SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQU_B_ACTB1430

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A  89
ASP A 128
LYS A 111
 None
 1.06A 1lquB-1bxzA:
3.3		 1lquB-1bxzA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		3 ASP A 194
ASP A 214
LYS A 205
 None
 1.04A 1lquB-1f0xA:
undetectable		 1lquB-1f0xA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gao FERREDOXIN I

(Azotobacter
vinelandii) 		PF00037
(Fer4)
PF11953
(DUF3470) 		3 ASP A  95
ASP A  93
LYS A 100
 None
 0.94A 1lquB-1gaoA:
undetectable		 1lquB-1gaoA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 ASP A  87
ASP A  38
LYS A 329
 None
 1.14A 1lquB-1i0aA:
undetectable		 1lquB-1i0aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		3 ASP A 212
ASP A  90
LYS A 216
 None
 1.13A 1lquB-1itxA:
undetectable		 1lquB-1itxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		3 ASP A 644
ASP A 392
LYS A 673
 None
 1.02A 1lquB-1l1lA:
undetectable		 1lquB-1l1lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 ASP A 554
ASP A 556
LYS A 506
 None
 1.06A 1lquB-1m1cA:
undetectable		 1lquB-1m1cA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m72 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		3 ASP A 125
ASP A 122
LYS A 169
 None
 1.13A 1lquB-1m72A:
undetectable		 1lquB-1m72A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n71 AAC(6')-II

(Enterococcus
faecium) 		PF00583
(Acetyltransf_1) 		3 ASP A 124
ASP A 165
LYS A 132
 None
 1.02A 1lquB-1n71A:
undetectable		 1lquB-1n71A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 ASP A 477
ASP A1062
LYS A 496
 None
 1.00A 1lquB-1ofeA:
undetectable		 1lquB-1ofeA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE

(Streptococcus
pneumoniae) 		PF08534
(Redoxin) 		3 ASP A  41
ASP A  39
LYS A  45
 None
 1.05A 1lquB-1psqA:
undetectable		 1lquB-1psqA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qa9 HUMAN CD2 PROTEIN

(Homo sapiens) 		PF07686
(V-set) 		3 ASP A  76
ASP A  40
LYS A  57
 None
 1.16A 1lquB-1qa9A:
undetectable		 1lquB-1qa9A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		3 ASP A 259
ASP A 242
LYS A 384
 None
 1.00A 1lquB-1qjsA:
undetectable		 1lquB-1qjsA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		3 ASP B   2
ASP B  79
LYS B 133
 None
 0.99A 1lquB-1spgB:
undetectable		 1lquB-1spgB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ASP A 329
ASP A 385
LYS A 293
 None
 1.02A 1lquB-1uokA:
undetectable		 1lquB-1uokA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		3 ASP A 109
ASP A 195
LYS A 113
 MLY  A 112 ( 3.8A)
MLY  A 107 ( 4.2A)
MLY  A 112 ( 2.9A)
 1.07A 1lquB-1vk1A:
undetectable		 1lquB-1vk1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlp NEUTROPHIL CYTOSOL
FACTOR 1

(Homo sapiens) 		PF00018
(SH3_1) 		3 ASP B 217
ASP B 221
LYS B 188
 None
 0.98A 1lquB-1wlpB:
undetectable		 1lquB-1wlpB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 ASP A  19
ASP A  21
LYS A 322
 None
 1.10A 1lquB-1wu7A:
undetectable		 1lquB-1wu7A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbf CLOSTRIDIUM
ACETOBUTYLICUM
Q97KL0

(Clostridium
acetobutylicum) 		PF01894
(UPF0047) 		3 ASP A  68
ASP A  14
LYS A  89
 None
 1.02A 1lquB-1xbfA:
undetectable		 1lquB-1xbfA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuv HYPOTHETICAL PROTEIN
MM0500

(Methanosarcina
mazei) 		PF08327
(AHSA1) 		3 ASP A  31
ASP A 162
LYS A 169
 None
 1.05A 1lquB-1xuvA:
undetectable		 1lquB-1xuvA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 ASP A 392
ASP A 243
LYS A 198
 None
ADP  A 900 ( 4.7A)
None
 1.08A 1lquB-1z6tA:
1.6		 1lquB-1z6tA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		3 ASP A 731
ASP A 882
LYS A 662
 None
 0.99A 1lquB-2aqxA:
undetectable		 1lquB-2aqxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ASP B 343
ASP B 339
LYS B 468
 None
 1.16A 1lquB-2bkuB:
undetectable		 1lquB-2bkuB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 ASP A 502
ASP A 401
LYS A 466
 None
 1.13A 1lquB-2d0vA:
undetectable		 1lquB-2d0vA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 287
ASP A 321
LYS A 328
 None
 0.93A 1lquB-2dphA:
2.2		 1lquB-2dphA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		3 ASP A 156
ASP A 164
LYS A 184
 UNL  A 288 (-3.1A)
None
None
 1.13A 1lquB-2g8lA:
undetectable		 1lquB-2g8lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		3 ASP C 209
ASP C  52
LYS C 139
 None
 1.11A 1lquB-2inpC:
undetectable		 1lquB-2inpC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ASP A 246
ASP A 242
LYS A 274
 None
GOL  A1979 (-2.7A)
None
 1.11A 1lquB-2ivfA:
undetectable		 1lquB-2ivfA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		3 ASP A 215
ASP A  68
LYS A  75
 None
 1.12A 1lquB-2jk0A:
undetectable		 1lquB-2jk0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		3 ASP A  98
ASP A  48
LYS A 103
 None
 0.93A 1lquB-2p82A:
undetectable		 1lquB-2p82A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ASP A 104
ASP A 106
LYS A 224
 None
 1.05A 1lquB-2qz9A:
5.8		 1lquB-2qz9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		3 ASP A 180
ASP A 174
LYS A 187
 TRE  A2001 (-4.0A)
None
None
 1.00A 1lquB-3a9gA:
undetectable		 1lquB-3a9gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASP A 423
ASP A 425
LYS A 353
 None
 1.13A 1lquB-3a9vA:
undetectable		 1lquB-3a9vA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER

(Escherichia
coli) 		PF03797
(Autotransporter) 		3 ASP A1111
ASP A1108
LYS A1147
 None
 1.12A 1lquB-3aehA:
undetectable		 1lquB-3aehA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		3 ASP A 362
ASP A 358
LYS A 397
 None
 1.13A 1lquB-3bf0A:
undetectable		 1lquB-3bf0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		3 ASP A 239
ASP A 269
LYS A 297
 None
 1.17A 1lquB-3cf4A:
2.5		 1lquB-3cf4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		3 ASP A 168
ASP A 162
LYS A 175
 None
 1.04A 1lquB-3dasA:
undetectable		 1lquB-3dasA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8t TAKEOUT-LIKE PROTEIN
1

(Epiphyas
postvittana) 		PF06585
(JHBP) 		3 ASP A  43
ASP A  46
LYS A 200
 None
 1.07A 1lquB-3e8tA:
undetectable		 1lquB-3e8tA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A  89
ASP A 128
LYS A 111
 None
 1.12A 1lquB-3fpcA:
undetectable		 1lquB-3fpcA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A  89
ASP A 128
LYS A 111
 None
 1.07A 1lquB-3fsrA:
3.4		 1lquB-3fsrA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		3 ASP A 206
ASP A 174
LYS A 338
 None
 1.07A 1lquB-3g0iA:
undetectable		 1lquB-3g0iA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ASP A  35
ASP A  37
LYS A  53
 None
 0.87A 1lquB-3hhdA:
undetectable		 1lquB-3hhdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		3 ASP A 327
ASP A 272
LYS A 183
 None
 1.00A 1lquB-3khzA:
undetectable		 1lquB-3khzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		3 ASP A 216
ASP A 242
LYS A 253
 None
None
SO4  A 392 ( 4.8A)
 0.99A 1lquB-3le2A:
undetectable		 1lquB-3le2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		3 ASP A 293
ASP A 298
LYS A 453
 None
 0.74A 1lquB-3lx6A:
3.1		 1lquB-3lx6A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		3 ASP A 293
ASP A 298
LYS A 453
 None
 0.90A 1lquB-3me5A:
2.8		 1lquB-3me5A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 ASP A  48
ASP A  44
LYS A  97
 None
 1.14A 1lquB-3moyA:
undetectable		 1lquB-3moyA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 ASP A 296
ASP A 316
LYS A 309
 None
 1.10A 1lquB-3msgA:
undetectable		 1lquB-3msgA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		3 ASP A 297
ASP A 299
LYS A 322
 None
 0.89A 1lquB-3mwgA:
undetectable		 1lquB-3mwgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		3 ASP C 172
ASP C 169
LYS C 129
 None
 0.88A 1lquB-3napC:
undetectable		 1lquB-3napC:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus) 		PF00100
(Zona_pellucida) 		3 ASP A 258
ASP A 254
LYS A 317
 None
 1.14A 1lquB-3nk4A:
undetectable		 1lquB-3nk4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		3 ASP A 128
ASP A 256
LYS A 224
 None
 1.15A 1lquB-3nnmA:
undetectable		 1lquB-3nnmA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		3 ASP A 167
ASP A  18
LYS A 185
 None
 1.00A 1lquB-3opxA:
2.0		 1lquB-3opxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 ASP A 392
ASP A 243
LYS A 198
 None
 1.03A 1lquB-3sfzA:
undetectable		 1lquB-3sfzA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb6 ARABINOSE METABOLISM
TRANSCRIPTIONAL
REPRESSOR

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		3 ASP A 302
ASP A 274
LYS A 320
 None
 1.09A 1lquB-3tb6A:
2.9		 1lquB-3tb6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN

(Candidatus
Pelagibacter
ubique) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 ASP A 271
ASP A  84
LYS A 277
 None
 1.12A 1lquB-3tfjA:
undetectable		 1lquB-3tfjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		3 ASP A  85
ASP A  91
LYS A 298
 None
 1.16A 1lquB-3tr5A:
undetectable		 1lquB-3tr5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		3 ASP A 470
ASP A 472
LYS A 400
 None
 1.16A 1lquB-3tsyA:
undetectable		 1lquB-3tsyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2h S-LAYER PROTEIN
MA0829

(Methanosarcina
acetivorans) 		PF07752
(S-layer) 		3 ASP A 467
ASP A 469
LYS A 390
 None
 0.95A 1lquB-3u2hA:
undetectable		 1lquB-3u2hA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 ASP A 250
ASP A 730
LYS A 735
 None
 0.91A 1lquB-3ummA:
undetectable		 1lquB-3ummA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		3 ASP A 197
ASP A 192
LYS A 205
 None
 1.11A 1lquB-4dolA:
undetectable		 1lquB-4dolA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE

(Burkholderia
thailandensis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ASP A 198
ASP A 231
LYS A 246
 None
 1.17A 1lquB-4f4hA:
2.4		 1lquB-4f4hA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		3 ASP A  95
ASP A 115
LYS A  99
 MLY  A  98 ( 3.7A)
MLY  A 114 ( 4.1A)
MLY  A  98 ( 2.8A)
 0.86A 1lquB-4fkmA:
undetectable		 1lquB-4fkmA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 ASP A 351
ASP A 248
LYS A 357
 None
 1.09A 1lquB-4fozA:
undetectable		 1lquB-4fozA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		3 ASP A 284
ASP A 286
LYS A 339
 None
 1.16A 1lquB-4jeuA:
undetectable		 1lquB-4jeuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpz FIBROBLAST GROWTH
FACTOR 13

(Homo sapiens) 		PF00167
(FGF) 		3 ASP A  43
ASP A  41
LYS A  19
 None
 1.13A 1lquB-4jpzA:
undetectable		 1lquB-4jpzA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 3 ASP A 329
ASP A 333
LYS A 182
 None
 0.98A 1lquB-4jzaA:
undetectable		 1lquB-4jzaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASP A3835
ASP A3829
LYS A3877
 None
 1.01A 1lquB-4kc5A:
undetectable		 1lquB-4kc5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		3 ASP A  51
ASP A 280
LYS A 460
 None
 1.12A 1lquB-4mt0A:
undetectable		 1lquB-4mt0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		3 ASP A 259
ASP A 277
LYS A 513
 None
 1.09A 1lquB-4o7dA:
undetectable		 1lquB-4o7dA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		3 ASP A 142
ASP A 171
LYS A 125
 None
 1.03A 1lquB-4oo3A:
2.8		 1lquB-4oo3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ASP A  26
ASP A  28
LYS A 363
 None
 0.94A 1lquB-4wojA:
2.6		 1lquB-4wojA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ASP A 104
ASP A 129
LYS A 247
 None
 0.90A 1lquB-4wojA:
2.6		 1lquB-4wojA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		3 ASP A  23
ASP A 232
LYS A  90
 None
 0.90A 1lquB-4xgjA:
2.1		 1lquB-4xgjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgx FAD:PROTEIN FMN
TRANSFERASE

(Escherichia
coli) 		PF02424
(ApbE) 		3 ASP A  51
ASP A  53
LYS A  61
 None
 0.99A 1lquB-4xgxA:
undetectable		 1lquB-4xgxA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 ASP A 255
ASP A 578
LYS A 432
 None
 1.08A 1lquB-4zajA:
3.8		 1lquB-4zajA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 3 ASP A 495
ASP A 500
LYS A 846
 None
 0.92A 1lquB-5b2oA:
undetectable		 1lquB-5b2oA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 3 ASP B 328
ASP B 384
LYS B 292
 BGC  B 601 ( 2.8A)
None
BTB  B 603 (-2.7A)
 1.07A 1lquB-5do8B:
undetectable		 1lquB-5do8B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		3 ASP A 396
ASP A 390
LYS A 202
 None
 1.17A 1lquB-5eutA:
undetectable		 1lquB-5eutA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		3 ASP A 217
ASP A 221
LYS A 173
 None
 1.16A 1lquB-5fyaA:
2.0		 1lquB-5fyaA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 3 ASP C 177
ASP C 179
LYS C 138
 None
 1.12A 1lquB-5gp4C:
undetectable		 1lquB-5gp4C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 3 ASP A 147
ASP A 139
LYS A 245
 None
 0.92A 1lquB-5gt5A:
undetectable		 1lquB-5gt5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 ASP g 398
ASP g  91
LYS g 162
 None
 1.07A 1lquB-5gw4g:
undetectable		 1lquB-5gw4g:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF03105
(SPX)
PF09359
(VTC) 		3 ASP A  89
ASP A 377
LYS A 428
 None
 1.07A 1lquB-5iigA:
undetectable		 1lquB-5iigA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip4 NEURONAL MIGRATION
PROTEIN DOUBLECORTIN

(Homo sapiens) 		PF03607
(DCX) 		3 ASP D 327
ASP D 322
LYS D 261
 None
 1.05A 1lquB-5ip4D:
undetectable		 1lquB-5ip4D:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF01156
(IU_nuc_hydro) 		3 ASP A  85
ASP A  94
LYS A 242
 None
 0.89A 1lquB-5mj7A:
undetectable		 1lquB-5mj7A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 3 ASP B  35
ASP B  37
LYS B  53
 None
 0.95A 1lquB-5my0B:
undetectable		 1lquB-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5onu OUTER MEMBRANE
PROTEIN OMPU

(Vibrio cholerae) 		no annotation 3 ASP A 135
ASP A 163
LYS A 181
 None
GOL  A 403 (-3.0A)
None
 1.11A 1lquB-5onuA:
undetectable		 1lquB-5onuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh INTERAPTIN

(Legionella
pneumophila) 		no annotation 3 ASP C 124
ASP C 214
LYS C 201
 None
 1.04A 1lquB-5oshC:
undetectable		 1lquB-5oshC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF04616
(Glyco_hydro_43) 		3 ASP A 218
ASP A 237
LYS A 191
 None
 0.95A 1lquB-5ta9A:
undetectable		 1lquB-5ta9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1w P2X PURINOCEPTOR

(Ailuropoda
melanoleuca) 		PF00864
(P2X_receptor) 		3 ASP A 141
ASP A 121
LYS A 136
 None
 1.13A 1lquB-5u1wA:
undetectable		 1lquB-5u1wA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiv BIFUNCTIONAL
THYMIDYLATE/URIDYLAT
E KINASE

(Candida
albicans) 		PF02223
(Thymidylate_kin) 		3 ASP A 146
ASP A 190
LYS A 171
 None
 0.90A 1lquB-5uivA:
3.1		 1lquB-5uivA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A 113
ASP A  73
LYS A 140
 None
 1.12A 1lquB-5ulvA:
6.6		 1lquB-5ulvA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Leishmania
donovani) 		PF00579
(tRNA-synt_1b) 		3 ASP A 574
ASP A 563
LYS A 385
 None
 1.11A 1lquB-5usfA:
undetectable		 1lquB-5usfA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x88 CUTINASE

(Malbranchea
cinnamomea) 		no annotation 3 ASP A  20
ASP A  17
LYS A 100
 None
 1.16A 1lquB-5x88A:
3.7		 1lquB-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyk PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		no annotation 3 ASP E 111
ASP E  71
LYS E 196
 None
 0.94A 1lquB-5xykE:
undetectable		 1lquB-5xykE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 3 ASP B 193
ASP B 207
LYS B 270
 None
 1.07A 1lquB-5y6qB:
undetectable		 1lquB-5y6qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 3 ASP B 290
ASP B 274
LYS B 296
 None
 0.70A 1lquB-5yllB:
undetectable		 1lquB-5yllB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 3 ASP E 865
ASP E 860
LYS E 889
 None
 1.14A 1lquB-6c3pE:
undetectable		 1lquB-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1i -

(-) 		no annotation 3 ASP A 141
ASP A 258
LYS A 265
 MN  A 409 (-2.6A)
None
OHI  A 264 ( 3.0A)
 0.93A 1lquB-6g1iA:
undetectable		 1lquB-6g1iA:
undetectable