SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQT_B_ACTB1868_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b2h | PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN (Salmonellaenterica) |
PF00496(SBP_bac_5) | 3 | ALA A 90HIS A 91VAL A 94 | None | 0.41A | 1lqtB-1b2hA:undetectable | 1lqtB-1b2hA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4k | PROTEIN (ORNITHINEDECARBOXYLASE) (Lactobacillussp. 30A) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 3 | ALA A 299HIS A 300VAL A 303 | None | 0.36A | 1lqtB-1c4kA:2.1 | 1lqtB-1c4kA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7g | TYROSINEPHENOL-LYASE (Pantoeaagglomerans) |
PF01212(Beta_elim_lyase) | 3 | ALA A 415HIS A 416VAL A 419 | None | 0.31A | 1lqtB-1c7gA:undetectable | 1lqtB-1c7gA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e0t | PYRUVATE KINASE (Escherichiacoli) |
PF00224(PK)PF02887(PK_C) | 3 | ALA A 406HIS A 407VAL A 410 | None | 0.45A | 1lqtB-1e0tA:undetectable | 1lqtB-1e0tA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htj | KIAA0380 (Homo sapiens) |
PF09128(RGS-like) | 3 | ALA F 322HIS F 323VAL F 326 | None | 0.28A | 1lqtB-1htjF:undetectable | 1lqtB-1htjF:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lgh | LIGHT HARVESTINGCOMPLEX II (Phaeospirillummolischianum) |
PF00556(LHC) | 3 | ALA B 34HIS B 35VAL B 38 | BCL A 57 ( 3.7A)BCL B 59 (-3.5A)DET B 77 ( 4.5A) | 0.32A | 1lqtB-1lghB:undetectable | 1lqtB-1lghB:6.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhm | S-ADENOSYLMETHIONINEDECARBOXYLASE (Solanumtuberosum) |
PF01536(SAM_decarbox) | 3 | ALA A 208HIS A 209VAL A 212 | None | 0.36A | 1lqtB-1mhmA:undetectable | 1lqtB-1mhmA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oah | CYTOCHROME C NITRITEREDUCTASE (Desulfovibriodesulfuricans) |
PF02335(Cytochrom_C552) | 3 | ALA A 386HIS A 387VAL A 390 | None | 0.32A | 1lqtB-1oahA:undetectable | 1lqtB-1oahA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p5q | FK506-BINDINGPROTEIN 4 (Homo sapiens) |
PF00254(FKBP_C)PF00515(TPR_1)PF07719(TPR_2) | 3 | ALA A 362HIS A 363VAL A 366 | None | 0.35A | 1lqtB-1p5qA:undetectable | 1lqtB-1p5qA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t90 | PROBABLEMETHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Bacillussubtilis) |
PF00171(Aldedh) | 3 | ALA A 208HIS A 209VAL A 212 | NoneNAD A1490 (-3.5A)NAD A1490 (-4.5A) | 0.50A | 1lqtB-1t90A:2.8 | 1lqtB-1t90A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tl7 | ADENYLATE CYCLASE,TYPE V (Canis lupus) |
PF00211(Guanylate_cyc) | 3 | ALA A 456HIS A 457VAL A 460 | None | 0.46A | 1lqtB-1tl7A:undetectable | 1lqtB-1tl7A:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufr | PYR MRNA-BINDINGATTENUATION PROTEIN (Thermusthermophilus) |
PF00156(Pribosyltran) | 3 | ALA A 21HIS A 22VAL A 25 | None | 0.26A | 1lqtB-1ufrA:undetectable | 1lqtB-1ufrA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uz4 | MAN5A (Cellvibriomixtus) |
PF00150(Cellulase) | 3 | ALA A 314HIS A 315VAL A 318 | None | 0.42A | 1lqtB-1uz4A:undetectable | 1lqtB-1uz4A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wn2 | PEPTIDYL-TRNAHYDROLASE (Pyrococcushorikoshii) |
PF01981(PTH2) | 3 | ALA A 29HIS A 30VAL A 33 | None | 0.50A | 1lqtB-1wn2A:undetectable | 1lqtB-1wn2A:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xrc | S-ADENOSYLMETHIONINESYNTHETASE (Escherichiacoli) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 3 | ALA A 141HIS A 142VAL A 145 | None | 0.43A | 1lqtB-1xrcA:undetectable | 1lqtB-1xrcA:24.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z72 | TRANSCRIPTIONALREGULATOR, PUTATIVE (Streptococcuspneumoniae) |
PF03070(TENA_THI-4) | 3 | ALA A 136HIS A 137VAL A 140 | None | 0.49A | 1lqtB-1z72A:undetectable | 1lqtB-1z72A:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d2n | GIANT HEMOGLOBIN,B2(C) GLOBIN CHAIN (Oligobrachiamashikoi) |
PF00042(Globin) | 3 | ALA C 107HIS C 108VAL C 111 | NoneHEM C 200 (-3.9A)None | 0.45A | 1lqtB-2d2nC:undetectable | 1lqtB-2d2nC:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3e | DEFENSIN, MUTANTDEF-BBB (Anophelesgambiae) |
PF01097(Defensin_2) | 3 | ALA A 22HIS A 23VAL A 26 | None | 0.32A | 1lqtB-2e3eA:undetectable | 1lqtB-2e3eA:7.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fxv | XANTHINEPHOSPHORIBOSYLTRANSFERASE (Bacillussubtilis) |
PF00156(Pribosyltran) | 3 | ALA A 133HIS A 134VAL A 137 | None | 0.49A | 1lqtB-2fxvA:undetectable | 1lqtB-2fxvA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gnw | NON-SYMBIOTICHEMOGLOBIN 1 (Oryza sativa) |
PF00042(Globin) | 3 | ALA A 116HIS A 117VAL A 120 | NoneHEM A 166 (-4.8A)None | 0.48A | 1lqtB-2gnwA:undetectable | 1lqtB-2gnwA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h29 | PROBABLENICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Staphylococcusaureus) |
PF01467(CTP_transf_like) | 3 | ALA A 17HIS A 18VAL A 21 | DND A 998 (-3.1A)DND A 998 ( 4.6A)None | 0.34A | 1lqtB-2h29A:undetectable | 1lqtB-2h29A:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hfs | MEVALONATE KINASE,PUTATIVE (Leishmaniamajor) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 3 | ALA A 78HIS A 79VAL A 82 | None | 0.19A | 1lqtB-2hfsA:undetectable | 1lqtB-2hfsA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hro | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Staphylococcuscarnosus) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 3 | ALA A 76HIS A 77VAL A 80 | None | 0.47A | 1lqtB-2hroA:undetectable | 1lqtB-2hroA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7a | CYTOCHROME C NITRITEREDUCTASE NRFA (Desulfovibriovulgaris) |
PF02335(Cytochrom_C552) | 3 | ALA A 386HIS A 387VAL A 390 | None | 0.39A | 1lqtB-2j7aA:undetectable | 1lqtB-2j7aA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oqh | PUTATIVE ISOMERASE (Streptomycescoelicolor) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ALA A 308HIS A 309VAL A 312 | None | 0.50A | 1lqtB-2oqhA:undetectable | 1lqtB-2oqhA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pff | FATTY ACID SYNTHASESUBUNIT BETA (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF16073(SAT) | 3 | ALA B 247HIS B 248VAL B 251 | None | 0.52A | 1lqtB-2pffB:undetectable | 1lqtB-2pffB:9.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qrw | HEMOGLOBIN-LIKEPROTEIN HBO (Mycobacteriumtuberculosis) |
PF01152(Bac_globin) | 3 | ALA A 120HIS A 121VAL A 124 | HEM A 700 (-3.8A)NoneNone | 0.44A | 1lqtB-2qrwA:undetectable | 1lqtB-2qrwA:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt3 | N-ISOPROPYLAMMELIDEISOPROPYLAMIDOHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 3 | ALA A 111HIS A 112VAL A 115 | None | 0.42A | 1lqtB-2qt3A:undetectable | 1lqtB-2qt3A:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5u | REPLICATIVE DNAHELICASE (Mycobacteriumtuberculosis) |
PF00772(DnaB) | 3 | ALA A 61HIS A 62VAL A 65 | None | 0.28A | 1lqtB-2r5uA:undetectable | 1lqtB-2r5uA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vos | FOLYLPOLYGLUTAMATESYNTHASE PROTEINFOLC (Mycobacteriumtuberculosis) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 3 | ALA A 301HIS A 302VAL A 305 | None | 0.34A | 1lqtB-2vosA:4.0 | 1lqtB-2vosA:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w31 | GLOBIN (Geobactersulfurreducens) |
PF11563(Protoglobin) | 3 | ALA A 92HIS A 93VAL A 96 | HEM A 200 ( 3.8A)HEM A 200 (-3.5A)HEM A 200 (-4.6A) | 0.48A | 1lqtB-2w31A:undetectable | 1lqtB-2w31A:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wan | PULLULANASE (Bacillusacidopullulyticus) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 3 | ALA A 763HIS A 764VAL A 767 | None | 0.47A | 1lqtB-2wanA:undetectable | 1lqtB-2wanA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqd | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Staphylococcusaureus) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 3 | ALA A 77HIS A 78VAL A 81 | None | 0.27A | 1lqtB-2wqdA:undetectable | 1lqtB-2wqdA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 3 | ALA A 332HIS A 333VAL A 336 | None | 0.30A | 1lqtB-3ai7A:2.5 | 1lqtB-3ai7A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bv4 | FRUCTOSE-BISPHOSPHATE ALDOLASE A (Oryctolaguscuniculus) |
PF00274(Glycolytic) | 3 | ALA A 19HIS A 20VAL A 23 | None | 0.49A | 1lqtB-3bv4A:undetectable | 1lqtB-3bv4A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e74 | ALLANTOINASE (Escherichiacoli) |
PF01979(Amidohydro_1) | 3 | ALA A 208HIS A 209VAL A 212 | None | 0.41A | 1lqtB-3e74A:undetectable | 1lqtB-3e74A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5q | PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (Staphylococcusaureus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 3 | ALA A 218HIS A 219VAL A 222 | None | 0.47A | 1lqtB-3h5qA:2.1 | 1lqtB-3h5qA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hyv | SULFIDE-QUINONEREDUCTASE (Aquifexaeolicus) |
PF07992(Pyr_redox_2) | 3 | ALA A 325HIS A 326VAL A 329 | None | 0.49A | 1lqtB-3hyvA:8.2 | 1lqtB-3hyvA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3u | LIGNIN PEROXIDASE (Trametopsiscervina) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | ALA A 38HIS A 39VAL A 42 | NoneHEM A 338 (-4.6A)HEM A 338 ( 4.3A) | 0.26A | 1lqtB-3q3uA:undetectable | 1lqtB-3q3uA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r31 | BETAINE ALDEHYDEDEHYDROGENASE (Agrobacteriumfabrum) |
PF00171(Aldedh) | 3 | ALA A 432HIS A 433VAL A 436 | None | 0.33A | 1lqtB-3r31A:3.1 | 1lqtB-3r31A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjt | LIPOLYTIC PROTEING-D-S-L FAMILY (Alicyclobacillusacidocaldarius) |
PF13472(Lipase_GDSL_2) | 3 | ALA A 42HIS A 43VAL A 46 | None | 0.50A | 1lqtB-3rjtA:undetectable | 1lqtB-3rjtA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s55 | PUTATIVE SHORT-CHAINDEHYDROGENASE/REDUCTASE (Mycobacteroidesabscessus) |
PF00106(adh_short) | 3 | ALA A 183HIS A 184VAL A 187 | None | 0.51A | 1lqtB-3s55A:5.2 | 1lqtB-3s55A:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubl | GLUTATHIONETRANSFERASE (Leptospirainterrogans) |
PF13417(GST_N_3) | 3 | ALA A 158HIS A 159VAL A 162 | None | 0.30A | 1lqtB-3ublA:undetectable | 1lqtB-3ublA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vdg | PROBABLE GLUCARATEDEHYDRATASE (Mycolicibacteriumsmegmatis) |
PF13378(MR_MLE_C) | 3 | ALA A 67HIS A 68VAL A 71 | None | 0.27A | 1lqtB-3vdgA:undetectable | 1lqtB-3vdgA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0s | HYGROMYCIN-B4-O-KINASE (Escherichiacoli) |
PF01636(APH) | 3 | ALA A 123HIS A 193VAL A 195 | None | 0.47A | 1lqtB-3w0sA:undetectable | 1lqtB-3w0sA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjo | OCTAPRENYLDIPHOSPHATE SYNTHASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 3 | ALA A 315HIS A 316VAL A 319 | None | 0.38A | 1lqtB-3wjoA:undetectable | 1lqtB-3wjoA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zcj | CAGL (Helicobacterpylori) |
no annotation | 3 | ALA A 199HIS A 200VAL A 203 | MLY A 195 ( 3.7A)NoneMLY A 202 ( 3.3A) | 0.39A | 1lqtB-3zcjA:undetectable | 1lqtB-3zcjA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zib | RAP2A SMA2265 (Serratiamarcescens) |
PF16695(Tai4) | 3 | ALA A 73HIS A 74VAL A 77 | None | 0.36A | 1lqtB-3zibA:undetectable | 1lqtB-3zibA:12.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bb9 | GLUCOKINASEREGULATORY PROTEIN (Homo sapiens) |
no annotation | 3 | ALA A 277HIS A 278VAL A 281 | None | 0.51A | 1lqtB-4bb9A:2.2 | 1lqtB-4bb9A:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ber | PHOSPHOCHOLINETRANSFERASE ANKX (Legionellapneumophila) |
PF02661(Fic)PF12796(Ank_2) | 3 | ALA A 396HIS A 397VAL A 400 | None | 0.44A | 1lqtB-4berA:undetectable | 1lqtB-4berA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cob | KYNURENINEFORMAMIDASE (Pseudomonasaeruginosa) |
PF04199(Cyclase) | 3 | ALA A 160HIS A 161VAL A 164 | None ZN A 401 (-3.4A)None | 0.37A | 1lqtB-4cobA:undetectable | 1lqtB-4cobA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cog | KYNURENINEFORMAMIDASE (Burkholderiacenocepacia) |
PF04199(Cyclase) | 3 | ALA A 159HIS A 160VAL A 163 | None ZN A 401 ( 3.3A)None | 0.44A | 1lqtB-4cogA:undetectable | 1lqtB-4cogA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cqm | CARBONYL REDUCTASEFAMILY MEMBER 4 (Homo sapiens) |
PF13561(adh_short_C2) | 3 | ALA B 210HIS B 211VAL B 214 | None | 0.50A | 1lqtB-4cqmB:5.6 | 1lqtB-4cqmB:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvm | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D- ALANINE LIGASE (Pseudomonasaeruginosa) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 3 | ALA A 378HIS A 379VAL A 382 | None | 0.36A | 1lqtB-4cvmA:3.9 | 1lqtB-4cvmA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dvj | PUTATIVEZINC-DEPENDENTALCOHOLDEHYDROGENASEPROTEIN (Rhizobium etli) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 3 | ALA A 341HIS A 342VAL A 345 | None | 0.48A | 1lqtB-4dvjA:3.2 | 1lqtB-4dvjA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fu0 | D-ALANINE--D-ALANINELIGASE 7 (Enterococcusfaecalis) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 3 | ALA A 143HIS A 144VAL A 147 | None | 0.45A | 1lqtB-4fu0A:undetectable | 1lqtB-4fu0A:24.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gpc | HEME OXYGENASE (Corynebacteriumdiphtheriae) |
PF01126(Heme_oxygenase) | 3 | ALA A 127HIS A 128VAL A 131 | NoneNoneBLA A 901 (-4.4A) | 0.35A | 1lqtB-4gpcA:undetectable | 1lqtB-4gpcA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gr4 | NON-RIBOSOMALPEPTIDE SYNTHETASE (Streptomyceslydicus) |
PF00501(AMP-binding)PF03621(MbtH) | 3 | ALA A 111HIS A 112VAL A 115 | None | 0.39A | 1lqtB-4gr4A:undetectable | 1lqtB-4gr4A:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gr5 | NON-RIBOSOMALPEPTIDE SYNTHETASE (Streptomyceslydicus) |
PF00501(AMP-binding)PF03621(MbtH) | 3 | ALA A 111HIS A 112VAL A 115 | None | 0.39A | 1lqtB-4gr5A:undetectable | 1lqtB-4gr5A:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7a | CRISPR-ASSOCIATEDPROTEIN CSE2 (Thermusthermophilus) |
PF09485(CRISPR_Cse2) | 3 | ALA A 61HIS A 62VAL A 65 | None | 0.31A | 1lqtB-4h7aA:undetectable | 1lqtB-4h7aA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3m | AEROTAXIS TRANSDUCERAER2 (Pseudomonasaeruginosa) |
no annotation | 3 | ALA A 110HIS A 111VAL A 114 | None | 0.36A | 1lqtB-4i3mA:undetectable | 1lqtB-4i3mA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4icq | AMINOPEPTIDASE PEPS (Streptococcuspneumoniae) |
PF02073(Peptidase_M29) | 3 | ALA A 42HIS A 43VAL A 46 | None | 0.45A | 1lqtB-4icqA:undetectable | 1lqtB-4icqA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxy | TRANS-HEXAPRENYLTRANSTRANSFERASE (Pseudoalteromonasatlantica) |
PF00348(polyprenyl_synt) | 3 | ALA A 315HIS A 316VAL A 319 | None | 0.41A | 1lqtB-4jxyA:undetectable | 1lqtB-4jxyA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lc9 | GLUCOKINASEREGULATORY PROTEIN (Rattusnorvegicus) |
no annotation | 3 | ALA A 277HIS A 278VAL A 281 | None | 0.25A | 1lqtB-4lc9A:2.0 | 1lqtB-4lc9A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4li0 | GUANINE NUCLEOTIDEEXCHANGE FACTOR FORRAB-3A (Homo sapiens) |
PF06428(Sec2p) | 3 | ALA C 122HIS C 123VAL C 126 | None | 0.29A | 1lqtB-4li0C:undetectable | 1lqtB-4li0C:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovb | PROTEIN OSA (Shigellaflexneri) |
no annotation | 3 | ALA A 106HIS A 107VAL A 110 | NoneAUC A 203 (-3.7A)None | 0.25A | 1lqtB-4ovbA:undetectable | 1lqtB-4ovbA:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q73 | PROLINEDEHYDROGENASE (Bradyrhizobiumdiazoefficiens) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 3 | ALA A 550HIS A 551VAL A 554 | None | 0.52A | 1lqtB-4q73A:undetectable | 1lqtB-4q73A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmh | LP04448P (Drosophilamelanogaster) |
PF12348(CLASP_N) | 3 | ALA A 906HIS A 907VAL A 910 | None | 0.39A | 1lqtB-4qmhA:undetectable | 1lqtB-4qmhA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uds | MBDR REGULATOR (Azoarcus sp.CIB) |
PF00440(TetR_N) | 3 | ALA A 172HIS A 173VAL A 176 | None | 0.41A | 1lqtB-4udsA:undetectable | 1lqtB-4udsA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x28 | ACYL-COADEHYDROGENASE (Mycobacteriumtuberculosis) |
no annotation | 3 | ALA D 322HIS D 323VAL D 326 | None | 0.24A | 1lqtB-4x28D:undetectable | 1lqtB-4x28D:25.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuv | GLYCOSIDE HYDROLASEFAMILY 105 PROTEIN (Thielaviaterrestris) |
PF07470(Glyco_hydro_88) | 3 | ALA A 74HIS A 75VAL A 78 | None | 0.25A | 1lqtB-4xuvA:undetectable | 1lqtB-4xuvA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y96 | TRIOSEPHOSPHATEISOMERASE (Gemmataobscuriglobus) |
PF00121(TIM) | 3 | ALA A 190HIS A 191VAL A 194 | None | 0.37A | 1lqtB-4y96A:undetectable | 1lqtB-4y96A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5do7 | ATP-BINDING CASSETTESUB-FAMILY G MEMBER8 (Homo sapiens) |
PF00005(ABC_tran)PF01061(ABC2_membrane) | 3 | ALA B 248HIS B 249VAL B 252 | None | 0.50A | 1lqtB-5do7B:undetectable | 1lqtB-5do7B:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ffq | SHUY-LIKE PROTEIN (Escherichiacoli) |
PF13460(NAD_binding_10) | 3 | ALA A 85HIS A 86VAL A 89 | None | 0.42A | 1lqtB-5ffqA:5.1 | 1lqtB-5ffqA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fya | PATATIN-LIKEPROTEIN, PLPD (Pseudomonasaeruginosa) |
PF01734(Patatin) | 3 | ALA A 38HIS A 39VAL A 42 | None | 0.45A | 1lqtB-5fyaA:undetectable | 1lqtB-5fyaA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gwe | CYTOCHROME P450 (Corynebacteriumglutamicum) |
PF00067(p450) | 3 | ALA A 238HIS A 239VAL A 242 | None | 0.31A | 1lqtB-5gweA:undetectable | 1lqtB-5gweA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h1a | ICLR TRANSCRIPTIONFACTOR HOMOLOG (Microbacteriumsp.) |
PF01614(IclR)PF09339(HTH_IclR) | 3 | ALA A 44HIS A 45VAL A 48 | None | 0.49A | 1lqtB-5h1aA:undetectable | 1lqtB-5h1aA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikp | GLYCOGENPHOSPHORYLASE, BRAINFORM (Homo sapiens) |
PF00343(Phosphorylase) | 3 | ALA A 442HIS A 443VAL A 446 | None | 0.00A | 1lqtB-5ikpA:3.8 | 1lqtB-5ikpA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ipw | OLIGOPEPTIDE ABCTRANSPORTER,PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN, PUTATIVE (Thermotogamaritima) |
PF00496(SBP_bac_5) | 3 | ALA A 155HIS A 156VAL A 159 | None | 0.42A | 1lqtB-5ipwA:undetectable | 1lqtB-5ipwA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jm7 | AEROBACTIN SYNTHASEIUCA (Klebsiellapneumoniae) |
PF04183(IucA_IucC)PF06276(FhuF) | 3 | ALA A 396HIS A 397VAL A 400 | None | 0.31A | 1lqtB-5jm7A:undetectable | 1lqtB-5jm7A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ks8 | PYRUVATE CARBOXYLASESUBUNIT ALPHA (Methylobacillusflagellatus) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | ALA A 62HIS A 63VAL A 66 | None | 0.34A | 1lqtB-5ks8A:3.3 | 1lqtB-5ks8A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzl | HEME OXYGENASE (Leptospirainterrogans) |
PF01126(Heme_oxygenase) | 3 | ALA A 120HIS A 121VAL A 124 | NoneNoneHEM A 301 (-4.4A) | 0.42A | 1lqtB-5kzlA:undetectable | 1lqtB-5kzlA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5llt | NICOTINATE-NUCLEOTIDEADENYLYLTRANSFERASE (Plasmodiumfalciparum) |
PF01467(CTP_transf_like) | 3 | ALA A 19HIS A 20VAL A 23 | DND A 301 (-3.1A)DND A 301 (-4.2A)None | 0.31A | 1lqtB-5lltA:2.8 | 1lqtB-5lltA:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nr1 | FTSZ-BINDING PROTEINFZLA (Caulobactervibrioides) |
PF00043(GST_C)PF13417(GST_N_3) | 3 | ALA A 174HIS A 175VAL A 178 | None | 0.19A | 1lqtB-5nr1A:undetectable | 1lqtB-5nr1A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 3 | ALA A4005HIS A4006VAL A4009 | None | 0.40A | 1lqtB-5nugA:undetectable | 1lqtB-5nugA:7.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy0 | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Synechocystissp. PCC 6803) |
no annotation | 3 | ALA b 708HIS b 709VAL b 712 | CLA b1842 ( 3.9A)CLA b1842 (-3.9A)LMG b1851 (-4.5A) | 0.37A | 1lqtB-5oy0b:undetectable | 1lqtB-5oy0b:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tck | UNCHARACTERIZEDPROTEIN (Leishmaniadonovani) |
PF00439(Bromodomain) | 3 | ALA A 274HIS A 275VAL A 278 | None | 0.51A | 1lqtB-5tckA:undetectable | 1lqtB-5tckA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tqm | CINNAMOYL-COAREDUCTASE (Sorghum bicolor) |
PF01370(Epimerase) | 3 | ALA A 256HIS A 257VAL A 260 | None | 0.45A | 1lqtB-5tqmA:5.3 | 1lqtB-5tqmA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhk | O-GLCNACASETIM-BARREL DOMAIN (Homo sapiens) |
PF07555(NAGidase) | 3 | ALA A 192HIS A 193VAL A 196 | None | 0.32A | 1lqtB-5uhkA:undetectable | 1lqtB-5uhkA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhp | O-GLCNACASETIM-BARREL DOMAIN (Homo sapiens) |
PF07555(NAGidase) | 3 | ALA A 192HIS A 193VAL A 196 | None | 0.40A | 1lqtB-5uhpA:undetectable | 1lqtB-5uhpA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8k | P800 REACTION CENTERCORE PROTEIN (Heliobacteriummodesticaldum) |
PF00223(PsaA_PsaB) | 3 | ALA A 564HIS A 565VAL A 568 | GBF A1027 (-2.7A)GBF A1027 (-3.6A)GBF A1027 ( 4.3A) | 0.14A | 1lqtB-5v8kA:undetectable | 1lqtB-5v8kA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vev | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Neisseriagonorrhoeae) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 3 | ALA A 129HIS A 130VAL A 133 | None | 0.27A | 1lqtB-5vevA:5.0 | 1lqtB-5vevA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vvo | PROTEIN O-GLCNACASE (Homo sapiens) |
PF07555(NAGidase) | 3 | ALA A 192HIS A 193VAL A 196 | None | 0.34A | 1lqtB-5vvoA:undetectable | 1lqtB-5vvoA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wab | PUTATIVEBETA-GLUCOSIDASE (Bifidobacteriumadolescentis) |
no annotation | 3 | ALA A 303HIS A 304VAL A 307 | None | 0.29A | 1lqtB-5wabA:undetectable | 1lqtB-5wabA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wvb | CHITINASE (Ostriniafurnacalis) |
no annotation | 3 | ALA A 320HIS A 321VAL A 324 | None | 0.45A | 1lqtB-5wvbA:undetectable | 1lqtB-5wvbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjn | CYTOCHROME P450 (Corynebacteriumglutamicum) |
PF00067(p450) | 3 | ALA A 211HIS A 212VAL A 215 | None | 0.34A | 1lqtB-5xjnA:undetectable | 1lqtB-5xjnA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zq4 | SIDE (Legionellapneumophila) |
no annotation | 3 | ALA B 395HIS B 396VAL B 399 | None | 0.51A | 1lqtB-5zq4B:undetectable | 1lqtB-5zq4B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ar3 | GSI-IIC RT (Geobacillusstearothermophilus) |
no annotation | 3 | ALA A 116HIS A 117VAL A 120 | None | 0.29A | 1lqtB-6ar3A:undetectable | 1lqtB-6ar3A:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3b | APRAMETHYLTRANSFERASE 1 (Mooreabouillonii) |
no annotation | 3 | ALA A 9HIS A 10VAL A 13 | None | 0.41A | 1lqtB-6b3bA:undetectable | 1lqtB-6b3bA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6btm | ALTERNATIVE COMPLEXIII SUBUNIT D (Flavobacteriumjohnsoniae) |
no annotation | 3 | ALA D 112HIS D 113VAL D 116 | None | 0.43A | 1lqtB-6btmD:undetectable | 1lqtB-6btmD:undetectable |