SIMILAR PATTERNS OF AMINO ACIDS FOR 1LW0_A_NVPA999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		5 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.20A 1lw0A-1fztA:
undetectable		 1lw0A-1fztA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		5 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
 None
 0.53A 1lw0A-1harA:
26.4		 1lw0A-1harA:
43.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		5 VAL A 553
VAL A 673
GLY A 554
TRP A 546
LEU A 568
 None
 1.49A 1lw0A-1hn0A:
undetectable		 1lw0A-1hn0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		5 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.35A 1lw0A-1k7yA:
1.2		 1lw0A-1k7yA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 201
 None
 1.46A 1lw0A-1oypA:
undetectable		 1lw0A-1oypA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.07A 1lw0A-1oypA:
undetectable		 1lw0A-1oypA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.00A 1lw0A-1udqA:
undetectable		 1lw0A-1udqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 143
VAL A  95
TYR A  81
GLY A  79
LEU A 132
 None
 1.32A 1lw0A-1w78A:
undetectable		 1lw0A-1w78A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		5 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.37A 1lw0A-1wehA:
undetectable		 1lw0A-1wehA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.28A 1lw0A-1yhuA:
2.1		 1lw0A-1yhuA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A  60
VAL A  87
GLY A  88
LEU A  12
TYR A  44
 GOL  A1272 (-4.0A)
None
GOL  A1271 (-3.8A)
None
None
 1.12A 1lw0A-1yq9A:
undetectable		 1lw0A-1yq9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.43A 1lw0A-2c6rA:
undetectable		 1lw0A-2c6rA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)

(Equus caballus) 		PF00042
(Globin) 		5 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.43A 1lw0A-2dhbB:
undetectable		 1lw0A-2dhbB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwm 65 KDA VIRULENCE
PROTEIN

(Salmonella
enterica) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 427
VAL A 408
TYR A 412
GLY A 405
TYR A 432
 None
 1.49A 1lw0A-2gwmA:
undetectable		 1lw0A-2gwmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.44A 1lw0A-2h8qA:
undetectable		 1lw0A-2h8qA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.39A 1lw0A-2hlwA:
undetectable		 1lw0A-2hlwA:
14.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		10 LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.73A 1lw0A-2hnzA:
41.4		 1lw0A-2hnzA:
99.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
VAL A 179
TYR A 181
GLY A 190
 PC0  A 999 ( 3.9A)
None
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.8A)
 1.49A 1lw0A-2hnzA:
41.4		 1lw0A-2hnzA:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 130
VAL A 148
VAL A 230
GLY A 147
TYR A 196
 None
 1.24A 1lw0A-2ix4A:
undetectable		 1lw0A-2ix4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		5 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.17A 1lw0A-2qjoA:
undetectable		 1lw0A-2qjoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 LEU A 140
VAL A   5
VAL A 104
GLY A 102
LEU A 124
 None
 1.39A 1lw0A-2qzxA:
undetectable		 1lw0A-2qzxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		5 LEU A 141
VAL A  29
TYR A  27
GLY A 147
LEU A 392
 None
 1.19A 1lw0A-2rkvA:
1.8		 1lw0A-2rkvA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.41A 1lw0A-2vadA:
undetectable		 1lw0A-2vadA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6

(Homo sapiens) 		PF00651
(BTB) 		5 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.15A 1lw0A-2vkpA:
undetectable		 1lw0A-2vkpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 LEU A 377
VAL A 401
TYR A 361
GLY A 370
TYR A 408
 None
 1.47A 1lw0A-2yjqA:
undetectable		 1lw0A-2yjqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625

(Thermus
thermophilus) 		PF13277
(YmdB) 		5 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.35A 1lw0A-2z06A:
undetectable		 1lw0A-2z06A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN

(Aeropyrum
pernix) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.34A 1lw0A-3a5wA:
undetectable		 1lw0A-3a5wA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.03A 1lw0A-3b4tA:
undetectable		 1lw0A-3b4tA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.10A 1lw0A-3dd6A:
undetectable		 1lw0A-3dd6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		5 LEU A  61
VAL A  46
VAL A   6
TYR A  28
GLY A  30
 None
 1.20A 1lw0A-3dqpA:
undetectable		 1lw0A-3dqpA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A  91
VAL A 109
VAL A 191
GLY A 108
TYR A 157
 None
 1.36A 1lw0A-3e60A:
undetectable		 1lw0A-3e60A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 5 LEU L 273
VAL L 261
VAL L 328
TYR L 256
GLY L 254
 None
 1.19A 1lw0A-3g9kL:
undetectable		 1lw0A-3g9kL:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 5 LEU L 273
VAL L 261
VAL L 328
TYR L 256
LEU S 441
 None
 1.50A 1lw0A-3g9kL:
undetectable		 1lw0A-3g9kL:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 LEU A 371
VAL A 395
TYR A 355
GLY A 364
TYR A 402
 None
 1.39A 1lw0A-3ik2A:
undetectable		 1lw0A-3ik2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.39A 1lw0A-3lf4A:
undetectable		 1lw0A-3lf4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN

(Xanthomonas
campestris) 		PF00378
(ECH_1) 		5 LEU A 136
VAL A 155
VAL A  81
GLY A 133
LEU A 194
 None
 1.29A 1lw0A-3m6mA:
undetectable		 1lw0A-3m6mA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p56 RIBONUCLEASE H2
SUBUNIT A

(Homo sapiens) 		PF01351
(RNase_HII) 		5 LEU A 153
VAL A  33
VAL A 138
GLY A  32
TYR A 149
 None
 1.28A 1lw0A-3p56A:
3.1		 1lw0A-3p56A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.39A 1lw0A-3vreB:
undetectable		 1lw0A-3vreB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		5 LEU A 170
TYR A 177
GLY A 190
LEU A 145
TYR A 166
 None
 1.36A 1lw0A-4f1hA:
undetectable		 1lw0A-4f1hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5

(Homo sapiens) 		PF04106
(APG5) 		5 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.32A 1lw0A-4gdlB:
undetectable		 1lw0A-4gdlB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj9 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Bordetella
bronchiseptica) 		PF02962
(CHMI) 		5 LEU A  16
VAL A 116
TYR A   8
GLY A  75
LEU A 107
 None
 1.36A 1lw0A-4jj9A:
undetectable		 1lw0A-4jj9A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		5 LEU A  69
VAL A  92
TYR A  29
TRP A 158
TYR A  75
 None
 1.30A 1lw0A-4l22A:
1.6		 1lw0A-4l22A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		5 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.37A 1lw0A-4m5pA:
undetectable		 1lw0A-4m5pA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		5 LEU A 192
VAL A 168
VAL A 166
GLY A 167
TYR A 194
 None
 1.43A 1lw0A-4maeA:
undetectable		 1lw0A-4maeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntc GLIT

(Aspergillus
fumigatus) 		PF07992
(Pyr_redox_2) 		5 LEU A 146
VAL A 161
VAL A 159
TYR A 143
GLY A 160
 None
 1.43A 1lw0A-4ntcA:
undetectable		 1lw0A-4ntcA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		5 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.43A 1lw0A-4p6bA:
undetectable		 1lw0A-4p6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 495
VAL A 529
VAL A 549
GLY A 530
LEU A 491
 None
 1.48A 1lw0A-4qmkA:
undetectable		 1lw0A-4qmkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
 None
 1.40A 1lw0A-4tpnA:
undetectable		 1lw0A-4tpnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.38A 1lw0A-4wjsA:
undetectable		 1lw0A-4wjsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		5 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.42A 1lw0A-4xb0A:
undetectable		 1lw0A-4xb0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
 None
 1.36A 1lw0A-4xiiA:
1.5		 1lw0A-4xiiA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn0 AMYLOID BETA A4
PROTEIN

(Mus musculus) 		PF12925
(APP_E2) 		5 LEU B 419
VAL B 479
TYR B 474
LEU B 470
TYR B 401
 None
 1.40A 1lw0A-4yn0B:
undetectable		 1lw0A-4yn0B:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 LEU A  45
VAL A 127
TYR A  93
LEU A  82
TYR A 149
 None
 1.47A 1lw0A-5amqA:
6.4		 1lw0A-5amqA:
13.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LYS B 103
VAL B 106
VAL B 179
TYR B 181
TYR B 188
GLY B 190
 None
 0.61A 1lw0A-5c24B:
11.1		 1lw0A-5c24B:
96.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fol LEUCYL-TRNA
SYNTHETASE

(Cryptosporidium
muris) 		no annotation 5 VAL A 362
TYR A 354
TYR A 358
GLY A 360
TYR A 539
 None
 1.46A 1lw0A-5folA:
undetectable		 1lw0A-5folA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		5 LEU A 105
VAL A 173
VAL A 101
TRP A 195
LEU A 178
 None
 1.38A 1lw0A-5iqkA:
undetectable		 1lw0A-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 LEU A 453
VAL A 442
VAL A 406
TYR A 425
GLY A 407
 None
 1.48A 1lw0A-5m11A:
undetectable		 1lw0A-5m11A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
 None
 1.42A 1lw0A-5mg5A:
undetectable		 1lw0A-5mg5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 LEU A 471
VAL A 622
TYR A 620
GLY A 579
LEU A 361
 None
 1.14A 1lw0A-5n6vA:
undetectable		 1lw0A-5n6vA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-) 		no annotation 5 LEU A  93
VAL A  72
TYR A 100
GLY A  73
LEU A 122
 None
 1.38A 1lw0A-5ojrA:
undetectable		 1lw0A-5ojrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LYS B 102
VAL B 105
TYR B 180
TYR B 187
GLY B 189
 None
 0.48A 1lw0A-5ovnB:
10.5		 1lw0A-5ovnB:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 LEU A 474
LYS A 274
VAL A 469
GLY A 468
LEU A 271
 None
 1.40A 1lw0A-5t81A:
3.7		 1lw0A-5t81A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 5 LEU A  78
VAL A  24
GLY A  21
LEU A  81
TYR A  64
 None
 1.48A 1lw0A-5w1eA:
2.3		 1lw0A-5w1eA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.47A 1lw0A-5xbpA:
1.2		 1lw0A-5xbpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 5 LEU I  27
VAL I  94
VAL I  49
TYR I  66
LEU I  81
 None
 1.38A 1lw0A-6az1I:
2.4		 1lw0A-6az1I:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU I 284
VAL I 236
TYR I 234
GLY I 262
TYR I   9
 None
 1.44A 1lw0A-6esqI:
undetectable		 1lw0A-6esqI:
9.80