SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQU_B_ACTB1424

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebp EPO RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		4 ALA A  72
ARG A  80
GLN A  71
GLU A  41
 None
 1.41A 1lquB-1ebpA:
undetectable		 1lquB-1ebpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 ALA A 381
ARG A 387
GLN A 386
GLU A 384
 None
 1.33A 1lquB-1f5aA:
undetectable		 1lquB-1f5aA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ALA A1070
ARG A1007
GLN A1071
GLU A1072
 None
 1.47A 1lquB-1hzfA:
0.0		 1lquB-1hzfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llp LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A 316
ARG A 243
GLN A 315
GLU A 314
 None
 1.36A 1lquB-1llpA:
0.0		 1lquB-1llpA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 ALA A 148
ARG A 149
GLN A 192
GLU A 193
 None
 0.19A 1lquB-1lqtA:
62.7		 1lquB-1lqtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		4 ALA A 232
ARG A 193
GLN A 233
GLU A  81
 None
None
FON  A 330 (-3.2A)
None
 1.22A 1lquB-1qd1A:
0.0		 1lquB-1qd1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A 316
ARG A 243
GLN A 315
GLU A 314
 None
 1.33A 1lquB-1qpaA:
0.0		 1lquB-1qpaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz8 FAB 17B HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 0.85A 1lquB-1rz8B:
0.0		 1lquB-1rz8B:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soi MUTT/NUDIX FAMILY
PROTEIN

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		4 ALA A 128
ARG A 124
GLN A 129
GLU A 125
 None
 1.22A 1lquB-1soiA:
undetectable		 1lquB-1soiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		4 ALA A  94
ARG A  96
GLN A  91
GLU A  92
 None
 1.28A 1lquB-1t5eA:
undetectable		 1lquB-1t5eA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		4 ALA A 176
ARG A 173
GLN A 175
GLU A 174
 BR  A 309 ( 4.1A)
None
PO4  A 303 ( 4.7A)
None
 1.13A 1lquB-1to3A:
undetectable		 1lquB-1to3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0q IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 ALA A  88
ARG A  38
GLN A  39
GLU A  46
 None
 1.31A 1lquB-1u0qA:
undetectable		 1lquB-1u0qA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt5 ANTI EGFR ANTIBODY
FV REGION

(Homo sapiens) 		PF07686
(V-set) 		4 ALA A  92
ARG A  38
GLN A  39
GLU A  46
 None
 1.36A 1lquB-1wt5A:
undetectable		 1lquB-1wt5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 1.09A 1lquB-2d7tH:
undetectable		 1lquB-2d7tH:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A  75
ARG A 248
GLN A 242
GLU A  72
 None
 1.32A 1lquB-2dvlA:
undetectable		 1lquB-2dvlA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl5 IMMUNOGLOBULIN IGG1
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  88
ARG H  38
GLN H  39
GLU H  46
 None
 1.34A 1lquB-2fl5H:
undetectable		 1lquB-2fl5H:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjz CATALYTIC
ELIMINATION ANTIBODY
13G5 HEAVY CHAIN

(Mus musculus) 		no annotation 4 ALA H  88
ARG H  38
GLN H  39
GLU H  46
 None
 1.49A 1lquB-2gjzH:
undetectable		 1lquB-2gjzH:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 ALA A 257
ARG A 158
GLN A 258
GLU A  96
 None
 1.47A 1lquB-2l7bA:
undetectable		 1lquB-2l7bA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvq GLUTATHIONE
S-TRANSFERASE

(Ochrobactrum
anthropi) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ALA A  92
ARG A  93
GLN A  95
GLU A  96
 None
SO4  A5001 (-4.0A)
None
None
 1.42A 1lquB-2pvqA:
undetectable		 1lquB-2pvqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x89 ANTIBODY

(Camelus
dromedarius) 		PF07686
(V-set) 		4 ALA A  92
ARG A  38
GLN A  39
GLU A  46
 None
 1.47A 1lquB-2x89A:
undetectable		 1lquB-2x89A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05

(Homo sapiens) 		PF07686
(V-set) 		4 ALA D  40
ARG D  38
GLN D  43
GLU D  46
 None
 1.02A 1lquB-2xtjD:
undetectable		 1lquB-2xtjD:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Pseudomonas
aeruginosa) 		PF01063
(Aminotran_4) 		4 ALA A  62
ARG A 102
GLN A  65
GLU A  66
 None
CL  A1275 (-3.3A)
None
None
 0.92A 1lquB-2y4rA:
undetectable		 1lquB-2y4rA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 ALA A  20
ARG A  27
GLN A 393
GLU A 396
 None
 1.28A 1lquB-2ykyA:
1.4		 1lquB-2ykyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI

(Pseudomonas
putida) 		PF10778
(DehI) 		4 ALA A  68
ARG A 227
GLN A  67
GLU A  71
 None
 1.29A 1lquB-3bjxA:
undetectable		 1lquB-3bjxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 ALA A 250
ARG A 171
GLN A 246
GLU A  11
 None
 1.38A 1lquB-3cttA:
undetectable		 1lquB-3cttA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ALA A 560
ARG A 556
GLN A 561
GLU A 557
 None
 1.39A 1lquB-3fjoA:
undetectable		 1lquB-3fjoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 ALA A1345
ARG A1427
GLN A1348
GLU A1349
 None
 1.28A 1lquB-3fq8A:
undetectable		 1lquB-3fq8A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzu IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  42
ARG H  40
GLN H  45
GLU H  48
 None
 0.93A 1lquB-3fzuH:
undetectable		 1lquB-3fzuH:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkw HEAVY CHAIN OF THE
ANTIBODY NIMOTUZUMAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.96A 1lquB-3gkwH:
undetectable		 1lquB-3gkwH:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		4 ALA A  98
ARG A  79
GLN A  99
GLU A 104
 None
 1.26A 1lquB-3go4A:
undetectable		 1lquB-3go4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		4 ALA A  76
ARG A  60
GLN A  79
GLU A  80
 None
 1.22A 1lquB-3izkA:
undetectable		 1lquB-3izkA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0j V-TYPE ATP SYNTHASE,
SUBUNIT (VAPC-THERM)

(Thermus
thermophilus) 		PF16999
(V-ATPase_G_2) 		4 ALA I  71
ARG I  74
GLN I  72
GLU I  70
 None
 1.49A 1lquB-3j0jI:
undetectable		 1lquB-3j0jI:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF5

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ALA a 117
ARG a 113
GLN a 118
GLU a 114
 None
 1.42A 1lquB-3jb9a:
undetectable		 1lquB-3jb9a:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		4 ALA A 304
ARG A 307
GLN A 305
GLU A 306
 None
 1.24A 1lquB-3lkbA:
4.2		 1lquB-3lkbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qeg FAB FRAGMENT OF
HUMAN ANTI-HIV
ANTIBODY N12-I2,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.80A 1lquB-3qegH:
undetectable		 1lquB-3qegH:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 ALA A 303
ARG A 271
GLN A 306
GLU A 307
 None
 1.29A 1lquB-3ro2A:
undetectable		 1lquB-3ro2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0t PONEZUMAB HC FAB

(Homo sapiens) 		no annotation 4 ALA D  40
ARG D  38
GLN D  43
GLU D  46
 None
 0.96A 1lquB-3u0tD:
undetectable		 1lquB-3u0tD:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ALA A 190
ARG A 186
GLN A 197
GLU A 187
 None
 1.25A 1lquB-3vskA:
undetectable		 1lquB-3vskA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3f HEAVY CHAIN OF KMTR2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.90A 1lquB-3x3fH:
undetectable		 1lquB-3x3fH:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 NBKB6

(Lama glama) 		PF07686
(V-set) 		4 ALA B  40
ARG B  38
GLN B  39
GLU B  46
 None
 1.48A 1lquB-4aq1B:
undetectable		 1lquB-4aq1B:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN

(Escherichia
coli) 		PF05171
(HemS) 		4 ALA A 326
ARG A 329
GLN A 325
GLU A 324
 None
 1.28A 1lquB-4cdpA:
undetectable		 1lquB-4cdpA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxo ENDONUCLEASE 2

(Arabidopsis
thaliana) 		PF02265
(S1-P1_nuclease) 		4 ALA A 216
ARG A 246
GLN A 215
GLU A 212
 None
 1.19A 1lquB-4cxoA:
undetectable		 1lquB-4cxoA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ALA A 393
ARG A 337
GLN A 392
GLU A 373
 None
 1.48A 1lquB-4fozA:
undetectable		 1lquB-4fozA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fze N26_I1 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.83A 1lquB-4fzeH:
undetectable		 1lquB-4fzeH:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 ALA A 493
ARG A 475
GLN A 496
GLU A 494
 None
 0.97A 1lquB-4gfhA:
undetectable		 1lquB-4gfhA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbs PUTATIVE HYDROLASE

(Bacteroides
ovatus) 		PF16396
(DUF5005) 		4 ALA A 270
ARG A 268
GLN A 277
GLU A 279
 None
 1.43A 1lquB-4hbsA:
undetectable		 1lquB-4hbsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcr PF-547659 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.99A 1lquB-4hcrH:
undetectable		 1lquB-4hcrH:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3r HEAVY CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.93A 1lquB-4i3rH:
undetectable		 1lquB-4i3rH:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idj FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 1.08A 1lquB-4idjH:
undetectable		 1lquB-4idjH:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ALA A  40
ARG A  16
GLN A  41
GLU A  42
 None
 1.30A 1lquB-4iivA:
5.0		 1lquB-4iivA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpw HEAVY CHAIN OF
ANTIBODY 12A21

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  39
GLU H  46
 None
 1.49A 1lquB-4jpwH:
undetectable		 1lquB-4jpwH:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  40
ARG A  38
GLN A  43
GLU A  46
 None
 0.93A 1lquB-4jznA:
undetectable		 1lquB-4jznA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lle PROBABLE
TWO-COMPONENT SENSOR

(Pseudomonas
aeruginosa) 		PF16767
(KinB_sensor) 		4 ALA A  96
ARG A  95
GLN A  93
GLU A  92
 None
 1.44A 1lquB-4lleA:
undetectable		 1lquB-4lleA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.77A 1lquB-4lsqH:
undetectable		 1lquB-4lsqH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqt NANOBODY 9-8

(Lama glama) 		PF07686
(V-set) 		4 ALA B  43
ARG B  41
GLN B  46
GLU B  49
 None
 1.05A 1lquB-4mqtB:
undetectable		 1lquB-4mqtB:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc1 A20.1 VHH

(Lama glama) 		PF07686
(V-set) 		4 ALA C  99
ARG C  45
GLN C  46
GLU C  53
 None
 1.37A 1lquB-4nc1C:
undetectable		 1lquB-4nc1C:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nm4 ANTIBODY CR8043,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.87A 1lquB-4nm4H:
undetectable		 1lquB-4nm4H:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 1.01A 1lquB-4r96B:
undetectable		 1lquB-4r96B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ALA A 296
ARG A 447
GLN A 297
GLU A 461
 None
 1.19A 1lquB-4wboA:
undetectable		 1lquB-4wboA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ALA B 117
ARG B  63
GLN B  64
GLU B  71
 None
 1.36A 1lquB-4z0xB:
undetectable		 1lquB-4z0xB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d PINS

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 ALA B 326
ARG B 294
GLN B 329
GLU B 330
 None
 1.36A 1lquB-5a7dB:
undetectable		 1lquB-5a7dB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1x D4-30 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 0.92A 1lquB-5d1xB:
undetectable		 1lquB-5d1xB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk3 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 0.95A 1lquB-5dk3B:
undetectable		 1lquB-5dk3B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dr5 ABD09097 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  92
ARG H  38
GLN H  39
GLU H  46
 None
 1.45A 1lquB-5dr5H:
undetectable		 1lquB-5dr5H:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL31
UL34 PROTEIN

(Suid
alphaherpesvirus
1;
Suid
alphaherpesvirus
1) 		PF02718
(Herpes_UL31)
PF04541
(Herpes_U34) 		4 ALA A  37
ARG B   8
GLN A  38
GLU A  42
 None
 1.19A 1lquB-5e8cA:
undetectable		 1lquB-5e8cA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f96 HEAVY CHAIN OF
ANTIBODY CH235.12

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.93A 1lquB-5f96H:
undetectable		 1lquB-5f96H:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm1 LAMA VHH ANTIBODY
2E7

(Lama glama) 		PF07686
(V-set) 		4 ALA A  88
ARG A  38
GLN A  39
GLU A  46
 None
 1.39A 1lquB-5hm1A:
undetectable		 1lquB-5hm1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9q 3BNC55 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 0.60A 1lquB-5i9qB:
undetectable		 1lquB-5i9qB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpz SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 4 ALA A 327
ARG A 328
GLN A 330
GLU A 320
 None
 1.30A 1lquB-5jpzA:
undetectable		 1lquB-5jpzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxe PEMBROLIZUMAB FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA D  40
ARG D  38
GLN D  43
GLU D  46
 None
 0.80A 1lquB-5jxeD:
undetectable		 1lquB-5jxeD:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kan 16.G.07 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA G  40
ARG G  38
GLN G  43
GLU G  46
 None
 0.75A 1lquB-5kanG:
undetectable		 1lquB-5kanG:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  40
ARG A  38
GLN A  43
GLU A  46
 None
 0.78A 1lquB-5kn5A:
undetectable		 1lquB-5kn5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6y TRALOKINUMAB FAB
DIGEST VH

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.83A 1lquB-5l6yH:
undetectable		 1lquB-5l6yH:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ALA A 404
ARG A 405
GLN A 372
GLU A 371
 None
 1.18A 1lquB-5mzsA:
undetectable		 1lquB-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4g HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 1.14A 1lquB-5n4gH:
undetectable		 1lquB-5n4gH:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4j HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  39
ARG H  37
GLN H  42
GLU H  45
 None
 0.79A 1lquB-5n4jH:
undetectable		 1lquB-5n4jH:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp3 F-VHH-4

(Lama glama) 		PF07686
(V-set) 		4 ALA A  88
ARG A  38
GLN A  39
GLU A  46
 None
 1.34A 1lquB-5tp3A:
undetectable		 1lquB-5tp3A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT

(Homo sapiens) 		no annotation 4 ALA G  40
ARG G  38
GLN G  43
GLU G  46
 None
 0.79A 1lquB-5u0uG:
undetectable		 1lquB-5u0uG:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u68 MPE8

(Homo sapiens) 		PF07686
(V-set) 		4 ALA E 111
ARG E  57
GLN E  58
GLU E  65
 None
 1.38A 1lquB-5u68E:
undetectable		 1lquB-5u68E:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viy 8ANC195 G52K5 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA K  40
ARG K  38
GLN K  43
GLU K  46
 None
 0.90A 1lquB-5viyK:
undetectable		 1lquB-5viyK:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w08 K03.12 ANTIBODY
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA G  40
ARG G  38
GLN G  43
GLU G  46
 None
 0.90A 1lquB-5w08G:
undetectable		 1lquB-5w08G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl2 -

(-) 		no annotation 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.81A 1lquB-5wl2H:
undetectable		 1lquB-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5v ANTIBODY FAB AMMO1
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.99A 1lquB-6c5vH:
undetectable		 1lquB-6c5vH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 4 ALA A 172
ARG A 171
GLN A 176
GLU A 173
 None
 1.37A 1lquB-6f2tA:
undetectable		 1lquB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h0e -

(-) 		no annotation 4 ALA H  40
ARG H  38
GLN H  39
GLU H  46
 None
 1.49A 1lquB-6h0eH:
undetectable		 1lquB-6h0eH:
undetectable