  16
TYR A  29
GLY A  31
 None
 0.85A 1lweA-5cc2A:
undetectable		 1lweA-5cc2A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		4 LEU A  44
TYR A 260
GLY A  19
TYR A  39
 None
None
NA  A 604 ( 3.9A)
None
 0.88A 1lweA-5cxpA:
2.2		 1lweA-5cxpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  28
VAL H  35
TYR H 100
GLY H  34
 None
NA  H 301 ( 4.9A)
None
NA  H 301 ( 3.8A)
 0.94A 1lweA-5eorH:
undetectable		 1lweA-5eorH:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 LEU A  31
VAL A  15
GLY A  17
TYR A  42
 None
 0.97A 1lweA-5fqdA:
undetectable		 1lweA-5fqdA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU B 124
VAL B 366
GLY B 367
TYR B 128
 None
 0.97A 1lweA-5fwxB:
undetectable		 1lweA-5fwxB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		4 LEU A 217
VAL A 262
TYR A 243
GLY A 245
 None
 0.93A 1lweA-5gqtA:
undetectable		 1lweA-5gqtA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 LEU A 624
VAL A 620
TYR A 667
GLY A 631
 None
 1.02A 1lweA-5i08A:
undetectable		 1lweA-5i08A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  91
TYR L  93
TRP H  46
TYR L  38
 None
 0.95A 1lweA-5i8oL:
undetectable		 1lweA-5i8oL:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		4 LEU A  66
TYR A 285
GLY A  69
TRP A 605
 None
 1.03A 1lweA-5icqA:
3.2		 1lweA-5icqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		4 VAL A 181
TYR A 174
TYR A 178
GLY A 169
 None
 1.01A 1lweA-5k51A:
undetectable		 1lweA-5k51A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj4 PROTOCADHERIN-15

(Mus musculus) 		PF00028
(Cadherin) 		4 LEU A1084
VAL A1034
TYR A1069
GLY A1035
 None
 1.00A 1lweA-5kj4A:
undetectable		 1lweA-5kj4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l10 N-ACYLHOMOSERINE
LACTONE DEPENDENT
REGULATORY PROTEIN

(Burkholderia
cenocepacia) 		PF03472
(Autoind_bind) 		4 VAL A  39
TYR A  40
GLY A  57
TYR A  67
 None
None
None
GOL  A 201 ( 4.9A)
 0.96A 1lweA-5l10A:
undetectable		 1lweA-5l10A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 4 LEU B 112
VAL B 490
TYR B 492
GLY B 483
 None
 1.01A 1lweA-5oetB:
undetectable		 1lweA-5oetB:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 LEU B 439
VAL B 397
GLY B 444
TYR B 436
 None
 0.91A 1lweA-5ofbB:
undetectable		 1lweA-5ofbB:
8.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 LEU A  99
VAL A 105
GLY A 189
TYR A 317
 None
 0.63A 1lweA-5ovnA:
26.7		 1lweA-5ovnA:
56.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 VAL B 105
TYR B 180
TYR B 187
GLY B 189
 None
 0.37A 1lweA-5ovnB:
17.5		 1lweA-5ovnB:
60.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ua0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 LEU A  92
VAL A 113
TYR A 110
GLY A 114
 None
 0.82A 1lweA-5ua0A:
undetectable		 1lweA-5ua0A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwa PROBABLE
PHOSPHOLIPID-BINDING
PROTEIN MLAC

(Escherichia
coli) 		PF05494
(MlaC) 		4 LEU A 101
VAL A  77
GLY A  74
TYR A 100
 None
 0.96A 1lweA-5uwaA:
undetectable		 1lweA-5uwaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load) 		4 LEU A 184
VAL A 142
TYR A 162
TRP A 194
 None
 1.02A 1lweA-5w94A:
undetectable		 1lweA-5w94A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 4 LEU A 211
VAL A 206
TYR A 187
TRP A 392
 None
 0.95A 1lweA-5wixA:
undetectable		 1lweA-5wixA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-) 		no annotation 4 LEU A 211
TYR A 218
GLY A 225
TYR A 207
 None
 1.03A 1lweA-5y9pA:
3.1		 1lweA-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 LEU A 537
VAL A 498
TYR A 282
GLY A 499
 None
 0.71A 1lweA-6bfuA:
undetectable		 1lweA-6bfuA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 4 TYR I 234
TYR I 261
GLY I 279
TYR I   9
 None
 0.96A 1lweA-6esqI:
undetectable		 1lweA-6esqI:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fk6 RHODOPSIN

(Bos taurus) 		no annotation 4 LEU A  46
VAL A 300
GLY A  51
TYR A  43
 None
 0.94A 1lweA-6fk6A:
undetectable		 1lweA-6fk6A:
8.75