SIMILAR PATTERNS OF AMINO ACIDS FOR 1LWC_A_NVPA999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.47A 1lwcA-1axdA:
undetectable		 1lwcA-1axdA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LEU A 355
VAL A 290
TYR A 329
GLY A 289
LEU A 307
 None
 1.40A 1lwcA-1crkA:
2.9		 1lwcA-1crkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcu HYALURONOGLUCOSAMINI
DASE

(Apis mellifera) 		PF01630
(Glyco_hydro_56) 		5 LEU A 324
VAL A  17
GLY A 302
LEU A 278
TYR A 319
 None
 1.24A 1lwcA-1fcuA:
undetectable		 1lwcA-1fcuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		5 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.20A 1lwcA-1fztA:
undetectable		 1lwcA-1fztA:
17.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		5 LYS A 104
VAL A 179
TYR A 181
TYR A 188
GLY A 190
 None
 1.00A 1lwcA-1harA:
24.3		 1lwcA-1harA:
93.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		5 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
 None
 0.55A 1lwcA-1harA:
24.3		 1lwcA-1harA:
93.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		5 VAL A 553
VAL A 673
GLY A 554
TRP A 546
LEU A 568
 None
 1.47A 1lwcA-1hn0A:
0.0		 1lwcA-1hn0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr2 UROPORPHYRINOGEN-III
SYNTHASE

(Homo sapiens) 		PF02602
(HEM4) 		5 PRO A 142
LEU A  59
VAL A 107
GLY A 111
LEU A  50
 None
 1.27A 1lwcA-1jr2A:
undetectable		 1lwcA-1jr2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PRO A 263
LEU A 240
VAL A 189
GLY A 186
LEU A 260
 None
 1.50A 1lwcA-1rblA:
0.0		 1lwcA-1rblA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME

(Arabidopsis
thaliana) 		PF01946
(Thi4) 		5 PRO A  75
LEU A  52
VAL A 135
VAL A  44
LEU A 130
 None
 1.41A 1lwcA-1rp0A:
undetectable		 1lwcA-1rp0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		5 LEU A 312
VAL A 348
VAL A 337
TYR A 366
LEU A 350
 None
 1.42A 1lwcA-1txkA:
undetectable		 1lwcA-1txkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 PRO A  39
LEU A  41
VAL A 158
TYR A 176
GLY A 157
 None
 1.43A 1lwcA-1uzgA:
undetectable		 1lwcA-1uzgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		5 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.37A 1lwcA-1wehA:
undetectable		 1lwcA-1wehA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 PRO A 356
VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.97A 1lwcA-1wzaA:
undetectable		 1lwcA-1wzaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xk5 SNURPORTIN-1

(Homo sapiens) 		no annotation 5 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.38A 1lwcA-1xk5A:
undetectable		 1lwcA-1xk5A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxg ENTEROTOXIN

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 PRO A 206
LEU A  28
TYR A  87
GLY A  84
TYR A  29
 None
 1.30A 1lwcA-1xxgA:
undetectable		 1lwcA-1xxgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.29A 1lwcA-1yhuA:
undetectable		 1lwcA-1yhuA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A  60
VAL A  87
GLY A  88
LEU A  12
TYR A  44
 GOL  A1272 (-4.0A)
None
GOL  A1271 (-3.8A)
None
None
 1.13A 1lwcA-1yq9A:
undetectable		 1lwcA-1yq9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.38A 1lwcA-2c6rA:
2.0		 1lwcA-2c6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwj PUTATIVE
ENDONUCLEASE

(Aeropyrum
pernix) 		PF01042
(Ribonuc_L-PSP) 		5 PRO A  95
VAL A  23
VAL A 113
GLY A  25
LEU A 117
 None
 1.36A 1lwcA-2cwjA:
undetectable		 1lwcA-2cwjA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)

(Equus caballus) 		PF00042
(Globin) 		5 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.47A 1lwcA-2dhbB:
undetectable		 1lwcA-2dhbB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwm 65 KDA VIRULENCE
PROTEIN

(Salmonella
enterica) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 427
VAL A 408
TYR A 412
GLY A 405
TYR A 432
 None
 1.50A 1lwcA-2gwmA:
undetectable		 1lwcA-2gwmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.43A 1lwcA-2h8qA:
undetectable		 1lwcA-2h8qA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.36A 1lwcA-2hlwA:
undetectable		 1lwcA-2hlwA:
13.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		11 PRO A  95
LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.72A 1lwcA-2hnzA:
41.5		 1lwcA-2hnzA:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 130
VAL A 148
VAL A 230
GLY A 147
TYR A 196
 None
 1.22A 1lwcA-2ix4A:
undetectable		 1lwcA-2ix4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ku7 MLL1 PHD3-CYP33 RRM
CHIMERIC PROTEIN

(Homo sapiens) 		PF00076
(RRM_1)
PF00628
(PHD) 		5 PRO A  96
LEU A  27
VAL A  65
TYR A  67
LEU A  30
 None
 1.27A 1lwcA-2ku7A:
undetectable		 1lwcA-2ku7A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		5 LEU A  57
VAL A 300
VAL A 312
GLY A 308
TYR A  62
 None
 1.46A 1lwcA-2rinA:
undetectable		 1lwcA-2rinA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.40A 1lwcA-2vadA:
undetectable		 1lwcA-2vadA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PRO A  62
LEU A   4
TYR A  60
GLY A  51
LEU A  35
 None
 1.48A 1lwcA-2wskA:
undetectable		 1lwcA-2wskA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 LEU A 377
VAL A 401
TYR A 361
GLY A 370
TYR A 408
 None
 1.49A 1lwcA-2yjqA:
undetectable		 1lwcA-2yjqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625

(Thermus
thermophilus) 		PF13277
(YmdB) 		5 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.32A 1lwcA-2z06A:
undetectable		 1lwcA-2z06A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		5 PRO A 248
LEU A 265
VAL A 348
GLY A 349
LEU A 245
 None
 1.29A 1lwcA-3a77A:
undetectable		 1lwcA-3a77A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.12A 1lwcA-3b4tA:
undetectable		 1lwcA-3b4tA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A  32
VAL A  90
VAL A  43
TYR A  40
GLY A  72
 None
 1.32A 1lwcA-3b70A:
2.2		 1lwcA-3b70A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh2 ACETOACETATE
DECARBOXYLASE

(Clostridium
acetobutylicum) 		PF06314
(ADC) 		5 PRO A  50
LEU A  51
TYR A 240
LEU A 168
TYR A  92
 None
 1.50A 1lwcA-3bh2A:
undetectable		 1lwcA-3bh2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.16A 1lwcA-3dd6A:
undetectable		 1lwcA-3dd6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		5 LEU A  61
VAL A  46
VAL A   6
TYR A  28
GLY A  30
 None
 1.09A 1lwcA-3dqpA:
undetectable		 1lwcA-3dqpA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		5 PRO A 138
LEU A 154
GLY A  57
TRP A  44
LEU A 262
 HEM  A 296 (-4.4A)
None
None
HEM  A 296 (-3.5A)
None
 1.50A 1lwcA-3e2nA:
undetectable		 1lwcA-3e2nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PRO A 171
LEU A 190
VAL A 176
GLY A 183
LEU A  54
 None
 1.17A 1lwcA-3ic9A:
undetectable		 1lwcA-3ic9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 LEU A 371
VAL A 395
TYR A 355
GLY A 364
TYR A 402
 None
 1.40A 1lwcA-3ik2A:
2.4		 1lwcA-3ik2A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 5 PRO C  84
VAL C  72
VAL C  49
GLY C  58
LEU C  79
 None
 1.38A 1lwcA-3j9uC:
2.7		 1lwcA-3j9uC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF06094
(GGACT) 		5 PRO A  51
VAL A  63
TYR A 137
GLY A  65
LEU A  10
 PCA  A1001 (-4.1A)
None
NO3  A 154 (-4.8A)
None
PCA  A1001 (-3.7A)
 1.20A 1lwcA-3jucA:
undetectable		 1lwcA-3jucA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.38A 1lwcA-3lf4A:
undetectable		 1lwcA-3lf4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 PRO A 774
LEU A 778
VAL A 909
GLY A 907
LEU A 979
 None
 1.28A 1lwcA-3lj0A:
undetectable		 1lwcA-3lj0A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr1 METHIONINE
AMINOPEPTIDASE

(Rickettsia
prowazekii) 		PF00557
(Peptidase_M24) 		5 PRO A 178
LEU A 143
VAL A 137
GLY A 133
LEU A 181
 None
 1.30A 1lwcA-3mr1A:
undetectable		 1lwcA-3mr1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orh GUANIDINOACETATE
N-METHYLTRANSFERASE

(Homo sapiens) 		no annotation 5 PRO A 125
LEU A 159
GLY A 164
TRP A  87
LEU A  65
 None
 1.18A 1lwcA-3orhA:
undetectable		 1lwcA-3orhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.31A 1lwcA-3ov3A:
undetectable		 1lwcA-3ov3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvi HISTO-ASPARTIC
PROTEASE

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 TYR A 315
TYR A 151
GLY A 169
TRP A 190
TYR A 181
 TYR  A 315 ( 1.3A)
TYR  A 151 ( 1.3A)
GLY  A 169 ( 0.0A)
TRP  A 190 ( 0.5A)
TYR  A 181 ( 1.3A)
 1.41A 1lwcA-3qviA:
undetectable		 1lwcA-3qviA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		5 PRO I  34
LEU J 561
VAL I  66
VAL I 180
GLY I  67
 None
 1.17A 1lwcA-3s88I:
undetectable		 1lwcA-3s88I:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaj ENVELOPE PROTEIN

(Dengue virus) 		no annotation 5 PRO B  39
LEU B  41
VAL B 160
TYR B 178
GLY B 159
 None
 1.38A 1lwcA-3uajB:
undetectable		 1lwcA-3uajB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc0 ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot) 		5 PRO A  39
LEU A  41
VAL A 160
GLY A 159
LEU A 181
 None
None
None
GOL  A 337 ( 3.8A)
None
 1.35A 1lwcA-3uc0A:
undetectable		 1lwcA-3uc0A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc0 ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot) 		5 PRO A  39
LEU A  41
VAL A 160
TYR A 178
GLY A 159
 None
None
None
GOL  A 337 ( 4.8A)
GOL  A 337 ( 3.8A)
 1.39A 1lwcA-3uc0A:
undetectable		 1lwcA-3uc0A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 155
VAL A 113
VAL A  96
TYR A 102
TYR A 153
 None
 1.26A 1lwcA-3va6A:
undetectable		 1lwcA-3va6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.44A 1lwcA-3vreB:
undetectable		 1lwcA-3vreB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.46A 1lwcA-4aejA:
undetectable		 1lwcA-4aejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cby HISTONE DEACETYLASE
4

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 PRO A 727
VAL A 756
VAL A 754
GLY A 755
LEU A 722
 None
 1.48A 1lwcA-4cbyA:
undetectable		 1lwcA-4cbyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		5 LEU A 170
TYR A 177
GLY A 190
LEU A 145
TYR A 166
 None
 1.38A 1lwcA-4f1hA:
undetectable		 1lwcA-4f1hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE

(Rhodobacter
sphaeroides) 		PF02230
(Abhydrolase_2) 		5 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.37A 1lwcA-4ftwA:
undetectable		 1lwcA-4ftwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		5 LEU A 180
VAL A  87
VAL A 420
GLY A 165
TYR A 182
 None
 1.27A 1lwcA-4jndA:
undetectable		 1lwcA-4jndA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxb INVASION-ASSOCIATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		5 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.22A 1lwcA-4jxbA:
undetectable		 1lwcA-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 PRO A 392
VAL A 284
VAL A 287
GLY A 285
LEU A 370
 None
 1.41A 1lwcA-4kg7A:
1.7		 1lwcA-4kg7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		5 PRO A 122
VAL A 293
VAL A 288
GLY A 287
LEU A 107
 None
 1.18A 1lwcA-4lvqA:
undetectable		 1lwcA-4lvqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		5 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.34A 1lwcA-4m5pA:
undetectable		 1lwcA-4m5pA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		5 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.41A 1lwcA-4p6bA:
undetectable		 1lwcA-4p6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		5 PRO A 384
LEU A 279
VAL A 243
GLY A 257
LEU A 283
 None
 1.38A 1lwcA-4r9iA:
undetectable		 1lwcA-4r9iA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
 None
 1.43A 1lwcA-4tpnA:
undetectable		 1lwcA-4tpnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		5 LEU A 443
VAL A 410
VAL A 396
GLY A 397
LEU A 445
 None
 1.49A 1lwcA-4uwqA:
undetectable		 1lwcA-4uwqA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7v CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		5 LEU A 263
VAL A   5
GLY A 275
TRP A 278
LEU A 308
 None
 1.18A 1lwcA-4w7vA:
undetectable		 1lwcA-4w7vA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.44A 1lwcA-4wjsA:
undetectable		 1lwcA-4wjsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
 None
 1.35A 1lwcA-4xiiA:
1.5		 1lwcA-4xiiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn0 AMYLOID BETA A4
PROTEIN

(Mus musculus) 		PF12925
(APP_E2) 		5 LEU B 419
VAL B 479
TYR B 474
LEU B 470
TYR B 401
 None
 1.42A 1lwcA-4yn0B:
undetectable		 1lwcA-4yn0B:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE

(Thermus
thermophilus) 		PF00571
(CBS) 		5 PRO A  11
LEU A 117
VAL A  85
VAL A  37
GLY A  45
 None
 1.27A 1lwcA-5aweA:
3.4		 1lwcA-5aweA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 PRO A 503
LEU A 575
VAL A 531
VAL A 520
TYR A 564
 None
 1.42A 1lwcA-5azaA:
undetectable		 1lwcA-5azaA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LYS B 103
VAL B 106
VAL B 179
TYR B 181
TYR B 188
GLY B 190
 None
 0.68A 1lwcA-5c24B:
10.4		 1lwcA-5c24B:
96.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		5 LEU A 134
VAL A 174
VAL A 103
GLY A 150
LEU A 200
 None
 1.22A 1lwcA-5d1pA:
undetectable		 1lwcA-5d1pA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		5 LEU A 181
VAL A 242
VAL A 195
GLY A 166
LEU A 268
 None
 1.42A 1lwcA-5djsA:
undetectable		 1lwcA-5djsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ

(Salmonella
enterica) 		PF01832
(Glucosaminidase) 		5 PRO A 162
LEU A 178
VAL A 203
GLY A 188
LEU A 156
 IOD  A 401 ( 4.5A)
None
None
None
None
 1.42A 1lwcA-5dn5A:
undetectable		 1lwcA-5dn5A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT) 		5 LEU A 345
VAL A 320
GLY A 257
LEU A 267
TYR A 342
 None
 1.30A 1lwcA-5e4vA:
undetectable		 1lwcA-5e4vA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		5 PRO A 106
VAL A 394
TYR A 312
GLY A 384
TYR A 410
 None
 1.27A 1lwcA-5i6zA:
undetectable		 1lwcA-5i6zA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		5 LEU A 105
VAL A 173
VAL A 101
TRP A 195
LEU A 178
 None
 1.47A 1lwcA-5iqkA:
undetectable		 1lwcA-5iqkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU B 393
VAL B 354
VAL B 597
GLY B 598
LEU B 362
 None
 1.45A 1lwcA-5l3qB:
undetectable		 1lwcA-5l3qB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 PRO B 642
LEU B 655
VAL B 680
GLY B 682
LEU B 647
 None
 1.10A 1lwcA-5ldrB:
undetectable		 1lwcA-5ldrB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 LEU A 453
VAL A 442
VAL A 406
TYR A 425
GLY A 407
 None
 1.47A 1lwcA-5m11A:
undetectable		 1lwcA-5m11A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
 None
 1.44A 1lwcA-5mg5A:
undetectable		 1lwcA-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmy LYSOSTAPHIN

(Staphylococcus
simulans) 		no annotation 5 LEU A 361
VAL A 282
TYR A 327
GLY A 281
LEU A 258
 None
 1.44A 1lwcA-5nmyA:
undetectable		 1lwcA-5nmyA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 5 PRO A  69
LEU A  15
VAL A  78
VAL A  30
LEU A  93
 None
 1.29A 1lwcA-5o25A:
undetectable		 1lwcA-5o25A:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LYS B 102
VAL B 105
TYR B 180
TYR B 187
GLY B 189
 None
 0.50A 1lwcA-5ovnB:
9.7		 1lwcA-5ovnB:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 6 PRO A  94
LEU A  99
LYS A 102
VAL A 105
GLY A 189
TYR A 317
 None
 0.94A 1lwcA-5ovnA:
26.3		 1lwcA-5ovnA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 6 PRO A  94
LEU A  99
LYS A 102
VAL A 105
LEU A 233
TYR A 317
 None
 0.98A 1lwcA-5ovnA:
26.3		 1lwcA-5ovnA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 LEU A 474
LYS A 274
VAL A 469
GLY A 468
LEU A 271
 None
 1.42A 1lwcA-5t81A:
2.1		 1lwcA-5t81A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 5 PRO A 232
LEU A 234
VAL A 203
LEU A 279
TYR A 236
 None
 1.40A 1lwcA-5tu4A:
undetectable		 1lwcA-5tu4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 5 PRO C 427
VAL C 348
VAL C 370
GLY C 345
LEU C 457
 None
 1.30A 1lwcA-5v12C:
2.0		 1lwcA-5v12C:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 LEU C 299
LYS C 265
TYR C 206
GLY C 261
TYR C 269
 None
None
None
MCN  C 802 (-3.4A)
None
 1.30A 1lwcA-5y6qC:
undetectable		 1lwcA-5y6qC:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 5 LEU I  27
VAL I  94
VAL I  49
TYR I  66
LEU I  81
 None
 1.40A 1lwcA-6az1I:
undetectable		 1lwcA-6az1I:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 5 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.32A 1lwcA-6b7kA:
undetectable		 1lwcA-6b7kA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU I 284
VAL I 236
TYR I 234
GLY I 262
TYR I   9
 None
 1.44A 1lwcA-6esqI:
undetectable		 1lwcA-6esqI:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.40A 1lwcA-6fzwA:
undetectable		 1lwcA-6fzwA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gw5 -

(-) 		no annotation 5 PRO A 232
LEU A 238
VAL A  93
TYR A 100
GLY A  95
 None
 1.41A 1lwcA-6gw5A:
2.1		 1lwcA-6gw5A:
undetectable