SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQU_A_ACTA1423_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ARG A 103
LEU A  87
ASN A  84
VAL A  99
 NAG  A1348 (-3.9A)
None
None
None
 1.33A 1lquA-1h3jA:
0.0		 1lquA-1h3jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		4 ARG F 329
LEU F 436
ASN F 434
VAL F 326
 None
 1.42A 1lquA-1htjF:
undetectable		 1lquA-1htjF:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 ARG A 103
LEU A   9
ASN A  10
VAL A 117
 None
 1.49A 1lquA-1i9aA:
undetectable		 1lquA-1i9aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl7 MONOMER HEMOGLOBIN
COMPONENT III

(Glycera
dibranchiata) 		PF00042
(Globin) 		4 ARG A 117
LEU A  63
ASN A  22
VAL A  26
 None
 1.47A 1lquA-1jl7A:
undetectable		 1lquA-1jl7A:
16.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 ARG A 110
LEU A 112
ASN A 113
VAL A 322
 ACT  A1866 ( 2.5A)
ACT  A1866 (-4.1A)
ACT  A1866 (-4.4A)
ODP  A2458 ( 3.8A)
 0.03A 1lquA-1lqtA:
64.3		 1lquA-1lqtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 ARG B 205
LEU B  43
ASN B  40
VAL B 202
 None
 1.25A 1lquA-1wdwB:
2.2		 1lquA-1wdwB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 ARG 1 141
LEU 1 487
ASN 1 491
VAL 1 137
 None
 1.43A 1lquA-1y791:
2.5		 1lquA-1y791:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF06433
(Me-amine-dh_H) 		4 ARG A 175
LEU A 184
ASN A 180
VAL A 176
 None
 1.40A 1lquA-2i0sA:
undetectable		 1lquA-2i0sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwq MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ARG A1150
LEU A1202
ASN A1199
VAL A1239
 None
 1.38A 1lquA-2iwqA:
undetectable		 1lquA-2iwqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtp UNCHARACTERIZED
PROTEIN

(Ruegeria
pomeroyi) 		PF06684
(AA_synth) 		4 ARG A   5
LEU A 153
ASN A 154
VAL A  34
 None
 1.13A 1lquA-2qtpA:
undetectable		 1lquA-2qtpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 ARG A 141
LEU A 133
ASN A 135
VAL A 168
 None
 1.50A 1lquA-2v0jA:
2.7		 1lquA-2v0jA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ARG A 165
LEU A 180
ASN A 177
VAL A 157
 None
 0.97A 1lquA-2y3sA:
undetectable		 1lquA-2y3sA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ARG A 317
LEU A 331
ASN A 365
VAL A 316
 None
 1.04A 1lquA-2zyjA:
undetectable		 1lquA-2zyjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE

(Bacteroides
thetaiotaomicron) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ARG A  49
LEU A  36
ASN A  38
VAL A  54
 None
 1.34A 1lquA-3ct9A:
2.2		 1lquA-3ct9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 ARG A 323
LEU A 320
ASN A 319
VAL A 324
 None
 1.42A 1lquA-3e53A:
2.2		 1lquA-3e53A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0m CYSTEINE
DESULFURATION
PROTEIN SUFE

(Salmonella
enterica) 		PF02657
(SufE) 		4 ARG A  60
LEU A  37
ASN A  38
VAL A  58
 None
 1.37A 1lquA-3g0mA:
undetectable		 1lquA-3g0mA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		4 ARG A  20
LEU A  77
ASN A  76
VAL A  16
 None
 1.41A 1lquA-3gl5A:
undetectable		 1lquA-3gl5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwt 178AA LONG
HYPOTHETICAL
MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Sulfurisphaera
tokodaii) 		PF00994
(MoCF_biosynth) 		4 ARG A 177
LEU A  16
ASN A  17
VAL A 173
 None
 1.28A 1lquA-3iwtA:
5.4		 1lquA-3iwtA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		4 ARG A  60
LEU A  49
ASN A  48
VAL A  57
 None
 1.25A 1lquA-3qtgA:
undetectable		 1lquA-3qtgA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 ARG A 873
LEU A 874
ASN A 877
VAL A 870
 None
 1.36A 1lquA-3ux8A:
undetectable		 1lquA-3ux8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 ARG A 270
LEU A 306
ASN A 307
VAL A 340
 None
 1.49A 1lquA-4b46A:
3.3		 1lquA-4b46A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ARG A1259
LEU A1331
ASN A1329
VAL A1340
 None
 1.27A 1lquA-4bedA:
undetectable		 1lquA-4bedA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans) 		PF10275
(Peptidase_C65) 		4 ARG B  80
LEU B 160
ASN B 161
VAL B  95
 None
 1.29A 1lquA-4dhiB:
undetectable		 1lquA-4dhiB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans;
Homo sapiens) 		PF10275
(Peptidase_C65) 		4 ARG A  80
LEU A 160
ASN A 161
VAL A  95
 None
 1.18A 1lquA-4dhzA:
undetectable		 1lquA-4dhzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqz GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A  36
LEU A   3
ASN A 192
VAL A  34
 None
 1.08A 1lquA-4fqzA:
undetectable		 1lquA-4fqzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
NAD-BINDING

(Dyadobacter
fermentans) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ARG A 128
LEU A  13
ASN A  12
VAL A 127
 None
 1.23A 1lquA-4gbjA:
undetectable		 1lquA-4gbjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		4 ARG A 688
LEU A 654
ASN A 655
VAL A 689
 None
 1.08A 1lquA-4oe1A:
undetectable		 1lquA-4oe1A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 232
LEU A  49
ASN A  48
VAL A 104
 None
 1.18A 1lquA-4rvwA:
undetectable		 1lquA-4rvwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 ARG L 312
LEU L 116
ASN L 113
VAL L 475
 None
 1.30A 1lquA-4u9iL:
undetectable		 1lquA-4u9iL:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvf SITE-DETERMINING
PROTEIN

(Pseudomonas
aeruginosa) 		PF10609
(ParA) 		4 ARG A 260
LEU A 121
ASN A 120
VAL A  10
 None
None
None
IOD  A 302 (-4.5A)
 1.38A 1lquA-5jvfA:
3.3		 1lquA-5jvfA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40)
PF11816
(DUF3337) 		4 ARG B 655
LEU B 462
ASN B 461
VAL B 416
 None
 1.18A 1lquA-5k1bB:
undetectable		 1lquA-5k1bB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		4 ARG B 214
LEU B  52
ASN B  49
VAL B 211
 None
 1.29A 1lquA-5kinB:
1.6		 1lquA-5kinB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 ARG C3734
LEU C3680
ASN C3679
VAL C3728
 None
 1.26A 1lquA-5y3rC:
undetectable		 1lquA-5y3rC:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 4 ARG A 511
LEU A 477
ASN A 479
VAL A 508
 None
 1.43A 1lquA-5yemA:
5.2		 1lquA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 ARG X 213
LEU X 209
ASN X 206
VAL X 180
 None
 1.32A 1lquA-6elqX:
3.4		 1lquA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exc ICMP (DOTM)

(Legionella
pneumophila) 		no annotation 4 ARG A 202
LEU A 174
ASN A 173
VAL A 203
 None
 1.45A 1lquA-6excA:
undetectable		 1lquA-6excA:
undetectable