SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQU_A_ACTA1426_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 ASP A  54
HIS A  55
ARG A 162
GLU A 212
 None
FAD  A 801 ( 4.9A)
None
None
 0.47A 1lquA-1e1kA:
50.1		 1lquA-1e1kA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 ASP A  56
HIS A  57
ARG A 164
GLU A 214
 ACT  A1869 (-3.7A)
ACT  A1869 (-3.7A)
None
ACT  A1869 (-2.6A)
 0.54A 1lquA-1lqtA:
64.3		 1lquA-1lqtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE

(Escherichia
coli) 		PF02567
(PhzC-PhzF) 		4 ASP A 209
HIS A 254
ARG A 202
GLU A 207
 None
 0.97A 1lquA-1qy9A:
undetectable		 1lquA-1qy9A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		4 ASP A 166
HIS A 106
ARG A 214
GLU A 162
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 (-2.2A)
 0.59A 1lquA-3c37A:
0.0		 1lquA-3c37A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A  49
HIS A  90
ARG A  35
GLU A  47
 None
 1.28A 1lquA-3gdcA:
0.0		 1lquA-3gdcA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ASP A  42
HIS A 362
ARG A  36
GLU A  44
 None
 1.49A 1lquA-4e2zA:
0.0		 1lquA-4e2zA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		4 ASP A 451
HIS A  19
ARG A 453
GLU A  17
 None
 1.00A 1lquA-4fqdA:
0.0		 1lquA-4fqdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il3 STE24P

(Saccharomyces
mikatae) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		4 ASP A 394
HIS A 297
ARG A 440
GLU A 390
 None
ZN  A 501 (-3.2A)
None
ZN  A 501 (-1.7A)
 0.79A 1lquA-4il3A:
0.0		 1lquA-4il3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ASP A3765
HIS A3775
ARG A3751
GLU A3763
 None
 1.37A 1lquA-4kc5A:
0.1		 1lquA-4kc5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		4 ASP C 382
HIS C 350
ARG C 357
GLU C 354
 None
 1.27A 1lquA-4xgcC:
undetectable		 1lquA-4xgcC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A1186
HIS A1249
ARG A1184
GLU A1247
 None
 0.87A 1lquA-5epgA:
undetectable		 1lquA-5epgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 ASP A 382
HIS A 512
ARG A 320
GLU A 515
 None
 1.44A 1lquA-5h5mA:
undetectable		 1lquA-5h5mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus sp.
GHH01) 		PF00793
(DAHP_synth_1)
PF01817
(CM_2) 		4 ASP A 293
HIS A 296
ARG A 150
GLU A 322
 None
MN  A 401 ( 3.5A)
None
MN  A 401 (-1.9A)
 1.43A 1lquA-5j6fA:
1.3		 1lquA-5j6fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		4 ASP A 419
HIS A 335
ARG A 465
GLU A 415
 None
ZN  A 517 (-3.2A)
None
ZN  A 517 (-2.1A)
 0.81A 1lquA-5sytA:
undetectable		 1lquA-5sytA:
21.48