SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQT_A_ACTA1870

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 HIS A  57
PRO A  58
LYS A  59
ILE A  60
 ACT  A1869 (-3.7A)
ACT  A1870 (-3.3A)
ACT  A1870 (-4.8A)
FAD  A2457 ( 3.5A)
 0.31A 1lqtA-1lqtA:
66.0		 1lqtA-1lqtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3r DISABLED HOMOLOG 2

(Mus musculus) 		PF00640
(PID) 		4 HIS A 116
PRO A 117
LYS A 120
ILE A 121
 None
 0.75A 1lqtA-1p3rA:
0.0		 1lqtA-1p3rA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		4 HIS A 202
PRO A 203
LYS A 348
ILE A 347
 None
 1.28A 1lqtA-1vheA:
3.0		 1lqtA-1vheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htd PREDICTED
FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN FROM
COG3576 FAMILY
STRUCTURALLY RELATED
TO PYRIDOXINE
5'-PHOSPHATE OXIDASE

(Lactobacillus
delbrueckii) 		PF01243
(Putative_PNPOx) 		4 HIS A  48
PRO A  46
LYS A   8
ILE A 116
 None
None
SO4  A 123 (-2.8A)
None
 1.01A 1lqtA-2htdA:
undetectable		 1lqtA-2htdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		4 HIS A 107
PRO A 102
LYS A 103
ILE A 104
 None
 1.49A 1lqtA-2jjqA:
3.0		 1lqtA-2jjqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum) 		PF05368
(NmrA) 		4 HIS A  32
PRO A  33
LYS A   9
ILE A  10
 None
 1.34A 1lqtA-2qw8A:
6.6		 1lqtA-2qw8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4v FOLLISTATIN-LIKE 3

(Homo sapiens) 		PF07648
(Kazal_2)
PF09289
(FOLN) 		4 HIS C  50
PRO C  51
LYS C  54
ILE C  55
 None
 1.40A 1lqtA-3b4vC:
0.0		 1lqtA-3b4vC:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		4 HIS A  26
PRO A  27
LYS A   3
ILE A   4
 None
 1.40A 1lqtA-3c1oA:
6.6		 1lqtA-3c1oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 HIS A 790
PRO A 791
LYS A 792
ILE A 793
 None
 0.77A 1lqtA-3s9vA:
0.2		 1lqtA-3s9vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jry SB47 TCR ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 HIS D  96
PRO D 126
LYS D 125
ILE D 124
 None
 1.36A 1lqtA-4jryD:
undetectable		 1lqtA-4jryD:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pyrococcus
horikoshii) 		PF01867
(Cas_Cas1) 		4 HIS A 285
PRO A 286
LYS A 287
ILE A 288
 None
 1.15A 1lqtA-4wj0A:
undetectable		 1lqtA-4wj0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo4 DEPHOSPHO-COA KINASE

(Campylobacter
jejuni) 		PF01121
(CoaE) 		4 HIS A  90
PRO A  91
LYS A  92
ILE A  93
 None
 0.99A 1lqtA-4zo4A:
2.5		 1lqtA-4zo4A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv9 UNCONVENTIONAL
MYOSIN-VIIA

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 HIS A2152
PRO A2153
LYS A2156
ILE A2157
 None
 1.29A 1lqtA-5mv9A:
undetectable		 1lqtA-5mv9A:
22.51