SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQU_B_ACTB1431

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxd PROTEIN (OSMOLARITY
SENSOR PROTEIN
(ENVZ))

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 TRP A 435
ALA A 367
PHE A 369
SER A 360
 None
 1.45A 1lquB-1bxdA:
0.1		 1lquB-1bxdA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 TRP A  46
ALA A  71
PHE A  78
SER A 420
TRP A 423
 None
ACT  A1871 (-3.3A)
ACT  A1871 (-3.0A)
ACT  A1871 (-2.7A)
None
 0.13A 1lquB-1lqtA:
62.7		 1lquB-1lqtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og3 NUCLEOCAPSID PROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF00937
(Corona_nucleoca) 		4 ALA A 157
PHE A  54
SER A  52
TRP A  53
 None
 1.48A 1lquB-2og3A:
0.0		 1lquB-2og3A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ALA A 139
PHE A 142
SER A 162
TRP A 160
 None
 1.43A 1lquB-2vpwA:
0.0		 1lquB-2vpwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 TRP A 129
ALA A 176
PHE A 173
SER A 202
 None
 1.10A 1lquB-3u4jA:
2.2		 1lquB-3u4jA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 ALA A 191
PHE A 188
SER A 163
TRP A 160
 None
 1.32A 1lquB-4bevA:
2.7		 1lquB-4bevA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C

(Flavobacterium
johnsoniae) 		no annotation 4 TRP C 254
ALA C 247
PHE C 263
SER C 243
 None
 1.38A 1lquB-6btmC:
0.0		 1lquB-6btmC:
undetectable